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STREPTOZOCIN Drug Record

  • Summary
  • Interactions
  • Claims
  • STREPTOZOCIN chembl:CHEMBL1651906 ApprovedAntineoplasticImmunotherapy

    Alternate Names:

    ZANOSAR
    STREPTOZOTOCIN
    STZ
    NSC-37917
    STREPTOZOCIN
    NSC-85998
    U-9889

    Drug Info:

    (1 More Sources)

    Publications:

    Guttentag et al., 1992, Delayed hydrophobic surfactant protein (SP-B, SP-C) expression in fetuses of streptozotocin-treated rats., Am. J. Respir. Cell Mol. Biol.
    Koo et al., 1993, Early molecular changes associated with streptozotocin-induced diabetic bladder hypertrophy in the rat., Urol. Res.
    Afzal et al., 1989, Influence of verapamil on some subcellular defects in diabetic cardiomyopathy., Am. J. Physiol.
    Nasrallah et al., 2007, Renal prostaglandin E2 receptor (EP) expression profile is altered in streptozotocin and B6-Ins2Akita type I diabetic mice., Am. J. Physiol. Renal Physiol.
    Tamakawa et al., 1998, The augmentation of pituitary adenylate cyclase-activating polypeptide (PACAP) in streptozotocin-induced diabetic rats., Peptides
    Miyamoto et al., 1991, Diabetes and glucose transporter gene expression in rat small intestine., Biochem. Biophys. Res. Commun.
    Nerurkar et al., 1988, Insulin-dependent changes in lysosomal cathepsin D activity in rat liver, kidney, brain and heart., Diabetologia
    Broulík et al., 2003, The influence of nitric oxide synthase inhibitor L-NAME on bones of male rats with streptozotocin-induced diabetes., Physiol Res
    Murao et al., 1995, Suppression of episodic growth hormone secretion in streptozotocin-induced diabetic mice: time-course studies on the hypothalamic pituitary axis., Endocrinology
    Salers, 1994, Enhancement by streptozotocin-induced diabetes of pancreatic prolyl endopeptidase activity in neonatal rats., Regul. Pept.
    Baydas et al., 2003, Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats., Free Radic. Biol. Med.
    Rodgers et al., 1995, Corticosterone regulation of insulin-like growth factor I, IGF-binding proteins, and growth in streptozotocin-induced diabetic rats., Diabetes
    Luo et al., 1991, Differential expression of insulin-like growth factor-I and insulin-like growth factor binding protein-1 in the diabetic rat., Mol. Cell. Biochem.
    Garcia-Ocana et al., 2003, Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death., J. Biol. Chem.
    Li et al., 2000, [Effects of glibenclamide on mRNA level of ATP-sensitive potassium channels of heart in normal and streptozotocin-induced diabetic rats]., Zhonghua Yi Xue Za Zhi
    Namkoong et al., 2005, Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats., Diabetes
    Wu et al., 1997, Altered kidney matrix gene expression in early stages of experimental diabetes., Acta Anat (Basel)
    Cunningham et al., 1990, Development of a radioimmunoassay for neurone specific enolase (NSE) and its application in the study of patients receiving intra hepatic arterial streptozotocin and floxuridine., Clin. Chim. Acta
    Burcelin et al., 1993, Changes in uncoupling protein and GLUT4 glucose transporter expressions in interscapular brown adipose tissue of diabetic rats: relative roles of hyperglycaemia and hypoinsulinaemia., Biochem. J.
    Pabbidi et al., 2008, Direct role of streptozotocin in inducing thermal hyperalgesia by enhanced expression of transient receptor potential vanilloid 1 in sensory neurons., Mol. Pharmacol.
    Yousif et al., Phosphoinositide 3-kinase mediated signalling contributes to development of diabetes-induced abnormal vascular reactivity of rat carotid artery., Cell Biochem. Funct.
    Chai et al., 2007, Molecular basis of dysfunctional Kv channels in small coronary artery smooth muscle cells of streptozotocin-induced diabetic rats., Chin J Physiol
    Eizirik et al., 1993, Genotoxic agents increase expression of growth arrest and DNA damage--inducible genes gadd 153 and gadd 45 in rat pancreatic islets., Diabetes
    Asada et al., 1998, Overexpression of glucose transporter protein 5 in sciatic nerve of streptozotocin-induced diabetic rats., Neurosci. Lett.
    Jump et al., 1990, Insulin rapidly induces rat liver S14 gene transcription., Mol. Endocrinol.
    Giunti et al., 2008, Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells., Diabetologia
