DGIdb - TRIAZOLAM Drug Record

TRIAZOLAM chembl:CHEMBL646

Alternate Names:

U-33030
HALCION
KENTION
TRIAZOLAM CIV
TRIAZOLAM
N05CD05
TRIAZOLAMUM
pubchem.compound:5556
chembl:CHEMBL646
drugbank:00897
rxcui:10767
chemidplus:28911-01-5

Drug Info:

Year of Approval	1982
Drug Class	hypnotics and sedatives
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	analgesic,sedative
Drug Groups	investigational
Drug Categories	agents causing muscle toxicity
Drug Categories	benzodiazepine hypnotics and sedatives
Drug Categories	benzodiazepines and benzodiazepine derivatives
Drug Categories	cytochrome p-450 cyp2c8 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a5 substrates
Drug Categories	cytochrome p-450 cyp3a7 substrates
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs that are mainly renally excreted
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	triazolobenzodiazepines

(5 More Sources)

Publications:

Riss et al., 2008, Benzodiazepines in epilepsy: pharmacology and pharmacokinetics., Acta Neurol. Scand.
Möhler et al., 2002, A new benzodiazepine pharmacology., J. Pharmacol. Exp. Ther.
Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.
Zhu S et al., 2018, Structure of a human synaptic GABA<sub>A</sub> receptor., Nature
Sigel E et al., 2012, Structure, function, and modulation of GABA(A) receptors., J Biol Chem
Park et al., 1996, Characterization of peripheral benzodiazepine type sites in a cultured murine BV-2 microglial cell line., Glia

TRIAZOLAM BRDT

Interaction Score: 1.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
TRIAZOLAM BRD3

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
TRIAZOLAM PBRM1

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
TRIAZOLAM BRD2

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
TRIAZOLAM GABRR2

Interaction Score: 0.26

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name ARX-03, sufentanil + triazolam NanoTab

Novel drug target Established target

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial
TRIAZOLAM GABRR3

Interaction Score: 0.26

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name ARX-03, sufentanil + triazolam NanoTab

Novel drug target Established target

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial
TRIAZOLAM KAT2B

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
TRIAZOLAM GABRR1

Interaction Score: 0.24

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name ARX-03, sufentanil + triazolam NanoTab

Novel drug target Established target

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial
TRIAZOLAM BRD4

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
TRIAZOLAM CREBBP

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
TRIAZOLAM TSPO

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8787774

Sources:
TEND TTD
TRIAZOLAM GABRQ

Interaction Score: 0.17

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Trial Name ARX-03, sufentanil + triazolam NanoTab

Novel drug target Established target

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions
TRIAZOLAM GABRP

Interaction Score: 0.15

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

Trial Name ARX-03, sufentanil + triazolam NanoTab

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions
TRIAZOLAM GABRE

Interaction Score: 0.15

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Trial Name ARX-03, sufentanil + triazolam NanoTab

Novel drug target Established target

Direct Interaction yes

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions
TRIAZOLAM GABRD

Interaction Score: 0.15

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Trial Name ARX-03, sufentanil + triazolam NanoTab

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions
TRIAZOLAM GABRG1

Interaction Score: 0.15

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Trial Name ARX-03, sufentanil + triazolam NanoTab

Novel drug target Established target

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions
TRIAZOLAM GABRB1

Interaction Score: 0.14

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Trial Name ARX-03, sufentanil + triazolam NanoTab

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions
TRIAZOLAM GABRB3

Interaction Score: 0.14

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Trial Name ARX-03, sufentanil + triazolam NanoTab

Novel drug target Established target

Direct Interaction yes

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions
TRIAZOLAM GABRA5

Interaction Score: 0.13

Interaction Types & Directionality:

positive modulator (activating)

allosteric modulator

potentiator

Interaction Info:

Novel drug target Established target

Trial Name ARX-03, sufentanil + triazolam NanoTab

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial GuideToPharmacology ChemblInteractions
TRIAZOLAM GABRA1

Interaction Score: 0.13

Interaction Types & Directionality:

ligand

positive modulator (activating)

allosteric modulator

potentiator

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

Trial Name ARX-03, sufentanil + triazolam NanoTab

PMIDs:
18384456 11752090 29950725 23038269

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions
TRIAZOLAM GABRB2

Interaction Score: 0.13

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Novel drug target Established target

Trial Name ARX-03, sufentanil + triazolam NanoTab

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions
TRIAZOLAM GABRG3

Interaction Score: 0.13

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Trial Name ARX-03, sufentanil + triazolam NanoTab

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions
TRIAZOLAM GABRA2

Interaction Score: 0.13

Interaction Types & Directionality:

positive modulator (activating)

allosteric modulator

potentiator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Trial Name ARX-03, sufentanil + triazolam NanoTab

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial GuideToPharmacology ChemblInteractions
TRIAZOLAM GABRA3

Interaction Score: 0.13

Interaction Types & Directionality:

positive modulator (activating)

allosteric modulator

potentiator

Interaction Info:

Trial Name ARX-03, sufentanil + triazolam NanoTab

Novel drug target Established target

Direct Interaction? True

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial GuideToPharmacology ChemblInteractions
TRIAZOLAM GABRA4

Interaction Score: 0.12

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

Trial Name ARX-03, sufentanil + triazolam NanoTab

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions
TRIAZOLAM GABRA6

Interaction Score: 0.12

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

Trial Name ARX-03, sufentanil + triazolam NanoTab

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions
TRIAZOLAM GABRG2

Interaction Score: 0.11

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

PMIDs:
18384456 11752090

Sources:
TEND ChemblInteractions
TRIAZOLAM CYP3A5

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
TRIAZOLAM BAZ2B

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
TRIAZOLAM CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

