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ABCB1 Gene Record

  • Summary
  • Interactions
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  • ABCB1 5243 Druggable GenomeDrug Resistance

    Alternate Names:

    5243
    ATP BINDING CASSETTE SUBFAMILY B MEMBER 1
    ABCB1
    ABC20
    CD243
    CLCS
    GP170
    MDR1
    P-GP
    PGY1
    171050
    40
    ENSG00000085563
    OTTHUMG00000023393
    P08183
    MDR1_HUMAN
    4244
    PA267
    MULTIDRUG RESISTANCE PROTEIN 1 (P-GLYCOPROTEIN 1) (CD243 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P08183]
    CD_antigen=CD243
    P-glycoprotein 1
    ATP-binding cassette sub-family B member 1
    Multidrug resistance protein 1
    T25258
    p-170

    Gene Info:

    Transmembrane Helix Count 12
    Target Subclass ABCB
    Target Subclass Active_transporters
    Target Main Class Transporters
    Target Class Transporters
    Target Subclass TC:3.A.1.201.1
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001140
    Interpro Short Name ABC_transptr_TM_dom
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name ABC transporter, transmembrane domain
    Human Readable Name ABC TRANSPORTER
    Gene Biotype PROTEIN_CODING
    (12 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    CELL SURFACE
    DRUG RESISTANCE
    ABC TRANSPORTER
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Baietto L et al., 2015, Effect of SNPs in human ABCB1 on daptomycin pharmacokinetics in Caucasian patients., J Antimicrob Chemother
    Gréen et al., 2006, mdr-1 single nucleotide polymorphisms in ovarian cancer tissue: G2677T/A correlates with response to paclitaxel chemotherapy., Clin. Cancer Res.
    Spletstoser JT et al., 2006, Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells., Bioorg Med Chem Lett
    Nanovskaya et al., 2005, Role of P-glycoprotein in transplacental transfer of methadone., Biochem. Pharmacol.
    Uhr et al., 2004, P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into the mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6., J. Psychopharmacol. (Oxford)
    Nievergelt A et al., 2010, Identification of serotonin 5-HT1A receptor partial agonists in ginger., Bioorg Med Chem
    Marks KM et al., 2011, The selectivity of austocystin D arises from cell-line-specific drug activation by cytochrome P450 enzymes., J Nat Prod
    Juvale K et al., 2012, Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein., Bioorg Med Chem
    Ehmann F et al., 2014, European Medicines Agency initiatives and perspectives on pharmacogenomics., Br J Clin Pharmacol
    Ghanem et al., 2006, Induction of rat intestinal P-glycoprotein by spironolactone and its effect on absorption of orally administered digoxin., J. Pharmacol. Exp. Ther.
    Brandes et al., 2000, N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine (DPPE) a chemopotentiating and cytoprotective agent in clinical trials: interaction with histamine at cytochrome P450 3A4 and other isozymes that metabolize antineoplastic drugs., Cancer Chemother. Pharmacol.
    Vincent, 2006, Tesmilifene may enhance breast cancer chemotherapy by killing a clone of aggressive, multi-drug resistant cells through its action on the p-glycoprotein pump., Med. Hypotheses
    D'Emanuele et al., 2004, The use of a dendrimer-propranolol prodrug to bypass efflux transporters and enhance oral bioavailability., J Control Release
    Cunningham CW et al., 2008, Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs., J Med Chem
    Saiz-Rodríguez M et al., 2018, Effect of ABCB1 C3435T Polymorphism on Pharmacokinetics of Antipsychotics and Antidepressants., Basic Clin Pharmacol Toxicol
    Wang R et al., 2018, ABCB1 1199G > A Polymorphism Impacts Transport Ability of P-gp-Mediated Antipsychotics., DNA Cell Biol
    Vandenberghe F et al., 2015, Genetics-Based Population Pharmacokinetics and Pharmacodynamics of Risperidone in a Psychiatric Cohort., Clin Pharmacokinet
    Suzuki Y et al., 2014, Effect of risperidone metabolism and P-glycoprotein gene polymorphism on QT interval in patients with schizophrenia., Pharmacogenomics J
    Choong E et al., 2013, Pharmacogenetic study on risperidone long-acting injection: influence of cytochrome P450 2D6 and pregnane X receptor on risperidone exposure and drug-induced side-effects., J Clin Psychopharmacol
    Correia CT et al., 2010, Pharmacogenetics of risperidone therapy in autism: association analysis of eight candidate genes with drug efficacy and adverse drug reactions., Pharmacogenomics J
    Ogino J et al., 1996, Dendroamides, new cyclic hexapeptides from a blue-green alga. Multidrug-resistance reversing activity of dendroamide A., J Nat Prod
    Kang et al., 2007, The effect of MDR1 G2677T/A polymorphism on pharmacokinetics of gabapentin in healthy Korean subjects., Arch. Pharm. Res.
    Zhang Y et al., 2017, Correlation of MDR1 gene polymorphism with propofol combined with remifentanil anesthesia in pediatric tonsillectomy., Oncotarget
    Roberts RL et al., 2002, A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression., Pharmacogenomics J
    Colabufo NA et al., 2008, Synthesis and biological evaluation of (hetero)arylmethyloxy- and arylmethylamine-phenyl derivatives as potent P-glycoprotein modulating agents., J Med Chem
    Asano T et al., 2003, ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation., Pharmacogenetics
    Yokoi M et al., 2018, Genetic risk factors for chemotherapy-induced nausea and vomiting in patients with cancer receiving cisplatin-based chemotherapy., Support Care Cancer
    Tsuji D et al., 2017, Influence of ABCB1 and ABCG2 polymorphisms on the antiemetic efficacy in patients with cancer receiving cisplatin-based chemotherapy: a TRIPLE pharmacogenomics study., Pharmacogenomics J
    Weiss J et al., 2009, CYP2C19 genotype is a major factor contributing to the highly variable pharmacokinetics of voriconazole., J Clin Pharmacol
    Tong L et al., 2007, Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro., Antimicrob Agents Chemother
    Liu X et al., 2017, Impact of Single Nucleotide Polymorphisms on Plasma Concentrations of Efavirenz and Lopinavir/Ritonavir in Chinese Children Infected with the Human Immunodeficiency Virus., Pharmacotherapy
    Tsai MS et al., 2017, Treatment response to unboosted atazanavir in combination with tenofovir disoproxil fumarate and lamivudine in human immunodeficiency virus-1-infected patients who have achieved virological suppression: A therapeutic drug monitoring and pharmacogenetic study., J Microbiol Immunol Infect
    Bonora S et al., 2015, Successful pharmacogenetics-based optimization of unboosted atazanavir plasma exposure in HIV-positive patients: a randomized, controlled, pilot study (the REYAGEN study)., J Antimicrob Chemother
    Avihingsanon A et al., 2015, Pharmacogenetic testing can identify patients taking atazanavir at risk for hyperbilirubinemia., J Acquir Immune Defic Syndr
    Nishijima T et al., 2014, Single-nucleotide polymorphisms in the UDP-glucuronosyltransferase 1A-3' untranslated region are associated with atazanavir-induced nephrolithiasis in patients with HIV-1 infection: a pharmacogenetic study., J Antimicrob Chemother
    D'Avolio A et al., 2014, Intracellular accumulation of atazanavir/ritonavir according to plasma concentrations and OATP1B1, ABCB1 and PXR genetic polymorphisms., J Antimicrob Chemother
    Coelho AV et al., 2013, ABCB1 and ABCC1 variants associated with virological failure of first-line protease inhibitors antiretroviral regimens in Northeast Brazil patients., J Clin Pharmacol
    Lubomirov R et al., 2011, Association of pharmacogenetic markers with premature discontinuation of first-line anti-HIV therapy: an observational cohort study., J Infect Dis
    Park WB et al., 2010, Genetic factors influencing severe atazanavir-associated hyperbilirubinemia in a population with low UDP-glucuronosyltransferase 1A1*28 allele frequency., Clin Infect Dis
    Ma Q et al., 2007, Multidrug resistance 1 polymorphisms and trough concentrations of atazanavir and lopinavir in patients with HIV., Pharmacogenomics
    Rodríguez-Nóvoa S et al., 2007, Genetic factors influencing atazanavir plasma concentrations and the risk of severe hyperbilirubinemia., AIDS
    Hogg M et al., 1991, Chloride influx in human leucocytes: a triple-isotope technique for the assessment of chloride transporters., Clin Sci (Lond)
    Rodríguez Nóvoa et al., 2006, Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by the 3435C-->T polymorphism at the multidrug resistance gene 1., Clin. Infect. Dis.
    Haas DW et al., 2003, MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: an adult AIDS Clinical Trials Group study., J Acquir Immune Defic Syndr
    Gregers J et al., 2015, Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia., Pharmacogenomics J
    Castañeda-Gómez J et al., 2013, Purgin II, a resin glycoside ester-type dimer and inhibitor of multidrug efflux pumps from Ipomoea purga., J Nat Prod
