DGIdb - TRAMADOL Drug Record

TRAMADOL chembl:CHEMBL1237044 Approved

Alternate Names:

TRAMADOL
ETS6103
ETS-6103
ULTRAM
ULTRACET
TILODOL®
TRAMACET®
(1RS,2RS)-2-[(DIMETHYLAMINO)METHYL]-1-(3-METHOXYPHENYL)-CYCLO-HEXANOL
MAXITRAM®
chemidplus:2914-77-4
pubchem.compound:5523
chembl:CHEMBL1237044

Drug Info:

Drug Class	analgesics, opioid
Year of Approval	1995
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	analgesic

(3 More Sources)

Publications:

Sagata et al., 2002, Tramadol inhibits norepinephrine transporter function at desipramine-binding sites in cultured bovine adrenal medullary cells., Anesth. Analg.
Frink et al., 1996, Influence of tramadol on neurotransmitter systems of the rat brain., Arzneimittelforschung
Berrocoso et al., 2009, Cooperative opioid and serotonergic mechanisms generate superior antidepressant-like effects in a mice model of depression., Int. J. Neuropsychopharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Barakat A, 2019, Revisiting Tramadol: A Multi-Modal Agent for Pain Management., CNS Drugs
Muriel J et al., 2019, Pharmacogenetics and prediction of adverse events in prescription opioid use disorder patients., Basic Clin Pharmacol Toxicol
Liu YC et al., 2012, Human mu-opioid receptor gene A118G polymorphism predicts the efficacy of tramadol/acetaminophen combination tablets (ultracet) in oxaliplatin-induced painful neuropathy., Cancer
Potschka et al., 2000, Anticonvulsant and proconvulsant effects of tramadol, its enantiomers and its M1 metabolite in the rat kindling model of epilepsy., Br. J. Pharmacol.
Grond et al., 2004, Clinical pharmacology of tramadol., Clin Pharmacokinet
Raffa et al., 1992, Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic., J. Pharmacol. Exp. Ther.
Minami et al., 2007, Pharmacological aspects of the effects of tramadol on G-protein coupled receptors., J. Pharmacol. Sci.
Gillen et al., 2000, Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor., Naunyn Schmiedebergs Arch. Pharmacol.
Ide et al., 2006, Mu opioid receptor-dependent and independent components in effects of tramadol., Neuropharmacology
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Barann et al., 2006, Effects of tramadol and O-demethyl-tramadol on human 5-HT reuptake carriers and human 5-HT3A receptors: a possible mechanism for tramadol-induced early emesis., Eur. J. Pharmacol.
Driessen et al., 1992, Interaction of the central analgesic, tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitro., Br. J. Pharmacol.
Sun et al., 2003, Tramadol reduces the 5-HTP-induced head-twitch response in mice via the activation of mu and kappa opioid receptors., Life Sci.
Wendt FR et al., 2020, A genome-wide association study of tramadol metabolism from post-mortem samples., Pharmacogenomics J
Horishita et al., 2006, The tramadol metabolite, O-desmethyl tramadol, inhibits 5-hydroxytryptamine type 2C receptors expressed in Xenopus Oocytes., Pharmacology
Ogata et al., 2004, The inhibitory effects of tramadol on 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes., Anesth. Analg.
Gong L et al., 2014, PharmGKB summary: tramadol pathway., Pharmacogenet Genomics
Faron-Górecka et al., 2004, Long-term exposure of rats to tramadol alters brain dopamine and alpha 1-adrenoceptor function that may be related to antidepressant potency., Eur. J. Pharmacol.
Tzvetkov MV et al., 2011, Genetically polymorphic OCT1: another piece in the puzzle of the variable pharmacokinetics and pharmacodynamics of the opioidergic drug tramadol., Clin Pharmacol Ther
Wentland et al., 2009, Syntheses and opioid receptor binding properties of carboxamido-substituted opioids., Bioorg. Med. Chem. Lett.

TRAMADOL RGL4

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30971809

Sources:
PharmGKB
TRAMADOL ICA1

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30971809

Sources:
PharmGKB
TRAMADOL RFPL4B

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30971809

Sources:
PharmGKB
TRAMADOL HCN1

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30971809

Sources:
PharmGKB
TRAMADOL ARRB2

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30549211

Sources:
PharmGKB
TRAMADOL SULT1A3

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
TRAMADOL SLC6A2

Interaction Score: 0.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name PTI-601

Novel drug target Established target

Trial Name tramadol extended-release,Raliva ER

PMIDs:
11916794 8955860 19341511 11752352 31004280

Sources:
TdgClinicalTrial TEND
TRAMADOL SLC22A1

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21562485

Sources:
PharmGKB
TRAMADOL OPRM1

Interaction Score: 0.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name tramadol,Tridural, Ryzolt

Trial Name tramadol hydrochloride,Ultram

Trial Name tramadol extended-release,Raliva ER

PMIDs:
30549211 21837673 10991912 8955860 15509185 1309873 11752352 17380034 10961373 16793069 31004280

Sources:
TdgClinicalTrial TEND PharmGKB
TRAMADOL SLC6A4

Interaction Score: 0.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name PTI-601

