MK0683 |
VORINOSTAT |
MK-0683 |
ZOLINZA |
OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE |
SHH |
SUBEROYLANILIDE HYDROXAMIC ACID |
SAHA |
SUBERANILOHYDROXAMIC ACID |
pubchem.compound:5311 |
chembl:CHEMBL98 |
chemidplus:149647-78-9 |
drugbank:02546 |
rxcui:194337 |
Year of Approval | 2006 |
Drug Class | antineoplastic agents |
FDA Approval | Cutaneous T-cell lymphoma |
Drug Class | Small molecule inhibitor |
FDA Approval | approved |
Drug Class | Small Molecule |
Drug Indications | antineoplastic agent |
Drug Categories | amides |
Drug Categories | anilides |
Drug Categories | aniline compounds |
Drug Categories | hydroxamic acids |
Drug Categories | immunosuppressive agents |
Drug Categories | narrow therapeutic index drugs |
Drug Categories | potential qtc-prolonging agents |
Drug Categories | qtc prolonging agents |
inhibitor (inhibitory) |
Trial Name | Merck |
Novel drug target | Established target |
Mechanism of Interaction | Histone deacetylase 6 inhibitor |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | True |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Notes | |
Direct Interaction? | False |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Notes | |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Drug family | HDAC inhibitor |
Alteration | GNA11:Q209L,Q209P |
VORINOSTAT | DrugBank Drug Name |
149647-78-9 | CAS Number |
Zolinza | Drug Brand |
Drug Type | small molecule |
Drug Groups | approved |
Drug Groups | investigational |
VORINOSTAT | Primary Drug Name |
Drug Class | antineoplastic agents |
Year of Approval | 2006 |
ZOLINZA | Trade Name |
Drug Class | Small molecule inhibitor |
FDA Approval | Cutaneous T-cell lymphoma |
Drug Indications | antineoplastic agent |
Drug Class | Small Molecule |
FDA Approval | approved |
CHEMBL98 | ChEMBL Drug ID |
C1796 | NCI drug code |
VORINOSTAT | Primary Drug Name |
VORINOSTAT | Drug Generic Name |
ZOLINZA | Drug Trade Name |
VORINOSTAT | GuideToPharmacology Ligand Name |
D0E7PQ | TTD Drug ID |