DGIdb - VILDAGLIPTIN Drug Record

VILDAGLIPTIN chembl:CHEMBL142703 Approved

Alternate Names:

NVP-LAF237
NVP-LAF 237
LAF 237
LAF-237
VILDAGLIPTIN
GALVUS
LAF237
GALVUS®
JALRA
XILIARX
NVP-LAF-237
EQUA
chemidplus:274901-16-5
rxcui:596554
pubchem.compound:6918537
drugbank:04876
chembl:CHEMBL142703

Drug Info:

FDA Approval	approved
Drug Class	small molecule
Drug Indications	antidiabetic
Drug Categories	pyrrolidines
Drug Categories	agents causing angioedema
Drug Categories	blood glucose lowering agents
Drug Categories	nitriles

(3 More Sources)

Publications:

Gupta et al., 2009, Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes., Curr Drug Targets
Ahrén et al., 2004, Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes., Diabetes Care
Mentlein et al., 1993, Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum., Eur. J. Biochem.
Javorský M et al., 2016, A missense variant in GLP1R gene is associated with the glycaemic response to treatment with gliptins., Diabetes Obes Metab

VILDAGLIPTIN DPP4

Interaction Score: 3.92

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name vildagliptin, LAF 237,Galvus, Equa

Novel drug target Established target

Mechanism of Interaction Dipeptidyl peptidase IV inhibitor

PMIDs:
19149538 15562200 8100523

Sources:
DrugBank TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD
VILDAGLIPTIN GLP1R

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27160388

Sources:
PharmGKB

DrugBank: DB04876

Version: 5.1.7

Alternate Names:

VILDAGLIPTIN DrugBank Drug Name

274901-16-5 CAS Number

EQUA Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Gupta et al., 2009, Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes., Curr Drug Targets

Mentlein et al., 1993, Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum., Eur. J. Biochem.

Ahrén et al., 2004, Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes., Diabetes Care

TdgClinicalTrial: VILDAGLIPTIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antidiabetic

Drug Class small molecule

FDA Approval approved

Publications:
PharmGKB: vildagliptin
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Javorský M et al., 2016, A missense variant in GLP1R gene is associated with the glycaemic response to treatment with gliptins., Diabetes Obes Metab
TTD: Vildagliptin
- Version: 2020.06.01
Alternate Names:

D0L3DK TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178102929
- Version: 29-September-2020
Alternate Names:

VILDAGLIPTIN GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL142703
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL142703
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	vildagliptin, LAF 237,Galvus, Equa
Novel drug target	Established target
Mechanism of Interaction	Dipeptidyl peptidase IV inhibitor

VILDAGLIPTIN	DrugBank Drug Name
274901-16-5	CAS Number
EQUA	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

VILDAGLIPTIN Drug Record

VILDAGLIPTIN chembl:CHEMBL142703 Approved

Alternate Names:

Drug Info:

Publications:

VILDAGLIPTIN DPP4

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name vildagliptin, LAF 237,Galvus, Equa Novel drug target Established target Mechanism of Interaction Dipeptidyl peptidase IV inhibitor

PMIDs: 19149538 15562200 8100523

Sources: DrugBank TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

VILDAGLIPTIN GLP1R

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27160388

Sources: PharmGKB

DrugBank: DB04876

Alternate Names: VILDAGLIPTIN DrugBank Drug Name 274901-16-5 CAS Number EQUA Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

TdgClinicalTrial: VILDAGLIPTIN

Alternate Names:

Drug Info: Drug Indications antidiabetic Drug Class small molecule FDA Approval approved

Publications:

PharmGKB: vildagliptin

Alternate Names:

Drug Info:

Publications: Javorský M et al., 2016, A missense variant in GLP1R gene is associated with the glycaemic response to treatment with gliptins., Diabetes Obes Metab

TTD: Vildagliptin

Alternate Names: D0L3DK TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 178102929

Alternate Names: VILDAGLIPTIN GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL142703

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL142703

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name vildagliptin, LAF 237,Galvus, Equa

Novel drug target Established target

Mechanism of Interaction Dipeptidyl peptidase IV inhibitor

PMIDs:
19149538 15562200 8100523

Sources:
DrugBank TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
27160388

Sources:
PharmGKB

Alternate Names:

VILDAGLIPTIN DrugBank Drug Name

274901-16-5 CAS Number

EQUA Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Drug Info:

Drug Indications antidiabetic

Drug Class small molecule

FDA Approval approved

Publications:

Javorský M et al., 2016, A missense variant in GLP1R gene is associated with the glycaemic response to treatment with gliptins., Diabetes Obes Metab

Alternate Names:

D0L3DK TTD Drug ID

Alternate Names:

VILDAGLIPTIN GuideToPharmacology Ligand Name