• TEZAMPANEL chembl:CHEMBL14935

    Alternate Names:

    NGX-424
    LY-293558
    LY-293,558

    Drug Info:

    FDA Approval not approved
    Drug Class small molecule
    Drug Indications antimigraine agent,analgesic
    (0 More Sources)
  • Interaction Score: 4.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist
    Trial Name tezampanel, NGX424,NGX426

  • Interaction Score: 3.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name tezampanel, NGX424,NGX426
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 3.54

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Novel Target
    Trial Name tezampanel, NGX424,NGX426
    Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist

    PMIDs:
    None found


  • Interaction Score: 2.84

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist
    Direct Interaction yes
    Trial Name tezampanel, NGX424,NGX426

    PMIDs:
    None found


  • Interaction Score: 1.12

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

  • Interaction Score: 0.97

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name tezampanel, NGX424,NGX426
    Novel drug target Established target
    Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

  • Interaction Score: 0.95

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate receptor ionotropic kainate antagonist
    Direct Interaction yes
    Novel drug target Established target

    PMIDs:
    None found


  • Interaction Score: 0.79

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name tezampanel, NGX424,NGX426
    Novel drug target Established target
    Specific Action of the Ligand Antagonist

  • Interaction Score: 0.64

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name tezampanel, NGX424,NGX426
    Novel drug target Established target
    Direct Interaction yes