DGIdb - ZOLPIDEM Drug Record

ZOLPIDEM chembl:CHEMBL911 Approved

Alternate Names:

ZOLPIDEM CIV
ZOLPIDEM
AMBIEN
STILNOCT®
AMBIEN®
N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)IMIDAZO(1,2-A)PYRIDINE-3-ACETAMIDE
SL-80.0750-23N
ZOLPIDEMUM
SL 80.0750-23N
pubchem.compound:5732
rxcui:39993
chembl:CHEMBL911
drugbank:00425
chemidplus:82626-48-0

Drug Info:

Year of Approval	1992
Drug Class	hypnotics and sedatives
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	hypnotic
Drug Categories	benzodiazepine hypnotics and sedatives
Drug Categories	central nervous system depression
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 substrates
Drug Categories	gamma-aminobutyric acid-ergic agonist
Drug Categories	miscellaneous anxiolytics sedatives and hypnotics
Drug Categories	pyridines
Drug Categories	sleep aids, pharmaceutical

(4 More Sources)

Publications:

Crestani F et al., 2000, Mechanism of action of the hypnotic zolpidem in vivo., Br J Pharmacol
Smith et al., 2001, Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux., Mol. Pharmacol.
Tan KR et al., 2011, Hooked on benzodiazepines: GABAA receptor subtypes and addiction., Trends Neurosci
Vlainić et al., 2009, Effects of acute and repeated zolpidem treatment on pentylenetetrazole-induced seizure threshold and on locomotor activity: comparison with diazepam., Neuropharmacology
Pritchett et al., 1990, Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology., J. Neurochem.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Sramka M et al., 1975, Surgical complication of posterior hypothalamotomy., Confin Neurol
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Criswell HE et al., 1995, Effect of zolpidem on gamma-aminobutyric acid (GABA)-induced inhibition predicts the interaction of ethanol with GABA on individual neurons in several rat brain regions., J Pharmacol Exp Ther
Hadingham et al., 1996, Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors., Mol. Pharmacol.

ZOLPIDEM GABRA2

Interaction Score: 0.57

Interaction Types & Directionality:

agonist (activating)

allosteric modulator

Interaction Info:

Details of the Assay for Interaction Assay using recombinant GABA<sub>A</sub> channels with subunit composition; α2β1γ2.

Specific Action of the Ligand Positive

Endogenous Drug? False

PMIDs:
11090095 11306694 21353710 19345234 2157817

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology

ZOLPIDEM GABRA3

Interaction Score: 0.57

Interaction Types & Directionality:

agonist (activating)

allosteric modulator

Interaction Info:

Trial Name OX-22, zolpidem sublingual,Edluar, Sublinox

Novel drug target Established target

Direct Interaction? False

PMIDs:
11090095 11306694 21353710 19345234 2157817

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology

ZOLPIDEM GABRA1

Interaction Score: 0.53

Interaction Types & Directionality:

agonist (activating)

allosteric modulator

potentiator

Interaction Info:

Details of the Assay for Interaction Assay using recombinant GABA<sub>A</sub> channels with subunit composition; α1β3γ2.

Specific Action of the Ligand Positive

Endogenous Drug? False

PMIDs:
11306694 21353710 17139284 1093783 19345234 17016423 2157817

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

ZOLPIDEM GABRG2

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
7714808 8632757 19345234

Sources:
DrugBank
ZOLPIDEM TSPO

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
ZOLPIDEM GABRG3

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ZOLPIDEM CYP3A5

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ZOLPIDEM HSD17B10

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ZOLPIDEM CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB
ZOLPIDEM AR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00425

Version: 5.1.7

Alternate Names:

ZOLPIDEM DrugBank Drug Name

82626-48-0 CAS Number

Adormix Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories benzodiazepine hypnotics and sedatives

Publications:

Crestani F et al., 2000, Mechanism of action of the hypnotic zolpidem in vivo., Br J Pharmacol

Smith et al., 2001, Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux., Mol. Pharmacol.

