DGIdb - ROPIVACAINE Drug Record

ROPIVACAINE chembl:CHEMBL1077896 Approved

Alternate Names:

ROPIVACAINE
(-)-1-PROPYL-2',6'-PIPECOLOXYLIDIDE
LEA-103
AL-381
(S)-(-)-1-PROPYL-2',6'-PIPECOLOXYLIDIDE
ROPIVACAINA
ROPIVACAINUM
(S)-(−)-1-PROPYL-2',6'-PIPECOLOXYLIDIDE
(S)-ROPIVACAINE
NAROPIN®
ROPIVACAINE HYDROCHLORIDE
1-PROPYL-2',6'-PIPECOLOXYLIDIDE
(-)-1-PROPYL-2',6'-DIMETHYL-2-PIPERIDYLCARBOXYANILIDE
L-N-N-PROPYLPIPECOLIC ACID-2,6-XYLIDIDE
drugbank:00296
chembl:CHEMBL1077896
rxcui:35780
pubchem.compound:175805
chemidplus:84057-95-4

Drug Info:

Drug Class	anesthetics, local
Year of Approval	1996
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	anestethic

(3 More Sources)

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Liu et al., 2000, The effects of ropivacaine on sodium currents in dorsal horn neurons of neonatal rats., Anesth. Analg.
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

ROPIVACAINE CYB5R3

Interaction Score: 1.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ROPIVACAINE SCN10A

Interaction Score: 1.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ropivacaine HCl,Naropin

Novel drug target Established target

PMIDs:
17016423 17139284 10781449

Sources:
TdgClinicalTrial TEND TTD
ROPIVACAINE G6PD

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
ROPIVACAINE SCN5A

Interaction Score: 0.14

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand Pore blocker

Details of Interaction Blockade of inactivated channel

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
ROPIVACAINE CYP3A4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB

TEND: ROPIVACAINE
- Version: 01-August-2011
Alternate Names:

ROPIVACAINE Primary Drug Name

Drug Info:

Year of Approval 1996

Drug Class anesthetics, local

Publications:
TdgClinicalTrial: ROPIVACAINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications anestethic

Drug Class Small Molecule

FDA Approval approved

Publications:
PharmGKB: ropivacaine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
TTD: Ropivacaine
- Version: 2020.06.01
Alternate Names:

D09RHQ TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 223365937
- Version: 29-September-2020
Alternate Names:

ROPIVACAINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1077896
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Ropivacaine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	ropivacaine HCl,Naropin
Novel drug target	Established target

Specific Action of the Ligand	Pore blocker
Details of Interaction	Blockade of inactivated channel
Endogenous Drug?	False

ROPIVACAINE Drug Record

ROPIVACAINE chembl:CHEMBL1077896 Approved

Alternate Names:

Drug Info:

Publications:

ROPIVACAINE CYB5R3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

ROPIVACAINE SCN10A

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name ropivacaine HCl,Naropin Novel drug target Established target

PMIDs: 17016423 17139284 10781449

Sources: TdgClinicalTrial TEND TTD

ROPIVACAINE G6PD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

ROPIVACAINE SCN5A

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Specific Action of the Ligand Pore blocker Details of Interaction Blockade of inactivated channel Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

ROPIVACAINE CYP3A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

TEND: ROPIVACAINE

Alternate Names: ROPIVACAINE Primary Drug Name

Drug Info: Year of Approval 1996 Drug Class anesthetics, local

Publications:

TdgClinicalTrial: ROPIVACAINE

Alternate Names:

Drug Info: Drug Indications anestethic Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: ropivacaine

Alternate Names:

Drug Info:

Publications: Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

TTD: Ropivacaine

Alternate Names: D09RHQ TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 223365937

Alternate Names: ROPIVACAINE GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1077896

Alternate Names:

Drug Info:

Publications:

FDA: Ropivacaine

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ropivacaine HCl,Naropin

Novel drug target Established target

PMIDs:
17016423 17139284 10781449

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand Pore blocker

Details of Interaction Blockade of inactivated channel

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Alternate Names:

ROPIVACAINE Primary Drug Name

Drug Info:

Year of Approval 1996

Drug Class anesthetics, local

Drug Info:

Drug Indications anestethic

Drug Class Small Molecule

FDA Approval approved

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Alternate Names:

D09RHQ TTD Drug ID

Alternate Names:

ROPIVACAINE GuideToPharmacology Ligand Name