    Apostolova et al., 1997, Analysis of the possible protective role of metallothionein in streptozotocin-induced diabetes using metallothionein-null mice., J Trace Elem Med Biol
    Hrubec et al., 2006, Reduction in diabetes-induced craniofacial defects by maternal immune stimulation., Birth Defects Res. B Dev. Reprod. Toxicol.
    Enoki et al., 2003, Exercise training alleviates MCT1 and MCT4 reductions in heart and skeletal muscles of STZ-induced diabetic rats., J. Appl. Physiol.
    Ugochukwu et al., 2007, Caloric restriction inhibits up-regulation of inflammatory cytokines and TNF-alpha, and activates IL-10 and haptoglobin in the plasma of streptozotocin-induced diabetic rats., J. Nutr. Biochem.
    Bruno et al., 1994, Pituitary and hypothalamic somatostatin receptor subtype messenger ribonucleic acid expression in the food-deprived and diabetic rat., Endocrinology
    Soulimane-Mokhtari et al., 2008, Serum lipoprotein composition, lecithin cholesterol acyltransferase and tissue lipase activities in pregnant diabetic rats and their offspring receiving enriched n-3 PUFA diet., Gen. Physiol. Biophys.
    Peng et al., 1983, Alterations of microsomal monooxygenase system and carcinogen metabolism by streptozotocin-induced diabetes in rats., Carcinogenesis
    Kover et al., 2001, CD40/154 blockade and rejection of islet allografts in the streptozotocin and autoimmune diabetic rat., Pediatr Diabetes
    Nierkens et al., 2002, Selective requirement for CD40-CD154 in drug-induced type 1 versus type 2 responses to trinitrophenyl-ovalbumin., J. Immunol.
    Jesmin et al., 2006, Effects of dual endothelin receptor antagonist on antiapoptotic marker Bcl-2 expression in streptozotocin-induced diabetic rats., Exp. Biol. Med. (Maywood)
    Schmidt et al., 1989, Tyrosine hydroxylase activity in sympathetic nervous system of rats with streptozocin-induced diabetes., Diabetes
    Middlemas et al., 2003, Enhanced activation of axonally transported stress-activated protein kinases in peripheral nerve in diabetic neuropathy is prevented by neurotrophin-3., Brain
    Schmidt et al., 2000, Effect of streptozotocin-induced diabetes on NGF, P75(NTR) and TrkA content of prevertebral and paravertebral rat sympathetic ganglia., Brain Res.
    Silveira et al., 2002, The genetics of hypertension modifies the renal cell replication response induced by experimental diabetes., Diabetes
    Dombrowski et al., 1998, Selective impairment in GLUT4 translocation to transverse tubules in skeletal muscle of streptozotocin-induced diabetic rats., Diabetes
    Maor et al., 1999, The insulin-sensitive glucose transporter (GLUT4) is involved in early bone growth in control and diabetic mice, but is regulated through the insulin-like growth factor I receptor., Endocrinology
    Pedersen et al., 1990, Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM., Diabetes
    Barnett et al., 1993, Sex differences in the diabetes-induced modulation of rat hepatic cytochrome P450 proteins., Biochem. Pharmacol.
    Winocour et al., 1985, Effect of insulin treatment in streptozocin-induced diabetic rats on in vitro platelet function and plasma von Willebrand factor activity and factor VIII-related antigen., J. Lab. Clin. Med.
    Bivalacqua et al., 2005, Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy., J Sex Med
    Adachi et al., 2003, Morphological changes and increased sucrase and isomaltase activity in small intestines of insulin-deficient and type 2 diabetic rats., Endocr. J.
    Runge-Morris et al., 1995, Effects of streptozotocin-induced diabetes on rat liver sulfotransferase gene expression., Drug Metab. Dispos.
    Konrad et al., 2001, The potential mechanism of the diabetogenic action of streptozotocin: inhibition of pancreatic beta-cell O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase., Biochem. J.
    Pathak S et al., 2008, Chemical dissection of the link between streptozotocin, O-GlcNAc, and pancreatic cell death., Chem Biol
    Hiragushi et al., 2004, The role of adrenomedullin and receptors in glomerular hyperfiltration in streptozotocin-induced diabetic rats., Kidney Int.
    Fraley et al., 2004, Effects of diabetes and insulin on the expression of galanin-like peptide in the hypothalamus of the rat., Diabetes
  • STREPTOZOCIN   OGA

