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TESTOSTERONE Drug Record

  • Summary
  • Interactions
  • Claims
  • TESTOSTERONE chembl:CHEMBL386630 Approved

    Alternate Names:

    ANDROPATCH
    NATESTO
    ANDRODERM
    TESTIM 1%
    VOGELXO
    FORTESTA
    TESTOGEL
    TOSTRAN
    TESTIM
    INTRINSA
    TESTOPATCH
    TESTODERM
    TESTOPEL
    DELATESTRYL
    TESTOSTERONE CIII
    TESTODERM TTS
    STRIANT
    AXIRON
    NSC-9700
    ANDROGEL
    TESTOSTERONE
    ANDROGEL 1%
    STRIANT SR
    TESTORAL
    17-HYDROXY-ANDROST-4-EN-3-ONE
    17-HYDROXY-D4-ANDROSTEN-3-ONE
    17B-HYDROXY-ANDROST-4-EN-3-ON
    4-ANDROSTEN-3-ONE-17B-OL
    TESTOSTERONA
    VIROSTERONE
    17B-HYDROXY-(8A,10A)-ANDROST-4-EN-3-ONE
    D4-ANDROSTEN-17B-OL-3-ONE
    TESTOSTERONUM
    8-ISO-TESTOSTERONE
    4-ANDROSTEN-17BETA-OL-3-ONE
    17A-HYDROXY-14B-ANDROST-4-EN-3-ONE
    TESTRONE
    17A-HYDROXY-(13A)-ANDROST-4-EN-3-ONE
    RAC-17B-HYDROXY-(9B,10A)ANDROST-4-EN-3-ONE
    (+-)-TESTOSTERONE
    17BETA-HYDROXY-4-ANDROSTEN-3-ONE
    17B-HYDROXY-D4-ANDROSTEN-3-ONE
    17B-HYDROXY-(8A)-ANDROST-4-EN-3-ONE
    17B-HYDROXY-(9B,10A)-ANDROST-4-EN-3-ONE
    17B-HYDROXY-ANDROST-4-EN-3-ONE
    9B-TESTOSTERONE
    17-HYDROXY-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
    TESTOSTÉRONE
    RAC-17B-HYDROXY-ANDROST-4-EN-3-ONE
    ANDROST-4-EN-17B-OL-3-ONE
    (17B)-17-HYDROXY-ANDROST-4-EN-3-ONE
    4-ANDROSTEN-17Β-OL-3-ONE
    17B-HYDROXY-8A-ANDROST-4-EN-3-ONE
    (+-)-8-ISO-TESTOSTERONE
    17B-HYDROXY-(9B)-ANDROST-4-EN-3-ONE
    (+)-TESTOSTERONE
    TESTOSTERON
    17B-HYDROXYANDROST-4-EN-3-ONE
    9B,10A-TESTOSTERONE
    ANDROST-4-ENE-17B-OL-3-ONE
    LUMITESTOSTERON
    RAC-17B-HYDROXY-(8A)-ANDROST-4-EN-3-ONE
    RETROTESTOSTERONE
    17B-HYDROXYANDROST-4-ENE-3-ONE
    (+-)-RETROTESTOSTERONE
    17A-HYDROXY-13A-ANDROST-4-EN-3-ONE
    17B-HYDROXY-(13A)-ANDROST-4-EN-3-ONE
    MERTESTATE
    17B-HYDROXY-13A-ANDROST-4-EN-3-ONE
    17B-HYDROXY-(10A)-ANDROST-4-EN-3-ONE
    RAC-17B-HYDROXY-(13A)ANDROST-4-EN-3-ONE
    17B-TESTOSTERONE
    (1S,2R,10R,11S,14S,15S)-14-HYDROXY-2,15-DIMETHYLTETRACYCLO[8.7.0.0^{2,7}.0^{11,15}]HEPTADEC-6-EN-5-ONE
    17A-HYDROXY-ANDROST-4-EN-3-ONE
    13-ISO-TESTOSTERONE
    rxcui:10379
    chembl:CHEMBL386630
    chemidplus:58-22-0
    drugbank:00624
    pubchem.compound:6013

