• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

ZALCITABINE Drug Record

  • Summary
  • Interactions
  • Claims
  • ZALCITABINE chembl:CHEMBL853 Approved

    Alternate Names:

    RO-24-2027000
    RO-242027000
    HIVID
    DDC
    NSC-606170
    ZALCITABINE
    DIDEOXYCYTIDINE
    2',3'-DIDEOXYCYTIDINE
    4-AMINO-1-[(2R,5S)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL]PYRIMIDIN-2(1H)-ONE
    RO-242027000/RO-24-2027-000
    HIVID®
    4-AMINO-1-[(2R,5S)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL]PYRIMIDIN-2-ONE
    4-AMINO-1-[(2R,5S)-5-METHYLOLTETRAHYDROFURAN-2-YL]PYRIMIDIN-2-ONE
    4-AZANYL-1-[(2R,5S)-5-(HYDROXYMETHYL)OXOLAN-2-YL]PYRIMIDIN-2-ONE
    DDCYD
    4-AMINO-1-[(2R,5S)-5-(HYDROXYMETHYL)-2-TETRAHYDROFURANYL]-2-PYRIMIDINONE
    DIDEOXYCYTIDINE (DDC)
    4-AMINO-1-[(2R,5S)-5-(HYDROXYMETHYL)OXOLAN-2-YL]PYRIMIDIN-2-ONE
    rxcui:3363
    chemidplus:7481-89-2
    pubchem.compound:24066
    drugbank:00943
    chembl:CHEMBL853

    Drug Info:

    (0 More Sources)

    Publications:

    Kumar et al., 1994, Effect of chronic DDC treatment on LHRH and substance P amidation processes in the rat., Brain Res. Bull.
    Han et al., 2004, 2', 3'-Dideoxycytidine represses thymidine kinases 1 and 2 expression in T-lymphoid cells., Life Sci.
    Skuta et al., 1999, Molecular mechanism of the short-term cardiotoxicity caused by 2',3'-dideoxycytidine (ddC): modulation of reactive oxygen species levels and ADP-ribosylation reactions., Biochem. Pharmacol.
  • ZALCITABINE   TK2

    Interaction Score: 30.91

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14659972


    Sources:
    NCI

  • ZALCITABINE   GNRH1

    Interaction Score: 2.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7507399


    Sources:
    NCI

  • ZALCITABINE   HSPA4

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10591146


    Sources:
    NCI

  • ZALCITABINE   MAPK1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NCI: DDC

    • Version: 14-September-2017

    Alternate Names:
    C430 NCI drug code

    Drug Info:

    Publications:
    Kumar et al., 1994, Effect of chronic DDC treatment on LHRH and substance P amidation processes in the rat., Brain Res. Bull.
    Skuta et al., 1999, Molecular mechanism of the short-term cardiotoxicity caused by 2',3'-dideoxycytidine (ddC): modulation of reactive oxygen species levels and ADP-ribosylation reactions., Biochem. Pharmacol.
    Han et al., 2004, 2', 3'-Dideoxycytidine represses thymidine kinases 1 and 2 expression in T-lymphoid cells., Life Sci.

  • DTC: ZALCITABINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL853 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Zalcitabine

    • Version: 2020.06.01

    Alternate Names:
    D0Z9QR TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL853

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21