DGIdb - ABCC1 Gene Record

ABCC1 4363 Druggable Genome

Alternate Names:

4363
ATP BINDING CASSETTE SUBFAMILY C MEMBER 1
ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
158343
51
ENSG00000103222
OTTHUMG00000048267
P33527
MRP1_HUMAN
MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1
MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 (ATP-BINDING CASSETTE, SUB- FAMILY C, MEMBER 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P33527]
PA244
T11288
DFNA77

Gene Info:

Target Class	Transporters
Target Subclass	TC:3.A.1.208.8
Human Readable Name	DRUGGABLE GENOME
Target Subclass	Active_transporters
Transmembrane Helix Count	16
Target Main Class	Transporters
Target Subclass	ABCC
Interpro Short Name	ABC_transptr_TM_dom
Uniprot Status	Swiss-Prot
Interpro Name	ABC transporter, transmembrane domain
Interpro Type	Domain
Human Readable Name	ABC TRANSPORTER
Interpro Acc	IPR001140
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

TRANSPORTER
ABC TRANSPORTER
DRUGGABLE GENOME

Publications:

Weiss J et al., 2007, Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by nucleoside, nucleotide, and non-nucleoside reverse transcriptase inhibitors., Drug Metab Dispos
Perrotton T et al., 2007, (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1., J Biol Chem
Rappa et al., 2000, Novobiocin-induced VP-16 accumulation and MRP expression in human leukemia and ovarian carcinoma cells., Anticancer Drug Des.
Terashi et al., 2000, Interactions of ofloxacin and erythromycin with the multidrug resistance protein (MRP) in MRP-overexpressing human leukemia cells., Antimicrob. Agents Chemother.
Juvale K et al., 2012, 4-Substituted-2-phenylquinazolines as inhibitors of BCRP., Bioorg Med Chem Lett
Utsunomiya et al., 2000, Comparison of the accumulation and efflux kinetics of technetium-99m sestamibi and technetium-99m tetrofosmin in an MRP-expressing tumour cell line., Eur J Nucl Med
Martel et al., 1997, The MRD1 (P-glycoprotein) and MRP (P-190) transporters do not play a major role in the intrinsic multiple drug resistance of Jurkat T lymphocytes., Leuk. Res.
Xia et al., 2004, [Effects of hypoxia on expression of P-glycoprotein and multidrug resistance protein in human lung adenocarcinoma A549 cell line]., Zhonghua Yi Xue Za Zhi
Coelho AV et al., 2013, ABCB1 and ABCC1 variants associated with virological failure of first-line protease inhibitors antiretroviral regimens in Northeast Brazil patients., J Clin Pharmacol
Raggers et al., 1999, The human multidrug resistance protein MRP1 translocates sphingolipid analogs across the plasma membrane., J. Cell. Sci.
Bakos et al., 2000, Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions., Mol. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Depeille et al., 2004, Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects., Mol. Pharmacol.
Evers et al., 2000, Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export., Br. J. Cancer
Morrow et al., 1998, Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification. Mechanism of GST A1-1- and MRP1-associated resistance to chlorambucil in MCF7 breast carcinoma cells., J. Biol. Chem.
Chen et al., 2000, [Establishment of cisplatin-induced multidrug resistant human epithelial ovarian cancer cell line 3AO/cDDP and its expressions of multidrug resistance proteins]., Zhonghua Fu Chan Ke Za Zhi
Olson et al., 2002, The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1)., AIDS
Benderra et al., 1998, Role of the vacuolar H+-ATPase in daunorubicin distribution in etoposide-resistant MCF7 cells overexpressing the multidrug-resistance associated protein., Int. J. Oncol.
Lorico et al., 1995, Increased rate of adenosine triphosphate-dependent etoposide (VP-16) efflux in a murine leukemia cell line overexpressing the multidrug resistance-associated protein (MRP) gene., Cancer Res.
