DGIdb - VALPROIC ACID Drug Record

VALPROIC ACID chembl:CHEMBL109 Approved

Alternate Names:

STAVZOR
NSC-93819
CONVULEX
44089
VALPROIC ACID
DEPAKENE
DEPAKOTE
2-N-PROPYL-4-PENTENOIC ACID
DI-N-PROPYLACETIC ACID
2-PROPYLVALERIC ACID
N-DPA
VPA
A-44090
DPA
2-N-PROPYL-N-VALERIC ACID
DIPROPYLACETIC ACID
4-HEPTANECARBOXYLIC ACID
PROPYLVALERIC ACID
2-PROPYLPENTANOIC ACID
LEP321
chembl:CHEMBL109
rxcui:11118
chemidplus:99-66-1
pubchem.compound:3121
drugbank:00313

Drug Info:

(0 More Sources)

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
Petrelli R et al., 2014, From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine., Bioorg Med Chem Lett
Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett
Kehler L et al., 2000, Novel phosphinic and phosphonic acid analogues of the anticonvulsant valproic acid., Bioorg Med Chem Lett

VALPROIC ACID ALDH5A1

Interaction Score: 1.77

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Succinate semialdehyde dehydrogenase inhibitor

Direct Interaction yes

PMIDs:
11086726

Sources:
DTC ChemblInteractions
VALPROIC ACID ABAT

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11086726

Sources:
DTC
VALPROIC ACID HDAC11

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367 25304896 18294844

Sources:
DTC
VALPROIC ACID HDAC9

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367 25304896 18294844

Sources:
DTC
VALPROIC ACID HDAC10

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367 25304896 18294844

Sources:
DTC
VALPROIC ACID HDAC7

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367 25304896 18294844

Sources:
DTC
VALPROIC ACID HDAC5

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367 25304896 18294844

Sources:
DTC
VALPROIC ACID HDAC4

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367 25304896 18294844

Sources:
DTC
VALPROIC ACID HDAC8

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367 25304896 18294844

Sources:
DTC
VALPROIC ACID HDAC3

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367 25304896 18294844

Sources:
DTC
VALPROIC ACID HDAC2

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367 25304896 18294844

Sources:
DTC
VALPROIC ACID HDAC6

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367 25304896 18294844

Sources:
DTC
VALPROIC ACID HDAC1

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367 25304896 18294844

Sources:
DTC
VALPROIC ACID CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
VALPROIC ACID CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
VALPROIC ACID CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
VALPROIC ACID CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
VALPROIC ACID CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

DTC: VALPROIC ACID

Version: 02-September-2020

Alternate Names:

CHEMBL109 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett

Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol

ChemblDrugs: chembl:CHEMBL109
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL109
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Succinate semialdehyde dehydrogenase inhibitor
Direct Interaction	yes

VALPROIC ACID Drug Record

VALPROIC ACID chembl:CHEMBL109 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Succinate semialdehyde dehydrogenase inhibitor Direct Interaction yes

PMIDs: 11086726

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11086726

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367 25304896 18294844

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367 25304896 18294844

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367 25304896 18294844

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367 25304896 18294844

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367 25304896 18294844

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367 25304896 18294844

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367 25304896 18294844

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367 25304896 18294844

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367 25304896 18294844

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367 25304896 18294844

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367 25304896 18294844

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

DTC: VALPROIC ACID

Alternate Names: CHEMBL109 ChEMBL Drug ID

Drug Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Succinate semialdehyde dehydrogenase inhibitor

Direct Interaction yes

PMIDs:
11086726

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
11086726

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367 25304896 18294844

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367 25304896 18294844

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367 25304896 18294844

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367 25304896 18294844

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367 25304896 18294844

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367 25304896 18294844

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367 25304896 18294844

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367 25304896 18294844

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367 25304896 18294844

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367 25304896 18294844

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367 25304896 18294844

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

CHEMBL109 ChEMBL Drug ID