DGIdb - SERTINDOLE Drug Record

SERTINDOLE chembl:CHEMBL12713

Alternate Names:

SERTINDOLE
LU-23-174
LU 23-174
SERLECT
1-[2-[4-[5-CHLORO-1-(4-FLUOROPHENYL)-INDOL-3-YL]-1-PIPERIDYL]ETHYL]IMIDAZOLIDIN-2-ONE
SERTINDOLUM
SERTINDOL
SERLECT®
SERDOLECT®
chembl:CHEMBL12713
chemidplus:106516-24-9
rxcui:41996
drugbank:06144
pubchem.compound:60149

Drug Info:

FDA Approval	approved
Drug Class	small molecule
Drug Indications	antipsychotic agent
Year of Approval	not approved by the fda
Drug Class	antipsychotic agents

(1 More Sources)

Publications:

Mørk et al., 2009, Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved., Psychopharmacology (Berl.)
Cincotta et al., 2010, Emerging role of sertindole in the management of schizophrenia., Neuropsychiatr Dis Treat
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Lindström et al., 2006, Sertindole: efficacy and safety in schizophrenia., Expert Opin Pharmacother
Seeman, 2008, Dopamine D2(High) receptors moderately elevated by sertindole., Synapse
Rampe et al., 1998, The antipsychotic agent sertindole is a high affinity antagonist of the human cardiac potassium channel HERG., J. Pharmacol. Exp. Ther.
Kang et al., 2001, The antipsychotic drugs sertindole and pimozide block erg3, a human brain K(+) channel., Biochem. Biophys. Res. Commun.
Tang et al., 2001, Development and evaluation of high throughput functional assay methods for HERG potassium channel., J Biomol Screen
Roden DM, 2004, Drug-induced prolongation of the QT interval., N Engl J Med
Katchman AN et al., 2006, Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs., J Pharmacol Exp Ther
Aronov AM, 2005, Predictive in silico modeling for hERG channel blockers., Drug Discov Today
Hietala et al., 2001, Sertindole is a serotonin 5-HT2c inverse agonist and decreases agonist but not antagonist binding to 5-HT2c receptors after chronic treatment., Psychopharmacology (Berl.)
Schreiber et al., 1994, Blockade of the discriminative stimulus effects of DOI by MDL 100,907 and the 'atypical' antipsychotics, clozapine and risperidone., Eur. J. Pharmacol.
Pouzet et al., 2002, Effects of the 5-HT(6) receptor antagonist, SB-271046, in animal models for schizophrenia., Pharmacol. Biochem. Behav.
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

SERTINDOLE HTR6

Interaction Score: 2.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Serdolect

Novel drug target Established target

PMIDs:
11888555 19506838

Sources:
TdgClinicalTrial TEND
SERTINDOLE ADRA1D

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Serdolect

Novel drug target Established target

PMIDs:
16925508

Sources:
TdgClinicalTrial TEND
SERTINDOLE HTR2C

Interaction Score: 0.45

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Serdolect

PMIDs:
11594443 16925508

Sources:
TdgClinicalTrial TEND
SERTINDOLE ADRA1B

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Serdolect

Novel drug target Established target

PMIDs:
16925508

Sources:
TdgClinicalTrial TEND
SERTINDOLE HTR2A

Interaction Score: 0.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Serdolect

Novel drug target Established target

PMIDs:
11594443 7530204 16925508

Sources:
TdgClinicalTrial TEND
SERTINDOLE ADRA1A

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Serdolect

PMIDs:
11594443 16925508

Sources:
TdgClinicalTrial TEND
SERTINDOLE DRD2

Interaction Score: 0.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Serdolect

Novel drug target Established target

PMIDs:
19506838 20856607 11752352 16925508 18293356

Sources:
TdgClinicalTrial TEND
SERTINDOLE KCNH2

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Serdolect

Novel drug target Established target

PMIDs:
9694935 11511086 11689132 14999113 16278312 15718164

Sources:
TdgClinicalTrial PharmGKB
SERTINDOLE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB
SERTINDOLE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
SERTINDOLE AR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: SERTINDOLE
- Version: 01-August-2011
Alternate Names:

SERTINDOLE Primary Drug Name

Drug Info:

Drug Class antipsychotic agents

Year of Approval not approved by the fda

Publications:
TdgClinicalTrial: SERTINDOLE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antipsychotic agent

Drug Class small molecule

FDA Approval approved

Publications:

PharmGKB: sertindole

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Aronov AM, 2005, Predictive in silico modeling for hERG channel blockers., Drug Discov Today

Katchman AN et al., 2006, Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs., J Pharmacol Exp Ther

Roden DM, 2004, Drug-induced prolongation of the QT interval., N Engl J Med

DTC: SERTINDOLE
- Version: 02-September-2020
Alternate Names:

CHEMBL12713 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL12713
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	Serdolect
Novel drug target	Established target

Trial Name	Serdolect
Novel drug target	Established target

Novel drug target	Established target
Trial Name	Serdolect

Trial Name	Serdolect
Novel drug target	Established target

SERTINDOLE Drug Record

SERTINDOLE chembl:CHEMBL12713

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Serdolect Novel drug target Established target

PMIDs: 11888555 19506838

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Serdolect Novel drug target Established target

PMIDs: 16925508

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Serdolect

PMIDs: 11594443 16925508

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Serdolect Novel drug target Established target

PMIDs: 16925508

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Serdolect Novel drug target Established target

PMIDs: 11594443 7530204 16925508

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name Serdolect

PMIDs: 11594443 16925508

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Serdolect Novel drug target Established target

PMIDs: 19506838 20856607 11752352 16925508 18293356

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Serdolect Novel drug target Established target

PMIDs: 9694935 11511086 11689132 14999113 16278312 15718164

Sources: TdgClinicalTrial PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: SERTINDOLE

Alternate Names: SERTINDOLE Primary Drug Name

Drug Info: Drug Class antipsychotic agents Year of Approval not approved by the fda

Publications:

TdgClinicalTrial: SERTINDOLE

Alternate Names:

Drug Info: Drug Indications antipsychotic agent Drug Class small molecule FDA Approval approved

Publications:

PharmGKB: sertindole

Alternate Names:

Drug Info:

DTC: SERTINDOLE

Alternate Names: CHEMBL12713 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL12713

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Serdolect

Novel drug target Established target

PMIDs:
11888555 19506838

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Serdolect

Novel drug target Established target

PMIDs:
16925508

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Serdolect

PMIDs:
11594443 16925508

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Serdolect

Novel drug target Established target

PMIDs:
16925508

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Serdolect

Novel drug target Established target

PMIDs:
11594443 7530204 16925508

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Serdolect

PMIDs:
11594443 16925508

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Serdolect

Novel drug target Established target

PMIDs:
19506838 20856607 11752352 16925508 18293356

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Serdolect

Novel drug target Established target

PMIDs:
9694935 11511086 11689132 14999113 16278312 15718164

Sources:
TdgClinicalTrial PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

SERTINDOLE Primary Drug Name

Drug Info:

Drug Class antipsychotic agents

Year of Approval not approved by the fda

Drug Info:

Drug Indications antipsychotic agent

Drug Class small molecule

FDA Approval approved

Alternate Names:

CHEMBL12713 ChEMBL Drug ID