DGIdb - SECOBARBITAL Drug Record

SECOBARBITAL chembl:CHEMBL447

Alternate Names:

SECOBARBITAL
SECONAL
MEBALLYMAL
(+-)-SECOBARBITAL
5-ALLYL-5-(1-METHYLBUTYL)PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE
SECOBARBITALUM
5-(1-METHYLBUTYL)-5-(2-PROPENYL)-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
QUINALBARBITONE
SECOBARBITONE
5-ALLYL-5-(1-METHYLBUTYL)BARBITURIC ACID
5-ALLYL-5-(1-METHYLBUTYL)-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
SECONAL®
(±)-SECOBARBITAL
chemidplus:76-73-3
rxcui:9624
drugbank:00418
pubchem.compound:5193
chembl:CHEMBL447

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Hypnotics and Sedatives
Drug Indications	Adjuvants, anesthesia
Drug Class	hypnotics and sedatives
Year of Approval	approved before 1982
Drug Class	adjuvants, anesthesia
Drug Categories	anticholinergic agents
Drug Categories	anticonvulsants
Drug Categories	cytochrome p-450 cyp1a2 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp2c19 inducers
Drug Categories	cytochrome p-450 cyp2c19 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp2c9 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp3a inducers
Drug Categories	cytochrome p-450 cyp3a4 inducers
Drug Categories	cytochrome p-450 cyp3a4 inducers (strength unknown)
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	drugs that are mainly renally excreted
Drug Categories	nicotinic antagonists

(1 More Sources)

Publications:

Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
Daniell, 1994, Effect of anesthetic and convulsant barbiturates on N-methyl-D-aspartate receptor-mediated calcium flux in brain membrane vesicles., Pharmacology
Whiting, 2003, The GABAA receptor gene family: new opportunities for drug development., Curr Opin Drug Discov Devel
Miller et al., 1988, Acute barbiturate administration increases benzodiazepine receptor binding in vivo., Psychopharmacology (Berl.)
Peters et al., 1988, Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids., Br. J. Pharmacol.
Kirkness et al., 1986, The gamma-aminobutyrate/benzodiazepine receptor from pig brain. Purification and characterization of the receptor complex from cerebral cortex and cerebellum., Biochem. J.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

SECOBARBITAL GRIK2

Interaction Score: 1.17

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TEND TdgClinicalTrial DrugBank
SECOBARBITAL GABRA1

Interaction Score: 0.56

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
14579514 2906155 2850060 11264449 3006661 11752352 17139284 10209232 17016423 10487207

Sources:
TEND TdgClinicalTrial TTD DrugBank
SECOBARBITAL CHRNA4

Interaction Score: 0.54

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11264449 16248797 10487207

Sources:
TEND TdgClinicalTrial DrugBank
SECOBARBITAL GRIA2

Interaction Score: 0.53

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11264449 10487207

Sources:
TEND TdgClinicalTrial DrugBank
SECOBARBITAL CHRNA7

Interaction Score: 0.48

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 16248797 10487207

Sources:
TEND TdgClinicalTrial DrugBank
SECOBARBITAL GABRA6

Interaction Score: 0.33

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10209232

Sources:
TEND TdgClinicalTrial DrugBank
SECOBARBITAL GABRA5

Interaction Score: 0.3

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10209232

Sources:
TEND TdgClinicalTrial DrugBank
SECOBARBITAL GABRA2

Interaction Score: 0.29

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10209232

Sources:
TEND TdgClinicalTrial DrugBank
SECOBARBITAL GABRA3

Interaction Score: 0.29

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10209232

Sources:
TEND TdgClinicalTrial DrugBank
SECOBARBITAL GABRA4

Interaction Score: 0.26

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232

Sources:
TEND TdgClinicalTrial DrugBank
SECOBARBITAL GRIN1

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7862741

Sources:
DrugBank

DrugBank: DB00418

Version: 5.1.7

Alternate Names:

76-73-3 CAS Number

Novo-secobarb 100mg Drug Brand

Seconal Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups vet_approved

Publications:

Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.

Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.

Daniell, 1994, Effect of anesthetic and convulsant barbiturates on N-methyl-D-aspartate receptor-mediated calcium flux in brain membrane vesicles., Pharmacology

TEND: SECOBARBITAL
- Version: 01-August-2011
Alternate Names:

Drug Info:

Drug Class adjuvants, anesthesia

Year of Approval approved before 1982

Drug Class hypnotics and sedatives

Publications:
TdgClinicalTrial: SECOBARBITAL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Adjuvants, anesthesia

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

Publications:
TTD: Secobarbital
- Version: 2020.06.01
Alternate Names:

D00SJE TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL447
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

76-73-3	CAS Number
Novo-secobarb 100mg	Drug Brand
Seconal	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	vet_approved

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Novel drug target	Established target
Trial Name	-

Novel drug target	Established target
Trial Name	-

SECOBARBITAL Drug Record

SECOBARBITAL chembl:CHEMBL447

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 10487207

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 14579514 2906155 2850060 11264449 3006661 11752352 17139284 10209232 17016423 10487207

Sources: TEND TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 11264449 16248797 10487207

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 11264449 10487207

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 16248797 10487207

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 10209232

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 10209232

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 10209232

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 10209232

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10209232

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 7862741

Sources: DrugBank

DrugBank: DB00418

Alternate Names: 76-73-3 CAS Number Novo-secobarb 100mg Drug Brand Seconal Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups vet_approved

TEND: SECOBARBITAL

Alternate Names:

Drug Info: Drug Class adjuvants, anesthesia Year of Approval approved before 1982 Drug Class hypnotics and sedatives

Publications:

TdgClinicalTrial: SECOBARBITAL

Alternate Names:

Drug Info: Drug Indications Adjuvants, anesthesia Drug Indications Hypnotics and Sedatives Drug Class small molecule

Publications:

TTD: Secobarbital

Alternate Names: D00SJE TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL447

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
14579514 2906155 2850060 11264449 3006661 11752352 17139284 10209232 17016423 10487207

Sources:
TEND TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11264449 16248797 10487207

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11264449 10487207

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 16248797 10487207

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10209232

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10209232

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10209232

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10209232

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
7862741

Sources:
DrugBank

Alternate Names:

76-73-3 CAS Number

Novo-secobarb 100mg Drug Brand

Seconal Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups vet_approved

Drug Info:

Drug Class adjuvants, anesthesia

Year of Approval approved before 1982

Drug Class hypnotics and sedatives

Drug Info:

Drug Indications Adjuvants, anesthesia

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

Alternate Names:

D00SJE TTD Drug ID