Perloff et al., 2001, Ritonavir induces P-glycoprotein expression, multidrug resistance-associated protein (MRP1) expression, and drug transporter-mediated activity in a human intestinal cell line., J Pharm Sci
Hooijberg et al., 1999, Potent interaction of flavopiridol with MRP1., Br. J. Cancer
Chu et al., 1999, Active efflux of CPT-11 and its metabolites in human KB-derived cell lines., J. Pharmacol. Exp. Ther.
López-Rodríguez R et al., 2018, Replication study of polymorphisms associated with response to methotrexate in patients with rheumatoid arthritis., Sci Rep
Lima A et al., 2015, Pharmacogenomics of Methotrexate Membrane Transport Pathway: Can Clinical Response to Methotrexate in Rheumatoid Arthritis Be Predicted?, Int J Mol Sci
Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics
Warren RB et al., 2008, Genetic variation in efflux transporters influences outcome to methotrexate therapy in patients with psoriasis., J Invest Dermatol
Gourdeau et al., 2002, Antitumor activity of troxacitabine (Troxatyl) against anthracycline-resistant human xenografts., Cancer Chemother. Pharmacol.
Goldsborough AS et al., 2011, Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin., J Med Chem
Oshiro C et al., 2009, Taxane pathway., Pharmacogenet Genomics
Hosoi et al., 1998, Effect of MDR antagonists on the cidal activity of vincristine for cells expressing MDR-1 is superior to those expressing MRP., Int. J. Oncol.
Laochariyakul et al., 2003, Functional study of intracellular P-gp- and MRP1-mediated pumping of free cytosolic pirarubicin into acidic organelles in intrinsic resistant SiHa cells., Can. J. Physiol. Pharmacol.
Wang et al., 1998, Transcriptional suppression of multidrug resistance-associated protein (MRP) gene expression by wild-type p53., Cancer Res.
Clinckers et al., 2005, Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: concomitant use of hippocampal monoamines as pharmacodynamic markers for the anticonvulsant activity., J. Pharmacol. Exp. Ther.
Wong IL et al., 2009, Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives., J Med Chem
Wang et al., 2004, Annexin-I expression modulates drug resistance in tumor cells., Biochem. Biophys. Res. Commun.
Seral et al., 2003, Influence of P-glycoprotein and MRP efflux pump inhibitors on the intracellular activity of azithromycin and ciprofloxacin in macrophages infected by Listeria monocytogenes or Staphylococcus aureus., J. Antimicrob. Chemother.
Wittgen HG et al., 2011, Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1, MRP2, MRP3, and MRP4., Drug Metab Dispos
Gao C et al., 2012, Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics., Drug Metab Dispos
Gollapudi et al., 1997, Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells., Cancer Chemother. Pharmacol.
Li M et al., 2018, ABC transporter polymorphisms are associated with irinotecan pharmacokinetics and neutropenia., Pharmacogenomics J
Wojnowski L et al., 2005, NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity., Circulation
Li et al., 1999, [Modulation of multiple drug resistance by nomegestrol acetate and droloxifene in K562/A02]., Zhonghua Xue Ye Xue Za Zhi
Perez-Soler et al., 1997, Annamycin circumvents resistance mediated by the multidrug resistance-associated protein (MRP) in breast MCF-7 and small-cell lung UMCC-1 cancer cell lines selected for resistance to etoposide., Int. J. Cancer
Zembruski NC et al., 2011, Interaction potential of etravirine with drug transporters assessed in vitro., Antimicrob Agents Chemother
Bour-Dill et al., 2000, Determination of intracellular organelles implicated in daunorubicin cytoplasmic sequestration in multidrug-resistant MCF-7 cells using fluorescence microscopy image analysis., Cytometry
Lee WY et al., 2010, Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells., J Nat Prod
Hong et al., 2003, Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites., Biochem. Biophys. Res. Commun.

