DGIdb - STREPTOZOCIN Drug Record

STREPTOZOCIN chembl:CHEMBL1651906 ApprovedAntineoplasticImmunotherapy

Alternate Names:

ZANOSAR
STREPTOZOTOCIN
STZ
NSC-37917
STREPTOZOCIN
NSC-85998
U-9889

Drug Info:

(1 More Sources)

Publications:

Guttentag et al., 1992, Delayed hydrophobic surfactant protein (SP-B, SP-C) expression in fetuses of streptozotocin-treated rats., Am. J. Respir. Cell Mol. Biol.
Koo et al., 1993, Early molecular changes associated with streptozotocin-induced diabetic bladder hypertrophy in the rat., Urol. Res.
Afzal et al., 1989, Influence of verapamil on some subcellular defects in diabetic cardiomyopathy., Am. J. Physiol.
Nasrallah et al., 2007, Renal prostaglandin E2 receptor (EP) expression profile is altered in streptozotocin and B6-Ins2Akita type I diabetic mice., Am. J. Physiol. Renal Physiol.
Tamakawa et al., 1998, The augmentation of pituitary adenylate cyclase-activating polypeptide (PACAP) in streptozotocin-induced diabetic rats., Peptides
Miyamoto et al., 1991, Diabetes and glucose transporter gene expression in rat small intestine., Biochem. Biophys. Res. Commun.
Nerurkar et al., 1988, Insulin-dependent changes in lysosomal cathepsin D activity in rat liver, kidney, brain and heart., Diabetologia
Broulík et al., 2003, The influence of nitric oxide synthase inhibitor L-NAME on bones of male rats with streptozotocin-induced diabetes., Physiol Res
Murao et al., 1995, Suppression of episodic growth hormone secretion in streptozotocin-induced diabetic mice: time-course studies on the hypothalamic pituitary axis., Endocrinology
Salers, 1994, Enhancement by streptozotocin-induced diabetes of pancreatic prolyl endopeptidase activity in neonatal rats., Regul. Pept.
Baydas et al., 2003, Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats., Free Radic. Biol. Med.
Rodgers et al., 1995, Corticosterone regulation of insulin-like growth factor I, IGF-binding proteins, and growth in streptozotocin-induced diabetic rats., Diabetes
Luo et al., 1991, Differential expression of insulin-like growth factor-I and insulin-like growth factor binding protein-1 in the diabetic rat., Mol. Cell. Biochem.
Garcia-Ocana et al., 2003, Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death., J. Biol. Chem.
Li et al., 2000, [Effects of glibenclamide on mRNA level of ATP-sensitive potassium channels of heart in normal and streptozotocin-induced diabetic rats]., Zhonghua Yi Xue Za Zhi
Namkoong et al., 2005, Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats., Diabetes
Wu et al., 1997, Altered kidney matrix gene expression in early stages of experimental diabetes., Acta Anat (Basel)
Cunningham et al., 1990, Development of a radioimmunoassay for neurone specific enolase (NSE) and its application in the study of patients receiving intra hepatic arterial streptozotocin and floxuridine., Clin. Chim. Acta
Burcelin et al., 1993, Changes in uncoupling protein and GLUT4 glucose transporter expressions in interscapular brown adipose tissue of diabetic rats: relative roles of hyperglycaemia and hypoinsulinaemia., Biochem. J.
Pabbidi et al., 2008, Direct role of streptozotocin in inducing thermal hyperalgesia by enhanced expression of transient receptor potential vanilloid 1 in sensory neurons., Mol. Pharmacol.
Yousif et al., Phosphoinositide 3-kinase mediated signalling contributes to development of diabetes-induced abnormal vascular reactivity of rat carotid artery., Cell Biochem. Funct.
Chai et al., 2007, Molecular basis of dysfunctional Kv channels in small coronary artery smooth muscle cells of streptozotocin-induced diabetic rats., Chin J Physiol
Eizirik et al., 1993, Genotoxic agents increase expression of growth arrest and DNA damage--inducible genes gadd 153 and gadd 45 in rat pancreatic islets., Diabetes
Asada et al., 1998, Overexpression of glucose transporter protein 5 in sciatic nerve of streptozotocin-induced diabetic rats., Neurosci. Lett.
Jump et al., 1990, Insulin rapidly induces rat liver S14 gene transcription., Mol. Endocrinol.
Giunti et al., 2008, Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells., Diabetologia
Apostolova et al., 1997, Analysis of the possible protective role of metallothionein in streptozotocin-induced diabetes using metallothionein-null mice., J Trace Elem Med Biol
Hrubec et al., 2006, Reduction in diabetes-induced craniofacial defects by maternal immune stimulation., Birth Defects Res. B Dev. Reprod. Toxicol.
Enoki et al., 2003, Exercise training alleviates MCT1 and MCT4 reductions in heart and skeletal muscles of STZ-induced diabetic rats., J. Appl. Physiol.
Ugochukwu et al., 2007, Caloric restriction inhibits up-regulation of inflammatory cytokines and TNF-alpha, and activates IL-10 and haptoglobin in the plasma of streptozotocin-induced diabetic rats., J. Nutr. Biochem.
Bruno et al., 1994, Pituitary and hypothalamic somatostatin receptor subtype messenger ribonucleic acid expression in the food-deprived and diabetic rat., Endocrinology
Soulimane-Mokhtari et al., 2008, Serum lipoprotein composition, lecithin cholesterol acyltransferase and tissue lipase activities in pregnant diabetic rats and their offspring receiving enriched n-3 PUFA diet., Gen. Physiol. Biophys.
Peng et al., 1983, Alterations of microsomal monooxygenase system and carcinogen metabolism by streptozotocin-induced diabetes in rats., Carcinogenesis
Kover et al., 2001, CD40/154 blockade and rejection of islet allografts in the streptozotocin and autoimmune diabetic rat., Pediatr Diabetes
Nierkens et al., 2002, Selective requirement for CD40-CD154 in drug-induced type 1 versus type 2 responses to trinitrophenyl-ovalbumin., J. Immunol.
Jesmin et al., 2006, Effects of dual endothelin receptor antagonist on antiapoptotic marker Bcl-2 expression in streptozotocin-induced diabetic rats., Exp. Biol. Med. (Maywood)
Schmidt et al., 1989, Tyrosine hydroxylase activity in sympathetic nervous system of rats with streptozocin-induced diabetes., Diabetes
Middlemas et al., 2003, Enhanced activation of axonally transported stress-activated protein kinases in peripheral nerve in diabetic neuropathy is prevented by neurotrophin-3., Brain
Schmidt et al., 2000, Effect of streptozotocin-induced diabetes on NGF, P75(NTR) and TrkA content of prevertebral and paravertebral rat sympathetic ganglia., Brain Res.
Silveira et al., 2002, The genetics of hypertension modifies the renal cell replication response induced by experimental diabetes., Diabetes
Dombrowski et al., 1998, Selective impairment in GLUT4 translocation to transverse tubules in skeletal muscle of streptozotocin-induced diabetic rats., Diabetes
Maor et al., 1999, The insulin-sensitive glucose transporter (GLUT4) is involved in early bone growth in control and diabetic mice, but is regulated through the insulin-like growth factor I receptor., Endocrinology
Pedersen et al., 1990, Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM., Diabetes
Barnett et al., 1993, Sex differences in the diabetes-induced modulation of rat hepatic cytochrome P450 proteins., Biochem. Pharmacol.
Winocour et al., 1985, Effect of insulin treatment in streptozocin-induced diabetic rats on in vitro platelet function and plasma von Willebrand factor activity and factor VIII-related antigen., J. Lab. Clin. Med.
Bivalacqua et al., 2005, Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy., J Sex Med
Adachi et al., 2003, Morphological changes and increased sucrase and isomaltase activity in small intestines of insulin-deficient and type 2 diabetic rats., Endocr. J.
Runge-Morris et al., 1995, Effects of streptozotocin-induced diabetes on rat liver sulfotransferase gene expression., Drug Metab. Dispos.
Konrad et al., 2001, The potential mechanism of the diabetogenic action of streptozotocin: inhibition of pancreatic beta-cell O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase., Biochem. J.
Pathak S et al., 2008, Chemical dissection of the link between streptozotocin, O-GlcNAc, and pancreatic cell death., Chem Biol
Hiragushi et al., 2004, The role of adrenomedullin and receptors in glomerular hyperfiltration in streptozotocin-induced diabetic rats., Kidney Int.
Fraley et al., 2004, Effects of diabetes and insulin on the expression of galanin-like peptide in the hypothalamus of the rat., Diabetes

