DGIdb - STAUROSPORINE Drug Record

STAUROSPORINE chembl:CHEMBL388978

Alternate Names:

Drug Info:

(0 More Sources)

Publications:

Ahmed et al., 1997, Acute regulation of glucose transport in a monocyte-macrophage cell line: Glut-3 affinity for glucose is enhanced during the respiratory burst., Biochem. J.
Dornand et al., 1992, Contrasting effects of the protein kinase C inhibitor staurosporine on the interleukin-1 and phorbol ester activation pathways in the EL4-6.1 thymoma cell line., J. Cell. Physiol.
Desai et al., 1995, Control of 1,25-dihydroxyvitamin D3 receptor-mediated enhancement of osteocalcin gene transcription: effects of perturbing phosphorylation pathways by okadaic acid and staurosporine., Endocrinology
Namba et al., 2007, Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells., Mol. Pharmacol.
Blanc-Brude et al., 2007, IAP survivin regulates atherosclerotic macrophage survival., Arterioscler. Thromb. Vasc. Biol.
Schild et al., 2004, Three members of the connective tissue growth factor family CCN are differentially regulated by mechanical stress., Biochim. Biophys. Acta
Essmann et al., 2004, Apoptosis resistance of MCF-7 breast carcinoma cells to ionizing radiation is independent of p53 and cell cycle control but caused by the lack of caspase-3 and a caffeine-inhibitable event., Cancer Res.
Zhang et al., 2004, Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways., Mol. Cancer Ther.
Neumar et al., 2003, Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis., J. Biol. Chem.
Sharma et al., 1991, Phorbol-12-myristate-13-acetate (PMA) and inhibitors of protein kinase C alter glial fibrillary acidic protein (GFAP) mRNA levels., Glia
Sterin-Borda et al., Involvement of nitric oxide synthase and protein kinase C activation on chagasic antibodies action upon cardiac contractility., Mol. Cell. Biochem.
Yamada et al., 1996, Production of C-type natriuretic peptide in human aortic endothelial cells induced by activation of protein kinase C., Am. J. Hypertens.
Steller et al., 1996, Transformation by human papillomavirus 16 E6 and E7: role of the insulin-like growth factor 1 receptor., Cancer Res.
Llanos GG et al., 2012, Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells., Eur J Med Chem
Hedman et al., 1992, Regulation of LFA-1 avidity in human B cells. Requirements for dephosphorylation events for high avidity ICAM-1 binding., J. Immunol.
Huang et al., 2000, Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2., Proc. Natl. Acad. Sci. U.S.A.
Xiao et al., 1999, Involvement of p38 MAPK and ERK/MAPK pathways in staurosporine-induced production of macrophage inflammatory protein-2 in rat peritoneal neutrophils., Biochim. Biophys. Acta
Martín de la Vega et al., 1999, Resistance of initiation factor 2 (eIF-2alpha) kinases to staurosporine: an approach for assaying the kinases in crude extracts., Cell. Signal.
Lindner et al., 1992, Phorbol ester-induced down-regulation of the 80-kDa myristoylated alanine-rich C-kinase substrate-related protein in Swiss 3T3 fibroblasts. Inhibition by staurosporine., J. Biol. Chem.
Do et al., 2003, Effects of propofol on the activity of rat glutamate transporter type 3 expressed in Xenopus oocytes: the role of protein kinase C., Neurosci. Lett.
Do et al., 2002, The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and phosphatidylinositol 3-kinase., Anesth. Analg.
Edashige et al., 1992, Differentiation of HL-60 cells by phorbol ester is correlated with up-regulation of protein kinase C-alpha., Arch. Biochem. Biophys.
Szokodi et al., 2002, Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility., Circ. Res.
Kitagawa et al., 2002, Protective effect of apolipoprotein E against ischemic neuronal injury is mediated through antioxidant action., J. Neurosci. Res.
Nishimura et al., 1994, Staurosporine inhibits phorbol 12-myristate 13-acetate- and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells., Biochem. J.

STAUROSPORINE APLN

Interaction Score: 4.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12215493

Sources:
NCI
STAUROSPORINE MARCKSL1

Interaction Score: 4.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1730592

Sources:
NCI
STAUROSPORINE EIF2S1

Interaction Score: 4.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10400313

Sources:
NCI
STAUROSPORINE DIABLO

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15466201 14985459

Sources:
NCI
STAUROSPORINE CAST

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12576481

Sources:
NCI
STAUROSPORINE SLC1A1

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12759177 12401608

Sources:
NCI
STAUROSPORINE CXCL2

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10354507

Sources:
NCI
STAUROSPORINE NPPC

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8879350

Sources:
NCI
STAUROSPORINE APOE

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11948667

Sources:
NCI
STAUROSPORINE ITGAL

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1356124

Sources:
NCI
STAUROSPORINE CCN2

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15053922

Sources:
NCI
STAUROSPORINE ANXA1

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1444457

Sources:
NCI
STAUROSPORINE GFAP

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1720762

Sources:
NCI
STAUROSPORINE DDIT3

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17167033

Sources:
NCI
STAUROSPORINE IL2RA

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1560050

Sources:
NCI
STAUROSPORINE CASP3

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22705001

Sources:
DTC
STAUROSPORINE BIRC5

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17255535

Sources:
NCI
STAUROSPORINE IGF1R

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8895768

Sources:
NCI
STAUROSPORINE NOS1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8901458

Sources:
NCI
STAUROSPORINE CSF2

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9359403

Sources:
NCI
STAUROSPORINE IKBKB

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
STAUROSPORINE SLC2A4

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8068015

Sources:
NCI
STAUROSPORINE MAP2K1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
STAUROSPORINE EGFR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
STAUROSPORINE RECQL

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
STAUROSPORINE VDR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7588324

Sources:
NCI
STAUROSPORINE NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11035812

Sources:
NCI

NCI: STAUROSPORINE

Version: 14-September-2017

Alternate Names:

C1237 NCI drug code

Drug Info:

Publications:

Ahmed et al., 1997, Acute regulation of glucose transport in a monocyte-macrophage cell line: Glut-3 affinity for glucose is enhanced during the respiratory burst., Biochem. J.

Dornand et al., 1992, Contrasting effects of the protein kinase C inhibitor staurosporine on the interleukin-1 and phorbol ester activation pathways in the EL4-6.1 thymoma cell line., J. Cell. Physiol.

Namba et al., 2007, Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells., Mol. Pharmacol.

DTC: STAUROSPORINE
- Version: 02-September-2020
Alternate Names:

CHEMBL388978 ChEMBL Drug ID

Drug Info:

Publications:

Llanos GG et al., 2012, Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells., Eur J Med Chem
TTD: Staurosporine
- Version: 2020.06.01
Alternate Names:

D0E3TC TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL388978
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

STAUROSPORINE Drug Record

STAUROSPORINE chembl:CHEMBL388978

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12215493

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1730592

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10400313

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15466201 14985459

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12576481

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12759177 12401608

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10354507

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8879350

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11948667

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1356124

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15053922

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1444457

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1720762

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17167033

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1560050

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22705001

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17255535

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8895768

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8901458

Interaction Types & Directionality:

n/a

PMIDs:
12215493

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1730592

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10400313

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15466201 14985459

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12576481

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12759177 12401608

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10354507

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8879350

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11948667

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1356124

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15053922

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1444457

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1720762

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17167033

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1560050

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22705001

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17255535

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8895768

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8901458

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9359403

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
8068015

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
7588324

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11035812