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THIOTHIXENE Drug Record

  • Summary
  • Interactions
  • Claims
  • THIOTHIXENE chembl:CHEMBL1201 Approved

    Alternate Names:

    ORBINAMON
    TIOTIXENE
    NAVANE
    P-4657B
    THIOTHIXENE
    NAVANE®
    TIOTIXENO
    CIS-THIOTHIXENE
    TIOTIXENUM
    THIOTHIXINE
    rxcui:10510
    pubchem.compound:941651
    chemidplus:3313-26-6
    chembl:CHEMBL1201
    drugbank:01623

    Drug Info:

    (0 More Sources)

    Publications:

    Kusumi et al., 2000, Differential effects of subchronic treatments with atypical antipsychotic drugs on dopamine D2 and serotonin 5-HT2A receptors in the rat brain., J Neural Transm (Vienna)
    Yamada et al., 1995, Serotonin2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) inhibits chlorpromazine- and haloperidol-induced hypothermia in mice., Biol. Pharm. Bull.
    Oades et al., 2000, Neuropsychological and conditioned blocking performance in patients with schizophrenia: assessment of the contribution of neuroleptic dose, serum levels and dopamine D2-receptor occupancy., Behav Pharmacol
    Wu et al., 2006, Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients., Acta Pharmacol. Sin.
    Seeman, 2010, Dopamine D2 receptors as treatment targets in schizophrenia., Clin Schizophr Relat Psychoses
    Wu et al., 2005, Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients., Neurosci. Lett.
    Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry
    Shultz et al., 1987, Dopaminergic stimulation of cAMP accumulation in cultured rat mesangial cells., Am. J. Physiol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
  • THIOTHIXENE   DRD2

    Interaction Score: 0.84

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Dopamine D2 receptor antagonist
    Direct Interaction yes

    PMIDs:
    11103886 16867246 20643630 15694263 11873706 3039860 11752352


    Sources:
    ChemblInteractions TTD

  • THIOTHIXENE   HTR2A

    Interaction Score: 0.46

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    10821438 8593484


    Sources:
    ChemblInteractions

  • THIOTHIXENE   ATXN2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIOTHIXENE   IDH1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TTD: Thiothixene

    • Version: 2020.06.01

    Alternate Names:
    D0E0LQ TTD Drug ID

    Drug Info:

    Publications:

  • DTC: THIOTHIXENE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1201 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1201

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1201

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21