DGIdb - SECOBARBITAL Drug Record

SECOBARBITAL chembl:CHEMBL447

Alternate Names:

SECOBARBITAL
SECONAL
MEBALLYMAL
(+-)-SECOBARBITAL
5-ALLYL-5-(1-METHYLBUTYL)PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE
SECOBARBITALUM
5-(1-METHYLBUTYL)-5-(2-PROPENYL)-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
QUINALBARBITONE
SECOBARBITONE
5-ALLYL-5-(1-METHYLBUTYL)BARBITURIC ACID
5-ALLYL-5-(1-METHYLBUTYL)-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
SECONAL®
(±)-SECOBARBITAL
chemidplus:76-73-3
rxcui:9624
drugbank:00418
pubchem.compound:5193
chembl:CHEMBL447

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Hypnotics and Sedatives
Drug Indications	Adjuvants, anesthesia
Drug Class	hypnotics and sedatives
Year of Approval	approved before 1982
Drug Class	adjuvants, anesthesia

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Publications:

Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
Peters et al., 1988, Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids., Br. J. Pharmacol.
Miller et al., 1988, Acute barbiturate administration increases benzodiazepine receptor binding in vivo., Psychopharmacology (Berl.)
Kirkness et al., 1986, The gamma-aminobutyrate/benzodiazepine receptor from pig brain. Purification and characterization of the receptor complex from cerebral cortex and cerebellum., Biochem. J.
Whiting, 2003, The GABAA receptor gene family: new opportunities for drug development., Curr Opin Drug Discov Devel
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

SECOBARBITAL GRIK2

Interaction Score: 1.7

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND
SECOBARBITAL GABRA1

Interaction Score: 0.85

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2850060 11264449 2906155 3006661 14579514 10209232 11752352 10487207 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD
SECOBARBITAL CHRNA4

Interaction Score: 0.78

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
SECOBARBITAL GRIA2

Interaction Score: 0.77

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND
SECOBARBITAL CHRNA7

Interaction Score: 0.72

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
SECOBARBITAL GABRA6

Interaction Score: 0.34

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND
SECOBARBITAL GABRA5

Interaction Score: 0.32

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND
SECOBARBITAL GABRA3

Interaction Score: 0.31

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND
SECOBARBITAL GABRA2

Interaction Score: 0.3

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND
SECOBARBITAL GABRA4

Interaction Score: 0.26

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232

Sources:
TdgClinicalTrial TEND

TEND: SECOBARBITAL
- Version: 01-August-2011
Alternate Names:

Drug Info:

Drug Class adjuvants, anesthesia

Year of Approval approved before 1982

Drug Class hypnotics and sedatives

Publications:
TdgClinicalTrial: SECOBARBITAL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Adjuvants, anesthesia

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

Publications:
TTD: Secobarbital
- Version: 2020.06.01
Alternate Names:

D00SJE TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL447
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Novel drug target	Established target
Trial Name	-

Novel drug target	Established target
Trial Name	-

SECOBARBITAL Drug Record

SECOBARBITAL chembl:CHEMBL447

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2850060 11264449 2906155 3006661 14579514 10209232 11752352 10487207 17016423 17139284

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 16248797 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16248797 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10209232 11264449

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10209232 11264449

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10209232 11264449

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10209232 11264449

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10209232

Sources: TdgClinicalTrial TEND

TEND: SECOBARBITAL

Alternate Names:

Drug Info: Drug Class adjuvants, anesthesia Year of Approval approved before 1982 Drug Class hypnotics and sedatives

Publications:

TdgClinicalTrial: SECOBARBITAL

Alternate Names:

Drug Info: Drug Indications Adjuvants, anesthesia Drug Indications Hypnotics and Sedatives Drug Class small molecule

Publications:

TTD: Secobarbital

Alternate Names: D00SJE TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL447

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2850060 11264449 2906155 3006661 14579514 10209232 11752352 10487207 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232

Sources:
TdgClinicalTrial TEND

Drug Info:

Drug Class adjuvants, anesthesia

Year of Approval approved before 1982

Drug Class hypnotics and sedatives

Drug Info:

Drug Indications Adjuvants, anesthesia

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

Alternate Names:

D00SJE TTD Drug ID