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TACRINE Drug Record

  • Summary
  • Interactions
  • Claims
  • TACRINE chembl:CHEMBL95 Approved

    Alternate Names:

    TACRINE
    THA
    1,2,3,4-TETRAHYDRO-9-AMINOACRIDINE
    TACRINUM
    5-AMINO-6,7,8,9-TETRAHYDROACRIDINE
    TACRIN
    TETRAHYDROAMINACRINE
    TETRAHYDROAMINOACRIDINE
    COGNEX®
    CI-970
    1,2,3,4-TETRAHYDROACRIDIN-9-AMINE
    1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
    9-AMINO-1,2,3,4-TETRAHYDROACRIDINE
    rxcui:10318
    pubchem.compound:1935
    chemidplus:321-64-2
    drugbank:00382
    chembl:CHEMBL95

    Drug Info:

    Year of Approval 1993
    Drug Class nootropic agents
    FDA Approval 1993
    Drug Class small molecule
    Drug Indications Nootropic Agents
    (1 More Sources)

    Publications:

    Wang et al., 1999, Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE., Neuroreport
    Marco et al., 2003, Recent developments in the synthesis of acetylcholinesterase inhibitors., Mini Rev Med Chem
    Davis, 1999, Alzheimer's disease: seeking new ways to preserve brain function. Interview by Alice V. Luddington., Geriatrics
    Krustev et al., 2006, Calcium-independent tacrine-induced relaxation of rat gastric corpus smooth muscles., Can. J. Physiol. Pharmacol.
    Du et al., 2004, Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease., Curr. Pharm. Des.
    Traykov et al., 1999, In vivo PET study of cerebral [11C] methyl- tetrahydroaminoacridine distribution and kinetics in healthy human subjects., Eur. J. Neurol.
    Takatori, 2006, [Mechanisms of neuroprotective effects of therapeutic acetylcholinesterase inhibitors used in treatment of Alzheimer's disease]., Yakugaku Zasshi
    Ahmed et al., 2006, Inhibition of two different cholinesterases by tacrine., Chem. Biol. Interact.
    Wang et al., 1998, Anticholinesterase effects of huperzine A, E2020, and tacrine in rats., Zhongguo Yao Li Xue Bao
    Kosasa et al., 1999, Effect of donepezil hydrochloride (E2020) on basal concentration of extracellular acetylcholine in the hippocampus of rats., Eur. J. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Villarroya et al., 2004, New classes of AChE inhibitors with additional pharmacological effects of interest for the treatment of Alzheimer's disease., Curr. Pharm. Des.
    Huang L et al., 2014, Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease., Eur J Med Chem
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
  • TACRINE   ACHE

    Interaction Score: 5.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    10208549 12871155 10024872 17218977 15544504 10210906 16880719 16860785 10375753 10513568 11752352 15544507 25282266


    Sources:
    DTC TdgClinicalTrial TEND TTD

  • TACRINE   ALOX15

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TACRINE   CYP1A2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TACRINE   CYP2D6

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TACRINE   CYP3A4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TEND: TACRINE

    • Version: 01-August-2011

    Alternate Names:
    TACRINE Primary Drug Name

    Drug Info:
    Drug Class nootropic agents
    Year of Approval 1993

    Publications:

  • TdgClinicalTrial: TACRINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Nootropic Agents
    Drug Class small molecule
    FDA Approval 1993

    Publications:

  • DTC: TACRINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL95 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Huang L et al., 2014, Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease., Eur J Med Chem

  • TTD: Tacrine

    • Version: 2020.06.01

    Alternate Names:
    D0E6YQ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL95

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21