DGIdb - UPADACITINIB Drug Record

UPADACITINIB chembl:CHEMBL3622821

Alternate Names:

ABT-494
UPADACITINIB

Drug Info:

(1 More Sources)

Publications:

Biggioggero M et al., 2019, Upadacitinib and filgotinib: the role of JAK1 selective inhibition in the treatment of rheumatoid arthritis., Drugs Context
Parmentier JM et al., 2018, In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494)., BMC Rheumatol

UPADACITINIB JAK1

Interaction Score: 1.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
31692920 30886973

Sources:
GuideToPharmacology TTD
UPADACITINIB PTK2B

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
UPADACITINIB TYK2

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
UPADACITINIB JAK3

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
UPADACITINIB JAK2

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
UPADACITINIB CYP2D6

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA

TTD: ABT-494
- Version: 2020.06.01
Alternate Names:

D07JAG TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 315661321
- Version: 29-September-2020
Alternate Names:

UPADACITINIB GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL3622821
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: upadacitinib
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:
FDA: Upadacitinib
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

UPADACITINIB Drug Record

UPADACITINIB chembl:CHEMBL3622821

Alternate Names:

Drug Info:

Publications:

UPADACITINIB JAK1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: 31692920 30886973

Sources: GuideToPharmacology TTD

UPADACITINIB PTK2B

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

UPADACITINIB TYK2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

UPADACITINIB JAK3

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

UPADACITINIB JAK2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

UPADACITINIB CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

TTD: ABT-494

Alternate Names: D07JAG TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 315661321

Alternate Names: UPADACITINIB GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL3622821

Alternate Names:

Drug Info:

Publications:

PharmGKB: upadacitinib

Alternate Names:

Drug Info:

Publications:

FDA: Upadacitinib

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
31692920 30886973

Sources:
GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Alternate Names:

D07JAG TTD Drug ID

Alternate Names:

UPADACITINIB GuideToPharmacology Ligand Name