DrugBank: DB00897
- Version: 5.1.7
Alternate Names:

TRIAZOLAM DrugBank Drug Name

28911-01-5 CAS Number

Alti-triazolam Tab 0.125mg Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Zhu S et al., 2018, Structure of a human synaptic GABA<sub>A</sub> receptor., Nature

Sigel E et al., 2012, Structure, function, and modulation of GABA(A) receptors., J Biol Chem
TEND: TRIAZOLAM
- Version: 01-August-2011
Alternate Names:

TRIAZOLAM Primary Drug Name

Drug Info:

Drug Class hypnotics and sedatives

Year of Approval 1982

Publications:
TdgClinicalTrial: TRIAZOLAM
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications analgesic,sedative

Drug Class Small Molecule

FDA Approval approved

Publications:
DTC: TRIAZOLAM
- Version: 02-September-2020
Alternate Names:

CHEMBL646 ChEMBL Drug ID

Drug Info:

Publications:

Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.
GuideToPharmacology: 178103886
- Version: 29-September-2020
Alternate Names:

TRIAZOLAM GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Triazolam
- Version: 2020.06.01
Alternate Names:

D0U3LS TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL646
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL646
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: triazolam
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	ARX-03, sufentanil + triazolam NanoTab
Novel drug target	Established target

Mechanism of Interaction	GABA-A receptor; anion channel positive allosteric modulator
Direct Interaction	yes
Trial Name	ARX-03, sufentanil + triazolam NanoTab

TRIAZOLAM	DrugBank Drug Name
28911-01-5	CAS Number
Alti-triazolam Tab 0.125mg	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

positive modulator (activating)
potentiator

positive modulator (activating)
potentiator

positive modulator (activating)
potentiator

positive modulator (activating)
potentiator

TRIAZOLAM Drug Record

TRIAZOLAM chembl:CHEMBL646

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name ARX-03, sufentanil + triazolam NanoTab Novel drug target Established target

PMIDs: 18384456 11752090

Sources: TEND TdgClinicalTrial

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name ARX-03, sufentanil + triazolam NanoTab Novel drug target Established target

PMIDs: 18384456 11752090

Sources: TEND TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name ARX-03, sufentanil + triazolam NanoTab Novel drug target Established target

PMIDs: 18384456 11752090

Sources: TEND TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8787774

Sources: TEND TTD

Interaction Types & Directionality: positive modulator (activating) potentiator

Interaction Info: Trial Name ARX-03, sufentanil + triazolam NanoTab Novel drug target Established target Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

PMIDs: 18384456 11752090

Sources: TEND TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: positive modulator (activating) potentiator

Interaction Info: Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Direct Interaction yes Trial Name ARX-03, sufentanil + triazolam NanoTab

PMIDs: 18384456 11752090

Sources: TEND TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: positive modulator (activating) potentiator

Interaction Info: Trial Name ARX-03, sufentanil + triazolam NanoTab Novel drug target Established target Direct Interaction yes

PMIDs: 18384456 11752090

Sources: TEND TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: positive modulator (activating) potentiator

Interaction Info: Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Trial Name ARX-03, sufentanil + triazolam NanoTab

PMIDs: 18384456 11752090

Sources: TEND TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: positive modulator (activating) potentiator

Interaction Info: Trial Name ARX-03, sufentanil + triazolam NanoTab Novel drug target Established target Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

PMIDs: 18384456 11752090

Sources: TEND TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: positive modulator (activating) potentiator

Interaction Info: Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Trial Name ARX-03, sufentanil + triazolam NanoTab

PMIDs: 18384456 11752090

Sources: TEND TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: positive modulator (activating) potentiator

Interaction Info: Trial Name ARX-03, sufentanil + triazolam NanoTab Novel drug target Established target Direct Interaction yes

PMIDs: 18384456 11752090

Sources: TEND TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: positive modulator (activating) allosteric modulator potentiator

Interaction Info: Novel drug target Established target Trial Name ARX-03, sufentanil + triazolam NanoTab Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

PMIDs: 18384456 11752090

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name ARX-03, sufentanil + triazolam NanoTab

Novel drug target Established target

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name ARX-03, sufentanil + triazolam NanoTab

Novel drug target Established target

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name ARX-03, sufentanil + triazolam NanoTab

Novel drug target Established target

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
8787774

Sources:
TEND TTD

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Trial Name ARX-03, sufentanil + triazolam NanoTab

Novel drug target Established target

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

Trial Name ARX-03, sufentanil + triazolam NanoTab

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Trial Name ARX-03, sufentanil + triazolam NanoTab

Novel drug target Established target

Direct Interaction yes

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Trial Name ARX-03, sufentanil + triazolam NanoTab

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Trial Name ARX-03, sufentanil + triazolam NanoTab

Novel drug target Established target

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Trial Name ARX-03, sufentanil + triazolam NanoTab

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Trial Name ARX-03, sufentanil + triazolam NanoTab

Novel drug target Established target

Direct Interaction yes

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

allosteric modulator

potentiator

Interaction Info:

Novel drug target Established target

Trial Name ARX-03, sufentanil + triazolam NanoTab

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

ligand

positive modulator (activating)

allosteric modulator

potentiator

Interaction Info:

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Direct Interaction yes

Trial Name ARX-03, sufentanil + triazolam NanoTab

PMIDs:
18384456 11752090 29950725 23038269

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Novel drug target Established target

Trial Name ARX-03, sufentanil + triazolam NanoTab

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

potentiator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

Trial Name ARX-03, sufentanil + triazolam NanoTab

PMIDs:
18384456 11752090

Sources:
TEND TdgClinicalTrial ChemblInteractions