DGIdb - TAMSULOSIN Drug Record

TAMSULOSIN chembl:CHEMBL836 ApprovedAntineoplastic

Alternate Names:

HGP-0412
TAMSULOSIN
HIP1402
HIP-1402
TAMSULOSINE
LY-253351
5-[2-[2-(2-ETHOXYPHENOXY)ETHYLAMINO]PROPYL]-2-METHOXY-BENZENESULFONAMIDE
OMNIC®
TAMSULOSINA
TAMSULOSIN HYDROCHLORIDE
TAMSULOSINUM
(R)-5-(2-((2-(2-ETHOXYPHENOXY)ETHYL)AMINO)PROPYL)-2-METHOXYBENZENESULFONAMIDE
(-)-YM617
FLOMAX®
rxcui:77492
drugbank:00706
chemidplus:106133-20-4
pubchem.compound:129211
chembl:CHEMBL836

Drug Info:

Year of Approval	1997
Drug Class	antineoplastic agents
Drug Indications	for treatment of urinary symptoms associated with BPH
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of benign prostatic hyperplasia

(2 More Sources)

Publications:

Richardson et al., 1997, Pharmacology of tamsulosin: saturation-binding isotherms and competition analysis using cloned alpha 1-adrenergic receptor subtypes., Prostate
Ishiguro et al., 2002, Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling., Life Sci.
Michel et al., 2004, Efficacy and safety of tamsulosin in the treatment of urological diseases., Expert Opin Pharmacother
Taguchi et al., 1997, Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes., J. Pharmacol. Exp. Ther.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Michel et al., 1994, Functional studies on alpha 1-adrenoceptor subtypes mediating inotropic effects in rat right ventricle., Br. J. Pharmacol.
Abrams et al., 1997, A dose-ranging study of the efficacy and safety of tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist, in patients with benign prostatic obstruction (symptomatic benign prostatic hyperplasia)., Br J Urol
Lee et al., 1997, Clinical comparison of selective and non-selective alpha 1A-adrenoreceptor antagonists in benign prostatic hyperplasia: studies on tamsulosin in a fixed dose and terazosin in increasing doses., Br J Urol
Na et al., 1998, Clinical comparison of selective and non-selective alpha 1A-adrenoceptor antagonists for bladder outlet obstruction associated with benign prostatic hyperplasia: studies on tamsulosin and terazosin in Chinese patients. The Chinese Tamsulosin Study Group., J Med
Chen et al., 2009, Blockade of alpha 1A-adrenoceptor: a novel possible strategy for male contraception., Med. Hypotheses
Schulman et al., 1996, Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. Analysis of a multinational, multicentre, open-label study assessing the long-term efficacy and safety in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group., Eur. Urol.
Chapple et al., 1996, Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. A meta-analysis of two randomized, placebo-controlled, multicentre studies in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group., Eur. Urol.
Noble et al., 1997, The effects of tamsulosin, a high affinity antagonist at functional alpha 1A- and alpha 1D-adrenoceptor subtypes., Br. J. Pharmacol.
Lowe, 2005, Summary of clinical experiences with tamsulosin for the treatment of benign prostatic hyperplasia., Rev Urol
Tomiyama et al., 2006, [Effect of silodosin on intraurethral pressure increase induced by hypogastric nerve stimulation in dogs with benign prostatic hyperplasia]., Yakugaku Zasshi
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

TAMSULOSIN ADRA1D

Interaction Score: 3.57

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tamsulosin, YM-617,Harnal, Flomax

Novel drug target Established target

PMIDs:
14680444 12270758 8996174 9117115 11752352 16986050 16518087

Sources:
TdgClinicalTrial TEND
TAMSULOSIN ADRA1B

Interaction Score: 1.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tamsulosin, YM-617,Harnal, Flomax

Novel drug target Established target

PMIDs:
9294627 12270758 14680444 8996174 11752352 7911719

Sources:
TdgClinicalTrial TEND
TAMSULOSIN ADRA1A

Interaction Score: 1.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name dutasteride + tamsulosin,Jalyn

Novel drug target Established target

Trial Name tamsulosin, YM-617,Harnal, Flomax

PMIDs:
9352698 9352700 14680444 10503165 19427736 11752352 8647140 8647141

Sources:
TdgClinicalTrial TEND TTD
TAMSULOSIN CYP3A5

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
TAMSULOSIN CYP2D6

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
TAMSULOSIN CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB

TEND: TAMSULOSIN
- Version: 01-August-2011
Alternate Names:

TAMSULOSIN Primary Drug Name

Drug Info:

Drug Class antineoplastic agents

Year of Approval 1997

Publications:
TdgClinicalTrial: TAMSULOSIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of benign prostatic hyperplasia

Drug Class Small Molecule

FDA Approval approved

Publications:

PharmGKB: tamsulosin

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

TTD: Tamsulosin
- Version: 2020.06.01
Alternate Names:

D05MBZ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL836
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Tamsulosin
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	tamsulosin, YM-617,Harnal, Flomax
Novel drug target	Established target

Trial Name	dutasteride + tamsulosin,Jalyn
Novel drug target	Established target
Trial Name	tamsulosin, YM-617,Harnal, Flomax

TAMSULOSIN Drug Record

TAMSULOSIN chembl:CHEMBL836 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

TAMSULOSIN ADRA1D

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name tamsulosin, YM-617,Harnal, Flomax Novel drug target Established target

PMIDs: 14680444 12270758 8996174 9117115 11752352 16986050 16518087

Sources: TdgClinicalTrial TEND

TAMSULOSIN ADRA1B

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name tamsulosin, YM-617,Harnal, Flomax Novel drug target Established target

PMIDs: 9294627 12270758 14680444 8996174 11752352 7911719

Sources: TdgClinicalTrial TEND

TAMSULOSIN ADRA1A

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name dutasteride + tamsulosin,Jalyn Novel drug target Established target Trial Name tamsulosin, YM-617,Harnal, Flomax

PMIDs: 9352698 9352700 14680444 10503165 19427736 11752352 8647140 8647141

Sources: TdgClinicalTrial TEND TTD

TAMSULOSIN CYP3A5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

TAMSULOSIN CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

TAMSULOSIN CYP3A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

TEND: TAMSULOSIN

Alternate Names: TAMSULOSIN Primary Drug Name

Drug Info: Drug Class antineoplastic agents Year of Approval 1997

Publications:

TdgClinicalTrial: TAMSULOSIN

Alternate Names:

Drug Info: Drug Indications for treatment of benign prostatic hyperplasia Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: tamsulosin

Alternate Names:

Drug Info:

TTD: Tamsulosin

Alternate Names: D05MBZ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL836

Alternate Names:

Drug Info:

Publications:

FDA: Tamsulosin

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tamsulosin, YM-617,Harnal, Flomax

Novel drug target Established target

PMIDs:
14680444 12270758 8996174 9117115 11752352 16986050 16518087

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tamsulosin, YM-617,Harnal, Flomax

Novel drug target Established target

PMIDs:
9294627 12270758 14680444 8996174 11752352 7911719

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name dutasteride + tamsulosin,Jalyn

Novel drug target Established target

Trial Name tamsulosin, YM-617,Harnal, Flomax

PMIDs:
9352698 9352700 14680444 10503165 19427736 11752352 8647140 8647141

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Alternate Names:

TAMSULOSIN Primary Drug Name

Drug Info:

Drug Class antineoplastic agents

Year of Approval 1997

Drug Info:

Drug Indications for treatment of benign prostatic hyperplasia

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

D05MBZ TTD Drug ID