    Drug Info:

    Drug Indications for treatment of female sexual dysfunction
    Drug Indications hormone replacement,for treatment of female sexual dysfunction
    Drug Class Small Molecule
    Drug Indications hormone replacement
    FDA Approval approved
    Year of Approval approved before 1982
    Drug Class hormone replacement agents
    (4 More Sources)

    Publications:

    Kim et al., 1999, Microdeletions within the azoospermia factor subregions of the Y chromosome in patients with idiopathic azoospermia., Fertil. Steril.
    Small et al., 2006, The case for secondary hormonal therapies in the chemotherapy age., J. Urol.
    Maudsley et al., 2006, Gonadotropin-releasing hormone functionally antagonizes testosterone activation of the human androgen receptor in prostate cells through focal adhesion complexes involving Hic-5., Neuroendocrinology
    Petraki et al., 2007, Histopathological changes induced by therapies in the benign prostate and prostate adenocarcinoma., Histol. Histopathol.
    Omwancha et al., 2006, Selective androgen receptor modulators: in pursuit of tissue-selective androgens., Curr Opin Investig Drugs
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Lapauw et al., 2007, Is the effect of testosterone on body composition modulated by the androgen receptor gene CAG repeat polymorphism in elderly men?, Eur. J. Endocrinol.
    Dexheimer TS et al., 2009, 4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors., J Med Chem
    Leman et al., 2003, Regulation of androgen and vitamin d receptors by 1,25-dihydroxyvitamin D3 in human prostate epithelial and stromal cells., J. Urol.
    Lu et al., 1996, Regulation of renal oatp mRNA expression by testosterone., Am. J. Physiol.
    Courjault-Gautier et al., 1997, Activity and inducibility of drug-metabolizing enzymes in immortalized hepatocyte-like cells (mhPKT) derived from a L-PK/Tag1 transgenic mouse., Exp. Cell Res.
    Pastor-Soler et al., 2002, Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens., Biol. Reprod.
    Badran et al., Expression and regulation of aquaporins 1, 8, and 9 in the testis, efferent ducts, and epididymis of adult rats and during postnatal development., J. Androl.
    Redmond et al., The effects of testosterone on plasma and platelet monoamine oxidase (MAO) an plasma dopamine-beta-hydroxylase (DBH) activities in the male rhesus monkey., Psychosom Med
    Penning et al., 2000, Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones., Biochem. J.
    Falany et al., Steroid 3- and 17-OH UDP-glucuronosyltransferase activities in rat and rabbit liver microsomes., Drug Metab. Dispos.
    Mori et al., 2003, Effects of cigarette smoke and a heterocyclic amine, MeIQx on cytochrome P-450, mutagenic activation of various carcinogens and glucuronidation in rat liver., Mutagenesis
    Mori et al., 2002, Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver., Mutagenesis
    Tang et al., 1991, In vivo regulation of apolipoprotein A-I gene expression by estradiol and testosterone occurs at the translational level in inbred strains of mice., Biochem. Biophys. Res. Commun.
    Weiner et al., 1994, Induction of calcium-dependent nitric oxide synthases by sex hormones., Proc. Natl. Acad. Sci. U.S.A.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Bouret et al., 2000, Expression of GalR1 and GalR2 galanin receptor messenger ribonucleic acid in proopiomelanocortin neurons of the rat arcuate nucleus: effect of testosterone., Endocrinology
    Watabe et al., 1996, Identification of histone H2A.X as a growth factor secreted by an androgen-independent subline of mouse mammary carcinoma cells., J. Biol. Chem.
    Regnier et al., 1993, Differential sensitivity to androgens within a sexually dimorphic muscle of male frogs (Xenopus laevis)., J. Neurobiol.
