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WORTMANNIN Drug Record

  • Summary
  • Interactions
  • Claims
  • WORTMANNIN chembl:CHEMBL428496 Immunotherapy

    Alternate Names:

    WORTMANNIN

    Drug Info:

    (0 More Sources)

    Publications:

    Quevedo et al., 2000, Two different signal transduction pathways are implicated in the regulation of initiation factor 2B activity in insulin-like growth factor-1-stimulated neuronal cells., J. Biol. Chem.
    Davis et al., 1998, Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma., J. Neurosci.
    Kim et al., 2003, Effects of ethanol on the rat glutamate excitatory amino acid transporter type 3 expressed in Xenopus oocytes: role of protein kinase C and phosphatidylinositol 3-kinase., Alcohol. Clin. Exp. Res.
    Do et al., 2002, The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and phosphatidylinositol 3-kinase., Anesth. Analg.
    Keely et al., 1999, ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells., J. Biol. Chem.
    Okaichi et al., Low dose of wortmannin reduces radiosensitivity of human glioblastoma cells through the p53 pathway., Oncol. Rep.
    Yan et al., 2008, [Induction of insulin resistance induced by PI-3K inhibitor in porcine granulosa cells]., Zhonghua Fu Chan Ke Za Zhi
    Semiz et al., 2003, Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules., EMBO J.
    Bose et al., Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c., Nature
    Somwar et al., 2001, Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport., J. Biol. Chem.
    Hartwig et al., 1996, D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate., J. Biol. Chem.
    Zhang et al., 1995, Phosphatidylinositol (3,4,5)-trisphosphate stimulates phosphorylation of pleckstrin in human platelets., J. Biol. Chem.
    Pigazzi et al., 1999, Nitric oxide inhibits thrombin receptor-activating peptide-induced phosphoinositide 3-kinase activity in human platelets., J. Biol. Chem.
    Oki et al., 1999, Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4., Int. Immunol.
    Zhang et al., 2003, [EGF/PI3K signaling pathway regulates the expression of osteopontin in liver cancer HepG2 cells]., Zhonghua Yi Xue Za Zhi
    Kotelevets et al., 1998, Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion., J. Biol. Chem.
    Stein et al., 2006, Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane., J. Gen. Physiol.
    Liu et al., 2007, Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects., J. Biol. Chem.
    Wilson et al., 2005, Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+ sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855, but not Thr-697., Biochem. J.
    Ulrich et al., 1998, Specific TrkA survival signals interfere with different apoptotic pathways., Oncogene
    Nusser et al., 2002, Nerve growth factor signals through TrkA, phosphatidylinositol 3-kinase, and Rac1 to inactivate RhoA during the initiation of neuronal differentiation of PC12 cells., J. Biol. Chem.
    Tirosh et al., 1999, Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation., J. Biol. Chem.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Wang et al., 2006, HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways., J. Surg. Res.
    Duncan et al., 2005, Signal transduction pathways leading to increased eIF4E phosphorylation caused by oxidative stress., Free Radic. Biol. Med.
    Dunzendorfer et al., 1998, Signaling in neuropeptide-induced migration of human eosinophils., J. Leukoc. Biol.
    Yamaguchi et al., 2005, Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes., Am. J. Physiol. Endocrinol. Metab.
    Kang et al., 2002, Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress., Mol. Pharmacol.
  • WORTMANNIN   PLK2

    Interaction Score: 4.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17135248


    Sources:
    DTC

  • WORTMANNIN   EIF2B1

    Interaction Score: 4.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10764740


    Sources:
    NCI

  • WORTMANNIN   SLC1A1

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9502808 14574224 12401608


    Sources:
    NCI

  • WORTMANNIN   PRKAB1

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15928020


    Sources:
    NCI

  • WORTMANNIN   GADD45A

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12066222


    Sources:
    NCI

  • WORTMANNIN   SPP1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14703434


    Sources:
    NCI

  • WORTMANNIN   F2R

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8955143 7559410 10318860


    Sources:
    NCI

  • WORTMANNIN   PLK3

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17135248


    Sources:
    DTC

  • WORTMANNIN   MYO9B

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15823093


    Sources:
    NCI

  • WORTMANNIN   HGF

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9603913


    Sources:
    NCI

  • WORTMANNIN   SLC2A4

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18366935 12743033 12490950 11598141


    Sources:
    NCI

  • WORTMANNIN   CTLA4

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10464177


    Sources:
    NCI

  • WORTMANNIN   TAC1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9850167


    Sources:
    NCI

  • WORTMANNIN   NRG1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10559227


    Sources:
    NCI

  • WORTMANNIN   MAPK10

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15683719


    Sources:
    NCI

  • WORTMANNIN   HSPA4

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16979664


    Sources:
    NCI

  • WORTMANNIN   NTRK1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9484773 12133829


    Sources:
    NCI

  • WORTMANNIN   TRPV1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17074976


    Sources:
    NCI

  • WORTMANNIN   AKT1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10187855


    Sources:
    NCI

  • WORTMANNIN   PLK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17135248 10592235


    Sources:
    NCI

  • WORTMANNIN   THRB

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • WORTMANNIN   HSP90AA1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • WORTMANNIN   RECQL

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • WORTMANNIN   POLI

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • WORTMANNIN   NFE2L2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12391262


    Sources:
    DTC NCI

  • WORTMANNIN   MAPT

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • WORTMANNIN   VDR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • WORTMANNIN   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NCI: WORTMANNIN

    • Version: 14-September-2017

    Alternate Names:
    C1277 NCI drug code

    Drug Info:

    Publications:
    Quevedo et al., 2000, Two different signal transduction pathways are implicated in the regulation of initiation factor 2B activity in insulin-like growth factor-1-stimulated neuronal cells., J. Biol. Chem.
    Do et al., 2002, The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and phosphatidylinositol 3-kinase., Anesth. Analg.
    Davis et al., 1998, Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma., J. Neurosci.

  • DTC: WORTMANNIN

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL428496 ChEMBL Drug ID

    Drug Info:

    Publications:
    Liu et al., 2007, Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects., J. Biol. Chem.

  • ChemblDrugs: chembl:CHEMBL428496

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21