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STAVUDINE Drug Record

  • Summary
  • Interactions
  • Claims
  • STAVUDINE chembl:CHEMBL991 Approved

    Alternate Names:

    ZERIT XR
    STAVUDINE
    D-4T
    BMY-27857
    SANILVUDINE
    ZERIT
    NSC-163661
    D4T
    3'-DEOXY-2'-THYMIDINENE
    STAVUDIN
    ESTAVUDINA
    2',3'-DIDEHYDRO-3'-DEOXYTHIMIDINE
    1-(2,3-DIDEOXY-BETA-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE
    STV
    STAVUDINUM
    rxcui:59763
    drugbank:00649
    chemidplus:3056-17-5
    pubchem.compound:18283
    chembl:CHEMBL991

    Drug Info:

    (2 More Sources)

    Publications:

    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Moketla MB et al., 2018, Pharmacogenetic variation influences sensory neuropathy occurrence in Southern Africans treated with stavudine-containing antiretroviral therapy., PLoS One
    Habtewold A et al., 2013, Pharmacogenetic and pharmacokinetic aspects of CYP3A induction by efavirenz in HIV patients., Pharmacogenomics J
    Lavie et al., 2004, Structural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase., Mini Rev Med Chem
    Perno et al., 1989, Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine., J. Exp. Med.
    Chew CS et al., 2011, Tumour necrosis factor haplotypes associated with sensory neuropathy in Asian and Caucasian human immunodeficiency virus patients., Tissue Antigens
    Gisolf et al., 2000, Increasing cerebrospinal fluid chemokine concentrations despite undetectable cerebrospinal fluid HIV RNA in HIV-1-infected patients receiving antiretroviral therapy., J. Acquir. Immune Defic. Syndr.
    Nokta et al., 1997, Kinetics of tumor necrosis factor alpha and soluble TNFRII in HIV-infected patients treated with a triple combination of stavudine, didanosine, and hydroxyurea., AIDS Res. Hum. Retroviruses
  • STAVUDINE   SAMHD1

    Interaction Score: 8.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30273369


    Sources:
    PharmGKB

  • STAVUDINE   DTYMK

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15134538


    Sources:
    NCI

  • STAVUDINE   TNFRSF1B

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9430255


    Sources:
    NCI

  • STAVUDINE   CXCL10

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11141242


    Sources:
    NCI

  • STAVUDINE   CSF2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2538549


    Sources:
    NCI

  • STAVUDINE   CYP2B6

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23089673


    Sources:
    PharmGKB

  • STAVUDINE   HLA-B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • STAVUDINE   TNF

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20887379


    Sources:
    PharmGKB

  • STAVUDINE   PLK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • STAVUDINE   CYP2C9

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • STAVUDINE   CYP2C19

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • STAVUDINE   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • STAVUDINE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • STAVUDINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • NCI: STAVUDINE

    • Version: 14-September-2017

    Alternate Names:
    C1428 NCI drug code

    Drug Info:

    Publications:
    Nokta et al., 1997, Kinetics of tumor necrosis factor alpha and soluble TNFRII in HIV-infected patients treated with a triple combination of stavudine, didanosine, and hydroxyurea., AIDS Res. Hum. Retroviruses

  • NCI: D4T

    • Version: 14-September-2017

    Alternate Names:
    C1428 NCI drug code

    Drug Info:

    Publications:
    Perno et al., 1989, Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine., J. Exp. Med.
    Lavie et al., 2004, Structural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase., Mini Rev Med Chem
    Gisolf et al., 2000, Increasing cerebrospinal fluid chemokine concentrations despite undetectable cerebrospinal fluid HIV RNA in HIV-1-infected patients receiving antiretroviral therapy., J. Acquir. Immune Defic. Syndr.

  • DTC: STAVUDINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL991 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: stavudine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Moketla MB et al., 2018, Pharmacogenetic variation influences sensory neuropathy occurrence in Southern Africans treated with stavudine-containing antiretroviral therapy., PLoS One
    Habtewold A et al., 2013, Pharmacogenetic and pharmacokinetic aspects of CYP3A induction by efavirenz in HIV patients., Pharmacogenomics J
    Chew CS et al., 2011, Tumour necrosis factor haplotypes associated with sensory neuropathy in Asian and Caucasian human immunodeficiency virus patients., Tissue Antigens

  • TTD: Stavudine

    • Version: 2020.06.01

    Alternate Names:
    D0Z8EX TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL991

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21