    Rey et al., 1994, Anti-müllerian hormone in children with androgen insensitivity., J. Clin. Endocrinol. Metab.
    Ichas et al., 1994, Action of testosterone on the anti-müllerian activity of the chick embryonic testis assayed in vivo by organotypic grafting., Anat. Embryol.
    Zurita et al., 2003, Abnormal sex-duct development in female moles: the role of anti-Müllerian hormone and testosterone., Int. J. Dev. Biol.
    Voutilainen, 1992, Differentiation of the fetal gonad., Horm. Res.
    Sriraman et al., Müllerian inhibiting substance inhibits testosterone synthesis in adult rats., J. Androl.
    Heyn et al., 1998, Ultrastructural dynamics of human testicular cords from 6 to 16 weeks of embryonic development. Study by transmission and high resolution scanning electron microscopy., Ital J Anat Embryol
    Trbovich et al., 2001, Müllerian Inhibiting Substance lowers testosterone in luteinizing hormone-stimulated rodents., Proc. Natl. Acad. Sci. U.S.A.
    Furuya et al., 2000, Histochemical study of apoptotic epithelial cells depending on testosterone in primary cultured rat prostatic tissues., Histol. Histopathol.
    Robinson et al., 1997, Effects of a new 5 alpha reductase inhibitor (epristeride) on human prostate cell cultures., Prostate
    Azhar et al., 1989, The influence of estradiol on cholesterol processing by the corpus luteum., Biol. Reprod.
    Khurana et al., 1993, Receptor-mediated stimulatory effect of atrial natriuretic factor, brain natriuretic peptide, and C-type natriuretic peptide on testosterone production in purified mouse Leydig cells: activation of cholesterol side-chain cleavage enzyme., Endocrinology
    Neaves, 1975, Gonadotropin-induced proliferation of endoplasmic reticulum in an androgenic tumor and its relation to elevated plasma testosterone levels., Cancer Res.
    Johnson et al., 1991, The regulation of oxytocin receptor binding in the ventromedial hypothalamic nucleus by testosterone and its metabolites., Endocrinology
    Hu et al., 1998, Expression and regulation of interferon-gamma-inducible protein 10 gene in rat Leydig cells., Endocrinology
    Luine et al., 1980, Androgen affects cholinergic enzymes in syringeal motor neurons and muscle., Brain Res.
    Nanjee et al., 1988, Lack of association between plasma lecithin: cholesterol acyltransferase concentration and plasma sex hormone concentrations in men., Clin. Chim. Acta
    Li et al., 2001, Caveolin-1 mediates testosterone-stimulated survival/clonal growth and promotes metastatic activities in prostate cancer cells., Cancer Res.
    Rendic et al., 1999, Metabolism of anabolic steroids by recombinant human cytochrome P450 enzymes. Gas chromatographic-mass spectrometric determination of metabolites., J. Chromatogr. B Biomed. Sci. Appl.
    Khosla et al., 2002, Effect of estrogen versus testosterone on circulating osteoprotegerin and other cytokine levels in normal elderly men., J. Clin. Endocrinol. Metab.
    Chang FR et al., 2005, The transgenic Arabidopsis plant system, pER8-GFP, as a powerful tool in searching for natural product estrogen-agonists/antagonists., J Nat Prod
    Kojima H et al., 2003, Effects of a diphenyl ether-type herbicide, chlornitrofen, and its amino derivative on androgen and estrogen receptor activities., Environ Health Perspect
    Zhou J et al., 2000, Testosterone inhibits estrogen-induced mammary epithelial proliferation and suppresses estrogen receptor expression., FASEB J
  • TESTOSTERONE   AMH

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7962305 7818099 14584782 1292985 11545286 11315948 11248089


    Sources:
    NCI

  • TESTOSTERONE   USP9Y

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10439009


    Sources:
    NCI

  • TESTOSTERONE   CAV1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11389065


