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SULFINPYRAZONE Drug Record

  • Summary
  • Interactions
  • Claims
  • SULFINPYRAZONE chembl:CHEMBL832 Approved

    Alternate Names:

    SULPHINPYRAZONE
    ANTURANE
    SULFINPYRAZONE
    ANTURAN
    ANR315
    ANTURANE (TN)
    SUPHINPYRAZONE
    SULFOXYPHENYLPYRAZOLIDINE
    G 28315
    NSC 75925
    1,2-DIPHENYL-4-(2'-PHENYLSULFINETHYL)-3,5-PYRAZOLIDINEDIONE
    1,2-DIPHENYL-3,5-DIOXO-4-(2-PHENYLSULFINYLETHYL)PYRAZOLIDINE
    APO-SULFINPYRAZONE®
    4-(2-BENZENESULFINYLETHYL)-1,2-DIPHENYLPYRAZOLIDINE-3,5-DIONE
    ANTURANE®
    drugbank:01138
    rxcui:10205
    pubchem.compound:5342
    chemidplus:57-96-5
    chembl:CHEMBL832

    Drug Info:

    Year of Approval 1959
    Drug Class uricosuric agents
    FDA Approval 1959
    Drug Class small molecule
    Drug Indications Uricosuric Agents
    (3 More Sources)

    Publications:

    Tan PK et al., 2016, Mechanism of high affinity inhibition of the human urate transporter URAT1., Sci Rep
    Shin HJ et al., 2011, Interactions of urate transporter URAT1 in human kidney with uricosuric drugs., Nephrology (Carlton)
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Raggers et al., 1999, The human multidrug resistance protein MRP1 translocates sphingolipid analogs across the plasma membrane., J. Cell. Sci.
    Bakos et al., 2000, Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions., Mol. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Depeille et al., 2004, Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects., Mol. Pharmacol.
    Evers et al., 2000, Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export., Br. J. Cancer
    Morrow et al., 1998, Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification. Mechanism of GST A1-1- and MRP1-associated resistance to chlorambucil in MCF7 breast carcinoma cells., J. Biol. Chem.
    Ito et al., 2001, Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity., J. Biol. Chem.
    Morrow et al., 2000, Role of multidrug-resistance protein 2 in glutathione S-transferase P1-1-mediated resistance to 4-nitroquinoline 1-oxide toxicities in HepG2 cells., Mol. Carcinog.
    Flanagan et al., 2002, Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2)., Pharmacology
    Hagos et al., 2007, Human renal organic anion transporter 4 operates as an asymmetric urate transporter., J. Am. Soc. Nephrol.
    Korprasertthaworn P et al., 2012, Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity., Biochem Pharmacol
    Faucette et al., 2004, Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers., Drug Metab. Dispos.
  • SULFINPYRAZONE   SLC22A12

    Interaction Score: 2.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Solute carrier family 22 member 12 inhibitor
    Direct Interaction yes

    PMIDs:
    27713539 21272127


    Sources:
    ChemblInteractions

  • SULFINPYRAZONE   ABCC1

    Interaction Score: 0.93

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    9885294 10727523 11752352 15044619 10917554 9685354


    Sources:
    TdgClinicalTrial TEND TTD

  • SULFINPYRAZONE   FPR1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SULFINPYRAZONE   ABCC2

    Interaction Score: 0.78

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11500505 11108662 11834888 17229912 10727523 10917554


    Sources:
    TdgClinicalTrial TEND

  • SULFINPYRAZONE   UGT1A9

    Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22981363


    Sources:
    PharmGKB

  • SULFINPYRAZONE   NR1I2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    14977870


    Sources:
    PharmGKB

  • SULFINPYRAZONE   HPGD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SULFINPYRAZONE   KDM4E

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SULFINPYRAZONE   CYP3A4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528


    Sources:
    DTC PharmGKB

  • SULFINPYRAZONE   ALDH1A1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SULFINPYRAZONE   VDR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SULFINPYRAZONE   EHMT2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: SULFINPYRAZONE

    • Version: 01-August-2011

    Alternate Names:
    SULFINPYRAZONE Primary Drug Name

    Drug Info:
    Drug Class uricosuric agents
    Year of Approval 1959

    Publications:

  • TdgClinicalTrial: SULFINPYRAZONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Uricosuric Agents
    Drug Class small molecule
    FDA Approval 1959

    Publications:

  • PharmGKB: sulfinpyrazone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Korprasertthaworn P et al., 2012, Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity., Biochem Pharmacol
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

  • DTC: SULFINPYRAZONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL832 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Sulfinpyrazone

    • Version: 2020.06.01

    Alternate Names:
    D03DEI TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL832

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL832

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21