    Figueroa-González G et al., 2012, Reversal of multidrug resistance by morning glory resin glycosides in human breast cancer cells., J Nat Prod
    Aubrun F et al., 2018, Opioid-related genetic polymorphisms do not influence postoperative opioid requirement: A prospective observational study., Eur J Anaesthesiol
    Sadhasivam S et al., 2015, Opioid-induced respiratory depression: ABCB1 transporter pharmacogenetics., Pharmacogenomics J
    Venkatasubramanian R et al., 2014, ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children., Pharmacogenomics
    Bastami S et al., 2014, Influence of UGT2B7, OPRM1 and ABCB1 gene polymorphisms on postoperative morphine consumption., Basic Clin Pharmacol Toxicol
    Lötsch J et al., 2009, Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers., Pharmacogenet Genomics
    Campa D et al., 2008, Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief., Clin Pharmacol Ther
    Coulbault L et al., 2006, Environmental and genetic factors associated with morphine response in the postoperative period., Clin Pharmacol Ther
    Zembruski NC et al., 2011, Interaction potential of etravirine with drug transporters assessed in vitro., Antimicrob Agents Chemother
    Naito T et al., 2011, CYP3A5*3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone., J Clin Pharmacol
    Sakaeda et al., 2005, Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs., J. Pharm. Pharmacol.
    Bercovich D et al., 2006, The association of common SNPs and haplotypes in the CETP and MDR1 genes with lipids response to fluvastatin in familial hypercholesterolemia., Atherosclerosis
    Kim et al., 1999, Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein., Pharm. Res.
    Jordheim LP et al., 2015, Single nucleotide polymorphisms in ABCB1 and CBR1 can predict toxicity to R-CHOP type regimens in patients with diffuse non-Hodgkin lymphoma., Haematologica
    Moresco M et al., 2016, Pharmacogenetics and Treatment Response in Narcolepsy Type 1: Relevance of the Polymorphisms of the Drug Transporter Gene ABCB1., Clin Neuropharmacol
    Han et al., 2006, Effects of capsaicin on P-gp function and expression in Caco-2 cells., Biochem. Pharmacol.
    He H et al., 2014, Association of ABCB1 polymorphisms with the efficacy of ondansetron in chemotherapy-induced nausea and vomiting., Clin Ther
    Choi EM et al., 2010, Association of ABCB1 polymorphisms with the efficacy of ondansetron for postoperative nausea and vomiting., Anaesthesia
    Zheng H et al., 2002, The MDR1 polymorphisms at exons 21 and 26 predict steroid weaning in pediatric heart transplant patients., Hum Immunol
    Ghetie et al., Rituximab but not other anti-CD20 antibodies reverses multidrug resistance in 2 B lymphoma cell lines, blocks the activity of P-glycoprotein (P-gp), and induces P-gp to translocate out of lipid rafts., J. Immunother.
    He H et al., 2015, Association of ABCB1 polymorphisms with prognostic outcomes of anthracycline and cytarabine in Chinese patients with acute myeloid leukemia., Eur J Clin Pharmacol
    Megías-Vericat JE et al., 2015, Influence of ABCB1 polymorphisms upon the effectiveness of standard treatment for acute myeloid leukemia: a systematic review and meta-analysis of observational studies., Pharmacogenomics J
    Gréen H et al., 2012, Association of ABCB1 polymorphisms with survival and in vitro cytotoxicty in de novo acute myeloid leukemia with normal karyotype., Pharmacogenomics J
    Kim DH et al., 2006, Multidrug resistance-1 gene polymorphisms associated with treatment outcomes in de novo acute myeloid leukemia., Int J Cancer
    Chen et al., 2005, Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1., Drug Metab. Dispos.
    Mega JL et al., 2009, Identification of genetic variants associated with response to statin therapy., Arterioscler Thromb Vasc Biol
    Lou K et al., 2014, Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies., J Med Chem
    Silva GL et al., 2001, Modulation of the multidrug-resistance phenotype by new tropane alkaloid aromatic esters from Erythroxylum pervillei., J Nat Prod
    Liu XL et al., 2008, Functionalized chalcones as selective inhibitors of P-glycoprotein and breast cancer resistance protein., Bioorg Med Chem
    Juvale K et al., 2012, 4-Substituted-2-phenylquinazolines as inhibitors of BCRP., Bioorg Med Chem Lett
    Condello M et al., 2014, Voacamine modulates the sensitivity to doxorubicin of resistant osteosarcoma and melanoma cells and does not induce toxicity in normal fibroblasts., J Nat Prod
    Sánchez-Lázaro I et al., 2015, Association of SNPs with the efficacy and safety of immunosuppressant therapy after heart transplantation., Pharmacogenomics
    Lee J et al., 2015, The Effect of ABCB1 C3435T Polymorphism on Cyclosporine Dose Requirements in Kidney Transplant Recipients: A Meta-Analysis., Basic Clin Pharmacol Toxicol
    Sharaki O et al., 2015, Impact of CYP3A4 and MDR1 gene (G2677T) polymorphisms on dose requirement of the cyclosporine in renal transplant Egyptian recipients., Mol Biol Rep
    Ferraresso M et al., 2013, Long-term effects of ABCB1 and SXR SNPs on the systemic exposure to cyclosporine in pediatric kidney transplant patients., Pharmacogenomics
    Barbarino JM et al., 2013, PharmGKB summary: cyclosporine and tacrolimus pathways., Pharmacogenet Genomics
    García M et al., 2013, ABCB1 polymorphisms are associated with cyclosporine-induced nephrotoxicity and gingival hyperplasia in renal transplant recipients., Eur J Clin Pharmacol
    Santoro A et al., 2011, Pharmacogenetics of calcineurin inhibitors in Brazilian renal transplant patients., Pharmacogenomics
    Yanagimachi M et al., 2010, Influence of CYP3A5 and ABCB1 gene polymorphisms on calcineurin inhibitor-related neurotoxicity after hematopoietic stem cell transplantation., Clin Transplant
    Zhang YT et al., 2008, ABCB1 polymorphisms may have a minor effect on ciclosporin blood concentrations in myasthenia gravis patients., Br J Clin Pharmacol
    Beringer PM et al., 2008, Lack of effect of P-glycoprotein inhibition on renal clearance of dicloxacillin in patients with cystic fibrosis., Pharmacotherapy
    Grinyó J et al., 2008, Association of four DNA polymorphisms with acute rejection after kidney transplantation., Transpl Int
    Crettol S et al., 2008, Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients., Pharmacogenet Genomics
    Daniel F et al., 2007, Multidrug resistance gene-1 polymorphisms and resistance to cyclosporine A in patients with steroid resistant ulcerative colitis., Inflamm Bowel Dis
    Hesselink DA et al., 2003, Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus., Clin Pharmacol Ther
    Herweijer et al., 1990, Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine., J. Natl. Cancer Inst.
    Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics
    Mukonzo JK et al., 2013, Influence of efavirenz pharmacokinetics and pharmacogenetics on neuropsychological disorders in Ugandan HIV-positive patients with or without tuberculosis: a prospective cohort study., BMC Infect Dis
    Elens L et al., 2010, Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients., Pharmacogenomics
    Ribaudo HJ et al., 2010, Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study., J Infect Dis
    Ritchie MD et al., 2006, Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity., Clin Infect Dis
    Haas DW et al., 2005, Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study., J Infect Dis
    Fellay J et al., 2002, Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study., Lancet
    Goldsborough AS et al., 2011, Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin., J Med Chem
    Roberts RL et al., 2015, Pharmacogenetic considerations in the treatment of gout., Pharmacogenomics
    Brandt et al., 2006, The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy., Neurobiol. Dis.
    Keangpraphun T et al., 2015, Association of ABCB1 C3435T polymorphism with phenobarbital resistance in Thai patients with epilepsy., J Clin Pharm Ther
    Li M et al., 2018, ABC transporter polymorphisms are associated with irinotecan pharmacokinetics and neutropenia., Pharmacogenomics J
    Kim SW et al., 2013, ABCB1 c.2677G>T variation is associated with adverse reactions of OROS-methylphenidate in children and adolescents with ADHD., J Clin Psychopharmacol
    Banerjee et al., 1992, Down-regulation of ras and myc expression associated with mdr-1 overexpression in adriamycin-resistant tumor cells., Cell. Mol. Biol.
    Ando et al., 2000, Decitabine (5-Aza-2'-deoxycytidine) decreased DNA methylation and expression of MDR-1 gene in K562/ADM cells., Leukemia
    Mealey et al., 2002, Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells., Antimicrob. Agents Chemother.
    Pertusini et al., 2001, Investigating the platelet-sparing mechanism of paclitaxel/carboplatin combination chemotherapy., Blood
    Molnar et al., New silicon compounds as resistance modifiers against multidrug-resistant cancer cells., Anticancer Res.
    Limtrakul et al., 2004, Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids., BMC Cancer
