DGIdb - ZOLPIDEM Drug Record

ZOLPIDEM chembl:CHEMBL911 Approved

Alternate Names:

ZOLPIDEM CIV
ZOLPIDEM
AMBIEN
STILNOCT®
AMBIEN®
N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)IMIDAZO(1,2-A)PYRIDINE-3-ACETAMIDE
SL-80.0750-23N
ZOLPIDEMUM
SL 80.0750-23N
pubchem.compound:5732
rxcui:39993
chembl:CHEMBL911
drugbank:00425
chemidplus:82626-48-0

Drug Info:

Year of Approval	1992
Drug Class	hypnotics and sedatives
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	hypnotic

(3 More Sources)

Publications:

Smith et al., 2001, Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux., Mol. Pharmacol.
Pritchett et al., 1990, Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology., J. Neurochem.
Crestani F et al., 2000, Mechanism of action of the hypnotic zolpidem in vivo., Br J Pharmacol
Vlainić et al., 2009, Effects of acute and repeated zolpidem treatment on pentylenetetrazole-induced seizure threshold and on locomotor activity: comparison with diazepam., Neuropharmacology
Tan KR et al., 2011, Hooked on benzodiazepines: GABAA receptor subtypes and addiction., Trends Neurosci
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Sramka M et al., 1975, Surgical complication of posterior hypothalamotomy., Confin Neurol
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

ZOLPIDEM GABRA1

Interaction Score: 0.8

Interaction Types & Directionality:

agonist (activating)

allosteric modulator

potentiator

Interaction Info:

Details of the Assay for Interaction Assay using recombinant GABA<sub>A</sub> channels with subunit composition; α1β3γ2.

Specific Action of the Ligand Positive

Endogenous Drug? False

PMIDs:
2157817 17016423 17139284 11306694 19345234 21353710 1093783

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD

ZOLPIDEM GABRA3

Interaction Score: 0.68

Interaction Types & Directionality:

agonist (activating)

allosteric modulator

Interaction Info:

Trial Name OX-22, zolpidem sublingual,Edluar, Sublinox

Novel drug target Established target

Direct Interaction? False

PMIDs:
11306694 2157817 11090095 19345234 21353710

Sources:
TdgClinicalTrial TEND GuideToPharmacology

ZOLPIDEM GABRA2

Interaction Score: 0.68

Interaction Types & Directionality:

agonist (activating)

allosteric modulator

Interaction Info:

Details of the Assay for Interaction Assay using recombinant GABA<sub>A</sub> channels with subunit composition; α2β1γ2.

Specific Action of the Ligand Positive

Endogenous Drug? False

PMIDs:
11306694 2157817 11090095 19345234 21353710

Sources:
TdgClinicalTrial TEND GuideToPharmacology

ZOLPIDEM TSPO

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
ZOLPIDEM GABRG3

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ZOLPIDEM CYP3A5

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ZOLPIDEM HSD17B10

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ZOLPIDEM CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB
ZOLPIDEM AR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: ZOLPIDEM
- Version: 01-August-2011
Alternate Names:

ZOLPIDEM Primary Drug Name

Drug Info:

Drug Class hypnotics and sedatives

Year of Approval 1992

Publications:
TdgClinicalTrial: ZOLPIDEM
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications hypnotic

Drug Class Small Molecule

FDA Approval approved

Publications:
PharmGKB: zolpidem
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
TTD: Zolpidem
- Version: 2020.06.01
Alternate Names:

D0T1WN TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178101165
- Version: 29-September-2020
Alternate Names:

ZOLPIDEM GuideToPharmacology Ligand Name

Drug Info:

Publications:
DTC: ZOLPIDEM
- Version: 02-September-2020
Alternate Names:

CHEMBL911 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL911
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Details of the Assay for Interaction	Assay using recombinant GABA<sub>A</sub> channels with subunit composition; α1β3γ2.
Specific Action of the Ligand	Positive
Endogenous Drug?	False

Trial Name	OX-22, zolpidem sublingual,Edluar, Sublinox
Novel drug target	Established target
Direct Interaction?	False

ZOLPIDEM Drug Record

ZOLPIDEM chembl:CHEMBL911 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating) allosteric modulator potentiator

Interaction Info: Details of the Assay for Interaction Assay using recombinant GABA<sub>A</sub> channels with subunit composition; &alpha;1&beta;3&gamma;2. Specific Action of the Ligand Positive Endogenous Drug? False

PMIDs: 2157817 17016423 17139284 11306694 19345234 21353710 1093783

Sources: TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating) allosteric modulator

Interaction Info: Trial Name OX-22, zolpidem sublingual,Edluar, Sublinox Novel drug target Established target Direct Interaction? False

PMIDs: 11306694 2157817 11090095 19345234 21353710

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: agonist (activating) allosteric modulator

Interaction Info: Details of the Assay for Interaction Assay using recombinant GABA<sub>A</sub> channels with subunit composition; &alpha;2&beta;1&gamma;2. Specific Action of the Ligand Positive Endogenous Drug? False

PMIDs: 11306694 2157817 11090095 19345234 21353710

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: ZOLPIDEM

Alternate Names: ZOLPIDEM Primary Drug Name

Drug Info: Drug Class hypnotics and sedatives Year of Approval 1992

Publications:

TdgClinicalTrial: ZOLPIDEM

Alternate Names:

Drug Info: Drug Indications hypnotic Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: zolpidem

Alternate Names:

Drug Info:

Publications: Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

TTD: Zolpidem

Alternate Names: D0T1WN TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 178101165

Alternate Names: ZOLPIDEM GuideToPharmacology Ligand Name

Drug Info:

Publications:

DTC: ZOLPIDEM

Alternate Names: CHEMBL911 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL911

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

allosteric modulator

potentiator

Interaction Info:

Details of the Assay for Interaction Assay using recombinant GABA<sub>A</sub> channels with subunit composition; α1β3γ2.

Specific Action of the Ligand Positive

Endogenous Drug? False

PMIDs:
2157817 17016423 17139284 11306694 19345234 21353710 1093783

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

allosteric modulator

Interaction Info:

Trial Name OX-22, zolpidem sublingual,Edluar, Sublinox

Novel drug target Established target

Direct Interaction? False

PMIDs:
11306694 2157817 11090095 19345234 21353710

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

allosteric modulator

Interaction Info:

Details of the Assay for Interaction Assay using recombinant GABA<sub>A</sub> channels with subunit composition; α2β1γ2.

Specific Action of the Ligand Positive

Endogenous Drug? False

PMIDs:
11306694 2157817 11090095 19345234 21353710

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

ZOLPIDEM Primary Drug Name

Drug Info:

Drug Class hypnotics and sedatives

Year of Approval 1992

Drug Info:

Drug Indications hypnotic

Drug Class Small Molecule

FDA Approval approved

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Alternate Names:

D0T1WN TTD Drug ID

Alternate Names:

ZOLPIDEM GuideToPharmacology Ligand Name

Alternate Names:

CHEMBL911 ChEMBL Drug ID