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SECOBARBITAL Drug Record

  • Summary
  • Interactions
  • Claims
  • SECOBARBITAL chembl:CHEMBL447

    Alternate Names:

    SECOBARBITAL
    SECONAL
    MEBALLYMAL
    (+-)-SECOBARBITAL
    5-ALLYL-5-(1-METHYLBUTYL)PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE
    SECOBARBITALUM
    5-(1-METHYLBUTYL)-5-(2-PROPENYL)-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
    QUINALBARBITONE
    SECOBARBITONE
    5-ALLYL-5-(1-METHYLBUTYL)BARBITURIC ACID
    5-ALLYL-5-(1-METHYLBUTYL)-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
    SECONAL®
    (±)-SECOBARBITAL
    chemidplus:76-73-3
    rxcui:9624
    drugbank:00418
    pubchem.compound:5193
    chembl:CHEMBL447

    Drug Info:

    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications Hypnotics and Sedatives
    Drug Indications Adjuvants, anesthesia
    Drug Class hypnotics and sedatives
    Year of Approval approved before 1982
    Drug Class adjuvants, anesthesia
    Drug Categories anticholinergic agents
    Drug Categories anticonvulsants
    Drug Categories cytochrome p-450 cyp1a2 inducers (strength unknown)
    Drug Categories cytochrome p-450 cyp2c19 inducers
    Drug Categories cytochrome p-450 cyp2c19 inducers (strength unknown)
    Drug Categories cytochrome p-450 cyp2c9 inducers (strength unknown)
    Drug Categories cytochrome p-450 cyp3a inducers
    Drug Categories cytochrome p-450 cyp3a4 inducers
    Drug Categories cytochrome p-450 cyp3a4 inducers (strength unknown)
    Drug Categories cytochrome p-450 enzyme inducers
    Drug Categories drugs that are mainly renally excreted
    Drug Categories nicotinic antagonists
    (1 More Sources)

    Publications:

    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
    Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
    Daniell, 1994, Effect of anesthetic and convulsant barbiturates on N-methyl-D-aspartate receptor-mediated calcium flux in brain membrane vesicles., Pharmacology
    Whiting, 2003, The GABAA receptor gene family: new opportunities for drug development., Curr Opin Drug Discov Devel
    Miller et al., 1988, Acute barbiturate administration increases benzodiazepine receptor binding in vivo., Psychopharmacology (Berl.)
    Peters et al., 1988, Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids., Br. J. Pharmacol.
    Kirkness et al., 1986, The gamma-aminobutyrate/benzodiazepine receptor from pig brain. Purification and characterization of the receptor complex from cerebral cortex and cerebellum., Biochem. J.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
  • SECOBARBITAL   GRIK2

    Interaction Score: 1.17

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • SECOBARBITAL   GABRA1

    Interaction Score: 0.56

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    14579514 2906155 2850060 11264449 3006661 11752352 17139284 10209232 17016423 10487207


    Sources:
    TEND TdgClinicalTrial TTD DrugBank

  • SECOBARBITAL   CHRNA4

    Interaction Score: 0.54

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 16248797 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • SECOBARBITAL   GRIA2

    Interaction Score: 0.53

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • SECOBARBITAL   CHRNA7

    Interaction Score: 0.48

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 16248797 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • SECOBARBITAL   GABRA6

    Interaction Score: 0.33

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10209232


    Sources:
    TEND TdgClinicalTrial DrugBank

  • SECOBARBITAL   GABRA5

    Interaction Score: 0.3

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10209232


    Sources:
    TEND TdgClinicalTrial DrugBank

  • SECOBARBITAL   GABRA2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10209232


    Sources:
    TEND TdgClinicalTrial DrugBank

  • SECOBARBITAL   GABRA3

    Interaction Score: 0.29

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10209232


    Sources:
    TEND TdgClinicalTrial DrugBank

  • SECOBARBITAL   GABRA4

    Interaction Score: 0.26

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10209232


    Sources:
    TEND TdgClinicalTrial DrugBank

  • SECOBARBITAL   GRIN1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7862741


    Sources:
    DrugBank

  • DrugBank: DB00418

    • Version: 5.1.7

    Alternate Names:
    76-73-3 CAS Number
    Novo-secobarb 100mg Drug Brand
    Seconal Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups vet_approved

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
    Daniell, 1994, Effect of anesthetic and convulsant barbiturates on N-methyl-D-aspartate receptor-mediated calcium flux in brain membrane vesicles., Pharmacology

  • TEND: SECOBARBITAL

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Drug Class adjuvants, anesthesia
    Year of Approval approved before 1982
    Drug Class hypnotics and sedatives

    Publications:

  • TdgClinicalTrial: SECOBARBITAL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Adjuvants, anesthesia
    Drug Indications Hypnotics and Sedatives
    Drug Class small molecule

    Publications:

  • TTD: Secobarbital

    • Version: 2020.06.01

    Alternate Names:
    D00SJE TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL447

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2021-04-13