DGIdb - THIOPENTAL Drug Record

THIOPENTAL chembl:CHEMBL441 Approved

Alternate Names:

THIOPENTAL
THIOPENTAL CIII

Drug Info:

FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Anesthetics, Intravenous
Year of Approval	approved before 1982
Drug Class	anesthetics, intravenous

(0 More Sources)

Publications:

Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
Whiting, 2003, The GABAA receptor gene family: new opportunities for drug development., Curr Opin Drug Discov Devel
Grasshoff et al., 2008, Depression of spinal network activity by thiopental: shift from phasic to tonic GABA(A) receptor-mediated inhibition., Neuropharmacology
Patel et al., 2003, The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase., Br. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

THIOPENTAL GRIK2

Interaction Score: 1.5

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND
THIOPENTAL FAAH

Interaction Score: 0.8

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
12839875 11752352

Sources:
TTD
THIOPENTAL GRIA2

Interaction Score: 0.8

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND
THIOPENTAL CHRNA7

Interaction Score: 0.76

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
THIOPENTAL CHRNA4

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
THIOPENTAL GABRA1

Interaction Score: 0.43

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
14579514 10209232 18619475 11264449 10487207

Sources:
TdgClinicalTrial TEND
THIOPENTAL GABRA6

Interaction Score: 0.34

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND
THIOPENTAL GABRA5

Interaction Score: 0.31

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND
THIOPENTAL GABRA3

Interaction Score: 0.3

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND
THIOPENTAL GABRA2

Interaction Score: 0.29

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND
THIOPENTAL GABRA4

Interaction Score: 0.26

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232

Sources:
TdgClinicalTrial TEND

TdgClinicalTrial: THIOPENTAL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anesthetics, Intravenous

Drug Class small molecule

FDA Approval Approved before 1982

Publications:
TEND: THIOPENTAL
- Version: 01-August-2011
Alternate Names:

Drug Info:

Drug Class anesthetics, intravenous

Year of Approval approved before 1982

Publications:
TTD: Thiopental
- Version: 2020.06.01
Alternate Names:

D00MYT TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL441
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Novel drug target	Established target
Trial Name	-

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

THIOPENTAL Drug Record

THIOPENTAL chembl:CHEMBL441 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 12839875 11752352

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16248797 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16248797 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 14579514 10209232 18619475 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10209232 11264449

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 10209232 11264449

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10209232 11264449

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 10209232 11264449

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10209232

Sources: TdgClinicalTrial TEND

TdgClinicalTrial: THIOPENTAL

Alternate Names:

Drug Info: Drug Indications Anesthetics, Intravenous Drug Class small molecule FDA Approval Approved before 1982

Publications:

TEND: THIOPENTAL

Alternate Names:

Drug Info: Drug Class anesthetics, intravenous Year of Approval approved before 1982

Publications:

TTD: Thiopental

Alternate Names: D00MYT TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL441

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
12839875 11752352

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
14579514 10209232 18619475 11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232

Sources:
TdgClinicalTrial TEND

Drug Info:

Drug Indications Anesthetics, Intravenous

Drug Class small molecule

FDA Approval Approved before 1982

Drug Info:

Drug Class anesthetics, intravenous

Year of Approval approved before 1982

Alternate Names:

D00MYT TTD Drug ID