ANNAMYCIN ABCC1

Interaction Score: 2.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9096663

Sources:
NCI
DEXVERAPAMIL ABCC1

Interaction Score: 2.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17646169

Sources:
DTC
TROXACITABINE ABCC1

Interaction Score: 2.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12451476

Sources:
NCI
TIOPRONIN ABCC1

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21657271

Sources:
DTC
SULFINPYRAZONE ABCC1

Interaction Score: 0.93

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9885294 10727523 11752352 15044619 10917554 9685354

Sources:
TdgClinicalTrial TEND TTD
SCUTELLARIN ABCC1

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22822035

Sources:
DTC
EMTRICITABINE ABCC1

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17172311

Sources:
DTC
(S)-VERAPAMIL ABCC1

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17646169

Sources:
DTC
MK-571 ABCC1

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19725578

Sources:
DTC
DELAVIRDINE ABCC1

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17172311

Sources:
DTC
THYMIDINE ABCC1

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9379682

Sources:
NCI
NOVOBIOCIN ABCC1

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10901300

Sources:
NCI
DROLOXIFENE ABCC1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11721384

Sources:
NCI
PROBENECID ABCC1

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9182837

Sources:
NCI
RIMONABANT ABCC1

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21511945

Sources:
DTC
ETOPOSIDE PHOSPHATE ABCC1

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7671247

Sources:
NCI
PIRARUBICIN ABCC1

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12897808

Sources:
NCI
IRINOTECAN HYDROCHLORIDE ABCC1

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9918583

Sources:
NCI
TENIPOSIDE ABCC1

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9865734

Sources:
NCI
LAMIVUDINE ABCC1

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12218384 17172311 23996099

Sources:
DTC NCI PharmGKB
AZITHROMYCIN ABCC1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12697643

Sources:
NCI
LOPINAVIR ABCC1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23996099

Sources:
PharmGKB
RITONAVIR ABCC1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11745741 23996099

Sources:
NCI PharmGKB
ABACAVIR ABCC1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17172311

Sources:
DTC
OFLOXACIN ABCC1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10817732

Sources:
NCI
TENOFOVIR ABCC1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17172311

Sources:
DTC
PILOCARPINE ABCC1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15860570

Sources:
NCI
EFAVIRENZ ABCC1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21189339 17172311

Sources:
DTC
ALVOCIDIB ABCC1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10496352

Sources:
NCI
MELPHALAN ABCC1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14733945

Sources:
NCI
ADRIAMYCIN ABCC1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15130309

Sources:
NCI
ERYTHROMYCIN ABCC1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10817732

Sources:
NCI
VERAPAMIL ABCC1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19725578 17646169

Sources:
DTC
NEVIRAPINE ABCC1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17172311

Sources:
DTC
EPIGALOCATECHIN GALLATE ABCC1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14511674

Sources:
NCI
7-ETHYL-10-HYDROXYCAMPTOTHECIN ABCC1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27845419

Sources:
PharmGKB
BENZBROMARONE ABCC1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ZIDOVUDINE ABCC1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23996099

Sources:
PharmGKB
CYCLOSPORINE ABCC1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23017888 11189941

Sources:
DTC NCI
ETOPOSIDE ABCC1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9472114 7671247

Sources:
NCI
INDOMETHACIN ABCC1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20455578

Sources:
DTC
MONTELUKAST ABCC1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
METHOTREXATE ABCC1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29743634 26086825 21317831 18256692

Sources:
PharmGKB
DIPYRIDAMOLE ABCC1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9664131

Sources:
NCI
DAUNORUBICIN ABCC1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10655559

Sources:
NCI
DOCETAXEL ABCC1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21151855

Sources:
PharmGKB
DOXORUBICIN ABCC1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16330681

Sources:
PharmGKB
PACLITAXEL ABCC1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21151855

Sources:
PharmGKB
VINCRISTINE ABCC1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CISPLATIN ABCC1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11372415

Sources:
NCI

Ensembl: ENSG00000103222
- Version: 101_38
Alternate Names:

ABCC1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P33527
- Version: January-2014
Alternate Names:

ABCC1 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:3.A.1.208.8

Publications:
HopkinsGroom: P33527
- Version: 11-September-2012
Alternate Names:

P33527 Uniprot Accession

ENSG00000103222 Ensembl Gene Id

MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 Uniprot Protein Name

Gene Info:

Interpro Short Name ABC_transptr_TM_dom

Uniprot Status Swiss-Prot

Interpro Name ABC transporter, transmembrane domain

Gene Categories:

