DGIdb - RIVASTIGMINE Drug Record

RIVASTIGMINE chembl:CHEMBL636 Approved

Alternate Names:

KERSTIPON
VOLEZE
ALZEST
PROMETAX
ERASTIG
SDZ-212-713
SDZ-ENA-713
NIMVASTID
ELUDEN
ENA-713
ENA-713D
SOMNITON
RIVASTIGMINE
ONO-2540
EXELON
SDZ-212713
EXELON®
(S)-3-(1-(DIMETHYLAMINO)ETHYL)PHENYL ETHYLMETHYLCARBAMATE
M-((S)-1-(DIMETHYLAMINO)ETHYL)PHENYL ETHYLMETHYLCARBAMATE
ENA 713 FREE BASE
ENA713
pubchem.compound:77991
rxcui:183379
chembl:CHEMBL636
chemidplus:123441-03-2
drugbank:00989

Drug Info:

Drug Categories	phenylcarbamates
Drug Categories	neuroprotective agents
Drug Categories	bradycardia-causing agents
Drug Categories	anti-dementia drugs
Year of Approval	2000
Drug Class	nootropic agents
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of Alzheimer's disease
Drug Categories	compounds used in a research, industrial, or household setting
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 substrates
Drug Categories	parasympathomemetic (cholinergic) agents

(4 More Sources)

Publications:

Gottwald et al., 1999, Rivastigmine, a brain-region selective acetylcholinesterase inhibitor for treating Alzheimer's disease: review and current status., Expert Opin Investig Drugs
Naik et al., 2009, Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice., J Pharm Pharm Sci
Scacchi R et al., 2009, Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine., Am J Med Genet B Neuropsychiatr Genet
Lalli et al., 2008, Rivastigmine in Parkinson's disease dementia., Expert Rev Neurother
Greig et al., 2002, Butyrylcholinesterase: an important new target in Alzheimer's disease therapy., Int Psychogeriatr
Birks et al., 2009, Rivastigmine for Alzheimer's disease., Cochrane Database Syst Rev
Grossberg et al., 2000, Lack of adverse pharmacodynamic drug interactions with rivastigmine and twenty-two classes of medications., Int J Geriatr Psychiatry
Goldblum et al., 2000, Topical rivastigmine, a selective acetylcholinesterase inhibitor, lowers intraocular pressure in rabbits., J Ocul Pharmacol Ther
Stahl, 2000, The new cholinesterase inhibitors for Alzheimer's disease, Part 1: their similarities are different., J Clin Psychiatry
Onor et al., 2007, Rivastigmine in the treatment of Alzheimer's disease: an update., Clin Interv Aging
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Kennedy et al., 1999, Preferential cerebrospinal fluid acetylcholinesterase inhibition by rivastigmine in humans., J Clin Psychopharmacol
Farlow, 2003, Update on rivastigmine., Neurologist
Birks, 2006, Cholinesterase inhibitors for Alzheimer's disease., Cochrane Database Syst Rev
Han HJ et al., 2015, Effect of rivastigmine or memantine add-on therapy is affected by butyrylcholinesterase genotype in patients with probable Alzheimer's disease., Eur Neurol
Bassil et al., 2009, Novel regimens and delivery systems in the pharmacological treatment of Alzheimer's disease., CNS Drugs
Smith, 2009, Treatment of Alzheimer's disease in the long-term-care setting., Am J Health Syst Pharm
Blesa R et al., 2006, Effect of butyrylcholinesterase genotype on the response to rivastigmine or donepezil in younger patients with Alzheimer's disease., Pharmacogenet Genomics
O'Brien KK et al., 2003, Regulation of attention and response to therapy in dementia by butyrylcholinesterase., Pharmacogenetics
Yoon H et al., 2015, Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in Alzheimer's disease., Pharmacopsychiatry
Braga IL et al., 2015, Effect of APOE and CHRNA7 genotypes on the cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease., Am J Alzheimers Dis Other Demen

RIVASTIGMINE BCHE

Interaction Score: 8.44

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
16437532 11139819 19470293 18780301 18671661 25376930 12636181 19370562 11078030 19374459 18044073 11752352 19420308 17047484 12668920 14587496

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions
RIVASTIGMINE ACHE

Interaction Score: 4.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
11139819 19470293 18780301 18671661 12636181 19370562 10713582 10673128 11078030 18044073 11752352 10587286 14587496

