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TRIMETHOPRIM Drug Record

  • Summary
  • Interactions
  • Claims
  • TRIMETHOPRIM chembl:CHEMBL22 Approved

    Alternate Names:

    TRIMOPAN
    IPRAL
    NIH-204
    SYRAPRIM
    PROLOPRIN
    TRIPRIMIX 200
    PRIMSOL
    TRIMPEX
    TCMDC-125538
    NSC-106568
    PROLOPRIM
    TIEMPE
    BW-5672
    TRIMPEX 200
    TRIMETHOPRIM
    POLYTRIM
    MONOTRIM
    TRIMOGAL
    LEDATRIM
    BW-56-72
    TRIMETHOPRIME
    TRIMETHOPRIMUM
    2,4-DIAMINO-5-(3,4,5-TRIMETHOXYBENZYL)PYRIMIDINE
    TMP
    5-[(3,4,5-TRIMETHOXYPHENYL)METHYL]-2,4-PYRIMIDINEDIAMINE
    TRIMETOPRIMA
    TRIMÉTHOPRIME
    rxcui:10829
    drugbank:00440
    chemidplus:738-70-5
    chembl:CHEMBL22
    pubchem.compound:5578

    Drug Info:

    (2 More Sources)

    Publications:

    Nahimana et al., 2004, Mutations of Pneumocystis jirovecii dihydrofolate reductase associated with failure of prophylaxis., Antimicrob. Agents Chemother.
    Floris-Moore et al., 2003, Adverse reactions to trimethoprim/sulfamethoxazole in AIDS., Ann Pharmacother
    Rosowsky et al., 2004, Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase., J. Med. Chem.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Barrow et al., 2004, Functional cloning of Bacillus anthracis dihydrofolate reductase and confirmation of natural resistance to trimethoprim., Antimicrob. Agents Chemother.
    Laskowska et al., 2003, Trimethoprim induces heat shock proteins and protein aggregation in E. coli cells., Curr. Microbiol.
    Wen et al., 2002, Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively., Drug Metab. Dispos.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Hruska et al., 2005, The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects., Br J Clin Pharmacol
    Anderson et al., 1980, Effects of sulfamethoxazole and trimethoprim on human neutrophil and lymphocyte functions in vitro: in vivo effects of co-trimoxazole., Antimicrob. Agents Chemother.
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Wolkenstein P et al., 2000, Prospective evaluation of detoxification pathways as markers of cutaneous adverse reactions to sulphonamides in AIDS., Pharmacogenetics
  • TRIMETHOPRIM   DHFR

    Interaction Score: 2.62

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    15504856 14632594 15115391 11752352 15561838 14629008


    Sources:
    TTD

  • TRIMETHOPRIM   MPO

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7425598


    Sources:
    NCI

  • TRIMETHOPRIM   GSTM1

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11191886


    Sources:
    PharmGKB

  • TRIMETHOPRIM   CYP2C8

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15606443


    Sources:
    NCI

  • TRIMETHOPRIM   G6PD

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Combination therapy Sulfamethoxazole,Trimethoprim

    PMIDs:
    None found


    Sources:
    FDA

  • TRIMETHOPRIM   CYP1A2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12019187 22931300


    Sources:
    DTC NCI

  • TRIMETHOPRIM   CBX1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIMETHOPRIM   CYP2C9

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TRIMETHOPRIM   CYP3A4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528 22931300


    Sources:
    DTC PharmGKB

  • TRIMETHOPRIM   CYP2C19

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TRIMETHOPRIM   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • NCI: TRIMETHOPRIM

    • Version: 14-September-2017

    Alternate Names:
    C908 NCI drug code

    Drug Info:

    Publications:
    Hruska et al., 2005, The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects., Br J Clin Pharmacol
    Wen et al., 2002, Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively., Drug Metab. Dispos.
    Anderson et al., 1980, Effects of sulfamethoxazole and trimethoprim on human neutrophil and lymphocyte functions in vitro: in vivo effects of co-trimoxazole., Antimicrob. Agents Chemother.

  • DTC: TRIMETHOPRIM

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL22 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: trimethoprim

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Wolkenstein P et al., 2000, Prospective evaluation of detoxification pathways as markers of cutaneous adverse reactions to sulphonamides in AIDS., Pharmacogenetics
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

  • TTD: Trimethoprim

    • Version: 2020.06.01

    Alternate Names:
    D0AO5H TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL22

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Trimethoprim

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21