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STAUROSPORINE Drug Record

  • Summary
  • Interactions
  • Claims
  • STAUROSPORINE chembl:CHEMBL388978

    Alternate Names:

    Drug Info:

    (0 More Sources)

    Publications:

    Ahmed et al., 1997, Acute regulation of glucose transport in a monocyte-macrophage cell line: Glut-3 affinity for glucose is enhanced during the respiratory burst., Biochem. J.
    Dornand et al., 1992, Contrasting effects of the protein kinase C inhibitor staurosporine on the interleukin-1 and phorbol ester activation pathways in the EL4-6.1 thymoma cell line., J. Cell. Physiol.
    Desai et al., 1995, Control of 1,25-dihydroxyvitamin D3 receptor-mediated enhancement of osteocalcin gene transcription: effects of perturbing phosphorylation pathways by okadaic acid and staurosporine., Endocrinology
    Namba et al., 2007, Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells., Mol. Pharmacol.
    Blanc-Brude et al., 2007, IAP survivin regulates atherosclerotic macrophage survival., Arterioscler. Thromb. Vasc. Biol.
    Schild et al., 2004, Three members of the connective tissue growth factor family CCN are differentially regulated by mechanical stress., Biochim. Biophys. Acta
    Essmann et al., 2004, Apoptosis resistance of MCF-7 breast carcinoma cells to ionizing radiation is independent of p53 and cell cycle control but caused by the lack of caspase-3 and a caffeine-inhibitable event., Cancer Res.
    Zhang et al., 2004, Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways., Mol. Cancer Ther.
    Neumar et al., 2003, Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis., J. Biol. Chem.
    Sharma et al., 1991, Phorbol-12-myristate-13-acetate (PMA) and inhibitors of protein kinase C alter glial fibrillary acidic protein (GFAP) mRNA levels., Glia
    Sterin-Borda et al., Involvement of nitric oxide synthase and protein kinase C activation on chagasic antibodies action upon cardiac contractility., Mol. Cell. Biochem.
    Yamada et al., 1996, Production of C-type natriuretic peptide in human aortic endothelial cells induced by activation of protein kinase C., Am. J. Hypertens.
    Steller et al., 1996, Transformation by human papillomavirus 16 E6 and E7: role of the insulin-like growth factor 1 receptor., Cancer Res.
    Llanos GG et al., 2012, Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells., Eur J Med Chem
    Hedman et al., 1992, Regulation of LFA-1 avidity in human B cells. Requirements for dephosphorylation events for high avidity ICAM-1 binding., J. Immunol.
    Huang et al., 2000, Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2., Proc. Natl. Acad. Sci. U.S.A.
    Xiao et al., 1999, Involvement of p38 MAPK and ERK/MAPK pathways in staurosporine-induced production of macrophage inflammatory protein-2 in rat peritoneal neutrophils., Biochim. Biophys. Acta
    Martín de la Vega et al., 1999, Resistance of initiation factor 2 (eIF-2alpha) kinases to staurosporine: an approach for assaying the kinases in crude extracts., Cell. Signal.
    Lindner et al., 1992, Phorbol ester-induced down-regulation of the 80-kDa myristoylated alanine-rich C-kinase substrate-related protein in Swiss 3T3 fibroblasts. Inhibition by staurosporine., J. Biol. Chem.
    Do et al., 2003, Effects of propofol on the activity of rat glutamate transporter type 3 expressed in Xenopus oocytes: the role of protein kinase C., Neurosci. Lett.
    Do et al., 2002, The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and phosphatidylinositol 3-kinase., Anesth. Analg.
    Edashige et al., 1992, Differentiation of HL-60 cells by phorbol ester is correlated with up-regulation of protein kinase C-alpha., Arch. Biochem. Biophys.
    Szokodi et al., 2002, Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility., Circ. Res.
    Kitagawa et al., 2002, Protective effect of apolipoprotein E against ischemic neuronal injury is mediated through antioxidant action., J. Neurosci. Res.
    Nishimura et al., 1994, Staurosporine inhibits phorbol 12-myristate 13-acetate- and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells., Biochem. J.
  • STAUROSPORINE   APLN

    Interaction Score: 4.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12215493


    Sources:
    NCI

  • STAUROSPORINE   MARCKSL1

    Interaction Score: 4.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1730592


    Sources:
    NCI

  • STAUROSPORINE   EIF2S1

    Interaction Score: 4.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10400313


    Sources:
    NCI

  • STAUROSPORINE   DIABLO

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15466201 14985459


    Sources:
    NCI

  • STAUROSPORINE   CAST

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12576481


    Sources:
    NCI

  • STAUROSPORINE   SLC1A1

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12759177 12401608


    Sources:
    NCI

  • STAUROSPORINE   CXCL2

    Interaction Score: 0.92

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10354507


    Sources:
    NCI

  • STAUROSPORINE   NPPC

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8879350


    Sources:
    NCI

  • STAUROSPORINE   APOE

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11948667


    Sources:
    NCI

  • STAUROSPORINE   ITGAL

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1356124


    Sources:
    NCI

  • STAUROSPORINE   CCN2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15053922


    Sources:
    NCI

  • STAUROSPORINE   ANXA1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1444457


    Sources:
    NCI

  • STAUROSPORINE   GFAP

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1720762


    Sources:
    NCI

  • STAUROSPORINE   DDIT3

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17167033


    Sources:
    NCI

  • STAUROSPORINE   IL2RA

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1560050


    Sources:
    NCI

  • STAUROSPORINE   CASP3

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22705001


    Sources:
    DTC

  • STAUROSPORINE   BIRC5

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17255535


    Sources:
    NCI

  • STAUROSPORINE   IGF1R

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8895768


    Sources:
    NCI

  • STAUROSPORINE   NOS1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8901458


    Sources:
    NCI

  • STAUROSPORINE   CSF2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9359403


    Sources:
    NCI

  • STAUROSPORINE   IKBKB

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • STAUROSPORINE   SLC2A4

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8068015


    Sources:
    NCI

  • STAUROSPORINE   MAP2K1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • STAUROSPORINE   EGFR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • STAUROSPORINE   RECQL

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • STAUROSPORINE   VDR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7588324


    Sources:
    NCI

  • STAUROSPORINE   NFE2L2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11035812


    Sources:
    NCI

  • NCI: STAUROSPORINE

    • Version: 14-September-2017

    Alternate Names:
    C1237 NCI drug code

    Drug Info:

    Publications:
    Ahmed et al., 1997, Acute regulation of glucose transport in a monocyte-macrophage cell line: Glut-3 affinity for glucose is enhanced during the respiratory burst., Biochem. J.
    Dornand et al., 1992, Contrasting effects of the protein kinase C inhibitor staurosporine on the interleukin-1 and phorbol ester activation pathways in the EL4-6.1 thymoma cell line., J. Cell. Physiol.
    Namba et al., 2007, Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells., Mol. Pharmacol.

  • DTC: STAUROSPORINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL388978 ChEMBL Drug ID

    Drug Info:

    Publications:
    Llanos GG et al., 2012, Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells., Eur J Med Chem

  • TTD: Staurosporine

    • Version: 2020.06.01

    Alternate Names:
    D0E3TC TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL388978

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21