DGIdb - UPADACITINIB Drug Record

UPADACITINIB chembl:CHEMBL3622821

Alternate Names:

ABT-494
UPADACITINIB

Drug Info:

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational
Drug Categories	antirheumatic agents
Drug Categories	bcrp/abcg2 inhibitors
Drug Categories	bcrp/abcg2 substrates
Drug Categories	cytochrome p-450 cyp2d6 substrates
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 substrates
Drug Categories	cytochrome p-450 substrates
Drug Categories	disease-modifying antirheumatic agents
Drug Categories	enzyme inhibitors
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	janus kinase inhibitors
Drug Categories	oatp1b1/slco1b1 inhibitors
Drug Categories	p-glycoprotein inhibitors
Drug Categories	p-glycoprotein substrates
Drug Categories	protein kinase inhibitors

(2 More Sources)

Publications:

Parmentier JM et al., 2018, In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494)., BMC Rheumatol
Biggioggero M et al., 2019, Upadacitinib and filgotinib: the role of JAK1 selective inhibition in the treatment of rheumatoid arthritis., Drugs Context

UPADACITINIB JAK1

Interaction Score: 1.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
30886973 31692920

Sources:
TTD DrugBank GuideToPharmacology
UPADACITINIB PTK2B

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
UPADACITINIB TYK2

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
UPADACITINIB JAK3

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
UPADACITINIB JAK2

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
UPADACITINIB CYP2D6

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB

DrugBank: DB15091

Version: 5.1.7

Alternate Names:

UPADACITINIB DrugBank Drug Name

1310726-60-3 CAS Number

Rinvoq Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Parmentier JM et al., 2018, In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494)., BMC Rheumatol

Biggioggero M et al., 2019, Upadacitinib and filgotinib: the role of JAK1 selective inhibition in the treatment of rheumatoid arthritis., Drugs Context

TTD: ABT-494
- Version: 2020.06.01
Alternate Names:

D07JAG TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 315661321
- Version: 29-September-2020
Alternate Names:

UPADACITINIB GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL3622821
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: upadacitinib
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:
FDA: Upadacitinib
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

UPADACITINIB	DrugBank Drug Name
1310726-60-3	CAS Number
Rinvoq	Drug Brand

UPADACITINIB Drug Record

UPADACITINIB chembl:CHEMBL3622821

Alternate Names:

Drug Info:

Publications:

UPADACITINIB JAK1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: 30886973 31692920

Sources: TTD DrugBank GuideToPharmacology

UPADACITINIB PTK2B

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

UPADACITINIB TYK2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

UPADACITINIB JAK3

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

UPADACITINIB JAK2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

UPADACITINIB CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA PharmGKB

DrugBank: DB15091

Alternate Names: UPADACITINIB DrugBank Drug Name 1310726-60-3 CAS Number Rinvoq Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

Publications: Parmentier JM et al., 2018, In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494)., BMC Rheumatol Biggioggero M et al., 2019, Upadacitinib and filgotinib: the role of JAK1 selective inhibition in the treatment of rheumatoid arthritis., Drugs Context

TTD: ABT-494

Alternate Names: D07JAG TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 315661321

Alternate Names: UPADACITINIB GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL3622821

Alternate Names:

Drug Info:

Publications:

PharmGKB: upadacitinib

Alternate Names:

Drug Info:

Publications:

FDA: Upadacitinib

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
30886973 31692920

Sources:
TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA PharmGKB

Alternate Names:

UPADACITINIB DrugBank Drug Name

1310726-60-3 CAS Number

Rinvoq Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Parmentier JM et al., 2018, In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494)., BMC Rheumatol

Biggioggero M et al., 2019, Upadacitinib and filgotinib: the role of JAK1 selective inhibition in the treatment of rheumatoid arthritis., Drugs Context

Alternate Names:

D07JAG TTD Drug ID

Alternate Names:

UPADACITINIB GuideToPharmacology Ligand Name