• Interaction Score: 0.95

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Details of Interaction IC<sub>50</sub> for ROS1<sup>G2032R</sup> is 0.5 nM, and for ROS1<sup>D2033N</sup> is 0.2 nM
    Endogenous Drug? False

  • Interaction Score: 0.79

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Details of Interaction IC<sub>50</sub> for TRKC<sup>G623R</sup> is 4.5 nM.
    Endogenous Drug? False

  • Interaction Score: 0.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Details of Interaction IC<sub>50</sub> for TRKB<sup>G639R</sup> is 2.7 nM
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Details of Interaction IC<sub>50</sub> for ALK<sup>G1202R</sup> is 1.2 nM.
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Details of Interaction IC<sub>50</sub> for TRKA<sup>G595R</sup> is 2.7 nM
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found