DGIdb - SALMETEROL Drug Record

SALMETEROL chembl:CHEMBL1263 Approved

Alternate Names:

SEREVENT
SALMETEROL
BEGLAN
GR-33343-X
SN408D
NEOVENT
GR-33343X
SALMATEROL
VERTINE
SOLTEL
GR 33343X
SEREVENT®
SALMETEROLUM
chembl:CHEMBL1263
pubchem.compound:5152
chemidplus:89365-50-4
drugbank:00938
rxcui:36117

Drug Info:

Drug Class	bronchodilator agents
Year of Approval	1994
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	bronchodilator

(3 More Sources)

Publications:

Hoffmann et al., 2004, Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells., Naunyn Schmiedebergs Arch. Pharmacol.
Brogden et al., Salmeterol xinafoate: a review of its pharmacological properties and therapeutic potential in reversible obstructive airways disease., Allergol Immunopathol (Madr)
Finney et al., 2001, Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha)., Br. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Rong et al., 1999, Probing the salmeterol binding site on the beta 2-adrenergic receptor using a novel photoaffinity ligand, [(125)I]iodoazidosalmeterol., Biochemistry
Green et al., 2001, The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s)., Eur. J. Pharmacol.
Meliton et al., 2003, Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils., J. Allergy Clin. Immunol.
Zuurhout MJ et al., 2013, Arg16 ADRB2 genotype increases the risk of asthma exacerbation in children with a reported use of long-acting β2-agonists: results of the PACMAN cohort., Pharmacogenomics
Lipworth BJ et al., 2013, Tailored second-line therapy in asthmatic children with the Arg(16) genotype., Clin Sci (Lond)
Wechsler ME et al., 2009, Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial., Lancet
Basu K et al., 2009, Adrenergic beta(2)-receptor genotype predisposes to exacerbations in steroid-treated asthmatic patients taking frequent albuterol or salmeterol., J Allergy Clin Immunol
Bleecker ER et al., 2007, Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies., Lancet
Israel E et al., 2004, Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial., Lancet
Cazzola M et al., 2002, Clinical pharmacokinetics of salmeterol., Clin Pharmacokinet
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

SALMETEROL ADRB2

Interaction Score: 2.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Advair/Seretide/Adoair

Novel drug target Established target

Trial Name Serevent

PMIDs:
1359777 11250877 11752352 10471277 11516429 12897749 24279851 23126384 19932356 19800676 18156033 15500895 11825095

Sources:
TdgClinicalTrial TEND GuideToPharmacology PharmGKB TTD
SALMETEROL ADRB1

Interaction Score: 0.35

Interaction Types & Directionality:

inverse agonist (inhibitory)

Interaction Info:

PMIDs:
14730417

Sources:
DTC
SALMETEROL CYP3A5

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
SALMETEROL AR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: SALMETEROL
- Version: 01-August-2011
Alternate Names:

SALMETEROL Primary Drug Name

Drug Info:

Year of Approval 1994

Drug Class bronchodilator agents

Publications:
TdgClinicalTrial: SALMETEROL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications bronchodilator

Drug Class Small Molecule

FDA Approval approved

Publications:

PharmGKB: salmeterol

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

Lipworth BJ et al., 2013, Tailored second-line therapy in asthmatic children with the Arg(16) genotype., Clin Sci (Lond)

Israel E et al., 2004, Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial., Lancet

DTC: SALMETEROL
- Version: 02-September-2020
Alternate Names:

CHEMBL1263 ChEMBL Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650978
- Version: 29-September-2020
Alternate Names:

SALMETEROL GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Salmeterol
- Version: 2020.06.01
Alternate Names:

D0L5YV TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1263
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	Advair/Seretide/Adoair
Novel drug target	Established target
Trial Name	Serevent

SALMETEROL Drug Record

SALMETEROL chembl:CHEMBL1263 Approved

Alternate Names:

Drug Info:

Publications:

SALMETEROL ADRB2

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Advair/Seretide/Adoair Novel drug target Established target Trial Name Serevent

PMIDs: 1359777 11250877 11752352 10471277 11516429 12897749 24279851 23126384 19932356 19800676 18156033 15500895 11825095

Sources: TdgClinicalTrial TEND GuideToPharmacology PharmGKB TTD

SALMETEROL ADRB1

Interaction Types & Directionality: inverse agonist (inhibitory)

Interaction Info:

PMIDs: 14730417

Sources: DTC

SALMETEROL CYP3A5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

SALMETEROL AR

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: SALMETEROL

Alternate Names: SALMETEROL Primary Drug Name

Drug Info: Year of Approval 1994 Drug Class bronchodilator agents

Publications:

TdgClinicalTrial: SALMETEROL

Alternate Names:

Drug Info: Drug Indications bronchodilator Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: salmeterol

Alternate Names:

Drug Info:

DTC: SALMETEROL

Alternate Names: CHEMBL1263 ChEMBL Drug ID

Drug Info:

Publications:

GuideToPharmacology: 135650978

Alternate Names: SALMETEROL GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Salmeterol

Alternate Names: D0L5YV TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1263

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Advair/Seretide/Adoair

Novel drug target Established target

Trial Name Serevent

PMIDs:
1359777 11250877 11752352 10471277 11516429 12897749 24279851 23126384 19932356 19800676 18156033 15500895 11825095

Sources:
TdgClinicalTrial TEND GuideToPharmacology PharmGKB TTD

Interaction Types & Directionality:

inverse agonist (inhibitory)

PMIDs:
14730417

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

SALMETEROL Primary Drug Name

Drug Info:

Year of Approval 1994

Drug Class bronchodilator agents

Drug Info:

Drug Indications bronchodilator

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL1263 ChEMBL Drug ID

Alternate Names:

SALMETEROL GuideToPharmacology Ligand Name

Alternate Names:

D0L5YV TTD Drug ID