ABC TRANSPORTER, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000103222

Version: 26-July-2011

Alternate Names:

ABCC1 Display Id

ENSG00000103222 Ensembl Gene Id

MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 (ATP-BINDING CASSETTE, SUB- FAMILY C, MEMBER 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P33527] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TEND: P33527
- Version: 01-August-2011
Alternate Names:

MRP1_HUMAN Uniprot Id

ABCC1 Gene Symbol

ENSG00000103222 Ensembl Gene Id

Gene Info:

Target Subclass Active_transporters

Transmembrane Helix Count 16

Target Main Class Transporters

Publications:

PharmGKB: ABCC1

Version: 18-August-2020

Alternate Names:

PA244 PharmGKB ID

Gene Info:

Publications:

Visscher H et al., 2013, Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children., Pediatr Blood Cancer

Visscher H et al., 2012, Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children., J Clin Oncol

Wojnowski L et al., 2005, NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity., Circulation

NCI: ABCC1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Utsunomiya et al., 2000, Comparison of the accumulation and efflux kinetics of technetium-99m sestamibi and technetium-99m tetrofosmin in an MRP-expressing tumour cell line., Eur J Nucl Med

Hooijberg et al., 1999, Potent interaction of flavopiridol with MRP1., Br. J. Cancer

Seral et al., 2003, Influence of P-glycoprotein and MRP efflux pump inhibitors on the intracellular activity of azithromycin and ciprofloxacin in macrophages infected by Listeria monocytogenes or Staphylococcus aureus., J. Antimicrob. Chemother.

DTC: ABCC1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Weiss J et al., 2007, Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by nucleoside, nucleotide, and non-nucleoside reverse transcriptase inhibitors., Drug Metab Dispos

Perrotton T et al., 2007, (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1., J Biol Chem

Zembruski NC et al., 2011, Interaction potential of etravirine with drug transporters assessed in vitro., Antimicrob Agents Chemother

HingoraniCasas: ENSG00000103222
- Version: 31-May-2017
Alternate Names:

ENSG00000103222 Gene Symbol

ABCC1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: ABCC1
- Version: 01-February-2022
Alternate Names:

MRP GO Gene Synonym

MRP1 GO Gene Synonym

Gene Info:

Gene Categories:

ABC TRANSPORTER

Publications:
TTD: Multidrug resistance-associated protein 1
- Version: 2020.06.01
Alternate Names:

ABCC1 TTD Gene Abbreviation

T11288 TTD Target ID

Gene Info:

Publications:
Pharos: ABCC1
- Version: 01-February-2022
Alternate Names:

Multidrug resistance-associated protein 1 Gene Name

P33527 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:

P33527	Uniprot Accession
ENSG00000103222	Ensembl Gene Id
MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1	Uniprot Protein Name

ABCC1	Display Id
ENSG00000103222	Ensembl Gene Id
MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 (ATP-BINDING CASSETTE, SUB- FAMILY C, MEMBER 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P33527]	Description

MRP1_HUMAN	Uniprot Id
ABCC1	Gene Symbol
ENSG00000103222	Ensembl Gene Id

Multidrug resistance-associated protein 1	Gene Name
P33527	UniProt ID

Trial Name	-
Novel drug target	Established target

ABCC1 Gene Record

ABCC1 4363 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9096663

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17646169

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12451476

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21657271

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 9885294 10727523 11752352 15044619 10917554 9685354

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22822035

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17172311

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17646169

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19725578

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17172311

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9379682

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10901300

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11721384

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9182837

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21511945

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7671247

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12897808

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9918583

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
9096663

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17646169

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
12451476

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21657271

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9885294 10727523 11752352 15044619 10917554 9685354

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
22822035

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17172311

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17646169

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19725578

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17172311

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9379682

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10901300

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11721384

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9182837

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21511945

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
7671247

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12897808

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9918583

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9865734

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12218384 17172311 23996099

Sources:
DTC NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12697643

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23996099

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11745741 23996099

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17172311

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10817732

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17172311

Sources:
DTC

Interaction Types & Directionality:

n/a