DGIdb - ABCC3 Gene Record

ABCC3 8714 Druggable GenomeDrug Resistance

Alternate Names:

8714
ATP BINDING CASSETTE SUBFAMILY C MEMBER 3
ABCC3
ABC31
EST90757
MLP2
MOAT-D
MRP3
cMOAT2
604323
54
ENSG00000108846
OTTHUMG00000162245
O15438
CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 2
MRP3_HUMAN
CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 2 (MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 3) (MULTI-SPECIFIC ORGANIC ANION TRANPORTER-D) (MOAT-D). [SOURCE:UNIPROT/SWISSPROT;ACC:O15438]
6906
PA376

Gene Info:

Uniprot Evidence	1: Evidence at protein level
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Interpro Name	ABC transporter, transmembrane domain
Interpro Short Name	ABC_transptr_TM_dom
Human Readable Name	DRUGGABLE GENOME
Human Readable Name	ABC TRANSPORTER
Interpro Acc	IPR001140
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

TRANSPORTER
DRUG RESISTANCE
ABC TRANSPORTER
DRUGGABLE GENOME

Publications:

Weiss J et al., 2007, Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by nucleoside, nucleotide, and non-nucleoside reverse transcriptase inhibitors., Drug Metab Dispos
O'Brien et al., 2008, Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer., Cancer Res.
Caronia D et al., 2011, Effect of ABCB1 and ABCC3 polymorphisms on osteosarcoma survival after chemotherapy: a pharmacogenetic study., PLoS One
Ansari M et al., 2012, Polymorphism in multidrug resistance-associated protein gene 3 is associated with outcomes in childhood acute lymphoblastic leukemia., Pharmacogenomics J
Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics
de Waart DR et al., 2012, Oral availability of cefadroxil depends on ABCC3 and ABCC4., Drug Metab Dispos
Clemens E et al., 2020, Genetic variation of cisplatin-induced ototoxicity in non-cranial-irradiated pediatric patients using a candidate gene approach: The International PanCareLIFE Study., Pharmacogenomics J
Spracklen TF et al., 2017, Promoter region variation in NFE2L2 influences susceptibility to ototoxicity in patients exposed to high cumulative doses of cisplatin., Pharmacogenomics J
Carleton BC et al., 2014, Genetic markers of cisplatin-induced hearing loss in children., Clin Pharmacol Ther
Hahn D et al., 2020, Influence of MRP3 Genetics and Hepatic Expression Ontogeny for Morphine Disposition in Neonatal and Pediatric Patients., J Clin Pharmacol
Wittgen HG et al., 2011, Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1, MRP2, MRP3, and MRP4., Drug Metab Dispos
Zembruski NC et al., 2011, Interaction potential of etravirine with drug transporters assessed in vitro., Antimicrob Agents Chemother

CEFAMANDOLE ABCC3

Interaction Score: 1.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
CEFMETAZOLE ABCC3

Interaction Score: 1.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
CEFOXITIN ABCC3

Interaction Score: 1.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
EMTRICITABINE ABCC3

Interaction Score: 1.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17172311

Sources:
DTC
ETRAVIRINE ABCC3

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21189339

Sources:
DTC
CEPHRADINE ABCC3

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
CEFUROXIME ABCC3

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
CEPHALEXIN ABCC3

Interaction Score: 0.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
DELAVIRDINE ABCC3

Interaction Score: 0.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17172311

Sources:
DTC
RIMONABANT ABCC3

Interaction Score: 0.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21511945

Sources:
DTC
CEFOPERAZONE ABCC3

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
ABACAVIR ABCC3

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17172311

Sources:
DTC
CEFTRIAXONE ABCC3

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
TENOFOVIR ABCC3

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17172311

Sources:
DTC
EFAVIRENZ ABCC3

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21189339 17172311

Sources:
DTC
CEFACLOR ABCC3

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
LAMIVUDINE ABCC3

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17172311

Sources:
DTC PharmGKB
NEVIRAPINE ABCC3

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17172311

Sources:
DTC
MORPHINE ABCC3

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
32090339

Sources:
PharmGKB
METHOTREXATE ABCC3

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22016816 21606946 21317831

Sources:
PharmGKB
VINCRISTINE ABCC3

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22016816

Sources:
PharmGKB
CISPLATIN ABCC3

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31666714 27457817 25141953 22016816