    Kim RB et al., 2001, Identification of functionally variant MDR1 alleles among European Americans and African Americans., Clin Pharmacol Ther
    Wartenberg et al., 2003, Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species., FASEB J.
    Breitenstein B et al., 2016, Association of ABCB1 gene variants, plasma antidepressant concentration, and treatment response: Results from a randomized clinical study., J Psychiatr Res
    Huang X et al., 2013, ABCB6, ABCB1 and ABCG1 genetic polymorphisms and antidepressant response of SSRIs in Chinese depressive patients., Pharmacogenomics
    de Klerk OL et al., 2013, ABCB1 gene variants influence tolerance to selective serotonin reuptake inhibitors in a large sample of Dutch cases with major depressive disorder., Pharmacogenomics J
    Uhr M et al., 2008, Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression., Neuron
    Aksentijevich et al., 1996, Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity., Clin. Cancer Res.
    Billat PA et al., 2016, Multidrug resistance-associated protein 4 (MRP4) controls ganciclovir intracellular accumulation and contributes to ganciclovir-induced neutropenia in renal transplant patients., Pharmacol Res
    Miura M et al., 2006, Influence of ABCB1 C3435T polymorphism on the pharmacokinetics of lansoprazole and gastroesophageal symptoms in Japanese renal transplant recipients classified as CYP2C19 extensive metabolizers and treated with tacrolimus., Int J Clin Pharmacol Ther
    Gervasini et al., 2006, The effect of CYP2J2, CYP3A4, CYP3A5 and the MDR1 polymorphisms and gender on the urinary excretion of the metabolites of the H-receptor antihistamine ebastine: a pilot study., Br J Clin Pharmacol
    Wang et al., 2001, Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein., Drug Metab. Dispos.
    Langer et al., 2004, [Prediction of response to neoadjuvant chemotherapy in Barrett's carcinoma by quantitative gene expression analysis]., Verh Dtsch Ges Pathol
    Hou X et al., 2018, CYP2C19 and ABCB1 genetic polymorphisms correlate with the recurrence of ischemic cardiovascular adverse events after clopidogrel treatment., J Clin Lab Anal
    Danielak D et al., 2017, Influence of genetic co-factors on the population pharmacokinetic model for clopidogrel and its active thiol metabolite., Eur J Clin Pharmacol
    Olędzki S et al., 2017, Variability of platelet response to clopidogrel is not related to adverse cardiovascular events in patients with stable coronary artery disease undergoing percutaneous coronary intervention., Eur J Clin Pharmacol
    Zhai Y et al., 2017, Meta-analysis of effects of ABCB1 polymorphisms on clopidogrel response among patients with coronary artery disease., Eur J Clin Pharmacol
    Su J et al., 2017, The risk of clopidogrel resistance is associated with ABCB1 polymorphisms but not promoter methylation in a Chinese Han population., PLoS One
    Saydam F et al., 2017, The CYP2C19*2 and CYP2C19*17 Polymorphisms play a Vital Role in Clopidogrel Responsiveness after Percutaneous Coronary Intervention: A Pharmacogenomics Study., Basic Clin Pharmacol Toxicol
    Zhang HZ et al., 2017, CYP2C19 but not CYP2B6, CYP3A4, CYP3A5, ABCB1, PON1 or P2Y12 genetic polymorphism impacts antiplatelet response after clopidogrel in Koreans., Blood Coagul Fibrinolysis
    Calderón-Cruz B et al., 2015, C3435T polymorphism of the ABCB1 gene is associated with poor clopidogrel responsiveness in a Mexican population undergoing percutaneous coronary intervention., Thromb Res
    So DY et al., 2016, A prospective randomized evaluation of a pharmacogenomic approach to antiplatelet therapy among patients with ST-elevation myocardial infarction: the RAPID STEMI study., Pharmacogenomics J
    Wang XQ et al., 2015, Genetic polymorphisms of CYP2C19 2 and ABCB1 C3435T affect the pharmacokinetic and pharmacodynamic responses to clopidogrel in 401 patients with acute coronary syndrome., Gene
    Karaźniewicz-Łada M et al., 2015, Impact of common ABCB1 polymorphism on pharmacokinetics and pharmacodynamics of clopidogrel and its metabolites., J Clin Pharm Ther
    Latkovskis G et al., 2014, Role of genetic factors on the effect of additional loading doses and two maintenance doses used to overcome clopidogrel hyporesponsiveness., Medicina (Kaunas)
    Cresci S et al., 2014, Cytochrome p450 gene variants, race, and mortality among clopidogrel-treated patients after acute myocardial infarction., Circ Cardiovasc Genet
    Xie C et al., 2014, The effects of CES1A2 A(-816)C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary heart disease., Pharmacogenet Genomics
    Viviani Anselmi C et al., 2013, Routine assessment of on-clopidogrel platelet reactivity and gene polymorphisms in predicting clinical outcome following drug-eluting stent implantation in patients with stable coronary artery disease., JACC Cardiovasc Interv
    Zhang L et al., 2013, Genetic determinants of high on-treatment platelet reactivity in clopidogrel treated Chinese patients., Thromb Res
    Carlquist JF et al., 2013, Cardiovascular risk among patients on clopidogrel anti-platelet therapy after placement of drug-eluting stents is modified by genetic variants in both the CYP2C19 and ABCB1 genes., Thromb Haemost
    Tang XF et al., 2013, Effect of the CYP2C19 2 and 3 genotypes, ABCB1 C3435T and PON1 Q192R alleles on the pharmacodynamics and adverse clinical events of clopidogrel in Chinese people after percutaneous coronary intervention., Eur J Clin Pharmacol
    Su J et al., 2012, ABCB1 C3435T polymorphism and response to clopidogrel treatment in coronary artery disease (CAD) patients: a meta-analysis., PLoS One
    Wu H et al., 2012, Effects of CYP2C19 variant alleles on postclopidogrel platelet reactivity and clinical outcomes in an actual clinical setting in China., Pharmacogenet Genomics
    Verschuren JJ et al., 2013, Value of platelet pharmacogenetics in common clinical practice of patients with ST-segment elevation myocardial infarction., Int J Cardiol
    Chen DY et al., 2012, Paraoxonase-1 is not a major determinant of stent thrombosis in a Taiwanese population., PLoS One
    Price MJ et al., 2012, Influence of genetic polymorphisms on the effect of high- and standard-dose clopidogrel after percutaneous coronary intervention: the GIFT (Genotype Information and Functional Testing) study., J Am Coll Cardiol
    Bonello L et al., 2012, Factors associated with the failure of clopidogrel dose-adjustment according to platelet reactivity monitoring to optimize P2Y12-ADP receptor blockade., Thromb Res
    Delaney JT et al., 2012, Predicting clopidogrel response using DNA samples linked to an electronic health record., Clin Pharmacol Ther
    Jeong YH et al., 2011, Effect of CYP2C19*2 and *3 loss-of-function alleles on platelet reactivity and adverse clinical events in East Asian acute myocardial infarction survivors treated with clopidogrel and aspirin., Circ Cardiovasc Interv
    Cayla G et al., 2011, Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis., JAMA
    Simon T et al., 2011, Effect of paraoxonase-1 polymorphism on clinical outcomes in patients treated with clopidogrel after an acute myocardial infarction., Clin Pharmacol Ther
    Kassimis G et al., 2012, CYP2C19*2 and other genetic variants affecting platelet response to clopidogrel in patients undergoing percutaneous coronary intervention., Thromb Res
    Rideg O et al., 2011, Impact of genetic variants on post-clopidogrel platelet reactivity in patients after elective percutaneous coronary intervention., Pharmacogenomics
    Wallentin L et al., 2010, Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial., Lancet
    Mega JL et al., 2010, Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis., Lancet
    Jeong YH et al., 2010, Carriage of cytochrome 2C19 polymorphism is associated with risk of high post-treatment platelet reactivity on high maintenance-dose clopidogrel of 150 mg/day: results of the ACCEL-DOUBLE (Accelerated Platelet Inhibition by a Double Dose of Clopidogrel According to Gene Polymorphism) study., JACC Cardiovasc Interv
    Simon T et al., 2009, Genetic determinants of response to clopidogrel and cardiovascular events., N Engl J Med
    Taubert D et al., 2006, Impact of P-glycoprotein on clopidogrel absorption., Clin Pharmacol Ther
    Chu et al., 1999, Active efflux of CPT-11 and its metabolites in human KB-derived cell lines., J. Pharmacol. Exp. Ther.
    Yamazaki et al., 2005, Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2- and P-glycoprotein-mediated transport., Xenobiotica
    Kishi S et al., 2004, Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia., Blood
    Collett et al., 1999, Modulation of the permeability of H2 receptor antagonists cimetidine and ranitidine by P-glycoprotein in rat intestine and the human colonic cell line Caco-2., J. Pharmacol. Exp. Ther.
    Mickisch et al., 1991, Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance., Proc. Natl. Acad. Sci. U.S.A.
