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ZOLPIDEM Drug Record

  • Summary
  • Interactions
  • Claims
  • ZOLPIDEM chembl:CHEMBL911 Approved

    Alternate Names:

    ZOLPIDEM CIV
    ZOLPIDEM
    AMBIEN
    STILNOCT®
    AMBIEN®
    N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)IMIDAZO(1,2-A)PYRIDINE-3-ACETAMIDE
    SL-80.0750-23N
    ZOLPIDEMUM
    SL 80.0750-23N
    pubchem.compound:5732
    rxcui:39993
    chembl:CHEMBL911
    drugbank:00425
    chemidplus:82626-48-0

    Drug Info:

    Year of Approval 1992
    Drug Class hypnotics and sedatives
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications hypnotic
    Drug Categories benzodiazepine hypnotics and sedatives
    Drug Categories central nervous system depression
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 substrates
    Drug Categories gamma-aminobutyric acid-ergic agonist
    Drug Categories miscellaneous anxiolytics sedatives and hypnotics
    Drug Categories pyridines
    Drug Categories sleep aids, pharmaceutical
    (4 More Sources)

    Publications:

    Crestani F et al., 2000, Mechanism of action of the hypnotic zolpidem in vivo., Br J Pharmacol
    Smith et al., 2001, Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux., Mol. Pharmacol.
    Tan KR et al., 2011, Hooked on benzodiazepines: GABAA receptor subtypes and addiction., Trends Neurosci
    Vlainić et al., 2009, Effects of acute and repeated zolpidem treatment on pentylenetetrazole-induced seizure threshold and on locomotor activity: comparison with diazepam., Neuropharmacology
    Pritchett et al., 1990, Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology., J. Neurochem.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Sramka M et al., 1975, Surgical complication of posterior hypothalamotomy., Confin Neurol
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Criswell HE et al., 1995, Effect of zolpidem on gamma-aminobutyric acid (GABA)-induced inhibition predicts the interaction of ethanol with GABA on individual neurons in several rat brain regions., J Pharmacol Exp Ther
    Hadingham et al., 1996, Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors., Mol. Pharmacol.
  • ZOLPIDEM   GABRA2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    agonist (activating)
    allosteric modulator

    Interaction Info:
    Details of the Assay for Interaction Assay using recombinant GABA<sub>A</sub> channels with subunit composition; &alpha;2&beta;1&gamma;2.
    Specific Action of the Ligand Positive
    Endogenous Drug? False

    PMIDs:
    11090095 11306694 21353710 19345234 2157817


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • ZOLPIDEM   GABRA3

    Interaction Score: 0.57

    Interaction Types & Directionality:
    agonist (activating)
    allosteric modulator

    Interaction Info:
    Trial Name OX-22, zolpidem sublingual,Edluar, Sublinox
    Novel drug target Established target
    Direct Interaction? False

    PMIDs:
    11090095 11306694 21353710 19345234 2157817


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • ZOLPIDEM   GABRA1

    Interaction Score: 0.53

    Interaction Types & Directionality:
    agonist (activating)
    allosteric modulator
    potentiator

    Interaction Info:
    Details of the Assay for Interaction Assay using recombinant GABA<sub>A</sub> channels with subunit composition; &alpha;1&beta;3&gamma;2.
    Specific Action of the Ligand Positive
    Endogenous Drug? False

    PMIDs:
    11306694 21353710 17139284 1093783 19345234 17016423 2157817


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • ZOLPIDEM   GABRG2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    7714808 8632757 19345234


    Sources:
    DrugBank

  • ZOLPIDEM   TSPO

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • ZOLPIDEM   GABRG3

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ZOLPIDEM   CYP3A5

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ZOLPIDEM   HSD17B10

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ZOLPIDEM   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528


    Sources:
    PharmGKB

  • ZOLPIDEM   AR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB00425

    • Version: 5.1.7

    Alternate Names:
    ZOLPIDEM DrugBank Drug Name
    82626-48-0 CAS Number
    Adormix Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories benzodiazepine hypnotics and sedatives

    Publications:
    Crestani F et al., 2000, Mechanism of action of the hypnotic zolpidem in vivo., Br J Pharmacol
    Smith et al., 2001, Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux., Mol. Pharmacol.
    Tan KR et al., 2011, Hooked on benzodiazepines: GABAA receptor subtypes and addiction., Trends Neurosci

  • TEND: ZOLPIDEM

    • Version: 01-August-2011

    Alternate Names:
    ZOLPIDEM Primary Drug Name

    Drug Info:
    Drug Class hypnotics and sedatives
    Year of Approval 1992

    Publications:

  • TdgClinicalTrial: ZOLPIDEM

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications hypnotic
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • PharmGKB: zolpidem

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

  • TTD: Zolpidem

    • Version: 2020.06.01

    Alternate Names:
    D0T1WN TTD Drug ID

    Drug Info:

    Publications:

  • GuideToPharmacology: 178101165

    • Version: 29-September-2020

    Alternate Names:
    ZOLPIDEM GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • DTC: ZOLPIDEM

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL911 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL911

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2021-04-13