Novel drug target Established target

Trial Name tramadol extended-release,Raliva ER

PMIDs:
8955860 16427041 1596676 31004280

Sources:
TdgClinicalTrial TEND
TRAMADOL HTR2C

Interaction Score: 0.34

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tramadol,Tridural, Ryzolt

Trial Name tramadol hydrochloride,Ultram

Trial Name tramadol extended-release,Raliva ER

PMIDs:
16679816 15105221

Sources:
TdgClinicalTrial TEND TTD
TRAMADOL OPRD1

Interaction Score: 0.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
19027293 30549211 31004280

Sources:
PharmGKB
TRAMADOL OPRK1

Interaction Score: 0.2

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name PTI-601

Novel drug target Established target

Trial Name tramadol extended-release,Raliva ER

PMIDs:
12570923 31004280

Sources:
TdgClinicalTrial TEND
TRAMADOL CYP2B6

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24849324

Sources:
PharmGKB
TRAMADOL BDNF

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15464068

Sources:
NCI
TRAMADOL CYP3A5

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
TRAMADOL CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24849324

Sources:
PharmGKB
TRAMADOL CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA

TEND: TRAMADOL
- Version: 01-August-2011
Alternate Names:

Drug Info:

Year of Approval 1995

Drug Class analgesics, opioid

Publications:
TdgClinicalTrial: TRAMADOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved

Publications:
NCI: TRAMADOL
- Version: 14-September-2017
Alternate Names:

C29507 NCI drug code

Drug Info:

Publications:

Faron-Górecka et al., 2004, Long-term exposure of rats to tramadol alters brain dopamine and alpha 1-adrenoceptor function that may be related to antidepressant potency., Eur. J. Pharmacol.

PharmGKB: tramadol

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Muriel J et al., 2019, Pharmacogenetics and prediction of adverse events in prescription opioid use disorder patients., Basic Clin Pharmacol Toxicol

Wendt FR et al., 2020, A genome-wide association study of tramadol metabolism from post-mortem samples., Pharmacogenomics J

Tzvetkov MV et al., 2011, Genetically polymorphic OCT1: another piece in the puzzle of the variable pharmacokinetics and pharmacodynamics of the opioidergic drug tramadol., Clin Pharmacol Ther

TTD: Tramadol
- Version: 2020.06.01
Alternate Names:

D05GKD TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1237044
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Tramadol
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	PTI-601
Novel drug target	Established target
Trial Name	tramadol extended-release,Raliva ER

Trial Name	tramadol,Tridural, Ryzolt
Trial Name	tramadol hydrochloride,Ultram
Trial Name	tramadol extended-release,Raliva ER

TRAMADOL Drug Record

TRAMADOL chembl:CHEMBL1237044 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30971809

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30971809

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30971809

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30971809

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30549211

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name PTI-601 Novel drug target Established target Trial Name tramadol extended-release,Raliva ER

PMIDs: 11916794 8955860 19341511 11752352 31004280

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21562485

Sources: PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name tramadol,Tridural, Ryzolt Trial Name tramadol hydrochloride,Ultram Trial Name tramadol extended-release,Raliva ER

PMIDs: 30549211 21837673 10991912 8955860 15509185 1309873 11752352 17380034 10961373 16793069 31004280

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name PTI-601 Novel drug target Established target Trial Name tramadol extended-release,Raliva ER

PMIDs: 8955860 16427041 1596676 31004280

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name tramadol,Tridural, Ryzolt Trial Name tramadol hydrochloride,Ultram Trial Name tramadol extended-release,Raliva ER

PMIDs: 16679816 15105221

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 19027293 30549211 31004280

Sources: PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name PTI-601 Novel drug target Established target Trial Name tramadol extended-release,Raliva ER

PMIDs: 12570923 31004280

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24849324

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15464068

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24849324

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA

TEND: TRAMADOL

Alternate Names:

Drug Info: Year of Approval 1995 Drug Class analgesics, opioid

Interaction Types & Directionality:

n/a

PMIDs:
30971809

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30971809

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30971809

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30971809

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30549211

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name PTI-601

Novel drug target Established target

Trial Name tramadol extended-release,Raliva ER

PMIDs:
11916794 8955860 19341511 11752352 31004280

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
21562485

Sources:
PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name tramadol,Tridural, Ryzolt

Trial Name tramadol hydrochloride,Ultram

Trial Name tramadol extended-release,Raliva ER

PMIDs:
30549211 21837673 10991912 8955860 15509185 1309873 11752352 17380034 10961373 16793069 31004280

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name PTI-601

Novel drug target Established target

Trial Name tramadol extended-release,Raliva ER

PMIDs:
8955860 16427041 1596676 31004280

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tramadol,Tridural, Ryzolt

Trial Name tramadol hydrochloride,Ultram

Trial Name tramadol extended-release,Raliva ER

PMIDs:
16679816 15105221

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

PMIDs:
19027293 30549211 31004280

Sources:
PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name PTI-601

Novel drug target Established target

Trial Name tramadol extended-release,Raliva ER

PMIDs:
12570923 31004280

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
24849324

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15464068

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24849324

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Drug Info:

Year of Approval 1995

Drug Class analgesics, opioid

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C29507 NCI drug code

Publications:

Faron-Górecka et al., 2004, Long-term exposure of rats to tramadol alters brain dopamine and alpha 1-adrenoceptor function that may be related to antidepressant potency., Eur. J. Pharmacol.

Alternate Names:

D05GKD TTD Drug ID