DGIdb - TRIMETHOPRIM Drug Record

TRIMETHOPRIM chembl:CHEMBL22 Approved

Alternate Names:

TRIMOPAN
IPRAL
NIH-204
SYRAPRIM
PROLOPRIN
TRIPRIMIX 200
PRIMSOL
TRIMPEX
TCMDC-125538
NSC-106568
PROLOPRIM
TIEMPE
BW-5672
TRIMPEX 200
TRIMETHOPRIM
POLYTRIM
MONOTRIM
TRIMOGAL
LEDATRIM
BW-56-72
TRIMETHOPRIME
TRIMETHOPRIMUM
2,4-DIAMINO-5-(3,4,5-TRIMETHOXYBENZYL)PYRIMIDINE
TMP
5-[(3,4,5-TRIMETHOXYPHENYL)METHYL]-2,4-PYRIMIDINEDIAMINE
TRIMETOPRIMA
TRIMÉTHOPRIME
rxcui:10829
drugbank:00440
chemidplus:738-70-5
chembl:CHEMBL22
pubchem.compound:5578

Drug Info:

(2 More Sources)

Publications:

Nahimana et al., 2004, Mutations of Pneumocystis jirovecii dihydrofolate reductase associated with failure of prophylaxis., Antimicrob. Agents Chemother.
Floris-Moore et al., 2003, Adverse reactions to trimethoprim/sulfamethoxazole in AIDS., Ann Pharmacother
Rosowsky et al., 2004, Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase., J. Med. Chem.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Barrow et al., 2004, Functional cloning of Bacillus anthracis dihydrofolate reductase and confirmation of natural resistance to trimethoprim., Antimicrob. Agents Chemother.
Laskowska et al., 2003, Trimethoprim induces heat shock proteins and protein aggregation in E. coli cells., Curr. Microbiol.
Wen et al., 2002, Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively., Drug Metab. Dispos.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Hruska et al., 2005, The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects., Br J Clin Pharmacol
Anderson et al., 1980, Effects of sulfamethoxazole and trimethoprim on human neutrophil and lymphocyte functions in vitro: in vivo effects of co-trimoxazole., Antimicrob. Agents Chemother.
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Wolkenstein P et al., 2000, Prospective evaluation of detoxification pathways as markers of cutaneous adverse reactions to sulphonamides in AIDS., Pharmacogenetics

TRIMETHOPRIM DHFR

Interaction Score: 2.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15504856 14632594 15115391 11752352 15561838 14629008

Sources:
TTD
TRIMETHOPRIM MPO

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7425598

Sources:
NCI
TRIMETHOPRIM GSTM1

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11191886

Sources:
PharmGKB
TRIMETHOPRIM CYP2C8

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15606443

Sources:
NCI
TRIMETHOPRIM G6PD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Sulfamethoxazole,Trimethoprim

PMIDs:
None found

Sources:
FDA
TRIMETHOPRIM CYP1A2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12019187 22931300

Sources:
DTC NCI
TRIMETHOPRIM CBX1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIMETHOPRIM CYP2C9

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
TRIMETHOPRIM CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528 22931300

Sources:
DTC PharmGKB
TRIMETHOPRIM CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
TRIMETHOPRIM CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

NCI: TRIMETHOPRIM

Version: 14-September-2017

Alternate Names:

C908 NCI drug code

Drug Info:

Publications:

Hruska et al., 2005, The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects., Br J Clin Pharmacol

Wen et al., 2002, Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively., Drug Metab. Dispos.

Anderson et al., 1980, Effects of sulfamethoxazole and trimethoprim on human neutrophil and lymphocyte functions in vitro: in vivo effects of co-trimoxazole., Antimicrob. Agents Chemother.

DTC: TRIMETHOPRIM
- Version: 02-September-2020
Alternate Names:

CHEMBL22 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

PharmGKB: trimethoprim

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Wolkenstein P et al., 2000, Prospective evaluation of detoxification pathways as markers of cutaneous adverse reactions to sulphonamides in AIDS., Pharmacogenetics

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

TTD: Trimethoprim
- Version: 2020.06.01
Alternate Names:

D0AO5H TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL22
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Trimethoprim
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

TRIMETHOPRIM Drug Record

TRIMETHOPRIM chembl:CHEMBL22 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 15504856 14632594 15115391 11752352 15561838 14629008

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7425598

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11191886

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15606443

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Sulfamethoxazole,Trimethoprim

PMIDs: None found

Sources: FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12019187 22931300

Sources: DTC NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528 22931300

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

NCI: TRIMETHOPRIM

Alternate Names: C908 NCI drug code

Drug Info:

DTC: TRIMETHOPRIM

Alternate Names: CHEMBL22 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

PharmGKB: trimethoprim

Alternate Names:

Drug Info:

TTD: Trimethoprim

Alternate Names: D0AO5H TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL22

Alternate Names:

Drug Info:

Publications:

FDA: Trimethoprim

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
15504856 14632594 15115391 11752352 15561838 14629008

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
7425598

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11191886

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15606443

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Sulfamethoxazole,Trimethoprim

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

n/a

PMIDs:
12019187 22931300

Sources:
DTC NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9187528 22931300

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

C908 NCI drug code

Alternate Names:

CHEMBL22 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D0AO5H TTD Drug ID