DGIdb - TRANDOLAPRIL Drug Record

TRANDOLAPRIL chembl:CHEMBL1519 Approved

Alternate Names:

GOPTEN
ODRIK
INDOLAPRIL
TRANDOLAPRIL
RU-44570
MAVIK
MAVIK®
TRANDOLAPRILUM
CI-907
drugbank:00519
pubchem.compound:5484727
chemidplus:87679-37-6
rxcui:38454
chembl:CHEMBL1519

Drug Info:

Year of Approval	1996
Drug Class	antihypertensive agents
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antihypertensive agent
Drug Categories	ace inhibitors and calcium channel blockers
Drug Categories	agents causing angioedema
Drug Categories	agents causing hyperkalemia
Drug Categories	antihypertensive agents indicated for hypertension
Drug Categories	heterocyclic compounds, fused-ring

(4 More Sources)

Publications:

Piepho, 2000, Overview of the angiotensin-converting-enzyme inhibitors., Am J Health Syst Pharm
Song et al., 2002, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update., Clin Pharmacokinet
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Zhu HJ et al., 2009, Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril., Biochem Pharmacol
Gong Y et al., 2015, PTPRD gene associated with blood pressure response to atenolol and resistant hypertension., J Hypertens

TRANDOLAPRIL PTPRD

Interaction Score: 7.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26425837

Sources:
PharmGKB
TRANDOLAPRIL ACE

Interaction Score: 2.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name trandolapril,Gopten, Mavik, Odrik

Novel drug target Established target

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

PMIDs:
11030016 11929321 11752352

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
TRANDOLAPRIL CES1

Interaction Score: 1.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19185566

Sources:
PharmGKB

DrugBank: DB00519

Version: 5.1.7

Alternate Names:

TRANDOLAPRIL DrugBank Drug Name

87679-37-6 CAS Number

Apo-trandolapril Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories ace inhibitors and calcium channel blockers

Publications:

Piepho, 2000, Overview of the angiotensin-converting-enzyme inhibitors., Am J Health Syst Pharm

Song et al., 2002, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update., Clin Pharmacokinet

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

TEND: TRANDOLAPRIL
- Version: 01-August-2011
Alternate Names:

TRANDOLAPRIL Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1996

Publications:
TdgClinicalTrial: TRANDOLAPRIL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:

PharmGKB: trandolapril

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Zhu HJ et al., 2009, Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril., Biochem Pharmacol

Gong Y et al., 2015, PTPRD gene associated with blood pressure response to atenolol and resistant hypertension., J Hypertens

TTD: Trandolapril
- Version: 2020.06.01
Alternate Names:

D0M5OC TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178103069
- Version: 29-September-2020
Alternate Names:

TRANDOLAPRIL GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1519
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1519
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	trandolapril,Gopten, Mavik, Odrik
Novel drug target	Established target
Mechanism of Interaction	Angiotensin-converting enzyme inhibitor

TRANDOLAPRIL	DrugBank Drug Name
87679-37-6	CAS Number
Apo-trandolapril	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	ace inhibitors and calcium channel blockers

TRANDOLAPRIL Drug Record

TRANDOLAPRIL chembl:CHEMBL1519 Approved

Alternate Names:

Drug Info:

Publications:

TRANDOLAPRIL PTPRD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26425837

Sources: PharmGKB

TRANDOLAPRIL ACE

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name trandolapril,Gopten, Mavik, Odrik Novel drug target Established target Mechanism of Interaction Angiotensin-converting enzyme inhibitor

PMIDs: 11030016 11929321 11752352

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

TRANDOLAPRIL CES1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19185566

Sources: PharmGKB

DrugBank: DB00519

Alternate Names: TRANDOLAPRIL DrugBank Drug Name 87679-37-6 CAS Number Apo-trandolapril Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories ace inhibitors and calcium channel blockers

TEND: TRANDOLAPRIL

Alternate Names: TRANDOLAPRIL Primary Drug Name

Drug Info: Drug Class antihypertensive agents Year of Approval 1996

Publications:

TdgClinicalTrial: TRANDOLAPRIL

Alternate Names:

Drug Info: Drug Indications antihypertensive agent Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: trandolapril

Alternate Names:

Drug Info:

Publications: Zhu HJ et al., 2009, Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril., Biochem Pharmacol Gong Y et al., 2015, PTPRD gene associated with blood pressure response to atenolol and resistant hypertension., J Hypertens

TTD: Trandolapril

Alternate Names: D0M5OC TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 178103069

Alternate Names: TRANDOLAPRIL GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1519

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1519

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
26425837

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name trandolapril,Gopten, Mavik, Odrik

Novel drug target Established target

Mechanism of Interaction Angiotensin-converting enzyme inhibitor

PMIDs:
11030016 11929321 11752352

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
19185566

Sources:
PharmGKB

Alternate Names:

TRANDOLAPRIL DrugBank Drug Name

87679-37-6 CAS Number

Apo-trandolapril Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories ace inhibitors and calcium channel blockers

Alternate Names:

TRANDOLAPRIL Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1996

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:

Zhu HJ et al., 2009, Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril., Biochem Pharmacol

Gong Y et al., 2015, PTPRD gene associated with blood pressure response to atenolol and resistant hypertension., J Hypertens

Alternate Names:

D0M5OC TTD Drug ID

Alternate Names:

TRANDOLAPRIL GuideToPharmacology Ligand Name