DGIdb - TESTOLACTONE Drug Record

TESTOLACTONE chembl:CHEMBL1571 ApprovedAntineoplastic

Alternate Names:

FLUDESTRIN
NSC-23759
TESLAC
TESTOLACTONE
SQ-9538
TESTOLACTONE CIII
DELTA(1)-TESTOLOLACTONE
Δ1-TESTOLOLACTONE
1-DEHYDROTESTOLOLACTONE
TESTOLATTONE
TESLAC®
TESTOLACTONUM
13-HYDROXY-3-OXO-13,17-SECOANDROSTA-1,4-DIEN-17-OIC ACID DELTA-LACTONE
(4AS,4BR,10AR,10BS,12AS)-10A,12A-DIMETHYL-3,4,4A,5,6,10A,10B,11,12,12A-DECAHYDRO-2H-NAPHTHO[2,1-F]CHROMENE-2,8(4BH)-DIONE
TESTOLACTONA
D-HOMO-17A-OXAANDROSTA-1,4-DIENE-3,17-DIONE
13-HYDROXY-3-OXO-13,17-SECOANDROSTA-1,4-DIEN-17-OIC ACID Δ-LACTONE
1,2-DIDEHYDROTESTOLOLACTONE
drugbank:00894
chemidplus:968-93-4
rxcui:10378
pubchem.compound:13769
chembl:CHEMBL1571

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Antineoplastic Agents, Hormonal
Year of Approval	approved before 1982
Drug Class	antineoplastic agents, hormonal

(3 More Sources)

Publications:

Raman et al., 2002, Aromatase inhibitors for male infertility., J. Urol.
Cepa et al., 2005, Structure-activity relationships of new A,D-ring modified steroids as aromatase inhibitors: design, synthesis, and biological activity evaluation., J. Med. Chem.
Dunkel, 2006, Use of aromatase inhibitors to increase final height., Mol. Cell. Endocrinol.
Herzog et al., 1998, Testosterone versus testosterone and testolactone in treating reproductive and sexual dysfunction in men with epilepsy and hypogonadism., Neurology
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Serafini et al., 1987, Modulation of prolactin responses to gonadotropin releasing hormone by acute testosterone infusions in normal women., Gynecol. Endocrinol.

TESTOLACTONE CYP19A1

Interaction Score: 5.46

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Cytochrome P450 19A1 inhibitor

PMIDs:
11792932 16190763 16766117 9521275 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
TESTOLACTONE PRL

Interaction Score: 1.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3332537

Sources:
NCI
TESTOLACTONE AR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: TESTOLACTONE
- Version: 01-August-2011
Alternate Names:

TESTOLACTONE Primary Drug Name

Drug Info:

Drug Class antineoplastic agents, hormonal

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: TESTOLACTONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antineoplastic Agents, Hormonal

Drug Class small molecule

FDA Approval Approved before 1982

Publications:
NCI: TESTOLACTONE
- Version: 14-September-2017
Alternate Names:

C2301 NCI drug code

Drug Info:

Publications:

Serafini et al., 1987, Modulation of prolactin responses to gonadotropin releasing hormone by acute testosterone infusions in normal women., Gynecol. Endocrinol.
DTC: TESTOLACTONE
- Version: 02-September-2020
Alternate Names:

CHEMBL1571 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Testolactone
- Version: 2020.06.01
Alternate Names:

D0C7JF TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1571
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1571
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	Cytochrome P450 19A1 inhibitor

TESTOLACTONE Drug Record

TESTOLACTONE chembl:CHEMBL1571 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

TESTOLACTONE CYP19A1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Cytochrome P450 19A1 inhibitor

PMIDs: 11792932 16190763 16766117 9521275 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

TESTOLACTONE PRL

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3332537

Sources: NCI

TESTOLACTONE AR

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: TESTOLACTONE

Alternate Names: TESTOLACTONE Primary Drug Name

Drug Info: Drug Class antineoplastic agents, hormonal Year of Approval approved before 1982

Publications:

TdgClinicalTrial: TESTOLACTONE

Alternate Names:

Drug Info: Drug Indications Antineoplastic Agents, Hormonal Drug Class small molecule FDA Approval Approved before 1982

Publications:

NCI: TESTOLACTONE

Alternate Names: C2301 NCI drug code

Drug Info:

Publications: Serafini et al., 1987, Modulation of prolactin responses to gonadotropin releasing hormone by acute testosterone infusions in normal women., Gynecol. Endocrinol.

DTC: TESTOLACTONE

Alternate Names: CHEMBL1571 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Testolactone

Alternate Names: D0C7JF TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1571

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1571

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Cytochrome P450 19A1 inhibitor

PMIDs:
11792932 16190763 16766117 9521275 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
3332537

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

TESTOLACTONE Primary Drug Name

Drug Info:

Drug Class antineoplastic agents, hormonal

Year of Approval approved before 1982

Drug Info:

Drug Indications Antineoplastic Agents, Hormonal

Drug Class small molecule

FDA Approval Approved before 1982

Alternate Names:

C2301 NCI drug code

Publications:

Serafini et al., 1987, Modulation of prolactin responses to gonadotropin releasing hormone by acute testosterone infusions in normal women., Gynecol. Endocrinol.

Alternate Names:

CHEMBL1571 ChEMBL Drug ID

Alternate Names:

D0C7JF TTD Drug ID