DGIdb - SULFINPYRAZONE Drug Record

SULFINPYRAZONE chembl:CHEMBL832 Approved

Alternate Names:

SULPHINPYRAZONE
ANTURANE
SULFINPYRAZONE
ANTURAN
ANR315
ANTURANE (TN)
SUPHINPYRAZONE
SULFOXYPHENYLPYRAZOLIDINE
G 28315
NSC 75925
1,2-DIPHENYL-4-(2'-PHENYLSULFINETHYL)-3,5-PYRAZOLIDINEDIONE
1,2-DIPHENYL-3,5-DIOXO-4-(2-PHENYLSULFINYLETHYL)PYRAZOLIDINE
APO-SULFINPYRAZONE®
4-(2-BENZENESULFINYLETHYL)-1,2-DIPHENYLPYRAZOLIDINE-3,5-DIONE
ANTURANE®
drugbank:01138
rxcui:10205
pubchem.compound:5342
chemidplus:57-96-5
chembl:CHEMBL832

Drug Info:

Year of Approval	1959
Drug Class	uricosuric agents
FDA Approval	1959
Drug Class	small molecule
Drug Indications	Uricosuric Agents

(3 More Sources)

Publications:

Tan PK et al., 2016, Mechanism of high affinity inhibition of the human urate transporter URAT1., Sci Rep
Shin HJ et al., 2011, Interactions of urate transporter URAT1 in human kidney with uricosuric drugs., Nephrology (Carlton)
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Raggers et al., 1999, The human multidrug resistance protein MRP1 translocates sphingolipid analogs across the plasma membrane., J. Cell. Sci.
Bakos et al., 2000, Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions., Mol. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Depeille et al., 2004, Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects., Mol. Pharmacol.
Evers et al., 2000, Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export., Br. J. Cancer
Morrow et al., 1998, Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification. Mechanism of GST A1-1- and MRP1-associated resistance to chlorambucil in MCF7 breast carcinoma cells., J. Biol. Chem.
Ito et al., 2001, Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity., J. Biol. Chem.
Morrow et al., 2000, Role of multidrug-resistance protein 2 in glutathione S-transferase P1-1-mediated resistance to 4-nitroquinoline 1-oxide toxicities in HepG2 cells., Mol. Carcinog.
Flanagan et al., 2002, Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2)., Pharmacology
Hagos et al., 2007, Human renal organic anion transporter 4 operates as an asymmetric urate transporter., J. Am. Soc. Nephrol.
Korprasertthaworn P et al., 2012, Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity., Biochem Pharmacol
Faucette et al., 2004, Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers., Drug Metab. Dispos.

SULFINPYRAZONE SLC22A12

Interaction Score: 2.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Solute carrier family 22 member 12 inhibitor

Direct Interaction yes

PMIDs:
27713539 21272127

Sources:
ChemblInteractions
SULFINPYRAZONE ABCC1

Interaction Score: 0.93

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9885294 10727523 11752352 15044619 10917554 9685354

Sources:
TdgClinicalTrial TEND TTD
SULFINPYRAZONE FPR1

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SULFINPYRAZONE ABCC2

Interaction Score: 0.78

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11500505 11108662 11834888 17229912 10727523 10917554

Sources:
TdgClinicalTrial TEND
SULFINPYRAZONE UGT1A9

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22981363

Sources:
PharmGKB
SULFINPYRAZONE NR1I2

Interaction Score: 0.09

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
14977870

Sources:
PharmGKB
SULFINPYRAZONE HPGD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SULFINPYRAZONE KDM4E

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SULFINPYRAZONE CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
DTC PharmGKB
SULFINPYRAZONE ALDH1A1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SULFINPYRAZONE VDR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SULFINPYRAZONE EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: SULFINPYRAZONE
- Version: 01-August-2011
Alternate Names:

SULFINPYRAZONE Primary Drug Name

Drug Info:

Drug Class uricosuric agents

Year of Approval 1959

Publications:
TdgClinicalTrial: SULFINPYRAZONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Uricosuric Agents

Drug Class small molecule

FDA Approval 1959

Publications:

PharmGKB: sulfinpyrazone

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Korprasertthaworn P et al., 2012, Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity., Biochem Pharmacol

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

DTC: SULFINPYRAZONE
- Version: 02-September-2020
Alternate Names:

CHEMBL832 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Sulfinpyrazone
- Version: 2020.06.01
Alternate Names:

D03DEI TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL832
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL832
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Solute carrier family 22 member 12 inhibitor
Direct Interaction	yes

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

SULFINPYRAZONE Drug Record

SULFINPYRAZONE chembl:CHEMBL832 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Solute carrier family 22 member 12 inhibitor Direct Interaction yes

PMIDs: 27713539 21272127

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 9885294 10727523 11752352 15044619 10917554 9685354

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11500505 11108662 11834888 17229912 10727523 10917554

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22981363

Sources: PharmGKB

Interaction Types & Directionality: activator (activating)

Interaction Info:

PMIDs: 14977870

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: SULFINPYRAZONE

Alternate Names: SULFINPYRAZONE Primary Drug Name

Drug Info: Drug Class uricosuric agents Year of Approval 1959

Publications:

TdgClinicalTrial: SULFINPYRAZONE

Alternate Names:

Drug Info: Drug Indications Uricosuric Agents Drug Class small molecule FDA Approval 1959

Publications:

PharmGKB: sulfinpyrazone

Alternate Names:

Drug Info:

DTC: SULFINPYRAZONE

Alternate Names: CHEMBL832 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Sulfinpyrazone

Alternate Names: D03DEI TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL832

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL832

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Solute carrier family 22 member 12 inhibitor

Direct Interaction yes

PMIDs:
27713539 21272127

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9885294 10727523 11752352 15044619 10917554 9685354

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11500505 11108662 11834888 17229912 10727523 10917554

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
22981363

Sources:
PharmGKB

Interaction Types & Directionality:

activator (activating)

PMIDs:
14977870

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

SULFINPYRAZONE Primary Drug Name

Drug Info:

Drug Class uricosuric agents

Year of Approval 1959

Drug Info:

Drug Indications Uricosuric Agents

Drug Class small molecule

FDA Approval 1959

Alternate Names:

CHEMBL832 ChEMBL Drug ID

Alternate Names:

D03DEI TTD Drug ID