STREPTOZOCIN OGA

Interaction Score: 4.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11336633 18721751

Sources:
NCI
STREPTOZOCIN GALP

Interaction Score: 2.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15111492

Sources:
NCI
STREPTOZOCIN SULT1A2

Interaction Score: 2.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7600911

Sources:
NCI
STREPTOZOCIN SLC16A3

Interaction Score: 2.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12611763

Sources:
NCI
STREPTOZOCIN CTSD

Interaction Score: 2.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3282952

Sources:
NCI
STREPTOZOCIN SFTPB

Interaction Score: 2.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1386745

Sources:
NCI
STREPTOZOCIN HP

Interaction Score: 1.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16713232

Sources:
NCI
STREPTOZOCIN MT1H

Interaction Score: 1.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9176863

Sources:
NCI
STREPTOZOCIN SLC2A5

Interaction Score: 1.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9756334

Sources:
NCI
STREPTOZOCIN S100B

Interaction Score: 1.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14583344

Sources:
NCI
STREPTOZOCIN ADCYAP1

Interaction Score: 1.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9864055

Sources:
NCI
STREPTOZOCIN RAMP3

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14717924

Sources:
NCI
STREPTOZOCIN ATF2

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12805110

Sources:
NCI
STREPTOZOCIN UCP1

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8471028

Sources:
NCI
STREPTOZOCIN PREP

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8190911

Sources:
NCI
STREPTOZOCIN LCAT

Interaction Score: 0.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18436977

