DGIdb - RESERPINE Drug Record

RESERPINE chembl:CHEMBL772

Alternate Names:

RESERPINE
SERPALAN
RAU-SED
SANDRIL
SERPASIL
SERPANRAY
HISERPIA
SERPATE
NSC-59272
SERPIVITE
NSC-237659
ENT-50146
3,4,5-TRIMETHOXYBENZOYL METHYL RESERPATE
SERPALAN®
RESERPIN
(−)-RESERPINE
(3BETA,16BETA,17ALPHA,18BETA,20ALPHA)-11,17-DIMETHOXY-18-[(3,4,5-TRIMETHOXYBENZOYL)OXY]YOHIMBAN-16-CARBOXYLIC ACID METHYL ESTER
APOPLON
SER020
(-)-RESERPINE
pubchem.compound:5770
drugbank:00206
rxcui:9260
chemidplus:50-55-5
chembl:CHEMBL772

Drug Info:

Drug Class	antipsychotic agents
Drug Class	antihypertensive agents
Year of Approval	approved before 1982
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Antipsychotic Agents
Drug Indications	Antihypertensive Agents

(4 More Sources)

Publications:

Castañeda-Gómez J et al., 2013, Purgin II, a resin glycoside ester-type dimer and inhibitor of multidrug efflux pumps from Ipomoea purga., J Nat Prod
Figueroa-González G et al., 2012, Reversal of multidrug resistance by morning glory resin glycosides in human breast cancer cells., J Nat Prod
Wang et al., 2001, Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4., Chem. Res. Toxicol.
Mandela et al., Reserpine-induced reduction in norepinephrine transporter function requires catecholamine storage vesicles., Neurochem. Int.
Naudon et al., 1995, Time-course of modifications elicited by reserpine on the density and mRNA synthesis of the vesicular monoamine transporter, and on the density of the membrane dopamine uptake complex., Synapse
Erickson et al., 1992, Expression cloning of a reserpine-sensitive vesicular monoamine transporter., Proc. Natl. Acad. Sci. U.S.A.
Sievert et al., 2007, Specific derivatization of the vesicle monoamine transporter with novel carrier-free radioiodinated reserpine and tetrabenazine photoaffinity labels., Anal. Biochem.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
SCHLAGEL et al., 1957, Rauwolfia hypotension. II. Action of the alseroxylon alkaloids and epinephrine on the carotid pressoreceptors., J Am Pharm Assoc Am Pharm Assoc
FORD et al., 1958, Rauwolfia toxicity in the treatment of hypertension; comparative toxicity of reserpine and alseroxylon., Postgrad Med
Nakata et al., 1985, Alpha-adrenergic regulation of the activity of thymidylate synthetase and thymidine kinase during liver regeneration after partial hepatectomy., Eur. J. Pharmacol.
Mutafchiev, 1987, [Effect of reserpine on the lactose, iron and lactoferrin content of the milk of lactating rabbits]., Eksp Med Morfol
Merchenthaler et al., 1980, Immunohistochemical study of the LHRH-synthesizing neuron system of aged female rats., Cell Tissue Res.
Obata et al., 2000, Reserpine attenuates interstitial adenosine-mediated activation of ecto-5'-nucleotidase in rat hearts in vivo., Arch. Biochem. Biophys.
Marsden et al., 1982, Localization and release of 5-hydroxytryptamine thyrotrophin releasing hormone and substance P in rat ventral spinal cord., Comp. Biochem. Physiol. C, Comp. Pharmacol.
Gilbert et al., 1981, The effects of 5-hydroxytryptamine-depleting drugs on peptides in the ventral spinal cord., Eur. J. Pharmacol.
Lee et al., 2006, A role for vanilloid receptor 1 (TRPV1) and endocannabinnoid signalling in the regulation of spontaneous and L-DOPA induced locomotion in normal and reserpine-treated rats., Neuropharmacology
Heinroth et al., 1980, [Effect of antihypertensives on the activity of lipoprotein lipase of cardiac tissue in rabbits, and normotonic and spontaneously hypertensive rats]., Acta Biol. Med. Ger.
Cantarella et al., 2005, Adrenomedullin modulates COX-2 and HGF expression in reserpine-injuried gastric mucosa in the rat., Eur. J. Pharmacol.

