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VALPROIC ACID Drug Record

  • Summary
  • Interactions
  • Claims
  • VALPROIC ACID chembl:CHEMBL109 Approved

    Alternate Names:

    STAVZOR
    NSC-93819
    CONVULEX
    44089
    VALPROIC ACID
    DEPAKENE
    DEPAKOTE
    2-N-PROPYL-4-PENTENOIC ACID
    DI-N-PROPYLACETIC ACID
    2-PROPYLVALERIC ACID
    N-DPA
    VPA
    A-44090
    DPA
    2-N-PROPYL-N-VALERIC ACID
    DIPROPYLACETIC ACID
    4-HEPTANECARBOXYLIC ACID
    PROPYLVALERIC ACID
    2-PROPYLPENTANOIC ACID
    LEP321
    chembl:CHEMBL109
    rxcui:11118
    chemidplus:99-66-1
    pubchem.compound:3121
    drugbank:00313

    Drug Info:

    (0 More Sources)

    Publications:

    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
    Petrelli R et al., 2014, From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine., Bioorg Med Chem Lett
    Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett
    Kehler L et al., 2000, Novel phosphinic and phosphonic acid analogues of the anticonvulsant valproic acid., Bioorg Med Chem Lett
  • VALPROIC ACID   ALDH5A1

    Interaction Score: 2.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Succinate semialdehyde dehydrogenase inhibitor
    Direct Interaction yes

    PMIDs:
    11086726


    Sources:
    DTC ChemblInteractions

  • VALPROIC ACID   ABAT

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11086726


    Sources:
    DTC

  • VALPROIC ACID   HDAC11

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367 25304896 18294844


    Sources:
    DTC

  • VALPROIC ACID   HDAC9

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367 25304896 18294844


    Sources:
    DTC

  • VALPROIC ACID   HDAC10

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367 25304896 18294844


    Sources:
    DTC

  • VALPROIC ACID   HDAC5

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367 25304896 18294844


    Sources:
    DTC

  • VALPROIC ACID   HDAC7

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367 25304896 18294844


    Sources:
    DTC

  • VALPROIC ACID   HDAC8

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367 25304896 18294844


    Sources:
    DTC

  • VALPROIC ACID   HDAC3

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367 25304896 18294844


    Sources:
    DTC

  • VALPROIC ACID   HDAC4

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367 25304896 18294844


    Sources:
    DTC

  • VALPROIC ACID   HDAC2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367 25304896 18294844


    Sources:
    DTC

  • VALPROIC ACID   HDAC6

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367 25304896 18294844


    Sources:
    DTC

  • VALPROIC ACID   HDAC1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367 25304896 18294844


    Sources:
    DTC

  • VALPROIC ACID   CYP2C9

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • VALPROIC ACID   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • VALPROIC ACID   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • VALPROIC ACID   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • VALPROIC ACID   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • DTC: VALPROIC ACID

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL109 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett
    Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol

  • ChemblDrugs: chembl:CHEMBL109

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL109

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21