    Interaction Score: 4.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11336633 18721751


    Sources:
    NCI

  • STREPTOZOCIN   GALP

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15111492


    Sources:
    NCI

  • STREPTOZOCIN   SULT1A2

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7600911


    Sources:
    NCI

  • STREPTOZOCIN   SLC16A3

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12611763


    Sources:
    NCI

  • STREPTOZOCIN   CTSD

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3282952


    Sources:
    NCI

  • STREPTOZOCIN   SFTPB

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1386745


    Sources:
    NCI

  • STREPTOZOCIN   HP

    Interaction Score: 1.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16713232


    Sources:
    NCI

  • STREPTOZOCIN   MT1H

    Interaction Score: 1.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9176863


    Sources:
    NCI

  • STREPTOZOCIN   SLC2A5

    Interaction Score: 1.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9756334


    Sources:
    NCI

  • STREPTOZOCIN   S100B

    Interaction Score: 1.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14583344


    Sources:
    NCI

  • STREPTOZOCIN   ADCYAP1

    Interaction Score: 1.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9864055


    Sources:
    NCI

  • STREPTOZOCIN   RAMP3

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14717924


    Sources:
    NCI

  • STREPTOZOCIN   ATF2

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12805110


    Sources:
    NCI

  • STREPTOZOCIN   UCP1

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8471028


    Sources:
    NCI

  • STREPTOZOCIN   PREP

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8190911


    Sources:
    NCI

  • STREPTOZOCIN   LCAT

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18436977


    Sources:
    NCI

  • STREPTOZOCIN   THRSP

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2177838


    Sources:
    NCI

  • STREPTOZOCIN   ACP5

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14640894


    Sources:
    NCI

  • STREPTOZOCIN   SI

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12940455


    Sources:
    NCI

  • STREPTOZOCIN   KCNA2

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17982915


    Sources:
    NCI

  • STREPTOZOCIN   SLC5A1

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1722397


    Sources:
    NCI

  • STREPTOZOCIN   IGFBP1

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7589849 1713293


    Sources:
    NCI

  • STREPTOZOCIN   PTGER4

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16954344


    Sources:
    NCI

  • STREPTOZOCIN   SST

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7664670


    Sources:
    NCI

  • STREPTOZOCIN   CD40

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15016184 11937525


    Sources:
    NCI

  • STREPTOZOCIN   ENO2

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2146046


    Sources:
    NCI

  • STREPTOZOCIN   VWF

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3928783 16422885


    Sources:
    NCI

  • STREPTOZOCIN   CYP7B1

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8435090


    Sources:
    NCI

  • STREPTOZOCIN   SSTR1

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7956902


    Sources:
    NCI

  • STREPTOZOCIN   MYO9B

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2523196


    Sources:
    NCI

  • STREPTOZOCIN   CDKN1B

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11978652


    Sources:
    NCI

  • STREPTOZOCIN   HGF

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12403787


    Sources:
    NCI

  • STREPTOZOCIN   TH

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2568957


    Sources:
    NCI

  • STREPTOZOCIN   SLC2A4

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9421368 10098523 2354749


    Sources:
    NCI

  • STREPTOZOCIN   MMP2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9394952


    Sources:
    NCI

  • STREPTOZOCIN   DDIT3

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8482431


    Sources:
    NCI

  • STREPTOZOCIN   PRKAA1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15616011


    Sources:
    NCI

  • STREPTOZOCIN   KCNJ11

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11798815


    Sources:
    NCI

  • STREPTOZOCIN   HRAS

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8171758


    Sources:
    NCI

  • STREPTOZOCIN   TGFB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17968528


    Sources:
    NCI

  • STREPTOZOCIN   TRPV1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18089839


    Sources:
    NCI

  • STREPTOZOCIN   CSF2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16342200


    Sources:
    NCI

  • STREPTOZOCIN   BCL2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16741044


    Sources:
    NCI

  • STREPTOZOCIN   NTRK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10837808


    Sources:
    NCI

  • STREPTOZOCIN   PIK3CA

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16130182


    Sources:
    NCI

  • STREPTOZOCIN   CYP2D6

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6305526


    Sources:
    NCI

  • NCI: STREPTOZOTOCIN

    • Version: 14-September-2017

    Alternate Names:
    C845 NCI drug code

    Drug Info:

    Publications:
    Afzal et al., 1989, Influence of verapamil on some subcellular defects in diabetic cardiomyopathy., Am. J. Physiol.
    Broulík et al., 2003, The influence of nitric oxide synthase inhibitor L-NAME on bones of male rats with streptozotocin-induced diabetes., Physiol Res
    Murao et al., 1995, Suppression of episodic growth hormone secretion in streptozotocin-induced diabetic mice: time-course studies on the hypothalamic pituitary axis., Endocrinology

  • NCI: STREPTOZOCIN

    • Version: 14-September-2017

    Alternate Names:
    C845 NCI drug code

    Drug Info:

    Publications:
    Schmidt et al., 1989, Tyrosine hydroxylase activity in sympathetic nervous system of rats with streptozocin-induced diabetes., Diabetes
    Pedersen et al., 1990, Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM., Diabetes
    Winocour et al., 1985, Effect of insulin treatment in streptozocin-induced diabetic rats on in vitro platelet function and plasma von Willebrand factor activity and factor VIII-related antigen., J. Lab. Clin. Med.

  • NCI: STZ

    • Version: 14-September-2017

    Alternate Names:
    C845 NCI drug code

    Drug Info:

    Publications:
    Salers, 1994, Enhancement by streptozotocin-induced diabetes of pancreatic prolyl endopeptidase activity in neonatal rats., Regul. Pept.
    Yousif et al., Phosphoinositide 3-kinase mediated signalling contributes to development of diabetes-induced abnormal vascular reactivity of rat carotid artery., Cell Biochem. Funct.
    Middlemas et al., 2003, Enhanced activation of axonally transported stress-activated protein kinases in peripheral nerve in diabetic neuropathy is prevented by neurotrophin-3., Brain

  • TTD: Streptozocin

    • Version: 2020.06.01

    Alternate Names:
    D0I8RR TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1651906

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21