RESERPINE SLC18A2

Interaction Score: 1.76

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Synaptic vesicular amine transporter inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
20176067 8525459 1438304 17559790 11752352 17016423 17139284 13438725 13505370

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
RESERPINE LTF

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3608900

Sources:
NCI
RESERPINE GNRH1

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6996825

Sources:
NCI
RESERPINE HGF

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16081063

Sources:
NCI
RESERPINE NT5E

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10700389

Sources:
NCI
RESERPINE TAC1

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6183051 6174352

Sources:
NCI
RESERPINE LPL

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7282227

Sources:
NCI
RESERPINE TRPV1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16806299

Sources:
NCI
RESERPINE TYMS

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2866100

Sources:
NCI
RESERPINE PTGS2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16081063

Sources:
NCI
RESERPINE ABCB1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23273047 22148475

Sources:
DTC PharmGKB
RESERPINE THPO

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESERPINE NR1I2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
RESERPINE MPHOSPH8

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESERPINE CBX1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESERPINE ATAD5

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESERPINE KCNH2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESERPINE BAZ2B

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESERPINE MAPT

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESERPINE KDM4A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESERPINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11743742

Sources:
NCI
RESERPINE GMNN

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESERPINE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESERPINE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TdgClinicalTrial: RESERPINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Antipsychotic Agents

Drug Class small molecule

Publications:
TEND: RESERPINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Year of Approval approved before 1982

Drug Class antihypertensive agents

Drug Class antipsychotic agents

Publications:

NCI: RESERPINE

Version: 14-September-2017

Alternate Names:

C803 NCI drug code

Drug Info:

Publications:

Mutafchiev, 1987, [Effect of reserpine on the lactose, iron and lactoferrin content of the milk of lactating rabbits]., Eksp Med Morfol

Gilbert et al., 1981, The effects of 5-hydroxytryptamine-depleting drugs on peptides in the ventral spinal cord., Eur. J. Pharmacol.

Marsden et al., 1982, Localization and release of 5-hydroxytryptamine thyrotrophin releasing hormone and substance P in rat ventral spinal cord., Comp. Biochem. Physiol. C, Comp. Pharmacol.

DTC: RESERPINE

Version: 02-September-2020

Alternate Names:

CHEMBL772 ChEMBL Drug ID

Drug Info:

Publications:

Castañeda-Gómez J et al., 2013, Purgin II, a resin glycoside ester-type dimer and inhibitor of multidrug efflux pumps from Ipomoea purga., J Nat Prod

Figueroa-González G et al., 2012, Reversal of multidrug resistance by morning glory resin glycosides in human breast cancer cells., J Nat Prod

TTD: Reserpine
- Version: 2020.06.01
Alternate Names:

D0J4JM TTD Drug ID

Drug Info:

Publications:
PharmGKB: reserpine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL772
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL772
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Synaptic vesicular amine transporter inhibitor
Direct Interaction	yes
Trial Name	-

RESERPINE Drug Record

RESERPINE chembl:CHEMBL772

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Synaptic vesicular amine transporter inhibitor Direct Interaction yes Trial Name -

PMIDs: 20176067 8525459 1438304 17559790 11752352 17016423 17139284 13438725 13505370

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3608900

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6996825

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16081063

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10700389

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6183051 6174352

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7282227

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16806299

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2866100

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16081063

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23273047 22148475

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Synaptic vesicular amine transporter inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
20176067 8525459 1438304 17559790 11752352 17016423 17139284 13438725 13505370

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
3608900

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6996825

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16081063

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10700389

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6183051 6174352

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7282227

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16806299

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2866100

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16081063

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23273047 22148475

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
11743742

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Antipsychotic Agents

Drug Class small molecule

Drug Info:

Year of Approval approved before 1982

Drug Class antihypertensive agents

Drug Class antipsychotic agents

Alternate Names:

C803 NCI drug code

Alternate Names:

CHEMBL772 ChEMBL Drug ID

Alternate Names:

D0J4JM TTD Drug ID