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ABCC9 Gene Record

  • Summary
  • Interactions
  • Claims
  • ABCC9 10060 Druggable Genome

    Alternate Names:

    10060
    ATP BINDING CASSETTE SUBFAMILY C MEMBER 9
    ABCC9
    ABC37
    ATFB12
    CANTU
    CMD1O
    SUR2
    601439
    60
    ENSG00000069431
    OTTHUMG00000169094
    O60706
    ABCC9_HUMAN
    ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 9
    2746
    Sulfonylurea receptor 2
    BE0000469
    SULFONYLUREA RECEPTOR 2. [SOURCE:UNIPROT/SWISSPROT;ACC:O60706]
    NM_005691|NM_020297
    NP_005682|NP_064693
    PA396
    ATP-binding cassette transporter C9
    T02777

    Gene Info:

    Interpro Name ABC transporter, transmembrane domain
    Interpro Short Name ABC_transptr_TM_dom
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001140
    Interpro Type Domain
    Human Readable Name ABC TRANSPORTER
    Uniprot Evidence 1: Evidence at protein level
    GuideToPharmacology Gene Category Name ABCC subfamily
    GuideToPharmacology Gene Category ID 153
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    ABC TRANSPORTER
    DRUGGABLE GENOME

    Publications:

    Rainbow et al., 2004, Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels., Biochem. J.
    Wang et al., 2007, Involvement of ATP-sensitive potassium channels in proliferation and differentiation of rat preadipocytes., Sheng Li Xue Bao
    Zhao et al., 2006, Pretreatment with fosinopril or valsartan reduces myocardial no-reflow after acute myocardial infarction and reperfusion., Coron. Artery Dis.
    Hambrock et al., 2002, Glibenclamide binding to sulphonylurea receptor subtypes: dependence on adenine nucleotides., Br. J. Pharmacol.
    Felsch et al., 2004, Interaction of a novel dihydropyridine K+ channel opener, A-312110, with recombinant sulphonylurea receptors and KATP channels: comparison with the cyanoguanidine P1075., Br. J. Pharmacol.
    Hirvensalo P et al., 2018, Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics., Clin Pharmacol Ther
    Russ et al., 2003, Binding and effect of K ATP channel openers in the absence of Mg2+., Br. J. Pharmacol.
    Yang et al., 2007, Post-infarction treatment with simvastatin reduces myocardial no-reflow by opening of the KATP channel., Eur. J. Heart Fail.
    Bryan et al., 2007, ABCC8 and ABCC9: ABC transporters that regulate K+ channels., Pflugers Arch.
  • NICORANDIL   ABCC9

    Interaction Score: 3.1

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    12770942


    Sources:
    TTD DrugBank

  • GLYBURIDE   ABCC9

    Interaction Score: 1.35

    Interaction Types & Directionality:
    modulator

    Interaction Info:

    PMIDs:
    14672537 17294036 16845255 12145099 15023854


    Sources:
    DrugBank

  • SARAKALIM   ABCC9

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Sulfonylurea receptors; K-ATP channels opener
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PINACIDIL   ABCC9

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Sulfonylurea receptor 2, Kir6.2 opener
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NAMINIDIL   ABCC9

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sulfonylurea receptors; K-ATP channels opener

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TOLBUTAMIDE   ABCC9

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • GLIMEPIRIDE   ABCC9

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MONTELUKAST   ABCC9

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28940478


    Sources:
    PharmGKB

  • MINOXIDIL   ABCC9

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Sulfonylurea receptor 2, Kir6.2 opener
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ADENOSINE TRIPHOSPHATE   ABCC9

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16829188 16897043 16845255


    Sources:
    DrugBank

  • REPAGLINIDE   ABCC9

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Ensembl: ENSG00000069431

    • Version: 101_38

    Alternate Names:
    ABCC9 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000069431

    • Version: 26-July-2011

    Alternate Names:
    SULFONYLUREA RECEPTOR 2. [SOURCE:UNIPROT/SWISSPROT;ACC:O60706] Description
    ABCC9 Display Id
    ENSG00000069431 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: O60706

    • Version: 11-September-2012

    Alternate Names:
    ABCC9 Uniprot Gene Name
    O60706 Uniprot Accession
    10060 Entrez Gene Id

    Gene Info:
    Interpro Name ABC transporter, transmembrane domain
    Interpro Short Name ABC_transptr_TM_dom
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    ABC TRANSPORTER, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 10060

    • Version: 29-September-2020

    Alternate Names:
    60 HUGO Gene ID
    60 HUGO Gene Symbol
    ATP binding cassette subfamily C member 9 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name ABCC subfamily
    GuideToPharmacology Gene Category ID 153

    Gene Categories:
    TRANSPORTER

    Publications:

  • PharmGKB: ABCC9

    • Version: 18-August-2020

    Alternate Names:
    PA396 PharmGKB ID

    Gene Info:

    Publications:
    Hirvensalo P et al., 2018, Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics., Clin Pharmacol Ther

  • DrugBank: BE0000469

    • Version: 5.1.7

    Alternate Names:
    ABCC9 DrugBank Gene Name
    O60706 UniProt Accession
    10060 Entrez Gene Id

    Gene Info:

    Publications:
    Yang et al., 2007, Post-infarction treatment with simvastatin reduces myocardial no-reflow by opening of the KATP channel., Eur. J. Heart Fail.
    Bryan et al., 2007, ABCC8 and ABCC9: ABC transporters that regulate K+ channels., Pflugers Arch.
    Zhao et al., 2006, Pretreatment with fosinopril or valsartan reduces myocardial no-reflow after acute myocardial infarction and reperfusion., Coron. Artery Dis.

  • ChemblInteractions: SUR2

    • Version: chembl_23

    Alternate Names:
    SUR2 GENE_SYMBOL
    ABCC9 GENE_SYMBOL
    ATP-binding cassette sub-family C member 9 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000069431

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000069431 Gene Symbol
    ABCC9 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: ABCC9

    • Version: 03-September-2020

    Alternate Names:
    ATP-binding cassette sub-family C member 9 Gene Name
    O60706 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

  • GO: ABCC9

    • Version: 05-September-2020

    Alternate Names:
    SUR2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    ABC TRANSPORTER

    Publications:

  • TTD: ATP-binding cassette transporter C9

    • Version: 2020.06.01

    Alternate Names:
    ABCC9 TTD Gene Abbreviation
    T02777 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21