DGIdb - TRAZODONE Drug Record

TRAZODONE chembl:CHEMBL621 Approved

Alternate Names:

DESYREL
TRIALODINE
TRAZODONE
J10.767K
2-(3-[4-(3-CHLOROPHENYL)-1-PIPERAZINYL]PROPYL)[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3(2H)-ONE
DESYREL®
MOLIPAXIN®
TRAZODONA
TRAZODONUM
AF-1161
OLEPTRO®
pubchem.compound:5533
drugbank:00656
rxcui:10737
chemidplus:19794-93-5
chembl:CHEMBL621

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antidepressant
Year of Approval	1981
Drug Class	antidepressive agents, second-generation

(2 More Sources)

Publications:

Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Odagaki et al., 2005, Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding., J. Psychopharmacol. (Oxford)
Subhash et al., 2002, Alterations in 5-HT(1A) receptors and adenylyl cyclase response by trazodone in regions of rat brain., Life Sci.
Sultan MA et al., 2017, Adjunctive Trazodone and Depression Outcome in Adolescents Treated with Serotonin Re-uptake Inhibitors., J Can Acad Child Adolesc Psychiatry
Noguchi et al., 1992, The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking., Physiol. Behav.
Richelson et al., 1984, Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro., J. Pharmacol. Exp. Ther.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Ashford JW, 2019, Treatment of Alzheimer's Disease: Trazodone, Sleep, Serotonin, Norepinephrine, and Future Directions., J Alzheimers Dis
Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
Stahl SM, 2009, Mechanism of action of trazodone: a multifunctional drug., CNS Spectr
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Marek et al., 1992, A comparison of trazodone and fluoxetine: implications for a serotonergic mechanism of antidepressant action., Psychopharmacology (Berl.)
Price LH et al., 1986, Effects of trazodone treatment on alpha-2 adrenoceptor function in depressed patients., Psychopharmacology (Berl)
Conn et al., 1987, Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors., J. Pharmacol. Exp. Ther.
Fiorella et al., 1995, The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of m-chlorophenylpiperazine., Psychopharmacology (Berl.)
Pazzagli et al., 1999, Trazodone increases extracellular serotonin levels in the frontal cortex of rats., Eur. J. Pharmacol.
Balsara JJ et al., 2005, Effects of the antidepressant trazodone, a 5-HT 2A/2C receptor antagonist, on dopamine-dependent behaviors in rats., Psychopharmacology (Berl)
Marcoli et al., 2001, Inhibitory presynaptic 5-hydroxytryptamine(2A) receptors regulate evoked glutamate release from rat cerebellar mossy fibers., J. Pharmacol. Exp. Ther.
Luparini et al., 2004, A cortical GABA-5HT interaction in the mechanism of action of the antidepressant trazodone., Prog. Neuropsychopharmacol. Biol. Psychiatry
Stryjer R et al., 2003, Treatment of neuroleptic-induced akathisia with the 5-HT2A antagonist trazodone., Clin Neuropharmacol

TRAZODONE HTR1A

Interaction Score: 0.59

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name trazodone extended release, DDS-04A,Oleptro

Novel drug target Established target

PMIDs:
7855217 15888508 12127910 29056986

Sources:
TdgClinicalTrial TEND TTD
TRAZODONE HTR2C

Interaction Score: 0.57

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name trazodone extended release, DDS-04A,Oleptro

Novel drug target Established target

PMIDs:
3039120 7659770 1365657 10594316 15614572

Sources:
TdgClinicalTrial
TRAZODONE HTR2A

Interaction Score: 0.47

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name trazodone extended release, DDS-04A,Oleptro

PMIDs:
3039120 1365657 10594316 11714900 15610924 7855217 12782915 15614572

Sources:
TdgClinicalTrial TEND
TRAZODONE ADRA2A

Interaction Score: 0.4

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7855217 17016423 17139284 1365657 3016788