    Meschini et al., 2005, Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells., Int. J. Oncol.
    Meschini et al., 2003, Voacamine, a bisindolic alkaloid from Peschiera fuchsiaefolia, enhances the cytotoxic effect of doxorubicin on multidrug-resistant tumor cells., Int. J. Oncol.
    Ciccacci C et al., 2010, Nevirapine-induced hepatotoxicity and pharmacogenetics: a retrospective study in a population from Mozambique., Pharmacogenomics
    Haas DW et al., 2006, Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration., Clin Infect Dis
    Orlowski et al., 1998, Bromocriptine modulates P-glycoprotein function., Biochem. Biophys. Res. Commun.
    Shiraki et al., 2002, Bromocriptine reverses P-glycoprotein-mediated multidrug resistance in tumor cells., Jpn. J. Cancer Res.
    Leggas et al., 2006, Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo., Cancer Res.
    Ma Y et al., 2017, Determinants of Gefitinib toxicity in advanced non-small cell lung cancer (NSCLC): a pharmacogenomic study of metabolic enzymes and transporters., Pharmacogenomics J
    Kobayashi H et al., 2015, Relationship Among Gefitinib Exposure, Polymorphisms of Its Metabolizing Enzymes and Transporters, and Side Effects in Japanese Patients With Non-Small-Cell Lung Cancer., Clin Lung Cancer
    Ozvegy-Laczka et al., 2004, High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter., Mol. Pharmacol.
    Oshiro C et al., 2009, Taxane pathway., Pharmacogenet Genomics
    Cummins et al., 2004, CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam., J. Pharmacol. Exp. Ther.
    Mbatchi LC et al., 2017, Association of NR1I2, CYP3A5 and ABCB1 genetic polymorphisms with variability of temsirolimus pharmacokinetics and toxicity in patients with metastatic bladder cancer., Cancer Chemother Pharmacol
    Sam WJ et al., 2012, Associations of ABCB1 and IL-10 genetic polymorphisms with sirolimus-induced dyslipidemia in renal transplant recipients., Transplantation
    Hubensack et al., 2008, Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice., J. Cancer Res. Clin. Oncol.
    Gurley et al., 2006, Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans., Drug Metab. Dispos.
    Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
    Jorajuria et al., 2004, ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages., Antivir. Ther. (Lond.)
    El Ela et al., 2004, Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates., J. Pharm. Pharmacol.
    Mark et al., 2006, P-glycoprotein restricts access of cortisol and dexamethasone to the glucocorticoid receptor in placental BeWo cells., Endocrinology
    Breedveld et al., 2005, The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients., Cancer Res.
    Malmström A et al., 2020, ABCB1 single-nucleotide variants and survival in patients with glioblastoma treated with radiotherapy concomitant with temozolomide., Pharmacogenomics J
    Peck et al., 2001, Phase I and pharmacokinetic study of the novel MDR1 and MRP1 inhibitor biricodar administered alone and in combination with doxorubicin., J. Clin. Oncol.
    Kalra S et al., 2018, Association of CYP2C19*2 and ALDH1A1*1/*2 variants with disease outcome in breast cancer patients: results of a global screening array., Eur J Clin Pharmacol
    Caronia D et al., 2011, Effect of ABCB1 and ABCC3 polymorphisms on osteosarcoma survival after chemotherapy: a pharmacogenetic study., PLoS One
    Lal S et al., 2008, Influence of ABCB1 and ABCG2 polymorphisms on doxorubicin disposition in Asian breast cancer patients., Cancer Sci
    Maggini V et al., 2008, MDR1 diplotypes as prognostic markers in multiple myeloma., Pharmacogenet Genomics
    Miyachi et al., 1999, Microsatellite instability and clonal heterogeneity of MDR1 messenger RNA expression in trimetrexate-resistant human leukemia MOLT-3 cells developed in thymidine., Int. J. Cancer
    Jakubíková et al., 2001, Non-steroidal anti-inflammatory agent ibuprofen-induced apoptosis, cell necrosis and cell cycle alterations in human leukemic cells in vitro., Neoplasma
    Cusato J et al., 2015, Intracellular accumulation of boceprevir according to plasma concentrations and pharmacogenetics., Int J Antimicrob Agents
    Tan ZR et al., 2015, The influence of ABCB1 polymorphism C3435T on the pharmacokinetics of silibinin., J Clin Pharm Ther
    Li XQ et al., 2015, Reversal of P-gp and BCRP-mediated MDR by tariquidar derivatives., Eur J Med Chem
    Gawrońska-Szklarz B et al., 2005, Effect of CYP2C19 and MDR1 polymorphisms on cure rate in patients with acid-related disorders with Helicobacter pylori infection., Eur J Clin Pharmacol
    Sparreboom A et al., 2004, Pharmacogenetics of tipifarnib (R115777) transport and metabolism in cancer patients., Invest New Drugs
    Nies AT et al., 2008, Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1)., Naunyn Schmiedebergs Arch Pharmacol
    Nesi G et al., 2014, SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity., Eur J Med Chem
    Perestelo NR et al., 2011, Overcoming human P-glycoprotein-dependent multidrug resistance with novel dihydro-β-agarofuran sesquiterpenes., Eur J Med Chem
    Chae SW et al., 2015, Xanthone analogues as potent modulators of intestinal P-glycoprotein., Eur J Med Chem
    Tang X et al., 2012, Synthesis and evaluation of nitric oxide-releasing DDB derivatives as potential Pgp-mediated MDR reversal agents in MCF-7/Adr cells., Bioorg Med Chem Lett
    Gu X et al., 2012, Synthesis and biological evaluation of novel bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potent P-glycoprotein inhibitors., Eur J Med Chem
    Gu X et al., 2012, Synthesis and biological evaluation of bifendate-chalcone hybrids as a new class of potential P-glycoprotein inhibitors., Bioorg Med Chem
    Liu J et al., 2013, 20(S)-Protopanaxadiol (PPD) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs., Bioorg Med Chem
    Kónya et al., 2006, Inhibition of the MDR1 transporter by new phenothiazine derivatives., Biochem. Biophys. Res. Commun.
    Zhang J et al., 2018, Association between MDR<sub>1</sub>/CYP3A4/OPRM<sub>1</sub> gene polymorphisms and the post-caesarean fentanyl analgesic effect on Chinese women., Gene
    Dzambazovska-Trajkovska V et al., 2016, Association of Single-Nucleotide Polymorhism C3435T in the ABCB1 Gene with Opioid Sensitivity in Treatment of Postoperative Pain., Pril (Makedon Akad Nauk Umet Odd Med Nauki)
    Kim KM et al., 2013, Effects of genetic polymorphisms of OPRM1, ABCB1, CYP3A4/5 on postoperative fentanyl consumption in Korean gynecologic patients., Int J Clin Pharmacol Ther
    Takashina Y et al., 2012, Impact of CYP3A5 and ABCB1 gene polymorphisms on fentanyl pharmacokinetics and clinical responses in cancer patients undergoing conversion to a transdermal system., Drug Metab Pharmacokinet
    Park HJ et al., 2007, Genetic polymorphisms in the ABCB1 gene and the effects of fentanyl in Koreans., Clin Pharmacol Ther
    Wandel C et al., 2002, Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein., Anesthesiology
    Sangkuhl K et al., 2011, PharmGKB summary: citalopram pharmacokinetics pathway., Pharmacogenet Genomics
    Gouin-Thibault I et al., 2017, Interindividual variability in dabigatran and rivaroxaban exposure: contribution of ABCB1 genetic polymorphisms and interaction with clarithromycin., J Thromb Haemost
    Wang et al., 2005, P-glycoprotein does not actively transport nicotine and cotinine., Addict Biol
    Dimatteo C et al., 2016, Pharmacogenetics of dabigatran etexilate interindividual variability., Thromb Res
    Rybczynska et al., 2001, MDR1 causes resistance to the antitumour drug miltefosine., Br. J. Cancer
    Bailly et al., 1995, Effect of 5637-conditioned medium and recombinant cytokines on P-glycoprotein expression in a human GM-CSF-dependent leukemic myeloid cell line., Leukemia
    Ge H et al., 2006, Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells., Bioorg Med Chem Lett
    Zubiaur P et al., 2020, Influence of CYP2B6 activity score on the pharmacokinetics and safety of single dose efavirenz in healthy volunteers., Pharmacogenomics J
    Mukonzo JK et al., 2016, CYP2B6 genotype-based efavirenz dose recommendations during rifampicin-based antituberculosis cotreatment for a sub-Saharan Africa population., Pharmacogenomics
    Cusato J et al., 2016, Efavirenz pharmacogenetics in a cohort of Italian patients., Int J Antimicrob Agents
    Mukonzo JK et al., 2014, CYP2B6 genotype, but not rifampicin-based anti-TB cotreatments, explains variability in long-term efavirenz plasma exposure., Pharmacogenomics
    Mukonzo JK et al., 2014, Pharmacogenetic-based efavirenz dose modification: suggestions for an African population and the different CYP2B6 genotypes., PLoS One
    Cabrera Figueroa S et al., 2010, The convergence of therapeutic drug monitoring and pharmacogenetic testing to optimize efavirenz therapy., Ther Drug Monit
    Chen J et al., 2010, CYP2B6 polymorphism and nonnucleoside reverse transcriptase inhibitor plasma concentrations in Chinese HIV-infected patients., Ther Drug Monit
