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TROGLITAZONE Drug Record

  • Summary
  • Interactions
  • Claims
  • TROGLITAZONE chembl:CHEMBL408

    Alternate Names:

    TROGLITAZONE
    ROMOZIN
    GR92132X
    PRELAY
    REZULIN
    CS-045
    GR-92132X
    CI-991
    REZULIN®
    REZULIN (TN)
    ROMGLIZONE
    5-(4-(6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-YLMETHOXY)BENZYL)THIAZOLIDINE-2,4-DIONE
    (+-)-ALL-RAC-5-(P-((6-HYDROXY-2,5,7,8-TETRAMETHYL-2-CHROMANYL)METHOXY)BENZYL)-2,4-THIAZOLIDINEDIONE
    rxcui:72610
    chembl:CHEMBL408
    drugbank:00197
    pubchem.compound:5591
    chemidplus:97322-87-7

    Drug Info:

    (2 More Sources)

    Publications:

    Cominacini et al., 1999, The expression of adhesion molecules on endothelial cells is inhibited by troglitazone through its antioxidant activity., Cell Adhes. Commun.
    Petrova et al., 1999, Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2., Proc. Natl. Acad. Sci. U.S.A.
    Kitamura et al., 1999, Peroxisome proliferator-activated receptor gamma induces growth arrest and differentiation markers of human colon cancer cells., Jpn. J. Cancer Res.
    Demetri et al., 1999, Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma., Proc. Natl. Acad. Sci. U.S.A.
    Satoh et al., 1999, Prostaglandin J2 and its metabolites promote neurite outgrowth induced by nerve growth factor in PC12 cells., Biochem. Biophys. Res. Commun.
    Camp et al., 1999, PPARgamma activators down-regulate the expression of PPARgamma in 3T3-L1 adipocytes., FEBS Lett.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Baek et al., 2003, Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity., J. Biol. Chem.
    Hong SS et al., 2012, Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes., Bioorg Med Chem Lett
    MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol
    Hoang MH et al., 2012, Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells., Bioorg Med Chem Lett
    Hiep NT et al., 2012, Polyhydroxylated macrolides from Seimatosporium discosioides and their effects on the activation of peroxisome proliferator-activated receptor gamma., J Nat Prod
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Furuta et al., 2002, Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus., Diabetes Res. Clin. Pract.
    Sharma et al., 2004, Peroxisome proliferator-activated receptor gamma activation modulates cyclin D1 transcription via beta-catenin-independent and cAMP-response element-binding protein-dependent pathways in mouse hepatocytes., J. Biol. Chem.
    Watanabe et al., 2003, A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus., Clin. Pharmacol. Ther.
    Nozawa et al., 2004, Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity., Drug Metab. Dispos.
    Yoshioka et al., 2001, Troglitazone enhances glucose uptake induced by alpha-adrenoceptor stimulation via phosphatidylinositol 3-kinase in rat heart., Clin. Exp. Pharmacol. Physiol.
    Ohta et al., 2001, Ligands for peroxisome proliferator-activated receptor gamma inhibit growth and induce apoptosis of human papillary thyroid carcinoma cells., J. Clin. Endocrinol. Metab.
    Yamanaka et al., 2007, Comparison of the antidiabetic effects of brain-derived neurotrophic factor and thiazolidinediones in obese diabetic mice., Diabetes Obes Metab
    Lappas et al., 2002, Regulation of proinflammatory cytokines in human gestational tissues by peroxisome proliferator-activated receptor-gamma: effect of 15-deoxy-Delta(12,14)-PGJ(2) and troglitazone., J. Clin. Endocrinol. Metab.
    Watanabe et al., 2002, Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10., Drug Metab. Dispos.
    Yin et al., 2004, Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells., Oncogene
    Murata et al., 2000, Stimulation by eicosapentaenoic acids of leptin mRNA expression and its secretion in mouse 3T3-L1 adipocytes in vitro., Biochem. Biophys. Res. Commun.
    Piva et al., 2005, 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins., Blood
    Cefalu et al., 2004, Effects of insulin sensitizers on plaque vulnerability associated with elevated lipid content in atheroma in ApoE-knockout mice., Acta Diabetol
    Patel et al., 2005, Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma)., Cell. Signal.
  • TROGLITAZONE   VCAM1

    Interaction Score: 1.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10626906


    Sources:
    NCI

  • TROGLITAZONE   GADD45A

    Interaction Score: 0.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15064713


    Sources:
    NCI

  • TROGLITAZONE   UGT1A10

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12433820


    Sources:
    NCI

  • TROGLITAZONE   GSTT1

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12732844


    Sources:
    PharmGKB

  • TROGLITAZONE   LEP

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10753628


    Sources:
    NCI

  • TROGLITAZONE   APOE

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15057551


    Sources:
    NCI

  • TROGLITAZONE   PPARG

    Interaction Score: 0.29

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist
    Direct Interaction yes

    PMIDs:
    10200320 10076568 10097144 10222233 10214942 11752352 12475986 22342624 16680159 22579484 22424300


    Sources:
    DTC ChemblInteractions TTD

  • TROGLITAZONE   XIAP

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15498850


    Sources:
    NCI

  • TROGLITAZONE   CCND1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14764597


    Sources:
    NCI

  • TROGLITAZONE   GSTM1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12732844


    Sources:
    NCI

  • TROGLITAZONE   SLCO1B1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14977862


    Sources:
    NCI PharmGKB

  • TROGLITAZONE   MYC

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11344222


    Sources:
    NCI

  • TROGLITAZONE   SLC2A4

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11947963


    Sources:
    NCI

  • TROGLITAZONE   PIK3CB

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11553036


    Sources:
    NCI

  • TROGLITAZONE   CXCL8

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12364456


    Sources:
    NCI

  • TROGLITAZONE   BDNF

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17924870


    Sources:
    NCI

  • TROGLITAZONE   PIK3CG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15993751


    Sources:
    NCI

  • TROGLITAZONE   ALOX15B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TROGLITAZONE   NR1I2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • TROGLITAZONE   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TROGLITAZONE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TROGLITAZONE   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TROGLITAZONE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TROGLITAZONE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TROGLITAZONE   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NCI: TROGLITAZONE

    • Version: 14-September-2017

    Alternate Names:
    C1522 NCI drug code

    Drug Info:

    Publications:
    Cominacini et al., 1999, The expression of adhesion molecules on endothelial cells is inhibited by troglitazone through its antioxidant activity., Cell Adhes. Commun.
    Furuta et al., 2002, Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus., Diabetes Res. Clin. Pract.
    Piva et al., 2005, 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins., Blood

  • DTC: TROGLITAZONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL408 ChEMBL Drug ID

    Drug Info:

    Publications:
    Hoang MH et al., 2012, Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells., Bioorg Med Chem Lett
    Hong SS et al., 2012, Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes., Bioorg Med Chem Lett
    Hiep NT et al., 2012, Polyhydroxylated macrolides from Seimatosporium discosioides and their effects on the activation of peroxisome proliferator-activated receptor gamma., J Nat Prod

  • PharmGKB: troglitazone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Watanabe et al., 2003, A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus., Clin. Pharmacol. Ther.
    Nozawa et al., 2004, Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity., Drug Metab. Dispos.

  • TTD: Troglitazone

    • Version: 2020.06.01

    Alternate Names:
    D06XZW TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL408

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL408

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21