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TRAZODONE Drug Record

  • Summary
  • Interactions
  • Claims
  • TRAZODONE chembl:CHEMBL621 Approved

    Alternate Names:

    DESYREL
    TRIALODINE
    TRAZODONE
    J10.767K
    2-(3-[4-(3-CHLOROPHENYL)-1-PIPERAZINYL]PROPYL)[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3(2H)-ONE
    DESYREL®
    MOLIPAXIN®
    TRAZODONA
    TRAZODONUM
    AF-1161
    OLEPTRO®
    pubchem.compound:5533
    drugbank:00656
    rxcui:10737
    chemidplus:19794-93-5
    chembl:CHEMBL621

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antidepressant
    Year of Approval 1981
    Drug Class antidepressive agents, second-generation
    (2 More Sources)

    Publications:

    Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
    Odagaki et al., 2005, Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding., J. Psychopharmacol. (Oxford)
    Subhash et al., 2002, Alterations in 5-HT(1A) receptors and adenylyl cyclase response by trazodone in regions of rat brain., Life Sci.
    Sultan MA et al., 2017, Adjunctive Trazodone and Depression Outcome in Adolescents Treated with Serotonin Re-uptake Inhibitors., J Can Acad Child Adolesc Psychiatry
    Noguchi et al., 1992, The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking., Physiol. Behav.
    Richelson et al., 1984, Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro., J. Pharmacol. Exp. Ther.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Ashford JW, 2019, Treatment of Alzheimer's Disease: Trazodone, Sleep, Serotonin, Norepinephrine, and Future Directions., J Alzheimers Dis
    Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
    Stahl SM, 2009, Mechanism of action of trazodone: a multifunctional drug., CNS Spectr
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Marek et al., 1992, A comparison of trazodone and fluoxetine: implications for a serotonergic mechanism of antidepressant action., Psychopharmacology (Berl.)
    Price LH et al., 1986, Effects of trazodone treatment on alpha-2 adrenoceptor function in depressed patients., Psychopharmacology (Berl)
    Conn et al., 1987, Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors., J. Pharmacol. Exp. Ther.
    Fiorella et al., 1995, The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of m-chlorophenylpiperazine., Psychopharmacology (Berl.)
    Pazzagli et al., 1999, Trazodone increases extracellular serotonin levels in the frontal cortex of rats., Eur. J. Pharmacol.
    Balsara JJ et al., 2005, Effects of the antidepressant trazodone, a 5-HT 2A/2C receptor antagonist, on dopamine-dependent behaviors in rats., Psychopharmacology (Berl)
    Marcoli et al., 2001, Inhibitory presynaptic 5-hydroxytryptamine(2A) receptors regulate evoked glutamate release from rat cerebellar mossy fibers., J. Pharmacol. Exp. Ther.
    Luparini et al., 2004, A cortical GABA-5HT interaction in the mechanism of action of the antidepressant trazodone., Prog. Neuropsychopharmacol. Biol. Psychiatry
    Stryjer R et al., 2003, Treatment of neuroleptic-induced akathisia with the 5-HT2A antagonist trazodone., Clin Neuropharmacol
  • TRAZODONE   HTR1A

    Interaction Score: 0.59

    Interaction Types & Directionality:
    partial agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name trazodone extended release, DDS-04A,Oleptro
    Novel drug target Established target

    PMIDs:
    7855217 15888508 12127910 29056986


    Sources:
    TdgClinicalTrial TEND TTD

  • TRAZODONE   HTR2C

    Interaction Score: 0.57

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name trazodone extended release, DDS-04A,Oleptro
    Novel drug target Established target

    PMIDs:
    3039120 7659770 1365657 10594316 15614572


    Sources:
    TdgClinicalTrial

  • TRAZODONE   HTR2A

    Interaction Score: 0.47

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name trazodone extended release, DDS-04A,Oleptro

    PMIDs:
    3039120 1365657 10594316 11714900 15610924 7855217 12782915 15614572


    Sources:
    TdgClinicalTrial TEND

  • TRAZODONE   ADRA2A

    Interaction Score: 0.4

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7855217 17016423 17139284 1365657 3016788


    Sources:
    TEND

  • TRAZODONE   SLC6A4

    Interaction Score: 0.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name trazodone extended release, DDS-04A,Oleptro
    Novel drug target Established target

    PMIDs:
    9537821 20095366


    Sources:
    TdgClinicalTrial TEND

  • TRAZODONE   ADRA1A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7855217 30776014


    Sources:
    TEND

  • TRAZODONE   HRH1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    1353628 6086881 11752352


    Sources:
    TEND

  • TRAZODONE   SLC6A2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • TRAZODONE   CYP3A5

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18695978


    Sources:
    PharmGKB

  • TRAZODONE   ADRA1B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • TRAZODONE   KAT2A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRAZODONE   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRAZODONE   HSD17B10

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: TRAZODONE

    • Version: 01-August-2011

    Alternate Names:
    TRAZODONE Primary Drug Name

    Drug Info:
    Drug Class antidepressive agents, second-generation
    Year of Approval 1981

    Publications:

  • TdgClinicalTrial: TRAZODONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antidepressant
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • PharmGKB: trazodone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

  • TTD: Trazodone

    • Version: 2020.06.01

    Alternate Names:
    D00USF TTD Drug ID

    Drug Info:

    Publications:

  • DTC: TRAZODONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL621 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL621

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21