    Sources:
    NCI

  • TESTOSTERONE   CGA

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1157041


    Sources:
    NCI

  • TESTOSTERONE   GALR1

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10803589


    Sources:
    NCI

  • TESTOSTERONE   AQP9

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12021052 12002438


    Sources:
    NCI

  • TESTOSTERONE   LCAT

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3383436


    Sources:
    NCI

  • TESTOSTERONE   H2AX

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8810267


    Sources:
    NCI

  • TESTOSTERONE   UGT1A5

    Interaction Score: 0.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6138227 12473741 11971997


    Sources:
    NCI

  • TESTOSTERONE   TNFRSF11B

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11932280


    Sources:
    NCI

  • TESTOSTERONE   SOAT1

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2765620


    Sources:
    NCI

  • TESTOSTERONE   SLCO1A2

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8779895


    Sources:
    NCI

  • TESTOSTERONE   DBH

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    824661


    Sources:
    NCI

  • TESTOSTERONE   APOA1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1764091


    Sources:
    NCI

  • TESTOSTERONE   CHAT

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7378793


    Sources:
    NCI

  • TESTOSTERONE   NPPC

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8404664


    Sources:
    NCI

  • TESTOSTERONE   AKR1C3

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10998348


    Sources:
    NCI

  • TESTOSTERONE   MYO9B

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8409979


    Sources:
    NCI

  • TESTOSTERONE   CXCL10

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9681518


    Sources:
    NCI

  • TESTOSTERONE   OXTR

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1846593


    Sources:
    NCI

  • TESTOSTERONE   HNF4A

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9260906


    Sources:
    NCI

  • TESTOSTERONE   FAS

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10809356


    Sources:
    NCI

  • TESTOSTERONE   TGFB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9288184


    Sources:
    NCI

  • TESTOSTERONE   NOS1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7515189


    Sources:
    NCI

  • TESTOSTERONE   CYP2B6

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10630892


    Sources:
    NCI

  • TESTOSTERONE   TDP1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19883083


    Sources:
    DTC

  • TESTOSTERONE   ESR1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    16038533 12676605 10973921


    Sources:
    DTC

  • TESTOSTERONE   RXRA

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TESTOSTERONE   AR

    Interaction Score: 0.02

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Androgen Receptor agonist
    Direct Interaction yes
    Trial Name AA2600, androgen transmucosal film

    PMIDs:
    17084172 17202804 17128417 17086931 11752352 17322500


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND TTD

  • TESTOSTERONE   RORC

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TESTOSTERONE   NR3C1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TESTOSTERONE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300 9187528


    Sources:
    DTC PharmGKB

  • TESTOSTERONE   VDR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12796696


    Sources:
    NCI

  • TESTOSTERONE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TESTOSTERONE   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TESTOSTERONE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TdgClinicalTrial: TESTOSTERONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    FDA Approval approved
    Drug Indications hormone replacement
    Drug Class Small Molecule

    Publications:

  • TEND: TESTOSTERONE

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Drug Class hormone replacement agents
    Year of Approval approved before 1982

    Publications:

  • NCI: TESTOSTERONE

    • Version: 14-September-2017

    Alternate Names:
    C862 NCI drug code

    Drug Info:

    Publications:
    Kim et al., 1999, Microdeletions within the azoospermia factor subregions of the Y chromosome in patients with idiopathic azoospermia., Fertil. Steril.
    Leman et al., 2003, Regulation of androgen and vitamin d receptors by 1,25-dihydroxyvitamin D3 in human prostate epithelial and stromal cells., J. Urol.
    Lu et al., 1996, Regulation of renal oatp mRNA expression by testosterone., Am. J. Physiol.

  • DTC: TESTOSTERONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL386630 ChEMBL Drug ID

    Drug Info:

    Publications:
    Dexheimer TS et al., 2009, 4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors., J Med Chem
    Chang FR et al., 2005, The transgenic Arabidopsis plant system, pER8-GFP, as a powerful tool in searching for natural product estrogen-agonists/antagonists., J Nat Prod
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: testosterone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

  • TTD: Testosterone

    • Version: 2020.06.01

    Alternate Names:
    D06XMU TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL386630

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL386630

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21