DGIdb - VATALANIB Drug Record

VATALANIB chembl:CHEMBL101253 Antineoplastic

Alternate Names:

CGP-79787
ZK-222584
K-222584
PTK787
BAY-86-5127
VATALANIB
NVP-PTK787
PTK-787

Drug Info:

Drug Class	Kinase Inhibitors
FDA Approval	not approved
Drug Class	small molecule
Drug Indications	antineoplastic agent

(4 More Sources)

Publications:

Yamamoto et al., 2007, Vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK 222584 inhibits both the induction and elicitation phases of contact hypersensitivity., J. Dermatol.
Yan D et al., 2017, Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas., Oncogene

VATALANIB CSF1R

Interaction Score: 0.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

PMIDs:
28759044

Sources:
DTC ChemblInteractions CIViC
VATALANIB FLT1

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Vatalanib

Novel drug target Established target

Trial Name vatalanib, PTK 787

PMIDs:
17584317

Sources:
TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions
VATALANIB FLT4

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Vatalanib

Novel drug target Established target

Trial Name vatalanib, PTK 787

PMIDs:
17584317

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD
VATALANIB KIT

Interaction Score: 0.31

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name vatalanib, PTK 787

Novel drug target Established target

Trial Name Vatalanib

PMIDs:
None found

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions
VATALANIB PDGFRB

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Platelet-derived growth factor receptor inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions
VATALANIB KDR

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name Vatalanib

Novel drug target Established target

PMIDs:
17584317

Sources:
TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD
VATALANIB PDGFRA

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Platelet-derived growth factor receptor inhibitor

Direct Interaction yes

Trial Name vatalanib, PTK 787

PMIDs:
None found

Sources:
DTC TdgClinicalTrial ChemblInteractions
VATALANIB STK3

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VATALANIB FRK

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VATALANIB RPS6KB1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VATALANIB EGFR

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
VATALANIB NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VATALANIB AR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

MyCancerGenome: VATALANIB
- Version: 20-Jun-2017
Alternate Names:

PTK787 Development Name

CGP79787 Development Name

ZK222584 Development Name

Drug Info:

Drug Class Kinase Inhibitors

Publications:
TdgClinicalTrial: VATALANIB
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antineoplastic agent

Drug Class small molecule

FDA Approval not approved

Publications:
CIViC: VATALANIB
- Version: 14-September-2020
Alternate Names:

Drug Info:

Publications:

Yan D et al., 2017, Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas., Oncogene
TTD: VATALANIB
- Version: 2020.06.01
Alternate Names:

D0P6DJ TTD Drug ID

Drug Info:

Publications:
DTC: VATALANIB
- Version: 02-September-2020
Alternate Names:

CHEMBL101253 ChEMBL Drug ID

Drug Info:

Publications:
TALC: VATALANIB
- Version: 12-May-2016
Alternate Names:

VATALANIB Primary Drug Name

VATALANIB Drug Generic Name

PTK787 Drug Synonym

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL101253
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL101253
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Macrophage colony stimulating factor receptor inhibitor

Trial Name	Vatalanib
Novel drug target	Established target
Trial Name	vatalanib, PTK 787

Mechanism of Interaction	Platelet-derived growth factor receptor inhibitor
Direct Interaction	yes
Notes

PTK787	Development Name
CGP79787	Development Name
ZK222584	Development Name

VATALANIB	Primary Drug Name
VATALANIB	Drug Generic Name
PTK787	Drug Synonym

VATALANIB Drug Record

VATALANIB chembl:CHEMBL101253 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

PMIDs: 28759044

Sources: DTC ChemblInteractions CIViC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Vatalanib Novel drug target Established target Trial Name vatalanib, PTK 787

PMIDs: 17584317

Sources: TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Vatalanib Novel drug target Established target Trial Name vatalanib, PTK 787

PMIDs: 17584317

Sources: DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name vatalanib, PTK 787 Novel drug target Established target Trial Name Vatalanib

PMIDs: None found

Sources: TALC DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Platelet-derived growth factor receptor inhibitor Direct Interaction yes Notes

PMIDs: None found

Sources: TALC DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Trial Name Vatalanib Novel drug target Established target

PMIDs: 17584317

Sources: TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Platelet-derived growth factor receptor inhibitor Direct Interaction yes Trial Name vatalanib, PTK 787

PMIDs: None found

Sources: DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

MyCancerGenome: VATALANIB

Alternate Names: PTK787 Development Name CGP79787 Development Name ZK222584 Development Name

Drug Info: Drug Class Kinase Inhibitors

Publications:

TdgClinicalTrial: VATALANIB

Alternate Names:

Drug Info: Drug Indications antineoplastic agent Drug Class small molecule FDA Approval not approved

Publications:

CIViC: VATALANIB

Alternate Names:

Drug Info:

Publications: Yan D et al., 2017, Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas., Oncogene

TTD: VATALANIB

Alternate Names: D0P6DJ TTD Drug ID

Drug Info:

Publications:

DTC: VATALANIB

Alternate Names: CHEMBL101253 ChEMBL Drug ID

Drug Info:

Publications:

TALC: VATALANIB

Alternate Names: VATALANIB Primary Drug Name VATALANIB Drug Generic Name PTK787 Drug Synonym

Drug Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

PMIDs:
28759044

Sources:
DTC ChemblInteractions CIViC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Vatalanib

Novel drug target Established target

Trial Name vatalanib, PTK 787

PMIDs:
17584317

Sources:
TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Vatalanib

Novel drug target Established target

Trial Name vatalanib, PTK 787

PMIDs:
17584317

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name vatalanib, PTK 787

Novel drug target Established target

Trial Name Vatalanib

PMIDs:
None found

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Platelet-derived growth factor receptor inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name Vatalanib

Novel drug target Established target

PMIDs:
17584317

Sources:
TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Platelet-derived growth factor receptor inhibitor

Direct Interaction yes

Trial Name vatalanib, PTK 787

PMIDs:
None found

Sources:
DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

PTK787 Development Name

CGP79787 Development Name

ZK222584 Development Name

Drug Info:

Drug Class Kinase Inhibitors

Drug Info:

Drug Indications antineoplastic agent

Drug Class small molecule

FDA Approval not approved

Publications:

Yan D et al., 2017, Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas., Oncogene

Alternate Names:

D0P6DJ TTD Drug ID

Alternate Names:

CHEMBL101253 ChEMBL Drug ID

Alternate Names:

VATALANIB Primary Drug Name

VATALANIB Drug Generic Name

PTK787 Drug Synonym