• Interaction Score: 0.46

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction PI3-kinase class I inhibitor
    Specific Action of the Ligand Inhibition

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Approval Status Preclinical
    Evidence Type Actionable
    Approval Status Preclinical - Cell line xenograft

    PMIDs:
    26589432


    Sources:
    JAX-CKB CIViC

  • Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction PI3-kinase class I inhibitor
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction PI3-kinase class I inhibitor

    PMIDs:
    None found


  • Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy GDC-0032 + Neratinib
    Indication/Tumor Type uterine corpus serous adenocarcinoma
    Response Type sensitive


    Sources:
    JAX-CKB

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Response Type no benefit
    Indication/Tumor Type colorectal cancer
    Evidence Type Actionable

    PMIDs:
    28331003


    Sources:
    JAX-CKB