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SAPITINIB Drug Record

  • Summary
  • Interactions
  • Claims
  • SAPITINIB chembl:CHEMBL2408045 Antineoplastic

    Alternate Names:

    SAPITINIB
    AZD-8931
    AZD8931

    Drug Info:

    Drug Class Kinase Inhibitors
    (2 More Sources)

    Publications:

    Mu et al., 2014, AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor (EGFR), HER2, and HER3: preclinical activity in HER2 non-amplified inflammatory breast cancer models., J. Exp. Clin. Cancer Res.
    Hickinson et al., 2010, AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer., Clin. Cancer Res.
  • SAPITINIB   ERBB3

    Interaction Score: 2.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Receptor tyrosine-protein kinase erbB-3 inhibitor
    Direct Interaction yes
    Notes

    PMIDs:
    None found


    Sources:
    TALC MyCancerGenome ChemblInteractions

  • SAPITINIB   ERBB2

    Interaction Score: 0.84

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Receptor protein-tyrosine kinase erbB-2 inhibitor
    Direct Interaction yes

    PMIDs:
    24886365


    Sources:
    TALC MyCancerGenome JAX-CKB ChemblInteractions TTD

  • SAPITINIB   EGFR

    Interaction Score: 0.74

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Response Type sensitive
    combination therapy Sapitinib + Paclitaxel
    Indication/Tumor Type inflammatory breast carcinoma

    PMIDs:
    24886365 20145185


    Sources:
    TALC MyCancerGenome JAX-CKB ChemblInteractions

  • MyCancerGenome: AZD8931

    • Version: 20-Jun-2017

    Alternate Names:

    Drug Info:
    Drug Class Kinase Inhibitors

    Publications:

  • JAX-CKB: Sapitinib

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    Mu et al., 2014, AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor (EGFR), HER2, and HER3: preclinical activity in HER2 non-amplified inflammatory breast cancer models., J. Exp. Clin. Cancer Res.
    Hickinson et al., 2010, AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer., Clin. Cancer Res.

  • TALC: AZD8931

    • Version: 12-May-2016

    Alternate Names:
    MOMELOTINIB Drug Generic Name
    AZD8932 Drug Synonym
    AZD8933 Drug Synonym

    Drug Info:

    Publications:

  • TTD: AZD8931

    • Version: 2020.06.01

    Alternate Names:
    D0BM7M TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL2408045

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL2408045

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21