• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

RESERPINE Drug Record

  • Summary
  • Interactions
  • Claims
  • RESERPINE chembl:CHEMBL772

    Alternate Names:

    RESERPINE
    SERPALAN
    RAU-SED
    SANDRIL
    SERPASIL
    SERPANRAY
    HISERPIA
    SERPATE
    NSC-59272
    SERPIVITE
    NSC-237659
    ENT-50146
    3,4,5-TRIMETHOXYBENZOYL METHYL RESERPATE
    SERPALAN®
    RESERPIN
    (−)-RESERPINE
    (3BETA,16BETA,17ALPHA,18BETA,20ALPHA)-11,17-DIMETHOXY-18-[(3,4,5-TRIMETHOXYBENZOYL)OXY]YOHIMBAN-16-CARBOXYLIC ACID METHYL ESTER
    APOPLON
    SER020
    (-)-RESERPINE
    pubchem.compound:5770
    drugbank:00206
    rxcui:9260
    chemidplus:50-55-5
    chembl:CHEMBL772

    Drug Info:

    Drug Class antipsychotic agents
    Drug Class antihypertensive agents
    Year of Approval approved before 1982
    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications Antipsychotic Agents
    Drug Indications Antihypertensive Agents
    (4 More Sources)

    Publications:

    Castañeda-Gómez J et al., 2013, Purgin II, a resin glycoside ester-type dimer and inhibitor of multidrug efflux pumps from Ipomoea purga., J Nat Prod
    Figueroa-González G et al., 2012, Reversal of multidrug resistance by morning glory resin glycosides in human breast cancer cells., J Nat Prod
    Wang et al., 2001, Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4., Chem. Res. Toxicol.
    Mandela et al., Reserpine-induced reduction in norepinephrine transporter function requires catecholamine storage vesicles., Neurochem. Int.
    Naudon et al., 1995, Time-course of modifications elicited by reserpine on the density and mRNA synthesis of the vesicular monoamine transporter, and on the density of the membrane dopamine uptake complex., Synapse
    Erickson et al., 1992, Expression cloning of a reserpine-sensitive vesicular monoamine transporter., Proc. Natl. Acad. Sci. U.S.A.
    Sievert et al., 2007, Specific derivatization of the vesicle monoamine transporter with novel carrier-free radioiodinated reserpine and tetrabenazine photoaffinity labels., Anal. Biochem.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    SCHLAGEL et al., 1957, Rauwolfia hypotension. II. Action of the alseroxylon alkaloids and epinephrine on the carotid pressoreceptors., J Am Pharm Assoc Am Pharm Assoc
    FORD et al., 1958, Rauwolfia toxicity in the treatment of hypertension; comparative toxicity of reserpine and alseroxylon., Postgrad Med
    Nakata et al., 1985, Alpha-adrenergic regulation of the activity of thymidylate synthetase and thymidine kinase during liver regeneration after partial hepatectomy., Eur. J. Pharmacol.
    Mutafchiev, 1987, [Effect of reserpine on the lactose, iron and lactoferrin content of the milk of lactating rabbits]., Eksp Med Morfol
    Merchenthaler et al., 1980, Immunohistochemical study of the LHRH-synthesizing neuron system of aged female rats., Cell Tissue Res.
    Obata et al., 2000, Reserpine attenuates interstitial adenosine-mediated activation of ecto-5'-nucleotidase in rat hearts in vivo., Arch. Biochem. Biophys.
    Marsden et al., 1982, Localization and release of 5-hydroxytryptamine thyrotrophin releasing hormone and substance P in rat ventral spinal cord., Comp. Biochem. Physiol. C, Comp. Pharmacol.
    Gilbert et al., 1981, The effects of 5-hydroxytryptamine-depleting drugs on peptides in the ventral spinal cord., Eur. J. Pharmacol.
    Lee et al., 2006, A role for vanilloid receptor 1 (TRPV1) and endocannabinnoid signalling in the regulation of spontaneous and L-DOPA induced locomotion in normal and reserpine-treated rats., Neuropharmacology
    Heinroth et al., 1980, [Effect of antihypertensives on the activity of lipoprotein lipase of cardiac tissue in rabbits, and normotonic and spontaneously hypertensive rats]., Acta Biol. Med. Ger.
    Cantarella et al., 2005, Adrenomedullin modulates COX-2 and HGF expression in reserpine-injuried gastric mucosa in the rat., Eur. J. Pharmacol.
  • RESERPINE   SLC18A2

    Interaction Score: 1.76

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Synaptic vesicular amine transporter inhibitor
    Direct Interaction yes
    Trial Name -

    PMIDs:
    20176067 8525459 1438304 17559790 11752352 17016423 17139284 13438725 13505370


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • RESERPINE   LTF

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3608900


    Sources:
    NCI

  • RESERPINE   GNRH1

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6996825


    Sources:
    NCI

  • RESERPINE   HGF

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16081063


    Sources:
    NCI

  • RESERPINE   NT5E

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10700389


    Sources:
    NCI

  • RESERPINE   TAC1

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6183051 6174352


    Sources:
    NCI

  • RESERPINE   LPL

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7282227


    Sources:
    NCI

  • RESERPINE   TRPV1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16806299


    Sources:
    NCI

  • RESERPINE   TYMS

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2866100


    Sources:
    NCI

  • RESERPINE   PTGS2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16081063


    Sources:
    NCI

  • RESERPINE   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23273047 22148475


    Sources:
    DTC PharmGKB

  • RESERPINE   THPO

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESERPINE   NR1I2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • RESERPINE   MPHOSPH8

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESERPINE   CBX1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESERPINE   ATAD5

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESERPINE   KCNH2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESERPINE   BAZ2B

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESERPINE   MAPT

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESERPINE   KDM4A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESERPINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11743742


    Sources:
    NCI

  • RESERPINE   GMNN

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESERPINE   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESERPINE   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TdgClinicalTrial: RESERPINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antihypertensive Agents
    Drug Indications Antipsychotic Agents
    Drug Class small molecule

    Publications:

  • TEND: RESERPINE

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Year of Approval approved before 1982
    Drug Class antihypertensive agents
    Drug Class antipsychotic agents

    Publications:

  • NCI: RESERPINE

    • Version: 14-September-2017

    Alternate Names:
    C803 NCI drug code

    Drug Info:

    Publications:
    Mutafchiev, 1987, [Effect of reserpine on the lactose, iron and lactoferrin content of the milk of lactating rabbits]., Eksp Med Morfol
    Gilbert et al., 1981, The effects of 5-hydroxytryptamine-depleting drugs on peptides in the ventral spinal cord., Eur. J. Pharmacol.
    Marsden et al., 1982, Localization and release of 5-hydroxytryptamine thyrotrophin releasing hormone and substance P in rat ventral spinal cord., Comp. Biochem. Physiol. C, Comp. Pharmacol.

  • DTC: RESERPINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL772 ChEMBL Drug ID

    Drug Info:

    Publications:
    Castañeda-Gómez J et al., 2013, Purgin II, a resin glycoside ester-type dimer and inhibitor of multidrug efflux pumps from Ipomoea purga., J Nat Prod
    Figueroa-González G et al., 2012, Reversal of multidrug resistance by morning glory resin glycosides in human breast cancer cells., J Nat Prod

  • TTD: Reserpine

    • Version: 2020.06.01

    Alternate Names:
    D0J4JM TTD Drug ID

    Drug Info:

    Publications:

  • PharmGKB: reserpine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL772

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL772

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21