    Csajka C et al., 2003, Population pharmacokinetics and effects of efavirenz in patients with human immunodeficiency virus infection., Clin Pharmacol Ther
    Tavares LC et al., 2018, Association Between <i>ABCB1</i> Polymorphism and Stable Warfarin Dose Requirements in Brazilian Patients., Front Pharmacol
    Bryk AH et al., 2018, Bleeding predictors in patients following venous thromboembolism treated with vitamin K antagonists: Association with increased number of single nucleotide polymorphisms., Vascul Pharmacol
    de Oliveira Almeida VC et al., 2014, Polymorphisms of CYP2C9, VKORC1, MDR1, APOE and UGT1A1 genes and the therapeutic warfarin dose in Brazilian patients with thrombosis: a prospective cohort study., Mol Diagn Ther
    Zhang W et al., 2012, Genetic polymorphisms are associated with variations in warfarin maintenance dose in Han Chinese patients with venous thromboembolism., Pharmacogenomics
    Elgie et al., 1999, Comparison of P-glycoprotein expression and function with in vitro sensitivity to anthracyclines in AML., Adv. Exp. Med. Biol.
    Jakobsen Falk I et al., 2018, Pharmacogenetic study of the impact of ABCB1 single-nucleotide polymorphisms on lenalidomide treatment outcomes in patients with multiple myeloma: results from a phase IV observational study and subsequent phase II clinical trial., Cancer Chemother Pharmacol
    Sistonen J et al., 2012, Prediction of codeine toxicity in infants and their mothers using a novel combination of maternal genetic markers., Clin Pharmacol Ther
    Becker ML et al., 2009, Common genetic variation in the ABCB1 gene is associated with the cholesterol-lowering effect of simvastatin in males., Pharmacogenomics
    Becker ML et al., 2010, Influence of genetic variation in CYP3A4 and ABCB1 on dose decrease or switching during simvastatin and atorvastatin therapy., Pharmacoepidemiol Drug Saf
    Fiegenbaum et al., 2005, The role of common variants of ABCB1, CYP3A4, and CYP3A5 genes in lipid-lowering efficacy and safety of simvastatin treatment., Clin. Pharmacol. Ther.
    Zhao W et al., 2018, Developmental pharmacogenetics of CYP2C19 in neonates and young infants: omeprazole as a probe drug., Br J Clin Pharmacol
    Zhou X et al., 2015, Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells., J Nat Prod
    Zhu et al., 2006, Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana., J. Pharmacol. Exp. Ther.
    Gao C et al., 2012, Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics., Drug Metab Dispos
    Kadam P et al., 2016, Genetic determinants of lipid-lowering response to atorvastatin therapy in an Indian population., J Clin Pharm Ther
    Hoenig MR et al., 2011, The C3435T polymorphism in ABCB1 influences atorvastatin efficacy and muscle symptoms in a high-risk vascular cohort., J Clin Lipidol
    Keskitalo JE et al., 2008, ABCB1 haplotypes differentially affect the pharmacokinetics of the acid and lactone forms of simvastatin and atorvastatin., Clin Pharmacol Ther
    Rebecchi IM et al., 2009, ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment., Biochem Pharmacol
    Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
    Jeleń AM et al., 2015, The Influence of C3435T Polymorphism of the ABCB1 Gene on Genetic Susceptibility to Depression and Treatment Response in Polish Population - Preliminary Report., Int J Med Sci
    Jiménez-Varo E et al., 2014, Pharmacogenetics role in the safety of acenocoumarol therapy., Thromb Haemost
    He X et al., 2012, Effects of curcumin on the pharmacokinetics of talinolol in human with ABCB1 polymorphism., Xenobiotica
    Giovannetti E et al., 2011, Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy., Pharmacogenomics
    Gonzalez-Haba E et al., 2010, ABCB1 gene polymorphisms are associated with adverse reactions in fluoropyrimidine-treated colorectal cancer patients., Pharmacogenomics
    Wang et al., 2003, The farnesyl protein transferase inhibitor lonafarnib (SCH66336) is an inhibitor of multidrug resistance proteins 1 and 2., Chemotherapy
    Chan SL et al., 2017, Association and clinical utility of NAT2 in the prediction of isoniazid-induced liver injury in Singaporean patients., PLoS One
    Yimer G et al., 2011, Pharmacogenetic &amp; pharmacokinetic biomarker for efavirenz based ARV and rifampicin based anti-TB drug induced liver injury in TB-HIV infected patients., PLoS One
    Cramer JP et al., 2010, Low N-acetyltransferase 2 activity in isoniazid-associated acute hepatitis requiring liver transplantation., Transpl Int
    Shen C et al., 2017, Effects of ABCB1, ABCC2, UGT2B7 and HNF4α genetic polymorphisms on oxcarbazepine concentrations and therapeutic efficacy in patients with epilepsy., Seizure
    Matsui et al., 2002, Reduced effect of gemtuzumab ozogamicin (CMA-676) on P-glycoprotein and/or CD34-positive leukemia cells and its restoration by multidrug resistance modifiers., Leukemia
    Wang et al., 2006, Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein., Psychopharmacology (Berl.)
    Sharma A et al., 2012, Vemurafenib: targeted inhibition of mutated BRAF for treatment of advanced melanoma and its potential in other malignancies., Drugs
    Liu et al., Effect of P-glycoprotein inhibitors erythromycin and cyclosporin A on brain pharmacokinetics of nimodipine in rats., Eur J Drug Metab Pharmacokinet
    Numakura K et al., 2017, Clinical effects of single nucleotide polymorphisms on drug-related genes in Japanese metastatic renal cell carcinoma patients treated with sunitinib., Anticancer Drugs
    Chu YH et al., 2015, Association of ABCB1 and FLT3 Polymorphisms with Toxicities and Survival in Asian Patients Receiving Sunitinib for Renal Cell Carcinoma., PLoS One
    Teo YL et al., 2016, Effect of the CYP3A5 and ABCB1 genotype on exposure, clinical response and manifestation of toxicities from sunitinib in Asian patients., Pharmacogenomics J
    Beuselinck B et al., 2014, Efflux pump ABCB1 single nucleotide polymorphisms and dose reductions in patients with metastatic renal cell carcinoma treated with sunitinib., Acta Oncol
    Kim HR et al., 2013, Pharmacogenetic determinants associated with sunitinib-induced toxicity and ethnic difference in Korean metastatic renal cell carcinoma patients., Cancer Chemother Pharmacol
    Gassó P et al., 2014, Effect of CYP2D6, CYP2C9 and ABCB1 genotypes on fluoxetine plasma concentrations and clinical improvement in children and adolescent patients., Pharmacogenomics J
    Laurenty AP et al., 2013, Irreversible hepatotoxicity after administration of trabectedin to a pleiomorphic sarcoma patient with a rare ABCC2 polymorphism: a case report., Pharmacogenomics
    Gollapudi et al., 1997, Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells., Cancer Chemother. Pharmacol.
    van der Weide K et al., 2017, Genetic risk factors for clozapine-induced neutropenia and agranulocytosis in a Dutch psychiatric population., Pharmacogenomics J
    Lee ST et al., 2012, Association study of 27 annotated genes for clozapine pharmacogenetics: validation of preexisting studies and identification of a new candidate gene, ABCB1, for treatment response., J Clin Psychopharmacol
    Jaquenoud Sirot E et al., 2009, ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine., J Clin Psychopharmacol
    Mei Y et al., 2015, Role of SLCO1B1, ABCB1, and CHRNA1 gene polymorphisms on the efficacy of rocuronium in Chinese patients., J Clin Pharmacol
    Göktaş MT et al., 2016, Relationship between genetic polymorphisms of drug efflux transporter MDR1 (ABCB1) and response to losartan in hypertension patients., Eur Rev Med Pharmacol Sci
    Alenius M et al., 2008, Gene polymorphism influencing treatment response in psychotic patients in a naturalistic setting., J Psychiatr Res
    Lin YC et al., 2006, The relationship between P-glycoprotein (PGP) polymorphisms and response to olanzapine treatment in schizophrenia., Ther Drug Monit
    Foster et al., An in vitro evaluation of human cytochrome P450 3A4 and P-glycoprotein inhibition by garlic., J Pharm Pharm Sci
    Wu H et al., 2013, Association of ABCB1 genetic polymorphisms with susceptibility to colorectal cancer and therapeutic prognosis., Pharmacogenomics
    Narumiya K et al., 2011, Impact of ABCB1 C3435T polymorphism on lymph node regression in multimodality treatment of locally advanced esophageal cancer., Pharmacogenomics
    McLeod HL et al., 2010, Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741., J Clin Oncol
    Putnam WS et al., 2005, Effect of the MDR1 C3435T variant and P-glycoprotein induction on dicloxacillin pharmacokinetics., J Clin Pharmacol
    Deguchi Y et al., 2008, Comparison of imatinib, dasatinib, nilotinib and INNO-406 in imatinib-resistant cell lines., Leuk Res
    Katayama R et al., 2015, P-glycoprotein Mediates Ceritinib Resistance in Anaplastic Lymphoma Kinase-rearranged Non-small Cell Lung Cancer., EBioMedicine
  • VOACAMINE   ABCB1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    16273216 14612920 24720452