Sources:
TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
RIVASTIGMINE CHAT

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25730470

Sources:
PharmGKB
RIVASTIGMINE CHRNA7

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24951635

Sources:
PharmGKB

DrugBank: DB00989

Version: 5.1.7

Alternate Names:

RIVASTIGMINE DrugBank Drug Name

123441-03-2 CAS Number

Act Rivastigmine Patch 10 Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Birks, 2006, Cholinesterase inhibitors for Alzheimer's disease., Cochrane Database Syst Rev

Gottwald et al., 1999, Rivastigmine, a brain-region selective acetylcholinesterase inhibitor for treating Alzheimer's disease: review and current status., Expert Opin Investig Drugs

Naik et al., 2009, Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice., J Pharm Pharm Sci

TEND: RIVASTIGMINE
- Version: 01-August-2011
Alternate Names:

RIVASTIGMINE Primary Drug Name

Drug Info:

Drug Class nootropic agents

Year of Approval 2000

Publications:
TdgClinicalTrial: RIVASTIGMINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of Alzheimer's disease

Drug Class Small Molecule

FDA Approval approved

Publications:

PharmGKB: rivastigmine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Scacchi R et al., 2009, Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine., Am J Med Genet B Neuropsychiatr Genet

Braga IL et al., 2015, Effect of APOE and CHRNA7 genotypes on the cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease., Am J Alzheimers Dis Other Demen

Yoon H et al., 2015, Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in Alzheimer's disease., Pharmacopsychiatry

GuideToPharmacology: 178103215
- Version: 29-September-2020
Alternate Names:

RIVASTIGMINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Rivastigmine
- Version: 2020.06.01
Alternate Names:

D0WY5Q TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL636
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL636
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Mechanism of Interaction	Cholinesterases; ACHE & BCHE inhibitor
Direct Interaction	yes
Specific Action of the Ligand	Inhibition

RIVASTIGMINE	DrugBank Drug Name
123441-03-2	CAS Number
Act Rivastigmine Patch 10	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

RIVASTIGMINE Drug Record

RIVASTIGMINE chembl:CHEMBL636 Approved

Alternate Names:

Drug Info:

Publications:

RIVASTIGMINE BCHE

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: 16437532 11139819 19470293 18780301 18671661 25376930 12636181 19370562 11078030 19374459 18044073 11752352 19420308 17047484 12668920 14587496

Sources: TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

RIVASTIGMINE ACHE

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: 11139819 19470293 18780301 18671661 12636181 19370562 10713582 10673128 11078030 18044073 11752352 10587286 14587496

Sources: TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

RIVASTIGMINE CHAT

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25730470

Sources: PharmGKB

RIVASTIGMINE CHRNA7

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24951635

Sources: PharmGKB

DrugBank: DB00989

Alternate Names: RIVASTIGMINE DrugBank Drug Name 123441-03-2 CAS Number Act Rivastigmine Patch 10 Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

TEND: RIVASTIGMINE

Alternate Names: RIVASTIGMINE Primary Drug Name

Drug Info: Drug Class nootropic agents Year of Approval 2000

Publications:

TdgClinicalTrial: RIVASTIGMINE

Alternate Names:

Drug Info: Drug Indications for treatment of Alzheimer's disease Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: rivastigmine

Alternate Names:

Drug Info:

GuideToPharmacology: 178103215

Alternate Names: RIVASTIGMINE GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Rivastigmine

Alternate Names: D0WY5Q TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL636

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL636

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
16437532 11139819 19470293 18780301 18671661 25376930 12636181 19370562 11078030 19374459 18044073 11752352 19420308 17047484 12668920 14587496

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
11139819 19470293 18780301 18671661 12636181 19370562 10713582 10673128 11078030 18044073 11752352 10587286 14587496

Sources:
TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
25730470

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24951635

Sources:
PharmGKB

Alternate Names:

RIVASTIGMINE DrugBank Drug Name

123441-03-2 CAS Number

Act Rivastigmine Patch 10 Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Alternate Names:

RIVASTIGMINE Primary Drug Name

Drug Info:

Drug Class nootropic agents

Year of Approval 2000

Drug Info:

Drug Indications for treatment of Alzheimer's disease

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

RIVASTIGMINE GuideToPharmacology Ligand Name

Alternate Names:

D0WY5Q TTD Drug ID