DGIdb - TOLTERODINE Drug Record

TOLTERODINE chembl:CHEMBL1382 Approved

Alternate Names:

MARIOSEA XL
KABI-2234
DETRUSITOL XL
DETRUSITOL
NEDITOL XL
EFFLOSOMYL XL
BLERONE XL
INCONEX XL
PREBLACON XL
SANTIZOR XL
TOLTERODINE
TOLTERODINUM
(+)-TOLTERODINE
DETRUSITOL®
TOLTERODINA
DETROL®
(+)-(R)-2-(ALPHA-(2-(DIISOPROPYLAMINO)ETHYL)BENZYL)-P-CRESOL
chemidplus:124937-51-5
pubchem.compound:443879
rxcui:119565
drugbank:01036
chembl:CHEMBL1382

Drug Info:

Drug Class	small molecule
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of incontinence
Year of Approval	1998
Drug Class	antispasmodics
Drug Class	anti-incontinence agents

(2 More Sources)

Publications:

Maruyama et al., 2006, Human muscarinic receptor binding characteristics of antimuscarinic agents to treat overactive bladder., J. Urol.
McNamara et al., 2009, Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist., Eur. J. Pharmacol.
Sellers et al., 2000, M3 muscarinic receptors but not M2 mediate contraction of the porcine detrusor muscle in vitro., J Auton Pharmacol
Nelson et al., 2006, Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor., J. Pharmacol. Exp. Ther.
Schneider et al., 2004, Signal transduction underlying carbachol-induced contraction of human urinary bladder., J. Pharmacol. Exp. Ther.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Brynne N et al., 1998, Influence of CYP2D6 polymorphism on the pharmacokinetics and pharmacodynamic of tolterodine., Clin Pharmacol Ther
Wang H et al., 2017, Effect of 22 CYP2D6 variants found in the Chinese population on tolterodine metabolism in vitro., Chem Biol Interact
Malhotra B et al., 2011, Comparison of pharmacokinetic variability of fesoterodine vs. tolterodine extended release in cytochrome P450 2D6 extensive and poor metabolizers., Br J Clin Pharmacol
Oishi M et al., 2010, Effect of the CYP2D6*10 genotype on tolterodine pharmacokinetics., Drug Metab Dispos
Brynne N et al., 1999, Fluoxetine inhibits the metabolism of tolterodine-pharmacokinetic implications and proposed clinical relevance., Br J Clin Pharmacol
Brynne N et al., 1999, Tolterodine does not affect the human in vivo metabolism of the probe drugs caffeine, debrisoquine and omeprazole., Br J Clin Pharmacol

TOLTERODINE CHRM2

Interaction Score: 0.73

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name THVD-201

Novel drug target Established target

Trial Name tolterodine extended release capsules,Detrol LA

PMIDs:
19168050 11193006 16188951 14769832

Sources:
TdgClinicalTrial TEND
TOLTERODINE CHRM3

Interaction Score: 0.62

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name THVD-201

Novel drug target Established target

Trial Name tolterodine extended release capsules,Detrol LA

PMIDs:
19168050 11193006 11752352 14769832

Sources:
TdgClinicalTrial TEND TTD
TOLTERODINE CHRM4

Interaction Score: 0.56

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name THVD-201

Novel drug target Established target

Trial Name tolterodine extended release capsules,Detrol LA

PMIDs:
16406943

Sources:
TdgClinicalTrial
TOLTERODINE CHRM1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name THVD-201

Novel drug target Established target

Trial Name tolterodine extended release capsules,Detrol LA

PMIDs:
17016423 17139284 14769832

Sources:
TdgClinicalTrial TEND
TOLTERODINE CHRM5

Interaction Score: 0.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tolterodine extended release capsules,Detrol LA

Novel drug target Established target

Trial Name THVD-201

PMIDs:
16406943

Sources:
TdgClinicalTrial
TOLTERODINE CYP2D6

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9630826 28087463 21352267 20530222 10583026 10190648

Sources:
PharmGKB FDA
TOLTERODINE CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
TOLTERODINE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
TOLTERODINE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
TOLTERODINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

TdgClinicalTrial: TOLTERODINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of incontinence

Drug Class Small Molecule

FDA Approval approved

Publications:
TEND: TOLTERODINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Drug Class anti-incontinence agents

Drug Class antispasmodics

Year of Approval 1998

Publications:

PharmGKB: tolterodine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Malhotra B et al., 2011, Comparison of pharmacokinetic variability of fesoterodine vs. tolterodine extended release in cytochrome P450 2D6 extensive and poor metabolizers., Br J Clin Pharmacol

Oishi M et al., 2010, Effect of the CYP2D6*10 genotype on tolterodine pharmacokinetics., Drug Metab Dispos

Brynne N et al., 1999, Tolterodine does not affect the human in vivo metabolism of the probe drugs caffeine, debrisoquine and omeprazole., Br J Clin Pharmacol

TTD: Tolterodine
- Version: 2020.06.01
Alternate Names:

D0BZ7W TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1382
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Tolterodine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	THVD-201
Novel drug target	Established target
Trial Name	tolterodine extended release capsules,Detrol LA

TOLTERODINE Drug Record

TOLTERODINE chembl:CHEMBL1382 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name THVD-201 Novel drug target Established target Trial Name tolterodine extended release capsules,Detrol LA

PMIDs: 19168050 11193006 16188951 14769832

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name THVD-201 Novel drug target Established target Trial Name tolterodine extended release capsules,Detrol LA

PMIDs: 19168050 11193006 11752352 14769832

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name THVD-201 Novel drug target Established target Trial Name tolterodine extended release capsules,Detrol LA

PMIDs: 16406943

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name THVD-201 Novel drug target Established target Trial Name tolterodine extended release capsules,Detrol LA

PMIDs: 17016423 17139284 14769832

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name tolterodine extended release capsules,Detrol LA Novel drug target Established target Trial Name THVD-201

PMIDs: 16406943

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9630826 28087463 21352267 20530222 10583026 10190648

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

TdgClinicalTrial: TOLTERODINE

Alternate Names:

Drug Info: Drug Indications for treatment of incontinence Drug Class Small Molecule FDA Approval approved

Publications:

TEND: TOLTERODINE

Alternate Names:

Drug Info: Drug Class anti-incontinence agents Drug Class antispasmodics Year of Approval 1998

Publications:

PharmGKB: tolterodine

Alternate Names:

Drug Info:

TTD: Tolterodine

Alternate Names: D0BZ7W TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1382

Alternate Names:

Drug Info:

Publications:

FDA: Tolterodine

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name THVD-201

Novel drug target Established target

Trial Name tolterodine extended release capsules,Detrol LA

PMIDs:
19168050 11193006 16188951 14769832

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name THVD-201

Novel drug target Established target

Trial Name tolterodine extended release capsules,Detrol LA

PMIDs:
19168050 11193006 11752352 14769832

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name THVD-201

Novel drug target Established target

Trial Name tolterodine extended release capsules,Detrol LA

PMIDs:
16406943

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name THVD-201

Novel drug target Established target

Trial Name tolterodine extended release capsules,Detrol LA

PMIDs:
17016423 17139284 14769832

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tolterodine extended release capsules,Detrol LA

Novel drug target Established target

Trial Name THVD-201

PMIDs:
16406943

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
9630826 28087463 21352267 20530222 10583026 10190648

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Drug Info:

Drug Indications for treatment of incontinence

Drug Class Small Molecule

FDA Approval approved

Drug Info:

Drug Class anti-incontinence agents

Drug Class antispasmodics

Year of Approval 1998

Alternate Names:

D0BZ7W TTD Drug ID