DGIdb - WARFARIN Drug Record

WARFARIN VKORC1

Interaction Score: 26.74

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
17413769 17510308 11752352 17161452 17275317 17653141 31653973 31395958 29781049 29577257 29432897 29396738 29298995 29054760 28689179 28429387 28382498 28262345 28049362 28033245 27581200 27488176 27262824 27121899 26777610 26445138 26433837 26257249 26223945 26219158 25989350 25769357 25594941 25521356 25519826 25312789 25244877 25084205 25042728 25026456 25001883 24919870 24728385 24474498 24330000 24029542 24019055 23949431 23932037 23774101 23602689 23423913 23279643 23208322 23183958 23159229 23104259 23061746 22990331 22854539 22676192 22616655 22592842 22571356 22549502 22534826 22528326 22349464 22248286 22075505 22040439 22010099 21981797 21900891 21635147 21383771 21326313 21318593 21273734 21185752 21176721 21174619 21148049 21110192 20833980 20833655 20615525 20585834 20421126 20410877 20386359 20339978 20203262 20072124 19875892 19874474 19794411 19745563 19582440 19387626 19297219 19177029 19135231 19077919 18950464 18752379 18698879 18690342 18574025 18542936 18466099 18240904 18234403 18030307 17989110 17456829 17391071 17329985 17110455 17031720 16821005 16611750 11127854 9684798 17906972 17189218 17124101 17112295 17111199 17049586 17042764 17015052 16983400 16960144 16890578 16888441 16847429 16815313 16815312 16676068 16611310 16580898 16493479 16432637 16270629 16141794 15947090 15938684 15930419 15888487 15883587 15865594 15790782 15597574 15358623 14765195 14765194 14676821 12931134 11926893

Sources:
TdgClinicalTrial TEND GuideToPharmacology PharmGKB TTD FDA
WARFARIN NEDD4

Interaction Score: 3.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27488176

Sources:
PharmGKB
WARFARIN VKORC1L1

Interaction Score: 3.54

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
29054760

Sources:
TdgClinicalTrial TEND PharmGKB
WARFARIN DDHD1

Interaction Score: 3.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27488176

Sources:
PharmGKB
WARFARIN CYP4F11

Interaction Score: 3.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28620303

Sources:
PharmGKB
WARFARIN ASPH

Interaction Score: 3.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27488176

Sources:
PharmGKB
WARFARIN STX1B

Interaction Score: 3.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27740732

Sources:
PharmGKB
WARFARIN GAS6

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16014032

Sources:
NCI
WARFARIN PRSS53

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
WARFARIN GATA4

Interaction Score: 1.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29298995 25026456

Sources:
PharmGKB
WARFARIN STX4

Interaction Score: 0.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
WARFARIN THBD

Interaction Score: 0.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24602049

Sources:
PharmGKB
WARFARIN DNMT3A

Interaction Score: 0.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27740732

Sources:
PharmGKB
WARFARIN FPGS

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
WARFARIN PROS1

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
WARFARIN NQO1

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27740732 27581200 26257249 21923605

Sources:
PharmGKB
WARFARIN NR1I3

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29298995 25356900

Sources:
PharmGKB
WARFARIN CYP3A7

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3977899

Sources:
NCI
WARFARIN APOE

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29432897 21923605

Sources:
PharmGKB
WARFARIN VWF

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7626351

Sources:
NCI
WARFARIN CYP1A1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8689941 27740732

Sources:
PharmGKB
WARFARIN HNF4A

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25356900

Sources:
PharmGKB
WARFARIN PROC

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA
WARFARIN ALB

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17560104

Sources:
DTC
WARFARIN BGLAP

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9578515

Sources:
NCI
WARFARIN MTHFR

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14723717

Sources:
NCI
WARFARIN UGT1A1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29737521 26223945

Sources:
PharmGKB
WARFARIN APOB

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
WARFARIN ABCB1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29875668 29432897 25312789 22248286

Sources:
PharmGKB
WARFARIN CYP3A5

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
WARFARIN CYP2C19

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8723744 27356304 25652102 23941071 21692828 19752777 18574025

Sources:
PharmGKB
WARFARIN CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15050794

Sources:
NCI FDA
WARFARIN CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8723744 8689941 17392729

Sources:
PharmGKB
WARFARIN VDR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29298995

Sources:
PharmGKB
WARFARIN TP53

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WARFARIN CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11353757

Sources:
PharmGKB

Year of Approval	approved before 1982
Drug Class	anticoagulants
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Anticoagulants

Drug Indications	Anticoagulants
Drug Class	small molecule
FDA Approval	Approved before 1982

Drug Class	anticoagulants
Year of Approval	approved before 1982

Trial Name	-
Novel drug target	Established target
Specific Action of the Ligand	Inhibition

WARFARIN
NSC-59813
PANWARFIN
4-HYDROXY-3-(3-OXO-1-PHENYLBUTYL)COUMARIN
MAREVAN®
ZOOCOUMARIN
COUMAFENE
COUMADIN®
rxcui:11289
chembl:CHEMBL1464
pubchem.compound:54678486
chemidplus:81-81-2
drugbank:00682

WARFARIN Drug Record

WARFARIN chembl:CHEMBL1464 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Inhibition

Sources: TdgClinicalTrial TEND GuideToPharmacology PharmGKB TTD FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27488176

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 29054760

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27488176

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28620303

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27488176

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27740732

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16014032

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29298995 25026456

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24602049

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27740732

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27740732 27581200 26257249 21923605

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29298995 25356900

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3977899

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29432897 21923605

Sources: PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Inhibition

Sources:
TdgClinicalTrial TEND GuideToPharmacology PharmGKB TTD FDA

Interaction Types & Directionality:

n/a

PMIDs:
27488176

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
29054760

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27488176

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28620303

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27488176

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27740732

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16014032

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29298995 25026456

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24602049

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27740732

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
27740732 27581200 26257249 21923605

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29298995 25356900

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
3977899

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
29432897 21923605

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
7626351

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8689941 27740732

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25356900

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

n/a

PMIDs:
17560104

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9578515

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14723717

Sources:
NCI

Interaction Types & Directionality:

n/a