DGIdb - ZOLEDRONIC ACID Drug Record

ZOLEDRONIC ACID chembl:CHEMBL924 Approved

Alternate Names:

CGP-42446
ZOLEDRONIC ACID MONOHYDRATE
ZOMETA
ZOLEDRONIC ACID
ACLASTA
ZOLEDRONIC ACID HYDRATE
CGP-42446A
RECLAST
ZERLINDA
ACLASTA®
ZOLEDRONIC ACID, ANHYDROUS
RECLAST®
ZOL446
ZOLEDRONIC ACID ANHYDROUS
(1-HYDROXY-2-IMIDAZOL-1-YLETHYLIDENE)DIPHOSPHONIC ACID
ZOL
ANHYDROUS ZOLEDRONIC ACID
ZOLEDRONATE
(1-HYDROXY-2-(1H-IMIDAZOL-1-YL)ETHYLIDENE)BISPHOSPHONIC ACID
ZOMETA®
drugbank:00399
pubchem.compound:68740
chembl:CHEMBL924
rxcui:1546014
chemidplus:118072-93-8

Drug Info:

Drug Class	bisphosphonates
Year of Approval	2001
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antiosteoporotic agent

(3 More Sources)

Publications:

Marini F et al., 2011, Pharmacogenetics of bisphosphonate-associated osteonecrosis of the jaw., Front Biosci (Elite Ed)
Sarasquete ME et al., 2008, Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis., Blood
Heikkilä et al., 2002, Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines., Anticancer Drugs

ZOLEDRONIC ACID GGPS1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Zoledronic

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ZOLEDRONIC ACID FDPS

Interaction Score: 5.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Farnesyl diphosphate synthase inhibitor

Direct Interaction yes

Trial Name Zoledronic

PMIDs:
21196316

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
ZOLEDRONIC ACID PPCDC

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ZOLEDRONIC ACID CYP2C8

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18594024

Sources:
PharmGKB
ZOLEDRONIC ACID PLAU

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11984068

Sources:
NCI
ZOLEDRONIC ACID PPARG

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

TEND: ZOLEDRONATE
- Version: 01-August-2011
Alternate Names:

ZOLEDRONATE Primary Drug Name

Drug Info:

Year of Approval 2001

Drug Class bisphosphonates

Publications:
TdgClinicalTrial: ZOLEDRONATE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiosteoporotic agent

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: ZOLEDRONATE

Version: 14-September-2017

Alternate Names:

C1699 NCI drug code

Drug Info:

Publications:

Heikkilä et al., 2002, Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines., Anticancer Drugs

PharmGKB: zoledronate

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Marini F et al., 2011, Pharmacogenetics of bisphosphonate-associated osteonecrosis of the jaw., Front Biosci (Elite Ed)

Sarasquete ME et al., 2008, Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis., Blood

TTD: Zoledronate
- Version: 2020.06.01
Alternate Names:

D0VM2L TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL924
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL924
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Farnesyl diphosphate synthase inhibitor
Direct Interaction	yes
Trial Name	Zoledronic

Trial Name	Zoledronic
Novel drug target	Established target

ZOLEDRONIC ACID Drug Record

ZOLEDRONIC ACID chembl:CHEMBL924 Approved

Alternate Names:

Drug Info:

Publications:

ZOLEDRONIC ACID GGPS1

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Zoledronic Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

ZOLEDRONIC ACID FDPS

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Farnesyl diphosphate synthase inhibitor Direct Interaction yes Trial Name Zoledronic

PMIDs: 21196316

Sources: TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

ZOLEDRONIC ACID PPCDC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

ZOLEDRONIC ACID CYP2C8

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18594024

Sources: PharmGKB

ZOLEDRONIC ACID PLAU

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11984068

Sources: NCI

ZOLEDRONIC ACID PPARG

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

TEND: ZOLEDRONATE

Alternate Names: ZOLEDRONATE Primary Drug Name

Drug Info: Year of Approval 2001 Drug Class bisphosphonates

Publications:

TdgClinicalTrial: ZOLEDRONATE

Alternate Names:

Drug Info: Drug Indications antiosteoporotic agent Drug Class Small Molecule FDA Approval approved

Publications:

NCI: ZOLEDRONATE

Alternate Names: C1699 NCI drug code

Drug Info:

PharmGKB: zoledronate

Alternate Names:

Drug Info:

TTD: Zoledronate

Alternate Names: D0VM2L TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL924

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL924

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Zoledronic

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Farnesyl diphosphate synthase inhibitor

Direct Interaction yes

Trial Name Zoledronic

PMIDs:
21196316

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18594024

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11984068

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

ZOLEDRONATE Primary Drug Name

Drug Info:

Year of Approval 2001

Drug Class bisphosphonates

Drug Info:

Drug Indications antiosteoporotic agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C1699 NCI drug code

Alternate Names:

D0VM2L TTD Drug ID