Sources:
TEND
TRAZODONE SLC6A4

Interaction Score: 0.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name trazodone extended release, DDS-04A,Oleptro

Novel drug target Established target

PMIDs:
9537821 20095366

Sources:
TdgClinicalTrial TEND
TRAZODONE ADRA1A

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7855217 30776014

Sources:
TEND
TRAZODONE HRH1

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
1353628 6086881 11752352

Sources:
TEND
TRAZODONE SLC6A2

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
TRAZODONE CYP3A5

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
TRAZODONE ADRA1B

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
TRAZODONE KAT2A

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRAZODONE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRAZODONE HSD17B10

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: TRAZODONE
- Version: 01-August-2011
Alternate Names:

TRAZODONE Primary Drug Name

Drug Info:

Drug Class antidepressive agents, second-generation

Year of Approval 1981

Publications:
TdgClinicalTrial: TRAZODONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antidepressant

Drug Class Small Molecule

FDA Approval approved

Publications:
PharmGKB: trazodone
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
TTD: Trazodone
- Version: 2020.06.01
Alternate Names:

D00USF TTD Drug ID

Drug Info:

Publications:
DTC: TRAZODONE
- Version: 02-September-2020
Alternate Names:

CHEMBL621 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL621
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	trazodone extended release, DDS-04A,Oleptro
Novel drug target	Established target

partial agonist (activating)
antagonist (inhibitory)

agonist (activating)
antagonist (inhibitory)

TRAZODONE Drug Record

TRAZODONE chembl:CHEMBL621 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: partial agonist (activating) antagonist (inhibitory)

Interaction Info: Trial Name trazodone extended release, DDS-04A,Oleptro Novel drug target Established target

PMIDs: 7855217 15888508 12127910 29056986

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info: Trial Name trazodone extended release, DDS-04A,Oleptro Novel drug target Established target

PMIDs: 3039120 7659770 1365657 10594316 15614572

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name trazodone extended release, DDS-04A,Oleptro

PMIDs: 3039120 1365657 10594316 11714900 15610924 7855217 12782915 15614572

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 7855217 17016423 17139284 1365657 3016788

Sources: TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name trazodone extended release, DDS-04A,Oleptro Novel drug target Established target

PMIDs: 9537821 20095366

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 7855217 30776014

Sources: TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 1353628 6086881 11752352

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: TRAZODONE

Alternate Names: TRAZODONE Primary Drug Name

Drug Info: Drug Class antidepressive agents, second-generation Year of Approval 1981

Publications:

TdgClinicalTrial: TRAZODONE

Alternate Names:

Drug Info: Drug Indications antidepressant Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: trazodone

Alternate Names:

Drug Info:

Publications: Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

TTD: Trazodone

Alternate Names: D00USF TTD Drug ID

Drug Info:

Publications:

DTC: TRAZODONE

Alternate Names: CHEMBL621 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL621

Alternate Names:

Drug Info:

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name trazodone extended release, DDS-04A,Oleptro

Novel drug target Established target

PMIDs:
7855217 15888508 12127910 29056986

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name trazodone extended release, DDS-04A,Oleptro

Novel drug target Established target

PMIDs:
3039120 7659770 1365657 10594316 15614572

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name trazodone extended release, DDS-04A,Oleptro

PMIDs:
3039120 1365657 10594316 11714900 15610924 7855217 12782915 15614572

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
7855217 17016423 17139284 1365657 3016788

Sources:
TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name trazodone extended release, DDS-04A,Oleptro

Novel drug target Established target

PMIDs:
9537821 20095366

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
7855217 30776014

Sources:
TEND

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
1353628 6086881 11752352

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

TRAZODONE Primary Drug Name

Drug Info:

Drug Class antidepressive agents, second-generation

Year of Approval 1981

Drug Info:

Drug Indications antidepressant

Drug Class Small Molecule

FDA Approval approved

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

Alternate Names:

D00USF TTD Drug ID

Alternate Names:

CHEMBL621 ChEMBL Drug ID