Sources:
PharmGKB
DOXORUBICIN ABCC3

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22016816

Sources:
DTC PharmGKB
CYCLOPHOSPHAMIDE ABCC3

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22016816

Sources:
PharmGKB
PACLITAXEL ABCC3

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18593940

Sources:
CIViC

Ensembl: ENSG00000108846
- Version: 101_38
Alternate Names:

ABCC3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000108846

Version: 26-July-2011

Alternate Names:

ABCC3 Display Id

CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 2 (MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 3) (MULTI-SPECIFIC ORGANIC ANION TRANPORTER-D) (MOAT-D). [SOURCE:UNIPROT/SWISSPROT;ACC:O15438] Description

ENSG00000108846 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: O15438
- Version: 11-September-2012
Alternate Names:

ABCC3 Uniprot Gene Name

CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 2 Uniprot Protein Name

8714 Entrez Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Type Domain

Uniprot Status Swiss-Prot

Gene Categories:

ABC TRANSPORTER, DRUGGABLE GENOME

Publications:

PharmGKB: ABCC3

Version: 18-August-2020

Alternate Names:

PA376 PharmGKB ID

Gene Info:

Publications:

Carleton BC et al., 2014, Genetic markers of cisplatin-induced hearing loss in children., Clin Pharmacol Ther

Caronia D et al., 2011, Effect of ABCB1 and ABCC3 polymorphisms on osteosarcoma survival after chemotherapy: a pharmacogenetic study., PLoS One

Clemens E et al., 2020, Genetic variation of cisplatin-induced ototoxicity in non-cranial-irradiated pediatric patients using a candidate gene approach: The International PanCareLIFE Study., Pharmacogenomics J

CIViC: ABCC3
- Version: 14-September-2020
Alternate Names:

8714 Entrez Gene ID

6906 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

O'Brien et al., 2008, Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer., Cancer Res.

DTC: ABCC3

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Weiss J et al., 2007, Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by nucleoside, nucleotide, and non-nucleoside reverse transcriptase inhibitors., Drug Metab Dispos

de Waart DR et al., 2012, Oral availability of cefadroxil depends on ABCC3 and ABCC4., Drug Metab Dispos

Zembruski NC et al., 2011, Interaction potential of etravirine with drug transporters assessed in vitro., Antimicrob Agents Chemother

HingoraniCasas: ENSG00000108846
- Version: 31-May-2017
Alternate Names:

ENSG00000108846 Gene Symbol

ABCC3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: ABCC3
- Version: 01-February-2022
Alternate Names:

CMOAT2 GO Gene Synonym

MLP2 GO Gene Synonym

MRP3 GO Gene Synonym

Gene Info:

Gene Categories:

ABC TRANSPORTER

Publications:
Tempus: ABCC3
- Version: 11-November-2018
Alternate Names:

ABCC3 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: ABCC3
- Version: 01-February-2022
Alternate Names:

Canalicular multispecific organic anion transporter 2 Gene Name

O15438 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:

ABCC3	Display Id
CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 2 (MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 3) (MULTI-SPECIFIC ORGANIC ANION TRANPORTER-D) (MOAT-D). [SOURCE:UNIPROT/SWISSPROT;ACC:O15438]	Description
ENSG00000108846	Ensembl Gene Id

ABCC3	Uniprot Gene Name
CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 2	Uniprot Protein Name
8714	Entrez Gene Id

Canalicular multispecific organic anion transporter 2	Gene Name
O15438	UniProt ID

ABCC3 Gene Record

ABCC3 8714 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17172311

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21189339

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17172311

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21511945

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17172311

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17172311

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21189339 17172311

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17172311

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17172311

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17172311

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21189339

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17172311

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21511945

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17172311

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17172311

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21189339 17172311

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17172311

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17172311

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
32090339

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22016816 21606946 21317831

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22016816

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
31666714 27457817 25141953 22016816

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22016816

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22016816

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18593940

Sources:
CIViC

Alternate Names:

ABCC3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ABCC3 Display Id

CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 2 (MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 3) (MULTI-SPECIFIC ORGANIC ANION TRANPORTER-D) (MOAT-D). [SOURCE:UNIPROT/SWISSPROT;ACC:O15438] Description

ENSG00000108846 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME