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TAMSULOSIN Drug Record

  • Summary
  • Interactions
  • Claims
  • TAMSULOSIN chembl:CHEMBL836 ApprovedAntineoplastic

    Alternate Names:

    HGP-0412
    TAMSULOSIN
    HIP1402
    HIP-1402
    TAMSULOSINE
    LY-253351
    5-[2-[2-(2-ETHOXYPHENOXY)ETHYLAMINO]PROPYL]-2-METHOXY-BENZENESULFONAMIDE
    OMNIC®
    TAMSULOSINA
    TAMSULOSIN HYDROCHLORIDE
    TAMSULOSINUM
    (R)-5-(2-((2-(2-ETHOXYPHENOXY)ETHYL)AMINO)PROPYL)-2-METHOXYBENZENESULFONAMIDE
    (-)-YM617
    FLOMAX®
    rxcui:77492
    drugbank:00706
    chemidplus:106133-20-4
    pubchem.compound:129211
    chembl:CHEMBL836

    Drug Info:

    Year of Approval 1997
    Drug Class antineoplastic agents
    Drug Indications for treatment of urinary symptoms associated with BPH
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications for treatment of benign prostatic hyperplasia
    (2 More Sources)

    Publications:

    Richardson et al., 1997, Pharmacology of tamsulosin: saturation-binding isotherms and competition analysis using cloned alpha 1-adrenergic receptor subtypes., Prostate
    Ishiguro et al., 2002, Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling., Life Sci.
    Michel et al., 2004, Efficacy and safety of tamsulosin in the treatment of urological diseases., Expert Opin Pharmacother
    Taguchi et al., 1997, Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes., J. Pharmacol. Exp. Ther.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Michel et al., 1994, Functional studies on alpha 1-adrenoceptor subtypes mediating inotropic effects in rat right ventricle., Br. J. Pharmacol.
    Abrams et al., 1997, A dose-ranging study of the efficacy and safety of tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist, in patients with benign prostatic obstruction (symptomatic benign prostatic hyperplasia)., Br J Urol
    Lee et al., 1997, Clinical comparison of selective and non-selective alpha 1A-adrenoreceptor antagonists in benign prostatic hyperplasia: studies on tamsulosin in a fixed dose and terazosin in increasing doses., Br J Urol
    Na et al., 1998, Clinical comparison of selective and non-selective alpha 1A-adrenoceptor antagonists for bladder outlet obstruction associated with benign prostatic hyperplasia: studies on tamsulosin and terazosin in Chinese patients. The Chinese Tamsulosin Study Group., J Med
    Chen et al., 2009, Blockade of alpha 1A-adrenoceptor: a novel possible strategy for male contraception., Med. Hypotheses
    Schulman et al., 1996, Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. Analysis of a multinational, multicentre, open-label study assessing the long-term efficacy and safety in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group., Eur. Urol.
    Chapple et al., 1996, Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. A meta-analysis of two randomized, placebo-controlled, multicentre studies in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group., Eur. Urol.
    Noble et al., 1997, The effects of tamsulosin, a high affinity antagonist at functional alpha 1A- and alpha 1D-adrenoceptor subtypes., Br. J. Pharmacol.
    Lowe, 2005, Summary of clinical experiences with tamsulosin for the treatment of benign prostatic hyperplasia., Rev Urol
    Tomiyama et al., 2006, [Effect of silodosin on intraurethral pressure increase induced by hypogastric nerve stimulation in dogs with benign prostatic hyperplasia]., Yakugaku Zasshi
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
  • TAMSULOSIN   ADRA1D

    Interaction Score: 3.57

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name tamsulosin, YM-617,Harnal, Flomax
    Novel drug target Established target

    PMIDs:
    14680444 12270758 8996174 9117115 11752352 16986050 16518087


    Sources:
    TdgClinicalTrial TEND

  • TAMSULOSIN   ADRA1B

    Interaction Score: 1.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name tamsulosin, YM-617,Harnal, Flomax
    Novel drug target Established target

    PMIDs:
    9294627 12270758 14680444 8996174 11752352 7911719


    Sources:
    TdgClinicalTrial TEND

  • TAMSULOSIN   ADRA1A

    Interaction Score: 1.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name dutasteride + tamsulosin,Jalyn
    Novel drug target Established target
    Trial Name tamsulosin, YM-617,Harnal, Flomax

    PMIDs:
    9352698 9352700 14680444 10503165 19427736 11752352 8647140 8647141


    Sources:
    TdgClinicalTrial TEND TTD

  • TAMSULOSIN   CYP3A5

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18695978


    Sources:
    PharmGKB

  • TAMSULOSIN   CYP2D6

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • TAMSULOSIN   CYP3A4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528


    Sources:
    PharmGKB

  • TEND: TAMSULOSIN

    • Version: 01-August-2011

    Alternate Names:
    TAMSULOSIN Primary Drug Name

    Drug Info:
    Drug Class antineoplastic agents
    Year of Approval 1997

    Publications:

  • TdgClinicalTrial: TAMSULOSIN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications for treatment of benign prostatic hyperplasia
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • PharmGKB: tamsulosin

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

  • TTD: Tamsulosin

    • Version: 2020.06.01

    Alternate Names:
    D05MBZ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL836

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Tamsulosin

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21