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ZANUBRUTINIB Drug Record

  • Summary
  • Interactions
  • Claims
  • ZANUBRUTINIB chembl:CHEMBL3936761 Antineoplastic

    Alternate Names:

    BGB-3111
    ZANUBRUTINIB
    BRUKINSA
    drugbank:15035
    chembl:CHEMBL3936761
    chemidplus:1691249-45-2
    pubchem.compound:135565884

    Drug Info:

    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational
    Drug Categories antineoplastic agents
    Drug Categories cytochrome p-450 cyp2b6 inducers
    Drug Categories cytochrome p-450 cyp2b6 inducers (strength unknown)
    Drug Categories cytochrome p-450 cyp2b6 substrates
    Drug Categories cytochrome p-450 cyp2b6 substrates with a narrow therapeutic index
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a4 substrates
    Drug Categories cytochrome p-450 cyp3a4 substrates with a narrow therapeutic index
    Drug Categories cytochrome p-450 enzyme inducers
    Drug Categories cytochrome p-450 substrates
    Drug Categories enzyme inhibitors
    Drug Categories hematologic agents
    Drug Categories narrow therapeutic index drugs
    Drug Categories p-glycoprotein substrates
    Drug Categories protein kinase inhibitors
    Drug Categories teratogens
    (0 More Sources)

    Publications:

    Tam CS et al., 2019, Phase 1 study of the selective BTK inhibitor zanubrutinib in B-cell malignancies and safety and efficacy evaluation in CLL., Blood
    Tarantelli C et al., 2019, The Bruton tyrosine kinase inhibitor zanubrutinib (BGB-3111) demonstrated synergies with other anti-lymphoma targeted agents., Haematologica
    Guo Y et al., 2019, Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase., J Med Chem
  • ZANUBRUTINIB   TEC

    Interaction Score: 1.89

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    31340982 31381333


    Sources:
    DrugBank

  • ZANUBRUTINIB   BMX

    Interaction Score: 1.89

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    31340982 31381333


    Sources:
    DrugBank

  • ZANUBRUTINIB   TXK

    Interaction Score: 1.26

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    31381333


    Sources:
    DrugBank

  • ZANUBRUTINIB   FGR

    Interaction Score: 0.76

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    31381333


    Sources:
    DrugBank

  • ZANUBRUTINIB   PTK6

    Interaction Score: 0.76

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    31381333


    Sources:
    DrugBank

  • ZANUBRUTINIB   BTK

    Interaction Score: 0.6

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Inhibition of the enzymatic activity of recombinant human BTK in a TR-FRET assay.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    31340982 30679329 31381333


    Sources:
    TTD DrugBank GuideToPharmacology

  • ZANUBRUTINIB   ITK

    Interaction Score: 0.49

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    31340982 31381333


    Sources:
    DrugBank

  • ZANUBRUTINIB   BLK

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    31340982 31381333


    Sources:
    DrugBank

  • ZANUBRUTINIB   ERBB4

    Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    31340982 31381333


    Sources:
    DrugBank

  • ZANUBRUTINIB   FRK

    Interaction Score: 0.24

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    31381333


    Sources:
    DrugBank

  • ZANUBRUTINIB   JAK2

    Interaction Score: 0.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    31340982 31381333


    Sources:
    DrugBank

  • ZANUBRUTINIB   JAK3

    Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    31381333


    Sources:
    DrugBank

  • ZANUBRUTINIB   LCK

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    31381333


    Sources:
    DrugBank

  • ZANUBRUTINIB   ERBB2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    31340982 31381333


    Sources:
    DrugBank

  • ZANUBRUTINIB   EGFR

    Interaction Score: 0.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    31340982 31381333


    Sources:
    DrugBank

  • DrugBank: DB15035

    • Version: 5.1.7

    Alternate Names:
    ZANUBRUTINIB DrugBank Drug Name
    1691249-45-2 CAS Number
    Brukinsa Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Tam CS et al., 2019, Phase 1 study of the selective BTK inhibitor zanubrutinib in B-cell malignancies and safety and efficacy evaluation in CLL., Blood
    Guo Y et al., 2019, Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase., J Med Chem
    Tarantelli C et al., 2019, The Bruton tyrosine kinase inhibitor zanubrutinib (BGB-3111) demonstrated synergies with other anti-lymphoma targeted agents., Haematologica

  • GuideToPharmacology: 363894155

    • Version: 29-September-2020

    Alternate Names:
    ZANUBRUTINIB GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • TTD: BGB-3111

    • Version: 2020.06.01

    Alternate Names:
    D0UT4W TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL3936761

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21