DGIdb - TIOTROPIUM Drug Record

TIOTROPIUM chembl:CHEMBL1900528 Approved

Alternate Names:

TIOTROPIUM
SPIRIVA
SPIRIVA RESPIMAT
BRALTUS
pubchem.compound:3086655
chembl:CHEMBL1900528
chemidplus:186691-13-4
rxcui:69120
drugbank:01409

Drug Info:

Drug Class	bronchodilator agents
Year of Approval	2004
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of cystic fibrosis,for treatment of chronic obstructive pulmonary disorder (COPD)

(2 More Sources)

Publications:

Barnes, 2001, Tiotropium bromide., Expert Opin Investig Drugs
Barnes et al., 1995, Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease., Life Sci.
Hansel et al., 2002, Tiotropium bromide: a novel once-daily anticholinergic bronchodilator for the treatment of COPD., Drugs Today
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Park HW et al., 2009, Additive role of tiotropium in severe asthmatics and Arg16Gly in ADRB2 as a potential marker to predict response., Allergy

TIOTROPIUM CHRM3

Interaction Score: 1.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name tiotropium bromide,Spiriva

Specific Action of the Ligand Antagonist

PMIDs:
11281822 10188785 12582447 11752352

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD
TIOTROPIUM CHRM2

Interaction Score: 0.61

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
10188785 12582447

Sources:
TdgClinicalTrial GuideToPharmacology
TIOTROPIUM CHRM1

Interaction Score: 0.57

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tiotropium bromide,Spiriva

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
10188785 11281822 12582447

Sources:
TdgClinicalTrial GuideToPharmacology
TIOTROPIUM ADRB2

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19183167

Sources:
PharmGKB
TIOTROPIUM CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

TEND: TIOTROPIUM
- Version: 01-August-2011
Alternate Names:

TIOTROPIUM Primary Drug Name

Drug Info:

Year of Approval 2004

Drug Class bronchodilator agents

Publications:
TdgClinicalTrial: TIOTROPIUM
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of cystic fibrosis,for treatment of chronic obstructive pulmonary disorder (COPD)

Drug Class Small Molecule

FDA Approval approved

Publications:
PharmGKB: tiotropium
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Park HW et al., 2009, Additive role of tiotropium in severe asthmatics and Arg16Gly in ADRB2 as a potential marker to predict response., Allergy
TTD: Tiotropium
- Version: 2020.06.01
Alternate Names:

D0P1WA TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135651266
- Version: 29-September-2020
Alternate Names:

TIOTROPIUM GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1900528
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	tiotropium bromide,Spiriva
Specific Action of the Ligand	Antagonist

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	False

TIOTROPIUM Drug Record

TIOTROPIUM chembl:CHEMBL1900528 Approved

Alternate Names:

Drug Info:

Publications:

TIOTROPIUM CHRM3

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name tiotropium bromide,Spiriva Specific Action of the Ligand Antagonist

PMIDs: 11281822 10188785 12582447 11752352

Sources: TdgClinicalTrial TEND GuideToPharmacology TTD

TIOTROPIUM CHRM2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False

PMIDs: 10188785 12582447

Sources: TdgClinicalTrial GuideToPharmacology

TIOTROPIUM CHRM1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name tiotropium bromide,Spiriva Novel drug target Established target Specific Action of the Ligand Antagonist

PMIDs: 10188785 11281822 12582447

Sources: TdgClinicalTrial GuideToPharmacology

TIOTROPIUM ADRB2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19183167

Sources: PharmGKB

TIOTROPIUM CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

TEND: TIOTROPIUM

Alternate Names: TIOTROPIUM Primary Drug Name

Drug Info: Year of Approval 2004 Drug Class bronchodilator agents

Publications:

TdgClinicalTrial: TIOTROPIUM

Alternate Names:

Drug Info: Drug Indications for treatment of cystic fibrosis,for treatment of chronic obstructive pulmonary disorder (COPD) Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: tiotropium

Alternate Names:

Drug Info:

Publications: Park HW et al., 2009, Additive role of tiotropium in severe asthmatics and Arg16Gly in ADRB2 as a potential marker to predict response., Allergy

TTD: Tiotropium

Alternate Names: D0P1WA TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 135651266

Alternate Names: TIOTROPIUM GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1900528

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name tiotropium bromide,Spiriva

Specific Action of the Ligand Antagonist

PMIDs:
11281822 10188785 12582447 11752352

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
10188785 12582447

Sources:
TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tiotropium bromide,Spiriva

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
10188785 11281822 12582447

Sources:
TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
19183167

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

TIOTROPIUM Primary Drug Name

Drug Info:

Year of Approval 2004

Drug Class bronchodilator agents

Drug Info:

Drug Indications for treatment of cystic fibrosis,for treatment of chronic obstructive pulmonary disorder (COPD)

Drug Class Small Molecule

FDA Approval approved

Publications:

Park HW et al., 2009, Additive role of tiotropium in severe asthmatics and Arg16Gly in ADRB2 as a potential marker to predict response., Allergy

Alternate Names:

D0P1WA TTD Drug ID

Alternate Names:

TIOTROPIUM GuideToPharmacology Ligand Name