• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

TROPISETRON Drug Record

  • Summary
  • Interactions
  • Claims
  • TROPISETRON chembl:CHEMBL56564 Approved

    Alternate Names:

    TROPISETRON
    NAVOBAN
    ICS-205-930

    Drug Info:

    (1 More Sources)

    Publications:

    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Fischer et al., The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron., Drug Metab. Dispos.
    Arranz et al., 1998, Characterization of the 5-HT4 binding site in human brain., J Neural Transm (Vienna)
    Tzvetkov MV et al., 2012, Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT(3) antagonists tropisetron and ondansetron., Pharmacogenomics J
    Kim MK et al., 2003, Effect of the CYP2D6 genotype on the pharmacokinetics of tropisetron in healthy Korean subjects., Eur J Clin Pharmacol
    Kaiser R et al., 2002, Patient-tailored antiemetic treatment with 5-hydroxytryptamine type 3 receptor antagonists according to cytochrome P-450 2D6 genotypes., J Clin Oncol
    Bernand et al., 2000, Multifocal fixed drug eruption to paracetamol, tropisetron and ondansetron induced by interleukin 2., Dermatology (Basel)
  • TROPISETRON   SLC22A1

    Interaction Score: 1.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20921968


    Sources:
    PharmGKB

  • TROPISETRON   HTR4

    Interaction Score: 0.65

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    9826103


    Sources:
    NCI

  • TROPISETRON   IL2

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11053919


    Sources:
    NCI

  • TROPISETRON   JUN

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TROPISETRON   HTR3A

    Interaction Score: 0.2

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TROPISETRON   CYP2D6

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12728290 12065557


    Sources:
    PharmGKB

  • TROPISETRON   CYP3A4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528 8013282


    Sources:
    NCI PharmGKB

  • NCI: TROPISETRON

    • Version: 14-September-2017

    Alternate Names:
    C1131 NCI drug code

    Drug Info:

    Publications:
    Fischer et al., The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron., Drug Metab. Dispos.
    Arranz et al., 1998, Characterization of the 5-HT4 binding site in human brain., J Neural Transm (Vienna)
    Bernand et al., 2000, Multifocal fixed drug eruption to paracetamol, tropisetron and ondansetron induced by interleukin 2., Dermatology (Basel)

  • PharmGKB: tropisetron

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Kim MK et al., 2003, Effect of the CYP2D6 genotype on the pharmacokinetics of tropisetron in healthy Korean subjects., Eur J Clin Pharmacol
    Kaiser R et al., 2002, Patient-tailored antiemetic treatment with 5-hydroxytryptamine type 3 receptor antagonists according to cytochrome P-450 2D6 genotypes., J Clin Oncol

  • TTD: Tropisetron

    • Version: 2020.06.01

    Alternate Names:
    D0K0KH TTD Drug ID

    Drug Info:

    Publications:

  • DTC: TROPISETRON

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL56564 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL56564

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21