Tan KR et al., 2011, Hooked on benzodiazepines: GABAA receptor subtypes and addiction., Trends Neurosci

TEND: ZOLPIDEM
- Version: 01-August-2011
Alternate Names:

ZOLPIDEM Primary Drug Name

Drug Info:

Drug Class hypnotics and sedatives

Year of Approval 1992

Publications:
TdgClinicalTrial: ZOLPIDEM
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications hypnotic

Drug Class Small Molecule

FDA Approval approved

Publications:
PharmGKB: zolpidem
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
TTD: Zolpidem
- Version: 2020.06.01
Alternate Names:

D0T1WN TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178101165
- Version: 29-September-2020
Alternate Names:

ZOLPIDEM GuideToPharmacology Ligand Name

Drug Info:

Publications:
DTC: ZOLPIDEM
- Version: 02-September-2020
Alternate Names:

CHEMBL911 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL911
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Details of the Assay for Interaction	Assay using recombinant GABA<sub>A</sub> channels with subunit composition; α2β1γ2.
Specific Action of the Ligand	Positive
Endogenous Drug?	False

Trial Name	OX-22, zolpidem sublingual,Edluar, Sublinox
Novel drug target	Established target
Direct Interaction?	False

ZOLPIDEM	DrugBank Drug Name
82626-48-0	CAS Number
Adormix	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	benzodiazepine hypnotics and sedatives

ZOLPIDEM Drug Record

ZOLPIDEM chembl:CHEMBL911 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating) allosteric modulator

Interaction Info: Details of the Assay for Interaction Assay using recombinant GABA<sub>A</sub> channels with subunit composition; &alpha;2&beta;1&gamma;2. Specific Action of the Ligand Positive Endogenous Drug? False

PMIDs: 11090095 11306694 21353710 19345234 2157817

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: agonist (activating) allosteric modulator

Interaction Info: Trial Name OX-22, zolpidem sublingual,Edluar, Sublinox Novel drug target Established target Direct Interaction? False

PMIDs: 11090095 11306694 21353710 19345234 2157817

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: agonist (activating) allosteric modulator potentiator

Interaction Info: Details of the Assay for Interaction Assay using recombinant GABA<sub>A</sub> channels with subunit composition; &alpha;1&beta;3&gamma;2. Specific Action of the Ligand Positive Endogenous Drug? False

PMIDs: 11306694 21353710 17139284 1093783 19345234 17016423 2157817

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 7714808 8632757 19345234

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB00425

Alternate Names: ZOLPIDEM DrugBank Drug Name 82626-48-0 CAS Number Adormix Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories benzodiazepine hypnotics and sedatives

TEND: ZOLPIDEM

Alternate Names: ZOLPIDEM Primary Drug Name

Drug Info: Drug Class hypnotics and sedatives Year of Approval 1992

Publications:

TdgClinicalTrial: ZOLPIDEM

Alternate Names:

Drug Info: Drug Indications hypnotic Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: zolpidem

Alternate Names:

Drug Info:

Publications: Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

TTD: Zolpidem

Alternate Names: D0T1WN TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 178101165

Alternate Names: ZOLPIDEM GuideToPharmacology Ligand Name

Drug Info:

Publications:

DTC: ZOLPIDEM

Alternate Names: CHEMBL911 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL911

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

allosteric modulator

Interaction Info:

Details of the Assay for Interaction Assay using recombinant GABA<sub>A</sub> channels with subunit composition; α2β1γ2.

Specific Action of the Ligand Positive

Endogenous Drug? False

PMIDs:
11090095 11306694 21353710 19345234 2157817

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

allosteric modulator

Interaction Info:

Trial Name OX-22, zolpidem sublingual,Edluar, Sublinox

Novel drug target Established target

Direct Interaction? False

PMIDs:
11090095 11306694 21353710 19345234 2157817

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

allosteric modulator

potentiator

Interaction Info:

Details of the Assay for Interaction Assay using recombinant GABA<sub>A</sub> channels with subunit composition; α1β3γ2.

Specific Action of the Ligand Positive

Endogenous Drug? False

PMIDs:
11306694 21353710 17139284 1093783 19345234 17016423 2157817

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

PMIDs:
7714808 8632757 19345234

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

ZOLPIDEM DrugBank Drug Name

82626-48-0 CAS Number

Adormix Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories benzodiazepine hypnotics and sedatives

Alternate Names:

ZOLPIDEM Primary Drug Name

Drug Info:

Drug Class hypnotics and sedatives

Year of Approval 1992

Drug Info:

Drug Indications hypnotic

Drug Class Small Molecule

FDA Approval approved

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Alternate Names:

D0T1WN TTD Drug ID

Alternate Names:

ZOLPIDEM GuideToPharmacology Ligand Name

Alternate Names:

CHEMBL911 ChEMBL Drug ID