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THIOPENTAL Drug Record

  • Summary
  • Interactions
  • Claims
  • THIOPENTAL chembl:CHEMBL441 Approved

    Alternate Names:

    THIOPENTAL
    THIOPENTAL CIII

    Drug Info:

    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications Anesthetics, Intravenous
    Year of Approval approved before 1982
    Drug Class anesthetics, intravenous
    Drug Categories anticholinergic agents
    Drug Categories cytochrome p-450 cyp2c19 substrates
    Drug Categories cytochrome p-450 cyp2c19 substrates with a narrow therapeutic index
    Drug Categories cytochrome p-450 cyp3a inducers
    Drug Categories cytochrome p-450 cyp3a4 inducers
    Drug Categories cytochrome p-450 cyp3a4 inducers (strength unknown)
    Drug Categories cytochrome p-450 cyp3a4 inhibitors
    Drug Categories cytochrome p-450 cyp3a4 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 enzyme inducers
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories hypotensive agents
    Drug Categories narrow therapeutic index drugs
    Drug Categories nicotinic antagonists
    Drug Categories psycholeptics
    (1 More Sources)

    Publications:

    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
    Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
    Whiting, 2003, The GABAA receptor gene family: new opportunities for drug development., Curr Opin Drug Discov Devel
    Grasshoff et al., 2008, Depression of spinal network activity by thiopental: shift from phasic to tonic GABA(A) receptor-mediated inhibition., Neuropharmacology
    Patel et al., 2003, The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase., Br. J. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Hirota K et al., 2002, Interaction of intravenous anesthetics with recombinant human M1-M3 muscarinic receptors expressed in chinese hamster ovary cells., Anesth Analg
  • THIOPENTAL   GRIK2

    Interaction Score: 1.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • THIOPENTAL   FAAH

    Interaction Score: 0.82

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    12839875 11752352


    Sources:
    TTD DrugBank

  • THIOPENTAL   CHRNA4

    Interaction Score: 0.5

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 16248797 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • THIOPENTAL   GRIA2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • THIOPENTAL   CHRNA7

    Interaction Score: 0.44

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 16248797 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • THIOPENTAL   GABRA6

    Interaction Score: 0.3

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10209232


    Sources:
    TEND TdgClinicalTrial DrugBank

  • THIOPENTAL   GABRA1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    14579514 11264449 10209232 10487207 18619475


    Sources:
    TEND TdgClinicalTrial DrugBank

  • THIOPENTAL   GABRA5

    Interaction Score: 0.28

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 10209232


    Sources:
    TEND TdgClinicalTrial DrugBank

  • THIOPENTAL   GABRA2

    Interaction Score: 0.27

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 10209232


    Sources:
    TEND TdgClinicalTrial DrugBank

  • THIOPENTAL   GABRA3

    Interaction Score: 0.26

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10209232


    Sources:
    TEND TdgClinicalTrial DrugBank

  • THIOPENTAL   GABRA4

    Interaction Score: 0.24

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10209232


    Sources:
    TEND TdgClinicalTrial DrugBank

  • THIOPENTAL   CHRM3

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12456425


    Sources:
    DrugBank

  • DrugBank: DB00599

    • Version: 5.1.7

    Alternate Names:
    76-75-5 CAS Number
    Anestho Drug Brand
    Bensulf Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups vet_approved

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
    Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.

  • TdgClinicalTrial: THIOPENTAL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Anesthetics, Intravenous
    Drug Class small molecule
    FDA Approval Approved before 1982

    Publications:

  • TEND: THIOPENTAL

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Drug Class anesthetics, intravenous
    Year of Approval approved before 1982

    Publications:

  • TTD: Thiopental

    • Version: 2020.06.01

    Alternate Names:
    D00MYT TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL441

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2021-04-13