DGIdb - SUMATRIPTAN Drug Record

SUMATRIPTAN chembl:CHEMBL128 Approved

Alternate Names:

SUMATRIPTAN
TOSYMRA
N02CC01
IMITREX
1-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-METHYL-METHANESULFONAMIDE
3-[2-(DIMETHYLAMINO)ETHYL]-N-METHYLINDOLE-5-METHANESULFONAMIDE
(3-[2-(DIMETHYLAMINO)ETHYL]-1H-INDOL-5-YL)-N-METHYLMETHANESULFONAMIDE
IMIGRAN®
TRIPTAN
SUMATRIPTÁN
SUMATRAN
SUMATRIPTAN SUCCINATE
SUMATRIPTANUM
3-(2-(DIMETHYLAMINO)ETHYL)-N-METHYL-1H-INDOLE-5-METHANESULFONAMIDE
SUMAX
NP101
GR-43175C
chembl:CHEMBL128
pubchem.compound:5358
chemidplus:103628-46-2
rxcui:37418
drugbank:00669

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antimigraine agent
Drug Class	anti-migraine agents
Year of Approval	1992

(5 More Sources)

Publications:

Mitsikostas et al., 2002, 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis., Cephalalgia
Roy et al., 2000, Expression of 5-hydroxytryptamine receptor subtype messenger RNA in interstitial cells from human heart valves., J. Heart Valve Dis.
Mitsikostas et al., 1999, Both 5-HT1B and 5-HT1F receptors modulate c-fos expression within rat trigeminal nucleus caudalis., Eur. J. Pharmacol.
Nikai et al., 2008, Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan., Pain
Zohar et al., 2004, Serotonin-1D hypothesis of obsessive-compulsive disorder: an update., J Clin Psychiatry
Razzaque et al., 2002, 5-HT1B-receptors and vascular reactivity in human isolated blood vessels: assessment of the potential craniovascular selectivity of sumatriptan., Br J Clin Pharmacol
Baxter, 2001, Brain mediation of Anolis social dominance displays. III. Differential forebrain 3H-sumatriptan binding in dominant vs. submissive males., Brain Behav. Evol.
Akin et al., 2002, Involvement of 5-HT1B and 5-HT1D receptors in sumatriptan mediated vasocontractile response in rabbit common carotid artery., Br. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Koran et al., 2001, Sumatriptan, 5-HT(1D) receptors and obsessive-compulsive disorder., Eur Neuropsychopharmacol
Cohen et al., 1999, 5-Hydroxytryptamine(1A) receptor activation enhances norepinephrine release from nerves in the rabbit saphenous vein., J. Pharmacol. Exp. Ther.
Johnson et al., 2001, Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain., Eur. J. Pharmacol.
Pauwels et al., Present and future of 5-HT receptor agonists as antimigraine drugs., Clin Neuropharmacol
Janssen et al., 2004, Influence of 5-HT1 receptor agonists on feline stomach relaxation., Eur. J. Pharmacol.
Cohen et al., 2000, Contractile responses to sumatriptan and ergotamine in the rabbit saphenous vein: effect of selective 5-HT(1F) receptor agonists and PGF(2alpha)., Br. J. Pharmacol.
Razzaque et al., 1999, Vasoconstriction in human isolated middle meningeal arteries: determining the contribution of 5-HT1B- and 5-HT1F-receptor activation., Br J Clin Pharmacol
Cargnin S et al., 2014, Combined effect of common gene variants on response to drug withdrawal therapy in medication overuse headache., Eur J Clin Pharmacol
Grånäs et al., 1999, Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT(1B) receptor., Eur. J. Pharmacol.
Cohen et al., 1999, Multiple microvascular and astroglial 5-hydroxytryptamine receptor subtypes in human brain: molecular and pharmacologic characterization., J. Cereb. Blood Flow Metab.
Dupuis et al., 1999, Magnitude of 5-HT1B and 5-HT1A receptor activation in guinea-pig and rat brain: evidence from sumatriptan dimer-mediated [35S]GTPgammaS binding responses., Brain Res. Mol. Brain Res.
Schürks M et al., 2007, G protein beta3 polymorphism and triptan response in cluster headache., Clin Pharmacol Ther
Coulie et al., 1998, 5-Hydroxytryptamine-1 receptor activation inhibits endocrine pancreatic secretion in humans., Am. J. Physiol.
Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem

SUMATRIPTAN HTR1F

Interaction Score: 1.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
12110114 10225363 10367177 15178373 18723285 11752352 11015308 10073743

Sources:
TdgClinicalTrial TEND GuideToPharmacology
SUMATRIPTAN DBH

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25096645

Sources:
PharmGKB
SUMATRIPTAN HTR1D

Interaction Score: 0.95

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
12110114 10772044 10225363 18723285 15554784 11874390 11641558 12010765 11752352 11313163 10454495

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD
SUMATRIPTAN AQP4

Interaction Score: 0.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18572411

Sources:
DTC
SUMATRIPTAN HTR1B

Interaction Score: 0.82

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name MT 400,Treximet

Novel drug target Established target

Trial Name NP101,Zelrix

PMIDs:
10513577 10772044 10225363 18723285 11874390 10458598 12010765 12110114 11752352 10454495 10101238

