DGIdb - TENIPOSIDE Drug Record

TENIPOSIDE chembl:CHEMBL452231 ApprovedAntineoplasticImmunotherapy

Alternate Names:

VM-26
VUMON
NSC-122819
TENIPOSIDE
VM26
EPIDOPHYLLOTOXIN
TENIPOSIDUM
4'-DEMETHYLEPIPODOPHYLLOTOXIN 9-(4,6-O-(R)-2-THENYLIDENE-BETA-D-GLUCOPYRANOSIDE)
TENIPOSIDO
TENIPOSID
VUMON®
TÉNIPOSIDE
ISOSULFAN BLUE
rxcui:10362
chemidplus:29767-20-2
chembl:CHEMBL452231
pubchem.compound:452548
drugbank:00444

Drug Info:

Drug Class	antineoplastic agents
Year of Approval	1992
FDA Approval	1992
Drug Class	small molecule
Drug Indications	Antineoplastic Agents

(4 More Sources)

Publications:

Winter et al., 1998, Synergy of CD95 ligand and teniposide: no role of cleavable complex formation and enhanced CD95 expression., Eur. J. Pharmacol.
Brown et al., 1998, Immunohistochemical staining for DNA topoisomerase IIa in Hodgkin's disease., Am. J. Clin. Pathol.
Faure et al., 1996, [Topoisomerases: therapeutic value]., Ann Pharm Fr
Umanskaya et al., Inhibition of DNA topoisomerase II in living cells stimulates illegitimate recombination., Dokl. Biochem. Biophys.
de Lucio et al., 2005, Characterization of human NSCLC cell line with innate etoposide-resistance mediated by cytoplasmic localization of topoisomerase II alpha., Cancer Sci.
Winnicka et al., Cardiac glycosides in cancer research and cancer therapy., Acta Pol Pharm
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Uesaka et al., 2007, Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity., J. Neurooncol.
Brown CC et al., 2014, Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines., Pharmacogenomics
Wang et al., 1998, Transcriptional suppression of multidrug resistance-associated protein (MRP) gene expression by wild-type p53., Cancer Res.
Borgnetto et al., 1996, Drug-specific sites of topoisomerase II DNA cleavage in Drosophila chromatin: heterogeneous localization and reversibility., Cancer Res.
Weller et al., 1998, Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses., Int. J. Cancer

TENIPOSIDE NUP50

Interaction Score: 15.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24444404

Sources:
PharmGKB
TENIPOSIDE H2AW

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8620504

Sources:
NCI
TENIPOSIDE TOP2A

Interaction Score: 1.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction DNA topoisomerase II inhibitor

PMIDs:
9426516 8702194 16480143 16271071 17514873 11752352 17361331

Sources:
TdgClinicalTrial ChemblInteractions NCI TEND
TENIPOSIDE FAS

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9543255

Sources:
NCI
TENIPOSIDE TOP2B

Interaction Score: 0.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction DNA topoisomerase II inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
TENIPOSIDE BCL2

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9842975

Sources:
NCI
TENIPOSIDE ABCC1

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9865734

Sources:
NCI
TENIPOSIDE ABCB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

TEND: TENIPOSIDE
- Version: 01-August-2011
Alternate Names:

TENIPOSIDE Primary Drug Name

Drug Info:

Year of Approval 1992

Drug Class antineoplastic agents

Publications:
TdgClinicalTrial: TENIPOSIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antineoplastic Agents

Drug Class small molecule

FDA Approval 1992

Publications:

NCI: VM-26

Version: 14-September-2017

Alternate Names:

C857 NCI drug code

Drug Info:

Publications:

Wang et al., 1998, Transcriptional suppression of multidrug resistance-associated protein (MRP) gene expression by wild-type p53., Cancer Res.

Borgnetto et al., 1996, Drug-specific sites of topoisomerase II DNA cleavage in Drosophila chromatin: heterogeneous localization and reversibility., Cancer Res.

NCI: TENIPOSIDE

Version: 14-September-2017

Alternate Names:

C857 NCI drug code

Drug Info:

Publications:

Winter et al., 1998, Synergy of CD95 ligand and teniposide: no role of cleavable complex formation and enhanced CD95 expression., Eur. J. Pharmacol.

Gorczyca et al., 1992, Cell cycle-related expression of p120 nucleolar antigen in normal human lymphocytes and in cells of HL-60 and MOLT-4 leukemic lines: effects of methotrexate, camptothecin, and teniposide., Cancer Res.

Brown et al., 1998, Immunohistochemical staining for DNA topoisomerase IIa in Hodgkin's disease., Am. J. Clin. Pathol.

PharmGKB: teniposide
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Brown CC et al., 2014, Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines., Pharmacogenomics
TTD: Teniposide
- Version: 2020.06.01
Alternate Names:

D01DBQ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL452231
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL452231
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-
Mechanism of Interaction	DNA topoisomerase II inhibitor

Mechanism of Interaction	DNA topoisomerase II inhibitor
Direct Interaction	yes

TENIPOSIDE Drug Record

TENIPOSIDE chembl:CHEMBL452231 ApprovedAntineoplasticImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24444404

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8620504

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction DNA topoisomerase II inhibitor

PMIDs: 9426516 8702194 16480143 16271071 17514873 11752352 17361331

Sources: TdgClinicalTrial ChemblInteractions NCI TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9543255

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction DNA topoisomerase II inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9842975

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9865734

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

TEND: TENIPOSIDE

Alternate Names: TENIPOSIDE Primary Drug Name

Drug Info: Year of Approval 1992 Drug Class antineoplastic agents

Publications:

TdgClinicalTrial: TENIPOSIDE

Alternate Names:

Drug Info: Drug Indications Antineoplastic Agents Drug Class small molecule FDA Approval 1992

Publications:

NCI: VM-26

Alternate Names: C857 NCI drug code

Drug Info:

NCI: TENIPOSIDE

Alternate Names: C857 NCI drug code

Drug Info:

PharmGKB: teniposide

Alternate Names:

Drug Info:

Publications: Brown CC et al., 2014, Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines., Pharmacogenomics

TTD: Teniposide

Alternate Names: D01DBQ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL452231

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL452231

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
24444404

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
8620504

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction DNA topoisomerase II inhibitor

PMIDs:
9426516 8702194 16480143 16271071 17514873 11752352 17361331

Sources:
TdgClinicalTrial ChemblInteractions NCI TEND

Interaction Types & Directionality:

n/a

PMIDs:
9543255

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction DNA topoisomerase II inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
9842975

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9865734

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

TENIPOSIDE Primary Drug Name

Drug Info:

Year of Approval 1992

Drug Class antineoplastic agents

Drug Info:

Drug Indications Antineoplastic Agents

Drug Class small molecule

FDA Approval 1992

Alternate Names:

C857 NCI drug code

Alternate Names:

C857 NCI drug code

Publications:

Brown CC et al., 2014, Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines., Pharmacogenomics

Alternate Names:

D01DBQ TTD Drug ID