DGIdb - RIVASTIGMINE Drug Record

RIVASTIGMINE chembl:CHEMBL636 Approved

Alternate Names:

KERSTIPON
VOLEZE
ALZEST
PROMETAX
ERASTIG
SDZ-212-713
SDZ-ENA-713
NIMVASTID
ELUDEN
ENA-713
ENA-713D
SOMNITON
RIVASTIGMINE
ONO-2540
EXELON
SDZ-212713
EXELON®
(S)-3-(1-(DIMETHYLAMINO)ETHYL)PHENYL ETHYLMETHYLCARBAMATE
M-((S)-1-(DIMETHYLAMINO)ETHYL)PHENYL ETHYLMETHYLCARBAMATE
ENA 713 FREE BASE
ENA713
pubchem.compound:77991
rxcui:183379
chembl:CHEMBL636
chemidplus:123441-03-2
drugbank:00989

Drug Info:

Year of Approval	2000
Drug Class	nootropic agents
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of Alzheimer's disease

(3 More Sources)

Publications:

Greig et al., 2002, Butyrylcholinesterase: an important new target in Alzheimer's disease therapy., Int Psychogeriatr
Farlow, 2003, Update on rivastigmine., Neurologist
Stahl, 2000, The new cholinesterase inhibitors for Alzheimer's disease, Part 1: their similarities are different., J Clin Psychiatry
Grossberg et al., 2000, Lack of adverse pharmacodynamic drug interactions with rivastigmine and twenty-two classes of medications., Int J Geriatr Psychiatry
Gottwald et al., 1999, Rivastigmine, a brain-region selective acetylcholinesterase inhibitor for treating Alzheimer's disease: review and current status., Expert Opin Investig Drugs
Kennedy et al., 1999, Preferential cerebrospinal fluid acetylcholinesterase inhibition by rivastigmine in humans., J Clin Psychopharmacol
Goldblum et al., 2000, Topical rivastigmine, a selective acetylcholinesterase inhibitor, lowers intraocular pressure in rabbits., J Ocul Pharmacol Ther
Lalli et al., 2008, Rivastigmine in Parkinson's disease dementia., Expert Rev Neurother
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Naik et al., 2009, Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice., J Pharm Pharm Sci
Birks et al., 2009, Rivastigmine for Alzheimer's disease., Cochrane Database Syst Rev
Onor et al., 2007, Rivastigmine in the treatment of Alzheimer's disease: an update., Clin Interv Aging
Scacchi R et al., 2009, Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine., Am J Med Genet B Neuropsychiatr Genet
Han HJ et al., 2015, Effect of rivastigmine or memantine add-on therapy is affected by butyrylcholinesterase genotype in patients with probable Alzheimer's disease., Eur Neurol
Blesa R et al., 2006, Effect of butyrylcholinesterase genotype on the response to rivastigmine or donepezil in younger patients with Alzheimer's disease., Pharmacogenet Genomics
O'Brien KK et al., 2003, Regulation of attention and response to therapy in dementia by butyrylcholinesterase., Pharmacogenetics
Birks, 2006, Cholinesterase inhibitors for Alzheimer's disease., Cochrane Database Syst Rev
Smith, 2009, Treatment of Alzheimer's disease in the long-term-care setting., Am J Health Syst Pharm
Bassil et al., 2009, Novel regimens and delivery systems in the pharmacological treatment of Alzheimer's disease., CNS Drugs
Yoon H et al., 2015, Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in Alzheimer's disease., Pharmacopsychiatry
Braga IL et al., 2015, Effect of APOE and CHRNA7 genotypes on the cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease., Am J Alzheimers Dis Other Demen

RIVASTIGMINE BCHE

Interaction Score: 15.95

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
25376930 18780301 17047484 12668920 12636181 16437532 11078030 19420308 11139819 18671661 19374459 11752352 14587496 19370562 19470293 18044073

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB
RIVASTIGMINE ACHE

Interaction Score: 7.39

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
12636181 14587496 11078030 10713582 11139819 10587286 10673128 18671661 11752352 19470293 19370562 18044073 18780301

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB TTD
RIVASTIGMINE CHAT

Interaction Score: 3.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25730470

Sources:
PharmGKB
RIVASTIGMINE CHRNA7

Interaction Score: 0.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24951635

Sources:
PharmGKB

TEND: RIVASTIGMINE
- Version: 01-August-2011
Alternate Names:

RIVASTIGMINE Primary Drug Name

Drug Info:

Drug Class nootropic agents

Year of Approval 2000

Publications:
TdgClinicalTrial: RIVASTIGMINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of Alzheimer's disease

Drug Class Small Molecule

FDA Approval approved

Publications:

PharmGKB: rivastigmine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Scacchi R et al., 2009, Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine., Am J Med Genet B Neuropsychiatr Genet

Braga IL et al., 2015, Effect of APOE and CHRNA7 genotypes on the cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease., Am J Alzheimers Dis Other Demen

Yoon H et al., 2015, Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in Alzheimer's disease., Pharmacopsychiatry

GuideToPharmacology: 178103215
- Version: 29-September-2020
Alternate Names:

RIVASTIGMINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Rivastigmine
- Version: 2020.06.01
Alternate Names:

D0WY5Q TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL636
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL636
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Mechanism of Interaction	Cholinesterases; ACHE & BCHE inhibitor
Direct Interaction	yes
Specific Action of the Ligand	Inhibition

RIVASTIGMINE Drug Record

RIVASTIGMINE chembl:CHEMBL636 Approved

Alternate Names:

Drug Info:

Publications:

RIVASTIGMINE BCHE

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: 25376930 18780301 17047484 12668920 12636181 16437532 11078030 19420308 11139819 18671661 19374459 11752352 14587496 19370562 19470293 18044073

Sources: TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB

RIVASTIGMINE ACHE

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: 12636181 14587496 11078030 10713582 11139819 10587286 10673128 18671661 11752352 19470293 19370562 18044073 18780301

Sources: TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB TTD

RIVASTIGMINE CHAT

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25730470

Sources: PharmGKB

RIVASTIGMINE CHRNA7

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24951635

Sources: PharmGKB

TEND: RIVASTIGMINE

Alternate Names: RIVASTIGMINE Primary Drug Name

Drug Info: Drug Class nootropic agents Year of Approval 2000

Publications:

TdgClinicalTrial: RIVASTIGMINE

Alternate Names:

Drug Info: Drug Indications for treatment of Alzheimer's disease Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: rivastigmine

Alternate Names:

Drug Info:

GuideToPharmacology: 178103215

Alternate Names: RIVASTIGMINE GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Rivastigmine

Alternate Names: D0WY5Q TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL636

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL636

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
25376930 18780301 17047484 12668920 12636181 16437532 11078030 19420308 11139819 18671661 19374459 11752352 14587496 19370562 19470293 18044073

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
12636181 14587496 11078030 10713582 11139819 10587286 10673128 18671661 11752352 19470293 19370562 18044073 18780301

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
25730470

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24951635

Sources:
PharmGKB

Alternate Names:

RIVASTIGMINE Primary Drug Name

Drug Info:

Drug Class nootropic agents

Year of Approval 2000

Drug Info:

Drug Indications for treatment of Alzheimer's disease

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

RIVASTIGMINE GuideToPharmacology Ligand Name

Alternate Names:

D0WY5Q TTD Drug ID