Sources:
NCI
STREPTOZOCIN THRSP

Interaction Score: 0.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2177838

Sources:
NCI
STREPTOZOCIN ACP5

Interaction Score: 0.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14640894

Sources:
NCI
STREPTOZOCIN SI

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12940455

Sources:
NCI
STREPTOZOCIN KCNA2

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17982915

Sources:
NCI
STREPTOZOCIN SLC5A1

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1722397

Sources:
NCI
STREPTOZOCIN IGFBP1

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7589849 1713293

Sources:
NCI
STREPTOZOCIN PTGER4

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16954344

Sources:
NCI
STREPTOZOCIN SST

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7664670

Sources:
NCI
STREPTOZOCIN CD40

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15016184 11937525

Sources:
NCI
STREPTOZOCIN ENO2

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2146046

Sources:
NCI
STREPTOZOCIN VWF

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3928783 16422885

Sources:
NCI
STREPTOZOCIN CYP7B1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8435090

Sources:
NCI
STREPTOZOCIN SSTR1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7956902

Sources:
NCI
STREPTOZOCIN MYO9B

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2523196

Sources:
NCI
STREPTOZOCIN CDKN1B

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11978652

Sources:
NCI
STREPTOZOCIN HGF

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12403787

Sources:
NCI
STREPTOZOCIN TH

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2568957

Sources:
NCI
STREPTOZOCIN SLC2A4

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9421368 10098523 2354749

Sources:
NCI
STREPTOZOCIN MMP2

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9394952

Sources:
NCI
STREPTOZOCIN DDIT3

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8482431

Sources:
NCI
STREPTOZOCIN PRKAA1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15616011

Sources:
NCI
STREPTOZOCIN KCNJ11

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11798815

Sources:
NCI
STREPTOZOCIN HRAS

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8171758

Sources:
NCI
STREPTOZOCIN TGFB1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17968528

Sources:
NCI
STREPTOZOCIN TRPV1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18089839

Sources:
NCI
STREPTOZOCIN CSF2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16342200

Sources:
NCI
STREPTOZOCIN BCL2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16741044

Sources:
NCI
STREPTOZOCIN NTRK1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10837808

Sources:
NCI
STREPTOZOCIN PIK3CA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16130182

Sources:
NCI
STREPTOZOCIN CYP2D6

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6305526

Sources:
NCI

NCI: STREPTOZOTOCIN

Version: 14-September-2017

Alternate Names:

C845 NCI drug code

Drug Info:

Publications:

Afzal et al., 1989, Influence of verapamil on some subcellular defects in diabetic cardiomyopathy., Am. J. Physiol.

Broulík et al., 2003, The influence of nitric oxide synthase inhibitor L-NAME on bones of male rats with streptozotocin-induced diabetes., Physiol Res

Murao et al., 1995, Suppression of episodic growth hormone secretion in streptozotocin-induced diabetic mice: time-course studies on the hypothalamic pituitary axis., Endocrinology

NCI: STREPTOZOCIN

Version: 14-September-2017

Alternate Names:

C845 NCI drug code

Drug Info:

Publications:

Schmidt et al., 1989, Tyrosine hydroxylase activity in sympathetic nervous system of rats with streptozocin-induced diabetes., Diabetes

Pedersen et al., 1990, Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM., Diabetes

Winocour et al., 1985, Effect of insulin treatment in streptozocin-induced diabetic rats on in vitro platelet function and plasma von Willebrand factor activity and factor VIII-related antigen., J. Lab. Clin. Med.

NCI: STZ

Version: 14-September-2017

Alternate Names:

C845 NCI drug code

Drug Info:

Publications:

Salers, 1994, Enhancement by streptozotocin-induced diabetes of pancreatic prolyl endopeptidase activity in neonatal rats., Regul. Pept.

Yousif et al., Phosphoinositide 3-kinase mediated signalling contributes to development of diabetes-induced abnormal vascular reactivity of rat carotid artery., Cell Biochem. Funct.

Middlemas et al., 2003, Enhanced activation of axonally transported stress-activated protein kinases in peripheral nerve in diabetic neuropathy is prevented by neurotrophin-3., Brain

TTD: Streptozocin
- Version: 2020.06.01
Alternate Names:

D0I8RR TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1651906
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

STREPTOZOCIN Drug Record

STREPTOZOCIN chembl:CHEMBL1651906 ApprovedAntineoplasticImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11336633 18721751

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15111492

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7600911

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12611763

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3282952

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1386745

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16713232

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9176863

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9756334

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14583344

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9864055

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14717924

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12805110

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8471028

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8190911

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18436977

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2177838

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14640894

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12940455

Interaction Types & Directionality:

n/a

PMIDs:
11336633 18721751

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15111492

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7600911

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12611763

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3282952

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1386745

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16713232

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9176863

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9756334

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14583344

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9864055

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14717924

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12805110

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8471028

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8190911

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18436977

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2177838

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14640894

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12940455

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17982915

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1722397

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7589849 1713293

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16954344

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7664670

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15016184 11937525

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2146046

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3928783 16422885