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RESVERATROL Drug Record

  • Summary
  • Interactions
  • Claims
  • RESVERATROL chembl:CHEMBL165 Antineoplastic

    Alternate Names:

    BIA 6-512
    (E)-RESVERATROL
    NSC-327430
    RESVERATROL
    BIA-6-512
    3,5,4'-TRIHYDROXY-TRANS-STILBENE

    Drug Info:

    Drug Indications antidiabetic,antineoplastic agent
    FDA Approval not approved
    Drug Class small molecule
    Drug Indications for treatment of herpes simplex virus 1
    (0 More Sources)

    Publications:

    Ota H et al., 2013, trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence., J Nat Prod
    Milne et al., 2007, Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes., Nature
    Wu J et al., 2013, Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate., J Med Chem
    Hubbard BP et al., 2013, Evidence for a common mechanism of SIRT1 regulation by allosteric activators., Science
    Lakshminarasimhan M et al., 2013, Sirt1 activation by resveratrol is substrate sequence-selective., Aging (Albany NY)
    Su JL et al., 2007, Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol., J Biol Chem
    Ma et al., 2005, Effect of resveratrol on peritoneal macrophages in rats with severe acute pancreatitis., Inflamm. Res.
    Youn et al., 2005, Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex., J. Immunol.
    Miura et al., 2004, Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property., Clin. Exp. Metastasis
    Boissy et al., 2005, Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation., Cancer Res.
    Park JB, 2001, Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells., J Nat Prod
    Stewart et al., 2000, Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation., Biochem. Pharmacol.
    Aziz et al., 2005, Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease?, FASEB J.
    Aziz et al., Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin., Photochem. Photobiol.
    Baek et al., 2002, Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53., Carcinogenesis
    Sbarra et al., 2005, In vitro polyphenol effects on activity, expression and secretion of pancreatic bile salt-dependent lipase., Biochim. Biophys. Acta
    Mollerup et al., 2001, Lung carcinogenesis: resveratrol modulates the expression of genes involved in the metabolism of PAH in human bronchial epithelial cells., Int. J. Cancer
    Lu C et al., 2013, Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease., J Med Chem
    Ahn JS et al., 2007, Novel method for quantitative determination of amyloid fibrils of alpha-synuclein and amyloid beta/A4 protein by using resveratrol., Anal Biochem
    Poolman et al., 2005, Inhibition of the respiratory burst by resveratrol in human monocytes: correlation with inhibition of PI3K signaling., Free Radic. Biol. Med.
    Gagliano et al., 2005, Effect of resveratrol on matrix metalloproteinase-2 (MMP-2) and Secreted Protein Acidic and Rich in Cysteine (SPARC) on human cultured glioblastoma cells., Biomed. Pharmacother.
    Tseng et al., 2004, Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats., Clin. Cancer Res.
    Reagan-Shaw et al., 2004, Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skin., Oncogene
    Hsieh TC et al., 2014, Biochemical and cellular evidence demonstrating AKT-1 as a binding partner for resveratrol targeting protein NQO2., PLoS One
    Lekli et al., 2008, Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin., Am. J. Physiol. Heart Circ. Physiol.
    Lappano R et al., 2009, Structure-activity relationships of resveratrol and derivatives in breast cancer cells., Mol Nutr Food Res
    Bezstarosti et al., Differential proteomic profiling to study the mechanism of cardiac pharmacological preconditioning by resveratrol., J. Cell. Mol. Med.
    Wang et al., 2006, Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts., Biochem. Biophys. Res. Commun.
    Sakoguchi-Okada et al., 2007, Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells., Biochem. Pharmacol.
    Fulda et al., 2004, Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol., Cancer Res.
    de Medina P et al., 2005, Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators., J Med Chem
    Das et al., 2006, Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling., J. Pharmacol. Exp. Ther.
    Das J et al., 2011, Chemical modifications of resveratrol for improved protein kinase C alpha activity., Bioorg Med Chem
  • RESVERATROL   PECAM1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15041740


    Sources:
    NCI

  • RESVERATROL   RIPK1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16116226


    Sources:
    NCI

  • RESVERATROL   FOXO3

    Interaction Score: 1.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17513867


    Sources:
    DTC

  • RESVERATROL   DIABLO

    Interaction Score: 1.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15837718 15469386


    Sources:
    NCI

  • RESVERATROL   SLC2A3

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11277764


    Sources:
    DTC

  • RESVERATROL   CEL

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16099206


    Sources:
    NCI

  • RESVERATROL   GDF15

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11895857


    Sources:
    NCI

  • RESVERATROL   HSPB2

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17125593 16759640


    Sources:
    NCI

  • RESVERATROL   SIRT1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23859249 18046409 23316803 23471411 23524286


    Sources:
    DTC

  • RESVERATROL   PRKD1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11008129


    Sources:
    NCI

  • RESVERATROL   HGF

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15672869


    Sources:
    NCI

  • RESVERATROL   BIRC5

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17270149 15837718 14729643


    Sources:
    NCI

  • RESVERATROL   PRKCA

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21880495


    Sources:
    DTC

  • RESVERATROL   APP

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23799643 17597573


    Sources:
    DTC

  • RESVERATROL   BGLAP

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16267019


    Sources:
    NCI

  • RESVERATROL   MMP2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16084059


    Sources:
    NCI

  • RESVERATROL   IL1B

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16389574


    Sources:
    NCI

  • RESVERATROL   SLC2A4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18065527


    Sources:
    NCI

  • RESVERATROL   AKT1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    17513867 24968355


    Sources:
    DTC

  • RESVERATROL   GSTP1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11279601


    Sources:
    NCI

  • RESVERATROL   PDE4D

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Resveratrol
    Novel drug target Established target
    Trial Name SRT501

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • RESVERATROL   AHR

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15634023


    Sources:
    DTC

  • RESVERATROL   CDK2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15122319


    Sources:
    NCI

  • RESVERATROL   PDE4B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name SRT501
    Novel drug target Established target
    Trial Name Resveratrol

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • RESVERATROL   MAPK14

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16525036


    Sources:
    NCI

  • RESVERATROL   NFKB2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   GFER

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   RELA

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   PIK3CA

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15925284


    Sources:
    NCI

  • RESVERATROL   NFKB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   BRCA1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   ESR1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19496085


    Sources:
    DTC

  • RESVERATROL   SMN2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   SMN1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   NPC1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   HIF1A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   HTT

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   POLK

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   ATAD5

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   TP53

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   HSD17B10

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   MAPT

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TdgClinicalTrial: RESVERATROL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications for treatment of herpes simplex virus 1
    Drug Class small molecule
    FDA Approval not approved

    Publications:

  • NCI: RESVERATROL

    • Version: 14-September-2017

    Alternate Names:
    C1215 NCI drug code

    Drug Info:

    Publications:
    Ma et al., 2005, Effect of resveratrol on peritoneal macrophages in rats with severe acute pancreatitis., Inflamm. Res.
    Youn et al., 2005, Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex., J. Immunol.
    Miura et al., 2004, Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property., Clin. Exp. Metastasis

  • DTC: RESVERATROL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL165 ChEMBL Drug ID

    Drug Info:

    Publications:
    Su JL et al., 2007, Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol., J Biol Chem
    Das J et al., 2011, Chemical modifications of resveratrol for improved protein kinase C alpha activity., Bioorg Med Chem
    Wu J et al., 2013, Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate., J Med Chem

  • ChemblDrugs: chembl:CHEMBL165

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21