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ROXITHROMYCIN Drug Record

  • Summary
  • Interactions
  • Claims
  • ROXITHROMYCIN chembl:CHEMBL1214185 Approved

    Alternate Names:

    ROXITHROMYCIN
    RU-965
    RULIDE
    RU-28965
    RULID
    ROXITROMICINA
    (9E)-ERYTHROMYCIN 9-(O-((2-METHOXYETHOXY)METHYL)OXIME)
    ROXITHROMYCINE
    ROXITHROMYCINUM
    chembl:CHEMBL1214185
    pubchem.compound:6915744
    rxcui:9478
    chemidplus:80214-83-1
    drugbank:00778

    Drug Info:

    (0 More Sources)

    Publications:

    Tsuda et al., 2008, Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes., Antimicrob. Agents Chemother.
    Kawazu et al., 2000, Suppressive activity of a macrolide antibiotic, roxithromycin on co-stimulatory molecule expression on mouse splenocytes in vivo., Mediators Inflamm.
    Aktan et al., Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion., Pol J Pharmacol
    Cui et al., 2001, Effect of roxithromycin on eotaxin-primed reactive oxygen species from eosinophils., Int. Arch. Allergy Immunol.
    Konno et al., 1992, Influences of roxithromycin on cell-mediated immune responses., Life Sci.
    Polasek et al., 2006, Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate., Eur. J. Clin. Pharmacol.
    Takakusagi K et al., 2015, Multimodal biopanning of T7 phage-displayed peptides reveals angiomotin as a potential receptor of the anti-angiogenic macrolide Roxithromycin., Eur J Med Chem
  • ROXITHROMYCIN   AMOT

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25528335


    Sources:
    DTC

  • ROXITHROMYCIN   CCL11

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11408771


    Sources:
    NCI

  • ROXITHROMYCIN   CD86

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10877454


    Sources:
    NCI

  • ROXITHROMYCIN   CD80

    Interaction Score: 1.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10877454


    Sources:
    NCI

  • ROXITHROMYCIN   F2RL1

    Interaction Score: 1.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18212111


    Sources:
    DTC

  • ROXITHROMYCIN   XDH

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14730107


    Sources:
    NCI

  • ROXITHROMYCIN   IL2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1513198


    Sources:
    NCI

  • ROXITHROMYCIN   CYP3A4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16416302


    Sources:
    NCI

  • DTC: ROXITHROMYCIN

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1214185 ChEMBL Drug ID

    Drug Info:

    Publications:
    Tsuda et al., 2008, Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes., Antimicrob. Agents Chemother.
    Takakusagi K et al., 2015, Multimodal biopanning of T7 phage-displayed peptides reveals angiomotin as a potential receptor of the anti-angiogenic macrolide Roxithromycin., Eur J Med Chem

  • NCI: ROXITHROMYCIN

    • Version: 14-September-2017

    Alternate Names:
    C818 NCI drug code

    Drug Info:

    Publications:
    Polasek et al., 2006, Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate., Eur. J. Clin. Pharmacol.
    Cui et al., 2001, Effect of roxithromycin on eotaxin-primed reactive oxygen species from eosinophils., Int. Arch. Allergy Immunol.
    Kawazu et al., 2000, Suppressive activity of a macrolide antibiotic, roxithromycin on co-stimulatory molecule expression on mouse splenocytes in vivo., Mediators Inflamm.

  • ChemblDrugs: chembl:CHEMBL1214185

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21