    Sources:
    DTC

  • ZOSUQUIDAR   ABCB1

    Interaction Score: 0.77

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name zosuquidar, LY335979
    Novel drug target Novel Target

    PMIDs:
    18157518


    Sources:
    TdgClinicalTrial PharmGKB

  • TARIQUIDAR   ABCB1

    Interaction Score: 0.64

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction P-glycoprotein 1 inhibitor
    Direct Interaction yes
    Trial Name tariquidar

    PMIDs:
    21657271


    Sources:
    DTC TdgClinicalTrial ChemblInteractions PharmGKB

  • PERVILLEINE D   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11754602


    Sources:
    DTC

  • EPOTHILONE D   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24992153


    Sources:
    DTC

  • BRECANAVIR   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17664327


    Sources:
    DTC

  • CHEMBL306786   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16271474


    Sources:
    DTC

  • CHEMBL203365   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16271474


    Sources:
    DTC

  • PERVILLEINE F   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11754602


    Sources:
    DTC

  • CHEMBL408422   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18311899


    Sources:
    DTC

  • PERVILLEINE C   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11754602


    Sources:
    DTC

  • AUSTOCYSTIN D   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21348461


    Sources:
    DTC

  • CHEMBL410907   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18311899


    Sources:
    DTC

  • PERVILLEINE B   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11754602


    Sources:
    DTC

  • TAXOL C   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16289636


    Sources:
    DTC

  • CHEMBL595816   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22112540


    Sources:
    DTC

  • BISANTRENE   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9816258


    Sources:
    NCI

  • FLAVOKAWAIN A   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22112540


    Sources:
    DTC

  • CHEMBL217425   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18257545


    Sources:
    DTC

  • PURGIN II   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23273047


    Sources:
    DTC

  • MURUCOIDIN V   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22148475


    Sources:
    DTC

  • CHEMBL270688   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18257545


    Sources:
    DTC

  • BIRICODAR   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB TTD

  • DENDROAMIDE A   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8786364


    Sources:
    DTC

  • HETEROCODEINE   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18311899


    Sources:
    DTC

  • DAPTOMYCIN   ABCB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25239468


    Sources:
    PharmGKB

  • CLOPIDOGREL   ABCB1

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29397568 28914344 28589365 28378058 28358842 28135763 27380588 26362473 25850030 25542807 25430046 25060201 24762860 24535487 24262617 23726091 23364775 23150151 23056288 22990067 22940005 22723959 22624833 22285300 22190063 22045970 22028352 21918510 21831410 21806387 20801498 20801494 20650435 19106083 17112805


    Sources:
    PharmGKB

  • NELFINAVIR   ABCB1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17664327 23734829 20860463 20662624 16912956 16267764 11809184


    Sources:
    DTC PharmGKB

  • 3,4-DIHYDROXYXANTHONE   ABCB1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • METOCHALCONE   ABCB1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22112540


    Sources:
    DTC

  • GEMTUZUMAB OZOGAMICIN   ABCB1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11986941


    Sources:
    NCI

  • TALINOLOL   ABCB1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22725663


    Sources:
    PharmGKB

  • VALSPODAR   ABCB1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CHEMBL444075   ABCB1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26197160


    Sources:
    DTC

  • IVERMECTIN   ABCB1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DIHYDRO-12-HYDROXY-2,2-DIMETHYL-2H,6H-PYRANO[3,2-B]XANTHEN-6-ONE   ABCB1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MEFLOQUINE   ABCB1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ELACRIDAR   ABCB1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17932689


    Sources:
    PharmGKB

  • VALGANCICLOVIR   ABCB1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27402191


    Sources:
    PharmGKB

  • RITONAVIR   ABCB1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17664327 28718515 26857335 26174719 25622064 25151207 24997317 23996099 21288825 20504240 17324111 17148966 1655344 16355344 14600574


    Sources:
    DTC PharmGKB

  • DEXRAZOXANE   ABCB1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25567217 25558979 20938465 16331627


    Sources:
    PharmGKB

  • EFAVIRENZ   ABCB1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31628422 27045425 26774523 25303294 24497997 23734829 20860463 20720517 20662624 20625352 16912956 16267764 12545140 11809184 21189339


    Sources:
    DTC PharmGKB

  • DICLOXACILLIN   ABCB1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18576903 15778422


    Sources:
    PharmGKB

  • TRABECTEDIN   ABCB1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24024892


    Sources:
    PharmGKB

  • LONAFARNIB   ABCB1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14671431


    Sources:
    NCI

  • SCUTELLARIN   ABCB1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22822035


    Sources:
    DTC

  • RIVAROXABAN   ABCB1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27893182


    Sources:
    PharmGKB

  • FEXOFENADINE   ABCB1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11503014


    Sources:
    PharmGKB

  • DOMPERIDONE   ABCB1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15285840


    Sources:
    NCI PharmGKB

  • VENLAFAXINE   ABCB1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26757307 26704739 26664259 24192121 22641028 21449676 18215618


    Sources:
    PharmGKB

  • BAFETINIB   ABCB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18191450


    Sources:
    CIViC

  • HYDROXOCOBALAMIN   ABCB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • VINDESINE   ABCB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25637052


    Sources:
    PharmGKB

  • 2',4'-DIHYDROXYCHALCONE   ABCB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22112540


    Sources:
    DTC

  • ETRAVIRINE   ABCB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21189339


    Sources:
    DTC

  • CODEINE   ABCB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18311899 22398969


    Sources:
    DTC PharmGKB

  • VECURONIUM   ABCB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • SPARFLOXACIN   ABCB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • VERAPAMIL   ABCB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9862768 1671173 18257545 24607999 21856049 25686592 21348461 22209486 22405646 22429509 17964170 20363635 24992153 23683834 11754602


    Sources:
    DTC NCI

  • QUERCETIN-3'-O-PHOSPHATE   ABCB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name LIM-0705
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • CELIPROLOL   ABCB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ALISKIREN   ABCB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • VALINOMYCIN   ABCB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LOPINAVIR   ABCB1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23996099 17664327


