TAMOXIFEN Drug Record
-
TAMOXIFEN chembl:CHEMBL83 ApprovedAntineoplastic
Alternate Names:
ICI-47699 ICI-46474 SOLTAMOX NOLVADEX TAMOXIFEN TAMOXIFÈNE 1-P-BETA-DIMETHYLAMINOETHOXYPHENYL-TRANS-1,2-DIPHENYLBUT-1-ENE TRANS-TAMOXIFEN 1-PARA-BETA-DIMETHYLAMINOETHOXYPHENYL-TRANS-1,2-DIPHENYLBUT-1-ENE (Z)-2-(4-(1,2-DIPHENYL-1-BUTENYL)PHENOXY)-N,N-DIMETHYLETHANAMINE TAMOXIFENO (Z)-2-(PARA-(1,2-DIPHENYL-1-BUTENYL)PHENOXY)-N,N-DIMETHYLAMINE TAMOXIFENUM NOLVADEX® SOLTAMOX® ZD6157 TAMOXIFENE drugbank:00675 rxcui:10324 chembl:CHEMBL83 chemidplus:10540-29-1 pubchem.compound:2733526 Drug Info:
Drug Class antineoplastic agents, hormonal Year of Approval 1977 FDA Approval 1977 Drug Class small molecule Drug Indications Antineoplastic Agents, Hormonal Drug Categories stilbenes Drug Categories cardiotoxic antineoplastic agents Drug Categories cytochrome p-450 cyp1a2 substrates with a narrow therapeutic index Drug Categories cytochrome p-450 cyp2a6 substrates with a narrow therapeutic index Drug Categories cytochrome p-450 cyp2b6 inhibitors (moderate) Drug Categories cytochrome p-450 cyp2b6 substrates with a narrow therapeutic index Drug Categories cytochrome p-450 cyp2c19 substrates with a narrow therapeutic index Drug Categories cytochrome p-450 cyp2c9 inhibitors (strength unknown) Drug Categories cytochrome p-450 cyp2c9 substrates with a narrow therapeutic index Drug Categories cytochrome p-450 cyp2d6 inhibitors (strength unknown) Drug Categories cytochrome p-450 cyp2d6 substrates with a narrow therapeutic index Drug Categories cytochrome p-450 cyp2e1 substrates with a narrow therapeutic index Drug Categories cytochrome p-450 cyp3a substrates Drug Categories cytochrome p-450 cyp3a4 inducers Drug Categories cytochrome p-450 cyp3a4 inducers (strength unknown) Drug Categories cytochrome p-450 cyp3a4 inhibitors Drug Categories cytochrome p-450 cyp3a4 inhibitors (strength unknown) Drug Categories cytochrome p-450 cyp3a4 substrates with a narrow therapeutic index Drug Categories cytochrome p-450 cyp3a5 substrates Drug Categories cytochrome p-450 cyp3a5 substrates with a narrow therapeutic index Drug Categories cytochrome p-450 cyp3a7 substrates Drug Categories cytochrome p-450 cyp3a7 substrates with a narrow therapeutic index Drug Categories cytochrome p-450 enzyme inducers Drug Categories cytochrome p-450 enzyme inhibitors Drug Categories cytochrome p-450 substrates Drug Categories estrogen agonist/antagonist Drug Categories narrow therapeutic index drugs Drug Categories p-glycoprotein inducers Drug Categories p-glycoprotein inhibitors Drug Categories p-glycoprotein substrates Drug Categories potential qtc-prolonging agents Drug Categories qtc prolonging agents Drug Categories thyroxine-binding globulin inducers Drug Categories ugt2b7 substrates Drug Categories ugt2b7 substrates with narrow therapeutic index Publications:
-
Interaction Types & Directionality:
agonist (activating) antagonist (inhibitory) Interaction Info:
Specific Action of the Ligand Antagonist Endogenous Drug? False Specific Action of the Ligand Agonist -
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Specific Action of the Ligand Full agonist Endogenous Drug? False -
Interaction Types & Directionality:
agonist (activating) antagonist (inhibitory) Interaction Info:
Alteration ESR1:E380Q,.537.,.538.,L536.,P535H Drug family Hormonal therapy combination therapy [Tamoxifen,Letrozole,Anastrozole,Exemestane,Fulvestrant,LHRH analogues or antagonist] -
Interaction Types & Directionality:
n/a Interaction Info:
-
Interaction Types & Directionality:
n/a Interaction Info:
Alteration NF1:. Alteration NF1:del Drug family Hormonal therapy
-
Alternate Names:
TAMOXIFEN DrugBank Drug Name 10540-29-1 CAS Number Adifen Drug Brand Drug Info:
Drug Type small molecule Drug Groups approved Drug Categories anti-estrogens Publications:
-
Alternate Names:
TAMOXIFEN Primary Drug Name Drug Info:
Year of Approval 1977 Drug Class antineoplastic agents, hormonal Publications:
-
- Version: January-2014
Alternate Names:
Drug Info:
Drug Indications Antineoplastic Agents, Hormonal Drug Class small molecule FDA Approval 1977 Publications:
-
Alternate Names:
C855 NCI drug code Drug Info:
Publications:
-
Alternate Names:
CHEMBL83 ChEMBL Drug ID Drug Info:
Publications:
-
Alternate Names:
Drug Info:
Publications:
-
Alternate Names:
Drug Info:
Publications:
-
Alternate Names:
Drug Info:
Publications:
-
- Version: 29-September-2020
Alternate Names:
TAMOXIFEN GuideToPharmacology Ligand Name Drug Info:
Publications:
-
Alternate Names:
D07KSG TTD Drug ID Drug Info:
Publications:
-
- Version: ChEMBL_27
Alternate Names:
Drug Info:
Publications:
-
- Version: 15-June-2013
Alternate Names:
Drug Info:
Publications:
-
Alternate Names:
Drug Info:
Publications:
-
- Version: 26-July-2013
Alternate Names:
Drug Info:
Publications: