DGIdb - SOTALOL Drug Record

SOTALOL chembl:CHEMBL471 Approved

Alternate Names:

MJ-1999
SORINE
BETAPACE
SOTALOL
C07AA07
BETA-CARDONE
SOTALOLUM
4'-(1-HYDROXY-2-(ISOPROPYLAMINO)ETHYL)METHANE SULFONANILIDE
BETAPACE®
SOTALOLO
chemidplus:3930-20-9
pubchem.compound:5253
rxcui:9947
drugbank:00489
chembl:CHEMBL471

Drug Info:

FDA Approval	1992
Drug Class	small molecule
Drug Indications	Anti-Arrhythmia Agents
Year of Approval	1992
Drug Class	anti-arrhythmia agents

(3 More Sources)

Publications:

Joseph et al., 2004, Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers., Naunyn Schmiedebergs Arch. Pharmacol.
Yalcin et al., 2009, beta(2)-adrenoceptors are critical for antidepressant treatment of neuropathic pain., Ann. Neurol.
Doggrell, 1993, The effects of (+/-)-, (+)-, and (-)-atenolol, sotalol, and amosulalol on the rat left atria and portal vein., Chirality
Lowe et al., 2002, Comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium., Br. J. Pharmacol.
Juberg et al., 1985, Beta 1- and beta 2-adrenoceptor binding and functional response in right and left atria of rat heart., Naunyn Schmiedebergs Arch. Pharmacol.
el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
Fedida et al., 2006, The role of late I and antiarrhythmic drugs in EAD formation and termination in Purkinje fibers., J. Cardiovasc. Electrophysiol.
Shimizu et al., 2000, Effects of a K(+) channel opener to reduce transmural dispersion of repolarization and prevent torsade de pointes in LQT1, LQT2, and LQT3 models of the long-QT syndrome., Circulation
Wolpert et al., 2005, Clinical characteristics and treatment of short QT syndrome., Expert Rev Cardiovasc Ther
Numaguchi et al., 2000, Probing the interaction between inactivation gating and Dd-sotalol block of HERG., Circ. Res.
Wolpert et al., 2005, Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG., J. Cardiovasc. Electrophysiol.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

SOTALOL KCNE1

Interaction Score: 1.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
SOTALOL ADRB1

Interaction Score: 0.69

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
8095397 2865685 19259968 11752352 15060759 11815381 2903243

Sources:
DTC GuideToPharmacology TTD
SOTALOL ADRB2

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
15060759 19259968 8095397 11815381 2865685 2903243

Sources:
DTC GuideToPharmacology
SOTALOL KCNH2

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16686685 10931813 16076272 11090546 15673388

Sources:
TdgClinicalTrial TEND
SOTALOL CYP2C9

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
SOTALOL CYP2C19

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
SOTALOL CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
SOTALOL CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
SOTALOL CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
SOTALOL AR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: SOTALOL
- Version: 01-August-2011
Alternate Names:

SOTALOL Primary Drug Name

Drug Info:

Drug Class anti-arrhythmia agents

Year of Approval 1992

Publications:
TdgClinicalTrial: SOTALOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Class small molecule

FDA Approval 1992

Publications:

DTC: SOTALOL

Version: 02-September-2020

Alternate Names:

CHEMBL471 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

GuideToPharmacology: 178103870
- Version: 29-September-2020
Alternate Names:

SOTALOL GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Sotalol
- Version: 2020.06.01
Alternate Names:

D04VMT TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL471
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: sotalol
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	True

Novel drug target	Established target
Trial Name	-

SOTALOL Drug Record

SOTALOL chembl:CHEMBL471 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 8095397 2865685 19259968 11752352 15060759 11815381 2903243

Sources: DTC GuideToPharmacology TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 15060759 19259968 8095397 11815381 2865685 2903243

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 16686685 10931813 16076272 11090546 15673388

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: SOTALOL

Alternate Names: SOTALOL Primary Drug Name

Drug Info: Drug Class anti-arrhythmia agents Year of Approval 1992

Publications:

TdgClinicalTrial: SOTALOL

Alternate Names:

Drug Info: Drug Indications Anti-Arrhythmia Agents Drug Class small molecule FDA Approval 1992

Publications:

DTC: SOTALOL

Alternate Names: CHEMBL471 ChEMBL Drug ID

Drug Info:

GuideToPharmacology: 178103870

Alternate Names: SOTALOL GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Sotalol

Alternate Names: D04VMT TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL471

Alternate Names:

Drug Info:

Publications:

PharmGKB: sotalol

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
8095397 2865685 19259968 11752352 15060759 11815381 2903243

Sources:
DTC GuideToPharmacology TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
15060759 19259968 8095397 11815381 2865685 2903243

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16686685 10931813 16076272 11090546 15673388

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

SOTALOL Primary Drug Name

Drug Info:

Drug Class anti-arrhythmia agents

Year of Approval 1992

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Class small molecule

FDA Approval 1992

Alternate Names:

CHEMBL471 ChEMBL Drug ID

Alternate Names:

SOTALOL GuideToPharmacology Ligand Name

Alternate Names:

D04VMT TTD Drug ID