    Sources:
    DTC PharmGKB

  • TESMILIFENE   ABCB1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inducer (activating)

    Interaction Info:
    Trial Name tesmilifene
    Novel drug target Novel Target

    PMIDs:
    10755318 16413681


    Sources:
    TdgClinicalTrial

  • MILTIRONE   ABCB1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26339922


    Sources:
    DTC

  • MILTEFOSINE   ABCB1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11355955


    Sources:
    NCI

  • TIPIFARNIB   ABCB1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15122075


    Sources:
    PharmGKB

  • DELAVIRDINE   ABCB1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21189339


    Sources:
    DTC

  • REMIFENTANIL   ABCB1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29755652


    Sources:
    PharmGKB

  • CYCLOSPORINE   ABCB1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24992153 11754602 17964170 23017888 24720452 21348461 26107754 25536375 25240575 24088131 23922006 22886152 21806386 20030680 18717915 18576903 18444945 18334915 17206635 12966368 1972761


    Sources:
    DTC NCI PharmGKB

  • AMITRIPTYLINE   ABCB1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26704739 24192121 22641028 18215618


    Sources:
    PharmGKB

  • TERFENADINE   ABCB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16842392 11454724 10213372


    Sources:
    NCI PharmGKB

  • ROCURONIUM   ABCB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25279974


    Sources:
    PharmGKB

  • FLUVOXAMINE   ABCB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26704739 22641028 18215618


    Sources:
    PharmGKB

  • ACENOCOUMAROL   ABCB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24919870


    Sources:
    PharmGKB

  • CYANOCOBALAMIN   ABCB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DABIGATRAN   ABCB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27893182 27261537


    Sources:
    PharmGKB

  • TETRABENAZINE   ABCB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ONDANSETRON   ABCB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25012726 20707787


    Sources:
    PharmGKB

  • PENTAZOCINE   ABCB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • OXYCODONE   ABCB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21209234 19514130


    Sources:
    PharmGKB

  • VORICONAZOLE   ABCB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19033450


    Sources:
    PharmGKB

  • 2'-HYDROXYCHALCONE   ABCB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22112540


    Sources:
    DTC

  • DEXTROMETHORPHAN   ABCB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15582917


    Sources:
    NCI

  • MORPHINE   ABCB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29474345 25311385 25155932 24703092 19514130 17898703 16580900 18311899


    Sources:
    DTC PharmGKB

  • FENTANYL   ABCB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29601950 27883323 23557865 22277678 19514130 17192767 11964599


    Sources:
    PharmGKB

  • ISONIAZID   ABCB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29036176 22162992 19686464


    Sources:
    PharmGKB

  • QUINIDINE   ABCB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1671173


    Sources:
    NCI PharmGKB

  • ITRACONAZOLE   ABCB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15969931


    Sources:
    NCI PharmGKB

  • PROBENECID   ABCB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9182837


    Sources:
    NCI

  • PANTOPRAZOLE   ABCB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15976989


    Sources:
    PharmGKB

  • BOCEPREVIR   ABCB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25836019


    Sources:
    PharmGKB

  • RITUXIMAB   ABCB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16971809 25637052


    Sources:
    NCI PharmGKB

  • RANOLAZINE   ABCB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24433361


    Sources:
    PharmGKB

  • NEVIRAPINE   ABCB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20017669 16912957 16912956 21189339


    Sources:
    DTC PharmGKB

  • LEVOFLOXACIN   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DRONABINOL   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16439618


    Sources:
    NCI

  • AMPRENAVIR   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • BROMPERIDOL   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PAROXETINE   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26704739 24192121 22641028 21449676 18215618


    Sources:
    PharmGKB

  • DOXYCYCLINE   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11850258


    Sources:
    NCI PharmGKB

  • TANGERETIN   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SERTRALINE   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26704739 24192121 22641028 18215618


    Sources:
    PharmGKB

  • CLARITHROMYCIN   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16221754


    Sources:
    NCI PharmGKB

  • GRANISETRON   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29177570 27241063


    Sources:
    PharmGKB

  • LOSARTAN   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27338075


    Sources:
    PharmGKB

  • TRIMETREXATE   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10360822


    Sources:
    NCI

  • ATAZANAVIR   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16355344


    Sources:
    NCI

  • AMISULPRIDE   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29443543


    Sources:
    PharmGKB

  • RANITIDINE   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9862768


    Sources:
    NCI PharmGKB

  • GARLIC   ABCB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11466175


    Sources:
    NCI

  • FILGRASTIM   ABCB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7564516


    Sources:
    NCI

  • NITRENDIPINE   ABCB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ALDOSTERONE   ABCB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • NEFAZODONE   ABCB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • MODAFINIL   ABCB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26757307


    Sources:
    PharmGKB

  • AGOMELATINE   ABCB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • BROMOCRIPTINE   ABCB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9514944 11856485


    Sources:
    NCI

  • PROPRANOLOL   ABCB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15023456


    Sources:
    NCI PharmGKB

  • CERITINIB   ABCB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26870817


    Sources:
    CIViC

  • CITALOPRAM   ABCB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26704739 24192121 22641028 21546862 18215618


    Sources:
    PharmGKB

  • NORTRIPTYLINE   ABCB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12082591


    Sources:
    PharmGKB

  • MICONAZOLE   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15969931


    Sources:
    NCI

  • ARIPIPRAZOLE   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29443543


    Sources:
    PharmGKB

  • SILIBININ   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26595166


    Sources:
    PharmGKB

  • CLOMIPRAMINE   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • RESERPINE   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23273047 22148475


    Sources:
    DTC PharmGKB

  • ZIDOVUDINE   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23996099 22960662 15456083


    Sources:
    NCI PharmGKB

  • ADRIAMYCIN   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1363885 11069027


    Sources:
    NCI

  • SPIRONOLACTONE   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16740618


    Sources:
    NCI PharmGKB

  • SUNITINIB   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27564227 26244574 25778465 24874929 24013576


    Sources:
    PharmGKB

  • ATORVASTATIN   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26932749 21392722 19802823 19238649 18851956 16103896 15616150


    Sources:
    NCI PharmGKB

  • FLUOXETINE   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24663076 24192121 18215618


    Sources:
    PharmGKB

  • CHLORPROMAZINE   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16810505


    Sources:
    NCI PharmGKB

  • LENALIDOMIDE   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29177954


    Sources:
    PharmGKB

  • SUFENTANIL   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LEVETIRACETAM   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DEFEROXAMINE   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12514119


    Sources:
    NCI

  • WARFARIN   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29875668 29432897 25312789 22248286


    Sources:
    PharmGKB

  • IDARUBICIN   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25567217 25558979 20938465 16331627


    Sources:
    PharmGKB

  • CAPSAICIN   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16674925


    Sources:
    NCI

  • NIMODIPINE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14743973


    Sources:
    NCI

  • TEMSIROLIMUS   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28676933


    Sources:
    PharmGKB

  • METHYLPREDNISOLONE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14583680


    Sources:
    PharmGKB

  • RISPERIDONE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29723928 29443543 26129906 24589909 23609392 19997080


    Sources:
    PharmGKB

  • SAQUINAVIR   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PHENOTHIAZINE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16750172


    Sources:
    NCI

  • E-FLUPENTIXOL   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PROPAFENONE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • TENIPOSIDE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • QUININE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PREDNISOLONE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25582575 14583680


    Sources:
    PharmGKB

  • CYTARABINE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25567217 25558979 20938465 16331627


    Sources:
    PharmGKB

  • PRAVASTATIN   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15616150 19667110


    Sources:
    NCI PharmGKB

  • CRIZOTINIB   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26870817


    Sources:
    CIViC

  • DILTIAZEM   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • SIMVASTATIN   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15616150 19891551 19802823 16321621


    Sources:
    NCI PharmGKB

  • TEMOZOLOMIDE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31624332


    Sources:
    PharmGKB

  • SIMEPREVIR   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DAUNORUBICIN   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10500777 25567217 25558979 20938465 16331627


    Sources:
    NCI PharmGKB

  • PHENOBARBITAL   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16928449 25846690


    Sources:
    NCI PharmGKB

  • BLEOMYCIN   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25637052


    Sources:
    PharmGKB

  • VINCRISTINE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29938344 25637052 25582575 22016816 18408561


    Sources:
    PharmGKB

  • OXCARBAZEPINE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28837897


    Sources:
    PharmGKB

  • INDINAVIR   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • BEPRIDIL   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FLUPHENAZINE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LOPERAMIDE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CIMETIDINE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • VINBLASTINE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20363635 21348461