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology
SUMATRIPTAN GNB3

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17361120

Sources:
PharmGKB
SUMATRIPTAN GCG

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9486164

Sources:
NCI
SUMATRIPTAN HTR5A

Interaction Score: 0.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
SUMATRIPTAN COMT

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25096645

Sources:
PharmGKB
SUMATRIPTAN BDNF

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25096645

Sources:
PharmGKB
SUMATRIPTAN HTR1E

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
SUMATRIPTAN HTR1A

Interaction Score: 0.1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Trial Name MT 400,Treximet

PMIDs:
11513839

Sources:
TdgClinicalTrial GuideToPharmacology
SUMATRIPTAN HTR6

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
SUMATRIPTAN HTR7

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
SUMATRIPTAN OPRM1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25096645

Sources:
PharmGKB
SUMATRIPTAN HTR2B

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
SUMATRIPTAN HTR2A

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25096645

Sources:
PharmGKB
SUMATRIPTAN DRD2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25096645

Sources:
PharmGKB

TEND: SUMATRIPTAN
- Version: 01-August-2011
Alternate Names:

SUMATRIPTAN Primary Drug Name

Drug Info:

Year of Approval 1992

Drug Class anti-migraine agents

Publications:
TdgClinicalTrial: SUMATRIPTAN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antimigraine agent

Drug Class Small Molecule

FDA Approval approved

Publications:
NCI: SUMATRIPTAN
- Version: 14-September-2017
Alternate Names:

C1240 NCI drug code

Drug Info:

Publications:

Coulie et al., 1998, 5-Hydroxytryptamine-1 receptor activation inhibits endocrine pancreatic secretion in humans., Am. J. Physiol.
DTC: SUMATRIPTAN
- Version: 02-September-2020
Alternate Names:

CHEMBL128 ChEMBL Drug ID

Drug Info:

Publications:

Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem

PharmGKB: sumatriptan

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Cargnin S et al., 2014, Combined effect of common gene variants on response to drug withdrawal therapy in medication overuse headache., Eur J Clin Pharmacol

Schürks M et al., 2007, G protein beta3 polymorphism and triptan response in cluster headache., Clin Pharmacol Ther

GuideToPharmacology: 135651095
- Version: 29-September-2020
Alternate Names:

SUMATRIPTAN GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Sumatriptan
- Version: 2020.06.01
Alternate Names:

D0Z6UC TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL128
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL128
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False
Direct Interaction?	False

Trial Name	MT 400,Treximet
Novel drug target	Established target
Trial Name	NP101,Zelrix

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

SUMATRIPTAN Drug Record

SUMATRIPTAN chembl:CHEMBL128 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Direct Interaction? False

PMIDs: 12110114 10225363 10367177 15178373 18723285 11752352 11015308 10073743

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25096645

Sources: PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Direct Interaction? True

PMIDs: 12110114 10772044 10225363 18723285 15554784 11874390 11641558 12010765 11752352 11313163 10454495

Sources: TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18572411

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name MT 400,Treximet Novel drug target Established target Trial Name NP101,Zelrix

PMIDs: 10513577 10772044 10225363 18723285 11874390 10458598 12010765 12110114 11752352 10454495 10101238

Sources: TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17361120

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9486164

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25096645

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25096645

Sources: PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Trial Name MT 400,Treximet

PMIDs: 11513839

Sources: TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25096645

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25096645

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25096645

Sources: PharmGKB

TEND: SUMATRIPTAN

Alternate Names: SUMATRIPTAN Primary Drug Name

Drug Info: Year of Approval 1992 Drug Class anti-migraine agents

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
12110114 10225363 10367177 15178373 18723285 11752352 11015308 10073743

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
25096645

Sources:
PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
12110114 10772044 10225363 18723285 15554784 11874390 11641558 12010765 11752352 11313163 10454495

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
18572411

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name MT 400,Treximet

Novel drug target Established target

Trial Name NP101,Zelrix

PMIDs:
10513577 10772044 10225363 18723285 11874390 10458598 12010765 12110114 11752352 10454495 10101238

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
17361120

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9486164

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
25096645

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25096645

Sources:
PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Trial Name MT 400,Treximet

PMIDs:
11513839

Sources:
TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
25096645

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
25096645

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25096645

Sources:
PharmGKB

Alternate Names:

SUMATRIPTAN Primary Drug Name

Drug Info:

Year of Approval 1992

Drug Class anti-migraine agents

Drug Info:

Drug Indications antimigraine agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C1240 NCI drug code

Publications:

Coulie et al., 1998, 5-Hydroxytryptamine-1 receptor activation inhibits endocrine pancreatic secretion in humans., Am. J. Physiol.

Alternate Names:

CHEMBL128 ChEMBL Drug ID

Publications:

Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem

Publications:

Cargnin S et al., 2014, Combined effect of common gene variants on response to drug withdrawal therapy in medication overuse headache., Eur J Clin Pharmacol

Schürks M et al., 2007, G protein beta3 polymorphism and triptan response in cluster headache., Clin Pharmacol Ther

Alternate Names:

SUMATRIPTAN GuideToPharmacology Ligand Name

Alternate Names:

D0Z6UC TTD Drug ID