    Sources:
    DTC

  • DOXORUBICIN   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11408511 29938344 22016816 25637052 18377430 25582575 18408561


    Sources:
    NCI PharmGKB

  • FLUVASTATIN   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16002074


    Sources:
    PharmGKB

  • PREDNISONE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25637052 12175731


    Sources:
    PharmGKB

  • LOVASTATIN   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15616150 10213372


    Sources:
    NCI PharmGKB

  • CHEMBL533293   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OMEPRAZOLE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29377228 15976989


    Sources:
    PharmGKB

  • MAPROTILINE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • SIROLIMUS   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14569063 28676933 23073467


    Sources:
    NCI PharmGKB

  • GEFITINIB   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16651435 27089937 25554506 15155841


    Sources:
    NCI PharmGKB

  • DIGOXIN   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16674925 15969931


    Sources:
    NCI

  • CAPECITABINE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22026922 21142915


    Sources:
    PharmGKB

  • MITOMYCIN   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCORTISONE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16873536


    Sources:
    NCI PharmGKB

  • ASTEMIZOLE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ANASTROZOLE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FELODIPINE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LANSOPRAZOLE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17190370


    Sources:
    PharmGKB

  • LAMIVUDINE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23996099


    Sources:
    PharmGKB

  • METHADONE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15876424


    Sources:
    NCI

  • GABAPENTIN   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17328248


    Sources:
    NCI

  • NICARDIPINE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • VEMURAFENIB   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23116250


    Sources:
    PharmGKB

  • FENOFIBRATE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16316932


    Sources:
    NCI

  • PROPOFOL   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29755652


    Sources:
    PharmGKB

  • CLOZAPINE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27168101 22722500 19593168


    Sources:
    PharmGKB

  • TOPOTECAN   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DESIPRAMINE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • EPIRUBICIN   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15161039


    Sources:
    NCI

  • TETRACYCLINE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • COLCHICINE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25876828


    Sources:
    TEND PharmGKB

  • IBUPROFEN   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11583291


    Sources:
    NCI

  • PACLITAXEL   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16467099 16289636 15876424


    Sources:
    DTC NCI CIViC

  • OLANZAPINE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29443543 18086475 17038883


    Sources:
    PharmGKB

  • CARVEDILOL   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CAMPTOTHECIN   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9918583


    Sources:
    NCI

  • MIFEPRISTONE   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MELPHALAN   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ERYTHROMYCIN   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • KETOCONAZOLE   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • RIFAMPIN   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • IMATINIB   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15155841 15805252


    Sources:
    NCI

  • AMIODARONE   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • METHYLPHENIDATE   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23771192


    Sources:
    PharmGKB

  • LITHIUM   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • CURCUMIN   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15090070


    Sources:
    NCI PharmGKB

  • NICOTINE   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16191663


    Sources:
    NCI

  • NIFEDIPINE   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10213372


    Sources:
    NCI

  • CISPLATIN   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29938344 23746184 22016816 21332314 20530282


    Sources:
    PharmGKB

  • LAMOTRIGINE   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ETOPOSIDE   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12969965


    Sources:
    PharmGKB

  • IRINOTECAN   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27845419


    Sources:
    PharmGKB

  • 7-ETHYL-10-HYDROXYCAMPTOTHECIN   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DEXAMETHASONE   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29177954 18408561


    Sources:
    PharmGKB

  • SEVOFLURANE   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • RUCAPARIB   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ATENOLOL   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MIDAZOLAM   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • EVEROLIMUS   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DISULFIRAM   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DOCETAXEL   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21151855


    Sources:
    PharmGKB

  • CARBOPLATIN   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11157479


    Sources:
    NCI

  • MITOXANTRONE   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ERLOTINIB   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DIPYRIDAMOLE   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FLUOROURACIL   ABCB1

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16892554


    Sources:
    NCI

  • TAMOXIFEN   ABCB1

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HALOPERIDOL   ABCB1

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PROGESTERONE   ABCB1

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • SORAFENIB   ABCB1

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000085563

    • Version: 101_38

    Alternate Names:
    ABCB1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P08183

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000085563 Ensembl Gene Id
    P08183 Uniprot Accession
    5243 Entrez Gene Id

    Gene Info:
    Transmembrane Helix Count 12
    Target Subclass ABCB
    Target Subclass Active_transporters

    Publications:

  • TdgClinicalTrial: P08183

    • Version: January-2014

    Alternate Names:
    ABCB1 Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:3.A.1.201.1

    Publications:

  • HopkinsGroom: P08183

    • Version: 11-September-2012

    Alternate Names:
    MDR1_HUMAN Uniprot Id
    ENSG00000085563 Ensembl Gene Id
    MULTIDRUG RESISTANCE PROTEIN 1 Uniprot Protein Name

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001140
    Interpro Short Name ABC_transptr_TM_dom

    Gene Categories:
    ABC TRANSPORTER, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000085563

    • Version: 26-July-2011

    Alternate Names:
    MULTIDRUG RESISTANCE PROTEIN 1 (P-GLYCOPROTEIN 1) (CD243 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P08183] Description
    ENSG00000085563 Ensembl Gene Id
    ABCB1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: ABCB1

    • Version: 18-August-2020

    Alternate Names:
    PA267 PharmGKB ID

    Gene Info:

    Publications:
    Baietto L et al., 2015, Effect of SNPs in human ABCB1 on daptomycin pharmacokinetics in Caucasian patients., J Antimicrob Chemother
    Ehmann F et al., 2014, European Medicines Agency initiatives and perspectives on pharmacogenomics., Br J Clin Pharmacol
    Saiz-Rodríguez M et al., 2018, Effect of ABCB1 C3435T Polymorphism on Pharmacokinetics of Antipsychotics and Antidepressants., Basic Clin Pharmacol Toxicol

  • CIViC: ABCB1

    • Version: 14-September-2020

    Alternate Names:
    5243 Entrez Gene ID
    4244 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Gréen et al., 2006, mdr-1 single nucleotide polymorphisms in ovarian cancer tissue: G2677T/A correlates with response to paclitaxel chemotherapy., Clin. Cancer Res.
    Deguchi Y et al., 2008, Comparison of imatinib, dasatinib, nilotinib and INNO-406 in imatinib-resistant cell lines., Leuk Res
    Katayama R et al., 2015, P-glycoprotein Mediates Ceritinib Resistance in Anaplastic Lymphoma Kinase-rearranged Non-small Cell Lung Cancer., EBioMedicine

  • NCI: ABCB1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Kim et al., 1999, Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein., Pharm. Res.
    Banerjee et al., 1992, Down-regulation of ras and myc expression associated with mdr-1 overexpression in adriamycin-resistant tumor cells., Cell. Mol. Biol.
    Ando et al., 2000, Decitabine (5-Aza-2'-deoxycytidine) decreased DNA methylation and expression of MDR-1 gene in K562/ADM cells., Leukemia

  • DTC: ABCB1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Cunningham CW et al., 2008, Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs., J Med Chem
    Colabufo NA et al., 2008, Synthesis and biological evaluation of (hetero)arylmethyloxy- and arylmethylamine-phenyl derivatives as potent P-glycoprotein modulating agents., J Med Chem
    Juvale K et al., 2012, Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein., Bioorg Med Chem

  • HingoraniCasas: ENSG00000085563

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000085563 Gene Symbol
    ABCB1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: MDR1

    • Version: chembl_23

    Alternate Names:
    PGY1 GENE_SYMBOL
    ABCB1 GENE_SYMBOL
    Multidrug resistance protein 1 UNIPROT

    Gene Info:

    Publications:

  • HumanProteinAtlas: ABCB1

    • Version: 19.3

    Alternate Names:
    ENSG00000085563 Ensembl Gene ID
    ABC20 Human Protein Atlas Gene Synonym
    CD243 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSPORTER, CELL SURFACE, ENZYME

    Publications:

  • GO: ABCB1

    • Version: 01-February-2022

    Alternate Names:
    MDR1 GO Gene Synonym
    PGY1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, ABC TRANSPORTER

    Publications:

  • Tempus: ABCB1

    • Version: 11-November-2018

    Alternate Names:
    ABCB1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • TTD: Multidrug resistance protein 1

    • Version: 2020.06.01

    Alternate Names:
    ABCB1 TTD Gene Abbreviation
    T25258 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: ABCB1

    • Version: 01-February-2022

    Alternate Names:
    Multidrug resistance protein 1 Gene Name
    P08183 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21